Online citations, reference lists, and bibliographies.
← Back to Search

Evaluation Of Polymeric Nanoparticles Composed Of Cholic Acid And Methoxy Poly(ethylene Glycol).

I. Kim, S. H. Kim
Published 2001 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Amphiphilic polymeric conjugate based on cholic acid (CA) as the hydrophobic component and methoxy poly(ethylene glycol) (MPEG) as the hydrophilic component was synthesized using a 1,1'-carbonyldiimidazole (CDI) mediated conjugation. Fluorescence spectroscopy measurements suggested that CA and MPEG (abbreviated as CE) conjugate was associated in water to form polymeric core-shell type nanoparticles with a critical association concentration (CAC) value of 0.063 g l(-1). From the transmission electron microscope (TEM) observation, CE nanoparticles were almost spherical with a size range of approximately 10-30 nm in the dried state, which was in agreement with the result from particle size measurement using photon correlation spectroscopy (PCS). Clonazepam (CNZ) was physically loaded into the CE nanoparticles with a 16.2 wt.% loading. CNZ release was pseudo zero-order in kinetic terms for up to 3 days.
This paper references
Self-assembled hydrogel nanoparticles composed of dextran and poly(ethylene glycol) macromer.
I. Kim (2000)
Sensitivity enhancement of optical immunosensors with nanoparticles.
S. Kubitschko (1997)
Cellular Uptake of PEO Surface-Modified Nanoparticles: Evaluation of Nanoparticles Made of PLA: PEO Diblock and Triblock Copolymers
F. Jaeghere (2000)
Preparation of polymeric nanoparticles composed of cholic acid and poly(ethylene glycol) end-capped with a sugar moiety
I. Kim (2000)
Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly(ethylene oxide-aspartate) block copolymer-Adriamycin conjugates
G. Kwon (1994)
Pharmacokinetics of a novel HIV-1 protease inhibitor incorporated into biodegradable or enteric nanoparticles following intravenous and oral administration to mice.
J. C. Leroux (1995)
Environmental effects on vibronic band intensities in pyrene monomer fluorescence and their application in studies of micellar systems
K. Kalyanasundaram (1977)
Synthesis and characterization of block copolymers from D, L‐lactide and poly(ethylene glycol) with stannous chloride
X. Deng (1990)
Poly(styrene-ethylene oxide) block copolymer micelle formation in water: a fluorescence probe study
M. Wilhelm (1991)
Protein-resistant surfaces prepared by PEO-containing block copolymer surfactants.
J. Lee (1989)
Nanoparticle-based dmg delivery systems
J. Kreuter (1991)
Biodegradable long-circulating polymeric nanospheres.
R. Gref (1994)
Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood.
M. Yokoyama (1991)
Core-shell type polymeric nanoparticles composed of poly(L-lactic acid) and poly(N-isopropylacrylamide).
I. Kim (2000)
Synthesis of block polyesteramides containing biodegradable poly(L,L-lactide) segments.
Salvatore Andini (1988)
Biodistribution of Micelle-Forming Polymer–Drug Conjugates
G. Kwon (2004)
Nanoparticle technology for delivery of drugs across the blood-brain barrier.
U. Schroeder (1998)
Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer.
M. Yokoyama (1990)

This paper is referenced by
Polymeric nanoparticle composed of fatty acids and poly(ethylene glycol) as a drug carrier.
J. Lee (2003)
Development of polymeric nanoparticulate drug delivery systems: evaluation of nanoparticles based on biotinylated poly(ethylene glycol) with sugar moiety.
I. Kim (2003)
Well-defined, size-tunable, multifunctional micelles for efficient paclitaxel delivery for cancer treatment.
J. Luo (2010)
Formulation and evaluation of nanoparticles of some anticancer drugs for targeted delivery
Riddhi M. Dave (2013)
Développement de tensioactifs à base d’acides biliaires pegylés pour des applications pharmaceutiques
Frantz Le Dévédec (2013)
Using TEM to couple transient protein distribution and release for PLGA microparticles for potential use as vaccine delivery vehicles.
A. Zhao (2006)
Methoxy poly(ethylene glycol)-conjugated linoleic acid polymeric micelles for paclitaxel delivery
X. Feng (2006)
Synthesis of novel biodegradable and self-assembling methoxy poly(ethylene glycol)-palmitate nanocarrier for curcumin delivery to cancer cells.
A. Sahu (2008)
Biomaterials made of bile acids
J. Zhang (2009)
Surface Modification of Functional Nanoparticles for Controlled Drug Delivery
S. Choi (2003)
Aggregation behavior of pegylated bile acid derivatives.
F. Le Dévédec (2012)
Curcumin-loaded PLGA-PEG-PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo.
Zhimei Song (2011)
Self‐aggregates of cholic acid hydrazide–dextran conjugates as drug carriers
Qingguo Xu (2005)
Biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol) copolymers as drug delivery system.
Xiawei Wei (2009)
Adhesion, Friction, and Lubrication of Polymeric Nanoparticles and their Applications
Bassem A. Kheireddin (2013)
Renewable Biomaterials as Nanocarriers for Drug and Gene Delivery
Shi-miao Zhang (2017)
Acid-cleavable polymeric core-shell particles for delivery of hydrophobic drugs.
Y. Chan (2006)
A Synopsis of Nano-Technological Approaches Toward Anti-Epilepsy Therapy: Present and Future Research Implications.
N. Jabir (2015)
Preparation and characterization of stearic acid-pullulan nanoparticles
I. Kim (2010)
Surface-functionalized nanoparticles for controlled drug delivery.
S. Choi (2005)
In vitro and in vivo safety evaluation of biodegradable self-assembled monomethyl poly (ethylene glycol)-poly (ε-caprolactone)-poly (trimethylene carbonate) micelles.
Xi Yang (2014)
Sistemas poliméricos coloidais como meios de contraste em Imageologia por Ressonância Magnética
S. Gameiro (2004)
Development of a polymeric nanoparticulate drug delivery system. In vitro characterization of nanoparticles based on sugar-containing conjugates.
I. Kim (2002)
Surfactant free fabrication of polymeric nanoparticles by combined liquid-liquid phase separation and solvent/nonsolvent mixing technology.
J. Xiong (2004)
Self-assembling nanocomposites for protein delivery: supramolecular interactions between PEG-cholane and rh-G-CSF.
S. Salmaso (2012)
Semantic Scholar Logo Some data provided by SemanticScholar