Online citations, reference lists, and bibliographies.
← Back to Search

Distribution Of Salicylic Acid In Human Stratum Corneum Following Topical Application In Vivo: A Comparison Of Six Different Formulations.

J. Tsai, S. Chuang, M. Hsu, H. Sheu
Published 1999 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Distribution of salicylic acid in human stratum corneum from treatment of six different formulations was assessed by quantitation of drug content in sequentially tape-stripped stratum corneum after a single 2-h dose was applied unoccluded to skin on the ventral forearm of four female subjects. The profile and total amounts of stratum corneum removed in 20 tape-strips varied among different types of formulations. With or without normalization by the total stratum corneum weights removed, the extent of drug delivery to the stratum corneum decreased in the following order: SA (5%) > > SAC (10%), Duofilm (16.7%) > TSSS (2%) > SAO (10%), Salic (2.5%), the percentage in parentheses indicating the salicylic acid concentration in each formulation. The greatest topical bioavailability was observed for the alcoholic solution containing glycerol (SA). The 10% collodion formulation (SAC) was found to deliver an amount of salicylic acid into the stratum corneum 2-fold greater than 10% ointment formulation (SAO). Use of absorption ointment (TSSS) also increased the uptake of salicylic acid into the stratum corneum in comparison with formulations based on simple ointment (SAO) and oil in water (o/w) cream (Salic). The partitioning of salicylic acid from collodion formulations (SAC and Duofilm) appeared to be concentration-independent. The results of this study indicate that topical bioavailability of salicylic acid in the stratum corneum varies substantially among different formulations.
This paper references



This paper is referenced by
10.1080/01932690701346008
Study on the Photodegradation of Salicylic Acid in Different Vehicles in the Absence and in the Presence of TiO2
M. E. Carlotti (2007)
Evaluation of the pharmaceutical availability of erythromycin from topical formulations
Nyaradzo Mandimika (2008)
Combination therapy with hydrogen peroxide (4%), salicylic acid (0.5%) and D-panthenol (4%): efficacy and skyn tolerability in common acne vulgaris during sun exposure period.
F. Ricci (2016)
10.1016/J.JCHROMB.2007.01.031
Stable isotope dilution analysis of salicylic acid and hydroquinone in human skin samples by gas chromatography with mass spectrometric detection.
A. Judefeind (2007)
10.1016/J.DYEPIG.2017.08.039
Pyreneamide-based dipodal probes for ultra-sensitive and selective detection of 3,5-dinitrosalicylic acid in an aqueous solution
A. Kumar (2017)
10.1002/JPS.10536
Evaluation of in vivo bioequivalence methodology for topical clobetasol 17-propionate based on pharmacodynamic modeling using Chinese skin.
J. Tsai (2004)
10.1016/J.CEJ.2015.10.063
Selective separation of phenol from salicylic acid effluent over molecularly imprinted polystyrene nanospheres composite alumina membranes
Y. Liu (2016)
10.4333/KPS.2002.32.3.161
In Vitro and In Vivo Studies of Topical Delivery System of Gentisic Acid in Hairless Mice
Sheng Jie Bian (2002)
10.3109/03639045.2010.550299
Formulation study of topically applied O/W lotion containing vitamin D3 derivative, focusing on skin permeability of the drug
Shin-Ichi Harada (2011)
10.1016/J.IJPHARM.2004.11.032
Cutaneous bioassay of salicylic acid as a keratolytic.
S. Bashir (2005)
10.18433/J3C01R
Comparison of tape stripping with the human skin blanching assay for the bioequivalence assessment of topical clobetasol propionate formulations.
W. L. Au (2010)
10.1055/s-0033-1355351
Development and in-vitro characterization of fish oil oleogels containing benzoyl peroxide and salicylic acid as keratolytic agents.
K. Rehman (2014)
Towards a comprehensive resource for elucidating the pathogenesis of inherited keratodermas
M. Zamiri (2010)
10.1080/02652040802211345
Effect of alginate-pectin composition on drug release characteristics of microcapsules
S. Jaya (2009)
10.1016/S1773-2247(04)50023-0
Study on the release properties and stability of o/w emulsions containing salicylic acid and zinc oxide
M. E. Carlotti (2004)
10.4172/PHARMACEUTICAL-SCIENCES.1000255
Dermal and Transdermal Delivery of Active Substances from Semisolid Bases
A. Jankowski (2017)
10.1016/S0939-6411(01)00166-7
Passive skin penetration enhancement and its quantification in vitro.
K. Moser (2001)
10.1016/j.ejps.2010.11.003
Relevance of equivalence assessment of topical products based on the dermatopharmacokinetics approach.
A. Boix-Montañés (2011)
10.1002/JPS.21109
Relative bioavailability of salicylic acid following dermal application of a 30% salicylic acid skin peel preparation.
W. Fung (2008)
Evaluation of Effect of Temperature & Pressure on the Bioavailability of Diclofenac Topical Formulation
Rahul Mayee (2011)
10.1007/s00403-003-0414-7
Tape stripping and sodium dodecyl sulfate treatment increase the molecular weight cutoff of polyethylene glycol penetration across murine skin
J-C Tsai (2003)
10.1007/s12221-018-1106-4
Fabrication of Polyether Sulfone Blend Imprinted Membranes for Selective Adsorption of p-hydroxybenzonic from Salicylic Acid
Xiaolei Li (2018)
10.2174/1876502501002010009
Physical Characterization of Drug Loaded Microcapsules and Controlled In Vitro Release Study~!2008-11-21~!2009-08-22~!2010-03-25~!
S. Jaya (2010)
10.1002/jmr.2383
Water‐compatible silica sol–gel molecularly imprinted polymer as a potential delivery system for the controlled release of salicylic acid
B. Li (2014)
10.38212/2224-6614.2766
Content and Transdermal delivery of clobetasol 17-propionate from commercial creams and ointments
J. Tsai (2020)
10.1562/0031-8655(2000)0720681TAOAAH2.0.CO2
Topical Application of 5‐Aminolevulinic Acid Hexyl Ester and 5‐Aminolevulinic Acid to Normal Nude Mouse Skin: Differences in Protoporphyrin IX Fluorescence Kinetics and the Role of the Stratum Corneum ¶
J. Akker (2000)
10.1002/BKCS.10740
A Facile Method for Detection of Substituted Salicylic Acids Using Pyrenesulfonamide-Terminated Self-Assembled Monolayers on Silicon Oxide Surfaces
Gyeongyeop Han (2016)
10.1159/000093984
‘Keratolytic’ Properties of Benzoyl Peroxide and Retinoic Acid Resemble Salicylic Acid in Man
J. Waller (2006)
10.1177/0885328206056312
Polyvinyl Alcohol—Gelatin Patches of Salicylic Acid: Preparation, Characterization and Drug Release Studies
K. Pal (2006)
10.1039/C6RA17955J
Fabrication of highly selective molecularly imprinted membranes for the selective adsorption of methyl salicylate from salicylic acid
Yanli Mao (2016)
10.1016/j.ejpb.2008.10.001
Dermatopharmacokinetics of betamethasone 17-valerate: influence of formulation viscosity and skin surface cleaning procedure.
S. Wiedersberg (2009)
10.1016/j.ijpharm.2013.04.083
Topical corticosteroid delivery into human skin using hydrofluoroalkane metered dose aerosol sprays.
Monica L. Reid (2013)
See more
Semantic Scholar Logo Some data provided by SemanticScholar