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A Compensatory Mirror Cortical Mechanism For Facial Affect Processing In Schizophrenia
J. Quintana, Tom Davidson, E. Kovalik, S. Marder, J. Mazziotta
Published 2001 · Psychology, Medicine
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When primates passively observe other subjects perform specific gestures or actions, premotor and motor cortical areas involved in the internal representation and actual execution of those actions exhibit neuronal activation. This mirror mechanism matches observation, representation, and execution, facilitating internal motor rehearsal, imitation, recognition of actions by others and their meanings, and social learning. Schizophrenic patients have deficits in processing affect displayed by other people's faces, which likely relates to the poor social adaptation and functioning seen in the condition. We hypothesized that, when correctly performing working-memory tasks requiring facial affect processing, schizophrenic patients would show relative increased activity in brain areas involved in social learning and in the internal representation of facial expressions when compared to controls. We used functional magnetic resonance imaging in schizophrenic patients and normal controls to detect relative changes of blood flow in cortical areas related to the representation of facial expressions while the subjects performed simple working-memory tasks with facial emotion diagrams or color circles as cues. We found that, when the task cues were facial expressions in contrast to color circles, the schizophrenic group exhibited increased activation of the face movement areas in motor and pre-motor cortex.
This paper references
Schizophrenia and the response to facial emotions.
I. Pilowsky (1980)
Movement‐Related effects in fMRI time‐series
Karl J. Friston (1996)
The distributed human neural system for face perception
James V. Haxby (2000)
Artifacts due to stimulus correlated motion in functional imaging of the brain
J. Hajnal (1994)
Mnemonic and predictive functions of cortical neurons in a memory task
J. Quintana (1992)
Somatotopic mapping of the primary motor cortex in humans: activation studies with cerebral blood flow and positron emission tomography.
Scott T. Grafton (1991)
Common inhibitory mechanism in human inferior prefrontal cortex revealed by event-related functional MRI.
S. Konishi (1999)
Handbook of Social Functioning in Schizophrenia
K. Mueser (1998)
Neuropathological studies of schizophrenia: a selective review.
D. Weinberger (1983)
Responses of schizophrenics to expressions of the fundamental emotions.
F. E. Dougherty (1974)
The Prefrontal Cortex: Anatomy, Physiology, and Neuropsychology of the Frontal Lobe
J. Fuster (1997)
Structural abnormalities in the frontal system in schizophrenia. A magnetic resonance imaging study.
N. Andreasen (1986)
Facial emotion discrimination: III. Behavioral findings in schizophrenia
C. Heimberg (1992)
Emotional processing in schizophrenia across cultures: standardized measures of discrimination and experience
U. Habel (2000)
Automated image registration: I. General methods and intrasubject, intramodality validation.
R. Woods (1998)
Visuomotor neurons: ambiguity of the discharge or 'motor' perception?
L. Fadiga (2000)
From perception to action: temporal integrative functions of prefrontal and parietal neurons.
J. Quintana (1999)
Prefrontal cortex regulates inhibition and excitation in distributed neural networks.
R. Knight (1999)
Activation of the right inferior frontal cortex during assessment of facial emotion.
K. Nakamura (1999)
Affect perception and social knowledge in schizophrenia
Hellewell JSE (1998)
Activation of human primary motor cortex during action observation: a neuromagnetic study.
R. Hari (1998)
ABNORMALITIES OF CEREBRAL BLOOD FLOW DISTRIBUTION IN PATIENTS WITH CHRONIC SCHIZOPHRENIA
D. Ingvar (1974)
Processing of facial affect in schizophrenics: an fMRI study
A Hariri (1999)
Neurocognitive deficits and social functioning in outpatients with schizophrenia
F. Dickerson (1996)
cessing of facial affect in schizophrenics : an fMRI study
A Hariri (1999)
Differences in prefrontal and parietal association cortex activation between controls and schizophrenic patients during decision-making working memory
J Quintana (1999)
Neuropsychiatric Aspects of the Schizophrenias
DV Jeste (1996)
Judgment of emotion among chronic schizophrenics.
L. H. Muzekari (1977)
Information processing and attentional functioning in the developmental course of schizophrenic disorders.
K. Nuechterlein (1984)
Action recognition in the premotor cortex.
V. Gallese (1996)
Spikes versus BOLD: what does neuroimaging tell us about neuronal activity?
D. Heeger (2000)
Mental imaging of motor activity in humans
M. Jeannerod (1999)
Paranoid schizophrenic and normal subjects' perceptions of photographs of human faces.
C. Izard (1959)
Temporal dynamics of cortical representation for action.
N. Nishitani (2000)
Perception of Facial Emotion in Schizophrenic and Right Brain-Damaged Patients
J. Borod (1993)
Perception of an emotional continuum by schizophrenics, normal adults, and children.
I. Iscoe (1963)
Cognitive response profile of the human fusiform face area as determined by MEG.
E. Halgren (2000)
Possible involvement of primary motor cortex in mentally simulated movement: a functional magnetic resonance imaging study.
M. Roth (1996)
Facial affect recognition and information processing in schizophrenia and bipolar disorder
J. Addington (1998)
Facial-affect recognition and visual scanning behaviour in the course of schizophrenia
M. Streit (1997)
A cross-sectional study of emotion recognition in schizophrenics.
E. Walker (1980)
Functional imaging of memory retrieval in deficit vs nondeficit schizophrenia.
S. Heckers (1999)
Involvement of Primary Motor Cortex in Motor Imagery: A Neuromagnetic Study
A. Schnitzler (1997)
Gating and habituation deficits in the schizophrenia disorders.
D. Braff (1995)
Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence.
D. Weinberger (1986)
[Neuropsychological analysis of the frontal syndrome].
F. Lhermitte (1972)
Functional magnetic resonance imaging brain mapping in psychiatry: methodological issues illustrated in a study
JH Callicott (1998)
Mapping motor representations with positron emission tomography
J. Decety (1994)
Cortical mechanisms of human imitation.
M. Iacoboni (1999)
Analysis of functional MRI time‐series
Karl J. Friston (1994)
Spatial and temporal factors in the role of prefrontal and parietal cortex in visuomotor integration.
J. Quintana (1993)
Functional Magnetic Resonance Imaging Brain Mapping in Psychiatry: Methodological Issues Illustrated in a Study of Working Memory in Schizophrenia
J. Callicott (1998)
Language within our grasp
G. Rizzolatti (1998)
The Prefrontal Cortex
G. Tremblay (1989)
Resonance behaviors and mirror neurons.
G. Rizzolatti (1999)
fMRI Evaluation of Somatotopic Representation in Human Primary Motor Cortex
M. Lotze (2000)
Brain activity during observation of actions. Influence of action content and subject's strategy.
J. Decety (1997)
Automated image registration
R. Woods (1993)
Processing and Recognition of Facial Affect in Schizophrenia
E. J. Federman (1998)
Perseveration, inhibition and the prefrontal cortex: a new look
M. Hauser (1999)
Mirror neurons and the simulation theory of mind-reading
V. Gallese (1998)
Social perception from visual cues: role of the STS region
T. Allison (2000)
Multisubject fMRI Studies and Conjunction Analyses
Karl J. Friston (1999)
Differences in prefrontal and parietal association cortex activation between controls and schizophrenic patients during decision - making working memory tasks
J Quintana (1999)
What are the functional consequences of neurocognitive deficits in schizophrenia?
M. Green (1996)
The prefrontal cortex: Anatomy, physiology, and neuropsychology of the frontal lobe (2nd ed.)
G. Holmes (1989)
A direct quantitative relationship between the functional properties of human and macaque V5
G. Rees (2000)
The Prefrontal Cortex
J. Fuster (1980)
This paper is referenced by
Effects of sensorimotor learning on the human mirror neuron system
C. Catmur (2008)
Schizophrenia: from phenomenology to neurobiology
A. C. Wong (2003)
An expanded role for functional neuroimaging in schizophrenia
J. Callicott (2003)
Reduced motor facilitation during action observation in schizophrenia: A mirror neuron deficit?
P. Enticott (2008)
An fMRI study of facial emotion processing in children and adolescents with 22q11.2 deletion syndrome
R. Azuma (2014)
From Social Neurons to Social Cognition: Implications for Schizophrenia Research
M. Brüne (2011)
Volto, identità ed emozione nella schizofrenia: dalla percezione all’espressione
D. Papa (2007)
Recent structural and functional imaging findings in schizophrenia
M. Niznikiewicz (2003)
Amygdala connectivity during emotional face perception in psychotic disorders
A. Sabharwal (2020)
QT interval prolongation in patients on methadone with concomitant drugs.
V. Piguet (2004)
Psychosis and autism as diametrical disorders of the social brain.
B. Crespi (2008)
Pathological Imitative Behavior and Response Preparation in Schizophrenia
Denisas Dankinas (2017)
Mirror neuron function, psychosis, and empathy in schizophrenia
L. McCormick (2012)
Impaired white matter connectivity between regions containing mirror neurons, and relationship to negative symptoms and social cognition, in patients with first-episode schizophrenia
Yukiko Saito (2017)
Gaze cueing of attention: visual attention, social cognition, and individual differences.
Alexandra Frischen (2007)
The socio-emotional processing stream in Anorexia Nervosa
A. Oldershaw (2011)
Reconhecimento Emocional de faces em pessoas com Esquizofrenia: proposta de um programa com recurso à Realidade Virtual
Maria Teresa Souto (2013)
Brain dysfunctions during facial discrimination in schizophrenia: Selective association to affect decoding
J. Quintana (2011)
Emotion Recognition Deficits as a Neurocognitive Marker of Schizophrenia Liability
R. Schoeman (2009)
Echopraxia in Schizophrenia: Possible Mechanisms
S. Pridmore (2008)
Hyperactivation balances sensory processing deficits during mood induction in schizophrenia.
M. Dyck (2014)
Right lateral fusiform gyrus dysfunction during facial information processing in schizophrenia
J. Quintana (2003)
Reduced hippocampal activation during encoding and recognition of words in schizophrenia patients.
F. Jessen (2003)
Some markers of mirroring appear intact in schizophrenia: evidence from mu suppression
W. Horan (2014)
WORKING MEMORY PROCESSING OF FACIAL IMAGES IN SCHIZOPHRENIA: fMRI INVESTIGATION
S. Yoo (2005)
An f MRI study of facial emotion processing in children and adolescents with 22 q 11 . 2 deletion syndrome
Rayna Azuma (2015)
Psychosis: A costly by-product of social brain evolution in Homo sapiens
J. Burns (2006)
Amoxapine in schizophrenia: a negative double-blind controlled trial.
P. Fitzgerald (2004)
Abnormal frontal activation during the perception of biological motion in patients with schizophrenia
Modeling Schizophrenia by Altering cAMP Signaling in Human Neurons
Charishma Nallapati (2013)
Visual Attention, Social Cognition, and Individual Differences
A. Frischen (2007)
Prefrontal–posterior parietal networks in schizophrenia: primary dysfunctions and secondary compensations
J. Quintana (2003)See more