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Characterization Of Chitosan Hydrochloride-mucin Interaction By Means Of Viscosimetric And Turbidimetric Measurements.

S. Rossi, F. Ferrari, M. C. Bonferoni, C. Caramella
Published 2000 · Chemistry, Medicine

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In the present work the interaction between chitosan hydrochloride (HCS) and two different types of mucin - one obtained from bovine submaxillary glands and the other from porcine stomach - was investigated. Two hydration media were tested: distilled water and 0. 1 M HCl. Intrinsic viscosity, which provides information about polymeric chain conformation, was assessed in both media for HCS and bovine submaxillary mucin. Changes in the specific viscosity of HCS-mucin mixtures were observed as a function of the polymer:mucin weight ratio. The formation of interaction products was indicated by a minimum in the specific viscosity. Such a minimum occurred at different polymer:mucin weight ratios depending on the hydration medium and mucin type. This suggested a different stoichiometry of interaction. Turbidimetric measurements were also effected in order to evidentiate the eventual precipitation of the polymer-mucin interaction products. While in distilled water the precipitation of the interaction product did occur, in acidic medium, although a minimum in specific viscosity was observed, no precipitate was formed. The two techniques employed, viscosimetric and turbidimetric, allowed us to investigate for both mucins the influence of hydration medium on the formation of the HCS-mucin interaction products and to conclude that a slightly acid-neutral pH favours the interaction between HCS and mucins.
This paper references
Chitosan for enhanced intestinal permeability: prospects for derivatives soluble in neutral and basic environments.
A. Kotzé (1999)
Characteristics of polyion complexes of chitosan with sodium alginate and sodium polyacrylate
T. Takahashi (1990)
Drug release from oral mucosal adhesive tablets of chitosan and sodium alginate
S. Miyazaki (1995)
Influence of mucin type on polymer-mucin rheological interactions.
S. Rossi (1995)
In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers
C. Lehr (1992)
Sustained release chitosan microspheres prepared by novel spray drying methods.
P. He (1999)
Physical Pharmacy: Physical Chemical Principles in the Pharmaceutical Sciences
A. N. Martin (1969)
In vitro assessment of bioadhesion for periodontal and buccal drug delivery.
I. Needleman (1995)
Effect of interpolymer complex formation of chitosan with pectin or acacia on the release behaviour of chlorpromazine HCl
M. Meshali (1993)
Polymeric Chitosan‐based Vesicles for Drug Delivery
I. Uchegbu (1998)
Viscosity – Molecular Weight Relationships and Unperturbed Dimensions of Linear Chain Molecules
M. Kurata (1989)
Characterization of rheological and mucoadhesive properties of three grades of chitosan hydrochloride.
F. Ferrari (1997)
Chitosan and its use as a pharmaceutical excipient.
L. Illum (1998)
Effect of interpolymer complex formation on bioadhesive property and drug release phenomenon of compressed tablet consisting of chitosan and sodium hyaluronate.
K. Takayama (1990)
Chitosan: a unique polysaccharide for drug delivery.
O. Felt (1998)
Chitosan‐EDTA Conjugate: A Novel Polymer for Topical Gels
C. Valenta (1998)
Development of new chitosan-cellulose multicore microparticles for controlled drug delivery.
C. Remuñán-López (1998)
Are chitosan-mucin interactions specific to different regions of the stomach? Velocity ultracentrifugation offers a clue
M.P. Deacon (1999)
Bioadhesive Microspheres for Ophthalmic Administration of Acyclovir
I. Genta (1997)
Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery.
C. Remuñán‐López (1998)
Bioadhesion of hydrated chitosans: An in vitro and in vivo study
I. Henriksen (1996)

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Acrylated chitosan for mucoadhesive drug delivery systems.
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C. A. Silva (2012)
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C. Taylor (2005)
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