Online citations, reference lists, and bibliographies.
← Back to Search

Eudragit RS100 Nanosuspensions For The Ophthalmic Controlled Delivery Of Ibuprofen.

R. Pignatello, C. Bucolo, Piera Ferrara, A. Maltese, A. Puleo, G. Puglisi
Published 2002 · Medicine, Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Share
Topical application of non-steroidal anti-inflammatory drugs on the eye is a common treatment used to contrast the miosis induced by surgical traumas, such as cataract extraction. With the aim of improving the availability of sodium ibuprofen (IBU) at the intraocular level, IBU-loaded polymeric nanoparticle suspensions were made from inert polymer resins (Eudragit RS100). The nanosuspensions were prepared by a modification of the quasi-emulsion solvent diffusion technique using variable formulation parameters (drug-to-polymer ratio, total drug and polymer amount, stirring speed). Nanosuspensions had mean sizes around 100 nm and a positive charge (zeta-potential of +40/+60 mV), this makes them suitable for ophthalmic applications. Stability tests (up to 24 months storage at 4 degrees C or at room temperature) or freeze-drying were carried out to optimize a suitable pharmaceutical preparation. In vitro dissolution tests indicated a controlled release profile of IBU from nanoparticles. In vivo efficacy was assessed on the rabbit eye after induction of an ocular trauma (paracentesis). An inhibition of the miotic response to the surgical trauma was achieved, comparable to a control aqueous eye-drop formulation, even though a lower concentration of free drug in the conjunctival sac was reached from the nanoparticle system. Drug levels in the aqueous humour were also higher after application of the nanosuspensions; moreover, IBU-loaded nanosuspensions did not show toxicity on ocular tissues.
This paper references
10.1080/026520499288924
Effect of formulation variables on in vitro drug release and micromeritic properties of modified release ibuprofen microspheres.
D. Perumal (1999)
10.1016/S0169-409X(00)00117-4
Panoparticulate systems for improved drug delivery.
Y. Kawashima (2001)
10.1016/0168-3659(89)90059-X
Preparation and characterization of microspheres containing the anti-inflammatory agents, indomethacin, ibuprofen, and ketoprofen
R. Bodmeier (1989)
10.1080/026520400288337
In vitro release kinetics of Tolmetin from tabletted Eudragit microparticles.
R. Pignatello (2000)
10.1111/j.2042-7158.1991.tb03534.x
Improvement of Ocular Penetration of Amikacin Sulphate by Association to Poly(butylcyanoacrylate) Nanoparticles
C. Losa (1991)
10.1089/JOP.1991.7.227
The role of endogenous eicosanoids in rabbit-intraocular inflammation.
P. Kulkarni (1991)
10.1016/S0161-6420(89)32845-4
The effect of treatment with topical nonsteroidal anti-inflammatory drugs with and without intraoperative epinephrine on the maintenance of mydriasis during cataract surgery.
H. Gimbel (1989)
10.1080/107175401300002748
Preparation and analgesic activity of Eudragit RS100 microparticles containing diflunisal.
R. Pignatello (2001)
10.1016/S0378-5173(97)00083-5
Evaluation of cationic polymer-coated nanocapsules as ocular drug carriers
P. Calvo (1997)
10.1002/JPS.2600780118
Preparation of controlled-release microspheres of ibuprofen with acrylic polymers by a novel quasi-emulsion solvent diffusion method.
Y. Kawashima (1989)
10.1023/A:1018936205485
Poly(ε-Caprolactone) Nanocapsules in Carteolol Ophthalmic Delivery
L. Marchal-Heussler (2004)
10.1016/0378-5173(86)90053-0
Enhancement of the myotic response of rabbits with pilocarpine-loaded polybutylcyanoacrylate nanoparticles
T. Harmia (1986)
10.1016/S0142-9612(02)00080-7
Flurbiprofen-loaded acrylate polymer nanosuspensions for ophthalmic application.
R. Pignatello (2002)
10.1111/j.2042-7158.1995.tb06727.x
Effect of Sodium Naproxen on Inflammatory Response Induced by Anterior Chamber Paracentesis in the Rabbit
C. Bucolo (1995)
10.1016/S1350-9462(97)00002-5
Ophthalmic drug delivery systems—Recent advances
C. L. Bourlais (1998)
10.1248/CPB.41.191
Size Control of Ibuprofen Microspheres with an Acrylic Polymer by Changing the pH in an Aqueous Dispersion Medium and Its Mechanism
Y. Kawashima (1993)
10.1016/0013-9351(78)90092-0
Book reviewAdvances in modern toxicology: Vol. 3: Environmental Cancer. Edited by H. F. Kraybill and M. A. Mehlman. Halsted Press, New York 1977, 388 pp. $24.00
A. Frank (1978)
Properties of tolmetin-loaded Eudragit RL100 and Eudragit RS100 microparticles prepared by different techniques
R. Pignatello (1997)
10.3109/02652048609031575
Ocular drug delivery of progesterone using nanoparticles.
V. Li (1986)
10.1016/0168-3659(94)90225-9
Evaluation of pilocarpine-loaded albumin particles as drug delivery systems for controlled delivery in the eye. I: In vitro and in vivo characterisation
A. Zimmer (1994)
10.3928/1542-8877-19871201-05
Reduction of inflammation following cataract surgery by the nonsteroidal anti-inflammatory drug, flurbiprofen.
D. Sabiston (1987)
10.1001/ARCHOPHT.1986.01050150064027
Reduction of pupillary constriction during cataract surgery using suprofen.
W. Stark (1986)
10.1002/JPS.2600790914
Physical and chemical factors influencing the release of drugs from acrylic resin films.
M. Jenquin (1990)



This paper is referenced by
10.3109/10837450.2012.685654
A novel pH-dependant and double crosslinked polymethacrylate-based polysphere matrix for enteric delivery of isoniazid
Shivaan Cooppan (2013)
10.1016/j.ejpb.2017.01.007
Carvedilol‐loaded nanocapsules: Mucoadhesive properties and permeability across the sublingual mucosa
P. Chaves (2017)
10.5530/ijper.50.1.19
Evaluation of Gum Katira as a Model Sustained Release Adjuvant in the Preparation of Etodolac Loaded Microsphere
Biswajit Ruhidas (2016)
Review Article Ocular drug deliver and the importance of microemulsion as a potential delivery system
Habib Fawzia (2012)
10.1177/1120672118769776
Novel drug delivery systems for ocular therapy: With special reference to liposomal ocular delivery
Arpita Bhattacharjee (2019)
10.22038/IJBMS.2016.6940
Design of eudragit RL nanoparticles by nanoemulsion method as carriers for ophthalmic drug delivery of ketotifen fumarate
Saieede Soltani (2016)
10.1089/jop.2012.0200
Novel strategies for anterior segment ocular drug delivery.
K. Cholkar (2013)
10.1002/9780470571224.PSE359
Microemulsions as Drug Delivery Systems
R. Alany (2010)
10.1586/17469899.2.2.309
Advances in the topical ocular drug delivery
Y. Sultana (2007)
10.2174/138161209788923886
Nanocarriers in ocular drug delivery: an update review.
Sheetu Wadhwa (2009)
10.1016/j.colsurfb.2010.11.014
Naproxen-eudragit RS100 nanoparticles: preparation and physicochemical characterization.
Khosro Adibkia (2011)
Nanosuspension: A Nano-Heterogeneous Carrier for Drug Delivery System
Jadupati Malakar (2012)
10.1016/j.ejpb.2012.05.003
Full factorial design, physicochemical characterisation and biological assessment of cyclosporine A loaded cationic nanoparticles.
Kris Hermans (2012)
10.1201/B15642-4
Nanotechnology Applications in Ophthalmology
Eman Elhawy (2013)
10.1016/j.colsurfb.2016.04.054
PEGylated PLGA nanospheres optimized by design of experiments for ocular administration of dexibuprofen-in vitro, ex vivo and in vivo characterization.
E. Sánchez-López (2016)
Natural and synthetic oil phase transition microemulsions for ocular delivery of tropicamide: efficacy and safety -
Heba I El Agamy (2015)
10.1211/0022357023691
Nanosuspensions: a promising drug delivery strategy
V. Patravale (2004)
10.1016/j.jconrel.2018.06.031
Polymer‐based carriers for ophthalmic drug delivery
Julieta C. Imperiale (2018)
10.1016/j.ijpharm.2007.12.016
Studies on pharmacokinetics and tissue distribution of oridonin nanosuspensions.
L. Gao (2008)
10.1016/J.JDDST.2016.04.010
Development of mucoadhesive and thermosensitive eyedrops to improve the ophthalmic bioavailability of ibuprofen
Hugo Almeida (2016)
Development and Evaluation of Nanoparticulate Drug Delivery Systems for Anticancer Drugs
Srinivas Ganta (2008)
10.1016/j.ejpb.2010.01.011
Comparison of bioavailability of amorphous versus crystalline itraconazole nanoparticles via pulmonary administration in rats.
W. Yang (2010)
10.4018/978-1-4666-6304-6.CH009
Nanosuspensions in Nanobiomedicine
M. Lakshmipathy (2015)
10.1211/0022357023835
Eudragit RL100 nanoparticle system for the ophthalmic delivery of cloricromene
C. Bucolo (2004)
10.2147/IJN.S146346
Controlled drug delivery for glaucoma therapy using montmorillonite/Eudragit microspheres as an ion-exchange carrier
Shuangyan Tian (2018)
10.1080/10611860400015910
Cationic Vectors in Ocular Drug Delivery
L. Rabinovich-Guilatt (2004)
10.1007/s11095-005-6249-5
Molecular Properties of Ibuprofen and Its Solid Dispersions with Eudragit RL100 Studied by Solid-State Nuclear Magnetic Resonance
M. Geppi (2005)
10.1016/J.IJPHARM.2006.10.004
Phase transition water-in-oil microemulsions as ocular drug delivery systems: in vitro and in vivo evaluation.
Judy Chan (2007)
10.1016/j.ijbiomac.2016.04.070
Development of chitosan nanoparticles coated with hyaluronic acid for topical ocular delivery of dexamethasone.
M. A. Kalam (2016)
A REV IEW ON DRUG NANOCRYSTAL A CARRIER FREE DRUG DELIVERY
P. PatelAnita (2011)
10.3797/scipharm.0908-12
Cyclosporine A-Nanosuspension: Formulation, Characterization and In Vivo Comparison with a Marketed Formulation
M. Nakarani (2010)
NANOTECHNOLOGY: A NEW APPROACH FOR OCULAR DRUG DELIVERY SYSTEM
Meetali Mudgil (2012)
See more
Semantic Scholar Logo Some data provided by SemanticScholar