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Biodegradable Nanoparticles For Oral Delivery Of Peptides: Is There A Role For Polymers To Affect Mucosal Uptake?
T. Jung, W. Kamm, A. Breitenbach, E. Kaiserling, J. Xiao, T. Kissel
Published 2000 · Medicine, Chemistry
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Numerous authors have demonstrated uptake of micro- and nanospheres, consisting of natural or synthetic polymeric materials from the gastrointestinal tract over the past two decades. The exploitation of particulate carrier systems for the delivery of peptides and other hydrophilic macromolecules via the oral route remains a challenging task due to morphological and physiological absorption barriers in the gastrointestinal tract. This review examines recent progress in the field of nanoparticle uptake from this site of administration. Since most studies have been performed with poly(styrene) particles of different sizes relatively little is known about both the effect of physicochemical particle properties critical for absorption after peroral application, and the mechanisms of gastrointestinal particle uptake. Apart from particle size, type and composition of the polymers used for micro- or nanoencapsulation are crucial for an uptake and transport across mucosal barriers. Factors such as particle surface charge and hydrophilic/hydrophobic balance of these polymeric materials have not been investigated systematically since adjustment of these particle properties is almost impossible without synthetic modification of the polymers. The current findings will be reviewed and compared to those obtained with nanoparticles consisting of a novel class of charged comb polyesters, poly(2-sulfobutyl-vinyl alcohol)-graft-poly(D,L-lactic-co-glycolic acid), SB-PVAL-g-PLGA, allowing adjustment of physicochemical nanoparticle properties with a single class of polymers.
This paper references
Variations in lectin binding properties of intestinal M cells.
M. Jepson (1995)
Nanocapsules as carriers for oral peptide delivery
C. Damgé (1990)
The influence of age and particle number on absorption of polystyrene particles from the rat gut.
J. Seifert (1996)
Nanoparticle Uptake by the Rat Gastrointestinal Mucosa: Quantitation and Particle Size Dependency
P. Jani (1990)
Oral vaccination with alginate microsphere systems
T. Bowersock (1996)
Vitamin B12-mediated transport of nanoparticles across Caco-2 cells.
G. J. Russell-Jones (1999)
Poly(acrylic acid) microparticles widen the intercellular spaces of Caco-2 cell monolayers : An examination by confocal laser scanning microscopy
B. Kriwet (1996)
Use of vitamin B12 conjugates to deliver protein drugs by the oral route.
G. RussellJones (1998)
Uptake and transport of macromolecules by the intestine: possible role in clinical disorders (an update).
I. Sanderson (1993)
Oral Delivery and Fate of Poly(lactic acid) Microsphere‐encapsulated Interferon in Rats
J. Eyles (1997)
Comparative, quantitative study of lymphoid and non-lymphoid uptake of 60 nm polystyrene particles.
A. M. Hillery (1994)
The Effect of Size on Uptake of Orally Administered Latex Microparticles in the Small Intestine and Transport to Mesenteric Lymph Nodes
K. Carr (2004)
The phenomenon of persorption.
G. Volkheimer (1968)
Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the peyer's patches
J. Eldridge (1990)
Co-polymerised peptide particles (CPP) I: synthesis, characterisation and in vitro studies on a novel oral nanoparticulate delivery system
A. M. Hillery (1996)
Cellular and molecular mechanisms for induction of mucosal immunity.
P. Brandtzaeg (1998)
Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria.
S. Kernéis (1997)
Antigen sampling across epithelial barriers and induction of mucosal immune responses.
M. Neutra (1996)
Size effect on systemic and mucosal immune responses induced by oral administration of biodegradable microspheres.
Y. Tabata (1996)
Nanoparticles as carriers for oral peptide absorption: Studies on particle uptake and fate
A. T. Florence (1995)
Transmucosal penetration of bismuth particles in the human stomach.
C. Nwokolo (1992)
Transport of an influenza virus vaccine formulation (iscom) in Caco-2 cells.
L. Lazorova (1996)
The transport of microspheres from the gastro‐intestinal tract to inflammatory air pouches in the rat
H. O. Alpar (1989)
Effect of size, surface charge, and hydrophobicity on the translocation of polystyrene microspheres through gastrointestinal mucin
D. A. Norris (1997)
Intestinal transit of bioadhesive microspheres in an in situ loop in the rat—A comparative study with copolymers and blends based on poly(acrylic acid)
C. Lehr (1990)
Adsorption of proteins from solution at the solid-liquid interface.
W. Norde (1986)
New strategies for using mucosal vaccination to achieve more effective immunization.
R. Walker (1994)
Drug Absorption Enhancement: Concepts, Possibilities, Limitations and Trends
J. Boere (1994)
Oral and nasal immunization with microencapsulated clinically relevant proteins
H. O. Alpar (1998)
Intestinal absorption of PLAGA microspheres in the rat.
C. Damgé (1996)
Uptake and adjuvant activity of orally delivered saponin and ISCOM vaccines.
Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers.
D. Quintanar-Guerrero (1998)
Identification of some of the physico-chemical characteristics of microspheres which influence the induction of the immune response following mucosal delivery
H. O. Alpar (1994)
Studies on the uptake of tomato lectin nanoparticles in everted gut sacs.
B. Carreño-Gómez (1999)
Biologically erodable microspheres as potential oral drug delivery systems
E. Mathiowitz (1997)
Novel vaccination strategies for the control of mucosal infection.
A. Husband (1993)
Evaluation of nano- and microparticle uptake by the gastrointestinal tract.
Recent Advances in Intestinal Macromolecular Drug Delivery via Receptor-Mediated Transport Pathways
P. Swaan (2004)
Lectin-induced damage to the enterocyte brush border. An electron-microscopic study in rabbits.
C. Hart (1988)
Can intact liposomes be absorbed in the gut?
D. S. Deshmukh (1981)
The potential use of receptor-mediated endocytosis for oral drug delivery 1 PII of original article:
G. Russell-Jones (1996)
Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting
A. Frey (1996)
Biliary excretion of polystyrene microspheres with covalently linked FITC fluorescence after oral and parenteral administration to male Wistar rats.
P. U. Jani (1996)
Biodegradable comb polyesters: Part 1 synthesis, characterization and structural analysis of poly(lactide) and poly(lactide-coglycolide) grafted onto water-soluble poly(vinyl alcohol) as backbone
A. Breitenbach (1998)
M cells in Peyer's patches of the intestine.
A. Gebert (1996)
[Persorption of microparticles].
G. Volkheimer (1993)
The effect of adsorbed poloxamer 188 and 407 surfactants on the intestinal uptake of 60-nm polystyrene particles after oral administration in the rat
A. M. Hillery (1996)
Distribution and elimination of polymethyl methacrylate nanoparticles after peroral administration to rats.
M. Nefzger (1984)
Intestinal Uptake of Fluorescent Microspheres in Young and Aged Mice 1
M. Lefevre (1989)
Peroral administration of 14C-poly(D,L-lactic acid) nanoparticles coated with human serum albumin or polyvinyl alcohol to guinea pigs.
F. Landry (1998)
Drug-loaded nanoparticles – preparation methods and drug targeting issues
E. Alleman (1993)
The Transfer of Polystyrene Microspheres from the Gastrointestinal Tract to the Circulation after Oral Administration in the Rat
J. Eyles (1995)
Binding and Transport of Some Bioadhesive Plant Lectins Across Caco-2 Cell Monolayers
C. Lehr (2004)
Titanium dioxide (rutile) particle uptake from the rat GI tract and translocation to systemic organs after oral administration
P. U. Jani (1994)
Microparticulate absorption from the rat intestine
P. G. Jenkins (1994)
Endocytosis and transcytosis.
Lectins and bacterial invasion factors for controlling endo- and transcytosis of bioadhesive drug carrier systems☆
E. Haltner (1997)
Peroral administration of nanoparticles
J. Kreuter (1991)
Starch microspheres induce pulsatile delivery of drugs and peptides across the epithelial barrier by reversible separation of the tight junctions.
E. Björk (1995)
Further histological evidence of the gastrointestinal absorption of polystyrene nanospheres in the rat
P. U. Jani (1992)
Transcytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier
M. Bomsel (1997)
European Commission COST/STD Initiative. Report of the expert panel VI. Concerted efforts in the field of mucosal immunology.
J. Holmgren (1996)
Endocytosis and molecular sorting.
I. Mellman (1996)
The effect of physical barriers and properties on the oral absorption of particulates.
Binding and uptake of biodegradable poly-DL-lactide micro- and nanoparticles in intestinal epithelia.
S. McClean (1998)
Persorption of particles: physiology and pharmacology.
G. Volkheimer (1977)
Sulfobutylated poly(vinyl alcohol)-graft-poly(lactide-co-glycolide)s facilitate the preparation of small negatively charged biodegradable nanospheres.
T. Jung (2000)
Nanosphere and microsphere uptake via Peyer's patches: observation of the rate of uptake in the rat after a single oral dose
P. U. Jani (1992)
The Uptake and Translocation of Latex Nanospheres and Microspheres after Oral Administration to Rats
P. Jani (1989)
[Principles of particle resorption in the gastrointestinal tract].
W. Sass (1987)
Penetration and enzymatic barriers to peptide and protein absorption
V. Lee (1989)
Polymeric carriers for oral uptake of microparticulates.
Uptake and translocation of fluorescent latex particles by rabbit Peyer's patch follicle epithelium: a quantitative model for M cell uptake.
J. Pappo (1989)
Comparison of poly(DL-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells.
M. Jepson (1993)
In vitro permeability of PBCA nanoparticles through porcine small intestine.
D. Scherer (1993)
Rapid insorption of small particles in the gut.
W. Sass (1990)
Polymerized micelles and their use as adjuvants in immunology.
G. Birrenbach (1976)
This paper is referenced by
Poly(lactide-co-glycolide) nanoparticles for peroral delivery of bioactives
C. Grama (2011)
Mise au point de vecteurs colloïdaux pour améliorer l'absorption d'anticancéreux utilisés par voie orale
E. Roger (2009)
Analysis and entrapment of select antioxidants from chokecherry and Saskatoon berry fruits
K. Konecsni (2011)
Starch microparticles as vaccine adjuvant
N. Rydell (2005)
Poly (D, L-lactide-co-glycolide) and chitosan particles for oral delivery of model lipophilic vitamin
Abitha Murugeshu (2009)
Chitosan-based nanoparticles as a hepatitis B antigen delivery system.
Filipa Lebre (2012)
Novel self assembling nanoparticles for the oral administration of fondaparinux: Synthesis, characterization and in vivo evaluation
Bettina Ralay-Ranaivo (2014)
Probing insulin's secondary structure after entrapment into alginate/chitosan nanoparticles.
B. Sarmento (2007)
Lamotrigine loaded poly‐&egr;‐(d,l‐lactide‐co‐caprolactone) nanoparticles as brain delivery system
H. Ammar (2018)
Potential of nano-phytochemicals in cervical cancer therapy.
Neera Yadav (2020)
Optimized Formulation of High-Payload PLGA Nanoparticles Containing Insulin–Lauryl Sulfate Complex
Kai Shi (2009)
Breakup of inviscid compound liquid jets falling under gravity
Jamal Uddin (2010)
Design improvements to in vitro gastrointestinal models to evaluate effectiveness of insulin encapsulation in nanoparticles
Kaitlin E. Reilly (2011)
Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique.
W. Fan (2012)
The oral delivery of peptides and proteins: established versus recently patented approaches.
Louise Rosenmayr-Templeton (2013)
Mucosal Vaccination: Opportunities and Challenges
Olga Borges (2013)
Investigation of cationized triblock and diblock poly(ε-caprolactone)-co-poly(ethylene glycol) copolymers for oral delivery of enoxaparin: In vitro approach.
Pimchanok Charoongchit (2017)
Barrier characteristics of epithelial cultures modelling the airway and intestinal mucosa: a comparison.
D. Vllasaliu (2011)
Biodistribution, biocompatibility and targeted accumulation of magnetic nanoporous silica nanoparticles as drug carrier in orthopedics
H. C. Janßen (2020)
Increasing entrapment of peptides within poly(alkyl cyanoacrylate) nanoparticles prepared from water-in-oil microemulsions by copolymerization.
Mingtao Liang (2008)
Agile delivery of protein therapeutics to CNS.
X. Yi (2014)
Engineering tenofovir loaded chitosan nanoparticles to maximize microbicide mucoadhesion.
Jianing Meng (2011)
Role of Nanoparticles in Drug Delivery System : A Comprehensive review
C. Karuppusamy (2017)
Mechanistic study of the uptake of wheat germ agglutinin-conjugated PLGA nanoparticles by A549 cells.
Y. Mo (2004)
Diverse approaches for the enhancement of oral drug bioavailability
P. Fasinu (2011)
Preparation of chitosan-polyaspartic acid-5-fluorouracil nanoparticles and its anti-carcinoma effect on tumor growth in nude mice.
D. Zhang (2008)
DIFFERENT TECHNIQUES FOR PREPARATION OF POLYMERIC NANOPARTICLES-A
H. K. Yadav (2012)
Transfer of Lipophilic Markers from PLGA and Polystyrene Nanoparticles to Caco-2 Monolayers Mimics Particle Uptake
Peter Pietzonka (2004)
Challenges for the oral delivery of macromolecules
M. Goldberg (2003)
Effect of PEGylation on assembly morphology and cellular uptake of poly ethyleneimine-cholesterol conjugates for delivery of sorafenib tosylate in hepatocellular carcinoma
M. Monajati (2018)
Application of various strategies to enhance the solubility and bioavailability of Rosuvastatin calcium
Rai Muhammad Sarfraz (2016)
Microbiologically extracted poly(hydroxyalkanoates) and its amalgams as therapeutic nano-carriers in anti-tumor therapies.
Jay M. Korde (2020)See more