Online citations, reference lists, and bibliographies.
← Back to Search

Ocular Pharmacokinetics/pharmacodynamics

Nimit Worakul, J. Robinson
Published 1997 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Delivering drugs to the front of the eye is an exceedingly complicated issue because of the numerous protective mechanisms that are present in the eye to shield the visual pathway from foreign chemicals. Design of modern ocular drug delivery systems is based on an understanding of the drug disposition pathways in the eye and the overall ocular pharmacokinetic/pharmacodynamic profile. Appropriate mathematical models to describe and predict drug disposition and response have evolved over the past twenty years and have become reasonably sophisticated. In this paper we review various ocular pharmacokinetic/pharmacodynamic models for different model drugs and drug delivery systems.
This paper references
10.1016/0163-7258(82)90051-1
Kinetics of pharmacologic response.
N. Holford (1982)
10.1111/J.1365-2125.1974.TB00203.X
Dose-response relationships in tropicamide-induced mydriasis and cycloplegia.
S. Smith (1974)
10.3109/02652049109021873
Studies on the transport pathway of PBCA nanoparticles in ocular tissues.
A. Zimmer (1991)
10.1023/A:1016268922035
A Compartmental Model for the Ocular Pharmacokinetics of Cyclosporine in Rabbits
C. Oh (2004)
10.1006/EXER.1994.1200
Pharmacokinetics, acid-base balance and intraocular pressure effects of ethyloxaloylazolamide--a novel topically active carbonic anhydrase inhibitor.
M. Sharir (1994)
Preliminary study of prolonged acting drug delivery system for the treatment of glaucoma.
R. Gurny (1981)
Clinical pharmacokinetics of the eye. Proctor lecture.
S. Mishima (1981)
10.1002/JPS.2600740506
Topical carbonic anhydrase inhibitors IV: Relationship between excised corneal permeability and pharmacokinetic factors.
M. G. Eller (1985)
10.1002/JPS.2600651230
Mechanistic studies on transcorneal permeation of pilocarpine.
J. Sieg (1976)
10.1002/JPS.2600680606
Mechanistic and quantitative evaluation of precorneal pilocarpine disposition in albino rabbits.
V. Lee (1979)
A model to predict aqueous humor and plasma pharmacokinetics of ocularly applied drugs.
G. Grass (1993)
Toxicologic and pharmacokinetic analysis of intravitreal injections of foscarnet, either alone or in combination with ganciclovir.
P. Berthe (1994)
10.1001/ARCHOPHT.1979.01020010509028
Human tear buffering capacity.
L. Carney (1979)
Particulates (Nanoparticles and Microparticles)
J. Kreuter (1993)
10.1136/bjo.73.5.360
Relative bioavailability of pilocarpine from a novel ophthalmic delivery system and conventional eyedrop formulations.
J. Kelly (1989)
10.1093/BJA/51.7.579
Pharmacokinetics and pharmacodynamics.
C. J. Hull (1979)
10.1002/JPS.2600660222
Aqueous chamber drug distribution volume measurement in rabbits.
J. M. Conrad (1977)
10.1016/0169-409X(95)00010-5
Ocular absorption following topical delivery
K. Jaervinen (1995)
10.3109/03639049409038397
Drug Permeation Enhancement - Theory and Applications
D. Hsieh (1994)
10.1006/EXER.1993.1032
Ocular pharmacokinetics and pharmacodynamics in rabbits of ibopamine, a new mydriatic agent.
L. Soldati (1993)
10.1002/JPS.2600700915
Mechanistic studies on transcorneal permeation of fluorometholone.
J. Sieg (1981)
10.2165/00003088-199529020-00006
Clinical Pharmacokinetics of Various Topical Ophthalmic Delivery Systems
J. P. Frangie (1995)
The validity of rabbits for investigations on ophthalmic vehicles: a comparison of four different vehicles containing tropicamide in humans and rabbits.
M. Saettone (1982)
10.1002/JPS.2600650141
Corneal drug absorption: an illustration of parallel first-order absorption and rapid loss of drug from absorption depot.
M. Makoid (1976)
10.1016/0039-6257(84)90168-1
Ophthalmic drug delivery systems
J. Shell (1984)
10.1016/S0161-6420(91)32227-9
Device drug delivery to the eye. Collagen shields, iontophoresis, and pumps.
M. L. Friedberg (1991)
10.1001/ARCHOPHT.1986.01050180076033
Aminozolamide gel. A trial of a topical carbonic anhydrase inhibitor in ocular hypertension.
R. Lewis (1986)
10.1016/s0165-6147(96)90065-6
Remington:the science and practice of pharmacy
A. R. Gennaro (1995)
10.1089/JOP.1993.9.229
Theoretical corneal permeation model for ionizable drugs.
S. Friedrich (1993)
10.1097/00004397-198002030-00006
Pharmacokinetics of instilled drugs in the human eye.
S. Nagataki (1980)
10.1002/JPS.2600760802
Physicochemical determinants of drug diffusion across the conjunctiva, sclera, and cornea.
I. Ahmed (1987)
10.1016/0039-6257(93)90141-S
Minimizing systemic absorption of topically administered ophthalmic drugs.
A. Urtti (1993)
10.1089/JOP.1995.11.297
The effect of the low blink rate in rabbits on topical drug penetration.
D. Maurice (1995)
10.1001/ARCHOPHT.1993.01090040084037
Ocular penetration of ceftriaxone, ceftazidime, and vancomycin after subconjunctival injection in humans.
M. Barza (1993)
10.1089/JOP.1997.13.41
Penetration into the anterior chamber via the conjunctival/scleral pathway.
R. Schoenwald (1997)
Ocular disposition of aminozolamide in the rabbit eye.
M. Putnam (1987)
10.1089/JOP.1996.12.5
Pharmacokinetic differences between ocular inserts and eyedrops.
S. Friedrich (1996)
10.1007/BF01070899
A physiologically based pharmacokinetic model for the intraocular distribution of pilocarpine in rabbits
S. Miller (2005)
10.3109/02713689008997579
Corneal and conjunctival/scleral penetration of p-aminoclonidine, AGN 190342, and clonidine in rabbit eyes.
D. Chien (1990)
Conventional systems in ophthalmic drug delivery
O. Olejnik (1993)
10.1201/9780429276965
Handbook of pharmacokinetic/pharmacodynamic correlation
H. Derendorf (1995)
10.1201/9780429284755
Biopharmaceutics of Ocular Drug Delivery
P. Edman (1992)
10.1111/j.2042-7158.1986.tb04611.x
A comparison of the effect of viscosity on the precorneal residence of solutions in rabbit and man
I. Zaki (1986)
Permeation enhancement for ocular route of polypeptide administration
G. Chiou (1994)
10.1002/JPS.2600670507
Preliminary pharmacokinetic model of pilocarpine uptake and distribution in the eye.
K. Himmelstein (1978)
10.1002/JPS.2600680411
Pharmacokinetics of topically applied pilocarpine in the albino rabbit eye.
M. Makoid (1979)
10.1002/JPS.2600620712
Lacrimal and instilled fluid dynamics in rabbit eyes.
S. Chrai (1973)
10.1097/00004397-199303340-00009
Prolonged-Action Drops
D. Maurice (1993)
10.1016/S0014-4835(66)80009-X
New methods of measuring the rate of aqueous flow in man with fluorescein.
R. Jones (1966)
10.3109/02713688809031801
Comparison of conjunctival and corneal surface areas in rabbit and human.
M. Watsky (1988)
10.2165/00003088-199018040-00001
Ocular Drug Delivery
R. Schoenwald (1990)
10.1016/0378-5173(87)90092-5
Disposition of timolol and inulin in the rabbit eye following corneal versus non-corneal absorption
I. Ahmed (1987)
pH and drug ionization affects ocular pressure lowering of topical carbonic anhydrase inhibitors.
W. F. Brechue (1993)
Pharmacokinetic basis for nonadditivity of intraocular pressure lowering in timolol combinations.
V. Lee (1991)
10.1089/JOP.1986.2.67
Topical ocular drug delivery: recent developments and future challenges.
V. Lee (1986)
Pharmacokinetics : theory and methodology
M. Rowland (1986)
Importance of the noncorneal absorption route in topical ophthalmic drug delivery.
I. Ahmed (1985)
Animal pharmacokinetic studies
A. Urtii (1993)
10.1248/BPB.17.283
In vivo/in vitro correlation of intravitreal delivery of drugs with the help of computer simulation.
A. Ohtori (1994)
10.1248/CPB.30.3405
Use of fibrin film as a carrier for drug delivery: a long-acting delivery system for pilocarpine into the eye.
S. Miyazaki (1982)
10.1002/JPS.2600730509
Ocular delivery of pilocarpine from erodible matrices.
G. Grass (1984)



This paper is referenced by
10.1002/jps.23370
Influence of drug lipophilicity on drug release from sclera after iontophoretic delivery of mixed micellar carrier system to human sclera.
P. Chopra (2013)
10.1002/DDR.20317
Sustained ophthalmic in situ gel of ketorolac tromethamine: rheology and in vivo studies
A. S. Manjappa (2009)
Review article Cell culture models of the ocular barriers
M. Hornof (2005)
10.1007/s11095-004-7669-3
Assessment of Subconjunctival Delivery with Model Ionic Permeants and Magnetic Resonance Imaging
S. Li (2004)
10.1016/S0939-6411(98)00073-3
A pharmacokinetic model of intravitreal delivery of ganciclovir.
K. Tojo (1999)
10.1248/CPB.57.914
Design and evaluation of polymeric ocular drug delivery system.
A. Gorle (2009)
10.1016/j.ijpharm.2013.11.043
Acetazolamide encapsulated dendritic nano-architectures for effective glaucoma management in rabbits.
Vijay Mishra (2014)
10.1208/s12249-017-0725-1
Development of a Gastric Absorptive, Immediate Responsive, Oral Protein-Loaded Versatile Polymeric Delivery System
P. P. D. Kondiah (2017)
10.3109/10717544.2014.923065
Colloidal drug delivery system: amplify the ocular delivery
Ameeduzzafar (2016)
10.1016/j.ejpb.2017.01.008
Poloxamer‐based thermoresponsive ketorolac tromethamine in situ gel preparations: Design, characterisation, toxicity and transcorneal permeation studies
Zeinab M.A. Fathalla (2017)
10.1016/B978-1-4557-0737-9.00038-2
Chapter 38 – Drug Delivery
E. Lavik (2013)
10.1016/j.jconrel.2012.01.032
Sustained release micellar carrier systems for iontophoretic transport of dexamethasone across human sclera.
P. Chopra (2012)
Design development and evaluation of ophthalmic solid inserts and in situ gels of gatifloxacin
Venugopal Kolachina (2001)
Ocular Inserts: A Novel Controlled Drug Delivery System
K. S. Kumar (2013)
10.1089/JOP.1999.15.123
Non-invasive assessment of ocular pharmacokinetics using Confocal Raman Spectroscopy.
N. J. Bauer (1999)
10.1016/j.preteyeres.2009.11.002
A mass and solute balance model for tear volume and osmolarity in the normal and the dry eye
E. Gaffney (2010)
10.1016/J.EJPB.2005.01.009
Cell culture models of the ocular barriers.
M. Hornof (2005)
10.1007/s11095-016-1993-2
General Pharmacokinetic Model for Topically Administered Ocular Drug Dosage Forms
Feng Deng (2016)
10.1007/978-3-319-47691-9
Ocular Drug Delivery: Advances, Challenges and Applications
Richard T. Addo (2016)
SUSTAIN OPHTHALMIC DEL IVERY OF LEVOFLOXACIN FROM A pH - TRIGGERED IN SITU GELLING SYSTEM
Asija Rajes (2012)
10.1167/IOVS.03-0821
Magnetic resonance imaging study of current and ion delivery into the eye during transscleral and transcorneal iontophoresis.
S. Li (2004)
10.1089/JOP.1996.12.245
Ocular mini-tablets for controlled release of timolol: evaluation in rabbits.
P. Chetoni (1996)
10.1016/B978-1-4160-4673-8.10001-4
PART 1 – Principles of therapy
F. Ziemssen (2008)
10.3109/10837450902967947
Development and evaluation of ocular drug delivery system
A. Gorle (2010)
10.1016/j.addr.2008.09.002
Polyoxyethylated nonionic surfactants and their applications in topical ocular drug delivery.
Jim Jiao (2008)
10.1201/9780203912072-18
Microparticles and Nanoparticles in Ocular Drug Delivery
Murali K. Kothuri (2003)
10.1201/9780203910337.PT3
Ophthalmic Drug Delivery
P. Furrer (2002)
10.1002/jps.24480
The PK-Eye: A Novel In Vitro Ocular Flow Model for Use in Preclinical Drug Development.
S. Awwad (2015)
10.1016/J.JIEC.2016.05.030
Mathematical modelling of brimonidine absorption via topical delivery of microparticle formulations to the eye
C. Park (2016)
10.1111/J.1600-0420.2007.00885.X
Topical and systemic absorption in delivery of dexamethasone to the anterior and posterior segments of the eye.
H. Sigurdsson (2007)
10.1016/j.exer.2010.05.022
Ocular pharmacokinetic study of a corticosteroid by 19F MR.
X. Liu (2010)
10.1016/j.jddst.2020.101910
Development of acetazolamide loaded bilosomes for improved ocular delivery: Preparation, characterization and in vivo evaluation
A. M. Mohsen (2020)
See more
Semantic Scholar Logo Some data provided by SemanticScholar