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Caspases And Caspase Inhibitors.

P. Villa, S. Kaufmann, W. Earnshaw
Published 1997 · Biology, Medicine

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Five years ago, little was known about mechanisms of apoptotic execution. Now, one class of cell-death gene, the cysteine and aspartases (caspases) has come under intensive study. This review discusses the two classes of caspases, the reasons why humans may have so many caspase genes, the growing list of caspase substrates, and viral and pharmacological caspase inhibitors.
This paper references
10.1074/JBC.272.15.9677
Substrate Specificities of Caspase Family Proteases*
R. Talanian (1997)
10.1074/jbc.272.11.7421
Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis*
L. M. Martins (1997)
10.1126/SCIENCE.275.5303.1132
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
R. Kluck (1997)
10.1128/JVI.67.4.2168-2174.1993
An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif.
N. Crook (1993)
10.1074/JBC.272.18.11694
Cleavage of PITSLRE Kinases by ICE/CASP-1 and CPP32/CASP-3 during Apoptosis Induced by Tumor Necrosis Factor*
R. Beyaert (1997)
10.1083/JCB.128.1.201
Viral proteins E1B19K and p35 protect sympathetic neurons from cell death induced by NGF deprivation
I. Martinou (1995)
10.1074/jbc.272.12.7797
Target Protease Specificity of the Viral Serpin CrmA
Q. Zhou (1997)
10.1002/j.1460-2075.1994.tb06475.x
Baculovirus p35 prevents developmentally programmed cell death and rescues a ced‐9 mutant in the nematode Caenorhabditis elegans.
A. Sugimoto (1994)
10.1074/JBC.272.15.9621
A Novel Family of Viral Death Effector Domain-containing Molecules That Inhibit Both CD-95- and Tumor Necrosis Factor Receptor-1-induced Apoptosis*
S. Hu (1997)
10.1016/S0092-8674(00)81266-0
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
M. Muzio (1996)
10.1016/0092-8674(95)90150-7
Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death
B. Hay (1995)
10.1002/j.1460-2075.1996.tb00629.x
A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.
C. Duckett (1996)
10.1038/385086A0
RAIDD is a new 'death' adaptor molecule
H. Duan (1997)
10.1016/S0960-9822(06)00120-5
CED-4 induces chromatin condensation in Schizosaccharomyces pombe and is inhibited by direct physical association with CED-9
C. James (1997)
10.1042/BJ3230233
Actin is cleaved during constitutive apoptosis.
S. Brown (1997)
10.1074/jbc.272.24.15049
Identification of the MDM2 Oncoprotein as a Substrate for CPP32-like Apoptotic Proteases*
P. Erhardt (1997)
Baculovirus P35 inhibits the glucocorticoid-mediated pathway of cell death.
N. Robertson (1997)
10.1074/JBC.270.7.3255
Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product (*)
M. Tewari (1995)
10.1038/379349A0
Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
Peter Listen (1996)
10.1016/S0074-7696(08)62312-8
Cell death: the significance of apoptosis.
A. Wyllie (1980)
10.1038/380723A0
Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
M. Enari (1996)
10.1126/SCIENCE.275.5303.1122
Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death
A. Chinnaiyan (1997)
10.1128/MCB.15.5.2359
Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA.
A. K. Talley (1995)
10.1182/BLOOD.V88.6.1936.BLOODJOURNAL8861936
Activation of the CPP32 protease in apoptosis induced by 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents.
R. Datta (1996)
10.1002/(SICI)1097-4644(199701)64:1<33::AID-JCB6>3.0.CO;2-0
Mammalian cell death proteases: A family of highly conserved aspartate specific cysteine proteases
E. Alnemri (1997)
10.1084/JEM.184.4.1331
Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
S. Susin (1996)
10.1002/BIES.950190609
Death substrates come alive
A. Porter (1997)
10.1074/jbc.272.11.7223
Substrate and Inhibitor Specificity of Interleukin-1β-converting Enzyme and Related Caspases*
N. Margolin (1997)
10.1126/science.271.5250.805
Cell Killing by the Drosophila Gene reaper
K. White (1996)
10.1074/JBC.270.18.10377
Granzyme B Is Inhibited by the Cowpox Virus Serpin Cytokine Response Modifier A(*)
L. T. Quan (1995)
Involvement of a CrmA-insensitive ICE/Ced-3-like protease in ceramide-induced apoptosis.
H. Kojima (1996)
10.1016/0955-0674(95)80030-1
Molecular control of life and death.
J. Yuan (1995)
Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.
T. Fernandes-Alnemri (1995)
10.1074/JBC.272.14.8841
Bik and Bak Induce Apoptosis Downstream of CrmA but Upstream of Inhibitor of Apoptosis*
K. Orth (1997)
10.1074/JBC.270.28.16526
The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced Apoptosis (*)
D. R. Beidler (1995)
10.1038/371346A0
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
Y. Lazebnik (1994)
10.1126/SCIENCE.8303301
Prevention of vertebrate neuronal death by the crmA gene.
V. Gagliardini (1994)
10.1074/jbc.272.3.1965
Activation of a CrmA-insensitive, p35-sensitive Pathway in Ionizing Radiation-induced Apoptosis*
R. Datta (1997)
10.1016/S0014-5793(96)01284-7
Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl‐2, but not by CrmA
S. Geley (1997)
Expression of baculovirus P35 prevents cell death in Drosophila.
B. Hay (1994)
10.1074/JBC.271.9.4573
Molecular Ordering of the Cell Death Pathway
A. Chinnaiyan (1996)
10.1083/JCB.135.5.1377
A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA
S. Frisch (1996)
10.1016/S0092-8674(00)81334-3
Human ICE/CED-3 Protease Nomenclature
E. Alnemri (1996)
10.1126/SCIENCE.7569933
Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35.
N. Bump (1995)
10.1038/377248A0
Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
D. Xue (1995)
10.1128/JVI.70.9.6251-6259.1996
Apoptotic suppression by baculovirus P35 involves cleavage by and inhibition of a virus-induced CED-3/ICE-like protease.
J. Bertin (1996)
10.1128/MCB.17.5.2835
Doom, a product of the Drosophila mod(mdg4) gene, induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins.
A. Harvey (1997)
10.1038/sj.onc.1200919
Actin cleavage by CPP-32/apopain during the development of apoptosis
T. Mashima (1997)
10.1038/386517A0
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
M. Thome (1997)
10.1016/S0092-8674(94)90422-7
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death
Lin Wang (1994)
10.1038/40901
X-linked IAP is a direct inhibitor of cell-death proteases
Q. Deveraux (1997)
10.1074/jbc.272.5.2952
FLICE Induced Apoptosis in a Cell-free System
M. Muzio (1997)
10.1126/SCIENCE.275.5303.1129
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
J. Yang (1997)
10.1128/MCB.17.2.667
Characterization of reaper- and FADD-induced apoptosis in a lepidopteran cell line.
D. Vucic (1997)
10.1093/emboj/16.9.2271
Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells
L. Faleiro (1997)
10.1016/S0014-5793(96)01496-2
The interleukin 1β‐converting enzyme inhibitor CrmA prevents Apo1/Fas‐ but not glucocorticoid‐induced poly(ADP‐ribose) polymerase cleavage and apoptosis in lymphoblastic leukemia cells
S. Geley (1997)
10.1101/GAD.9.14.1694
The head involution defective gene of Drosophila melanogaster functions in programmed cell death.
M. E. Grether (1995)
10.1146/ANNUREV.CB.07.110191.003311
Mechanisms and functions of cell death.
R. Ellis (1991)
10.1074/JBC.271.35.20977
Molecular Ordering of Apoptotic Mammalian CED-3/ICE-like Proteases*
K. Orth (1996)
10.1126/SCIENCE.276.5318.1571
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2.
T. Rudel (1997)
10.1016/0092-8674(94)90506-1
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
M. Hengartner (1994)
10.1016/0092-8674(95)90149-3
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
M. Rothe (1995)
10.1016/S0092-8674(00)80197-X
DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis
X. Liu (1997)
10.1038/384368A0
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
K. Kuida (1996)
10.1128/MCB.14.8.5212
Control of programmed cell death by the baculovirus genes p35 and iap.
R. Clem (1994)
10.1126/SCIENCE.275.5303.1126
Interaction and Regulation of Subcellular Localization of CED-4 by CED-9
D. Wu (1997)
10.1038/sj.onc.1201131
Affinity labeling displays the stepwise activation of ICE-related proteases by Fas, staurosporine, and CrmA-sensitive caspase-8
A. Takahashi (1997)
10.1016/0092-8674(92)90223-Y
Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme
C. Ray (1992)



This paper is referenced by
10.1517/14728214.3.1.317
Inhibition of apoptosis: potential clinical targets
M. E. Nuttall (1998)
10.1074/JBC.273.25.15702
ERICE, a Novel FLICE-activatable Caspase*
E. Humke (1998)
10.1016/S0014-5793(98)00433-5
Proteolytic cleavage of HsRad51 during apoptosis
J. Flygare (1998)
10.1515/CCLM.1999.054
Depending on Their Concentration Oxidized Low Density Lipoproteins Stimulate Extracellular Matrix Synthesis or Induce Apoptosis in Human Coronary Artery Smooth Muscle Cells
M. Bachem (1999)
10.1385/1-59259-195-7:309
Apoptotic proteolytic cleavage of the presenilins by caspases.
T. Kim (2000)
10.1016/S0076-6879(06)14016-1
Development and implementation of multiplexed cell-based imaging assays.
Bonnie J Howell (2006)
10.1177/09680519010070041201
Pan-caspase inhibitor zVAD enhances cell death in RAW246.7 macrophages
Sung Ouk Kim (2001)
10.1016/J.VIROL.2005.03.026
African green monkey kidney Vero cells require de novo protein synthesis for efficient herpes simplex virus 1-dependent apoptosis.
M. Nguyen (2005)
Aspects of the regulation and role of focal adhesion kinase and Src in oncogenic transformation
Mahima Agochiya (2000)
10.1248/BPB.31.1131
Antiproliferative activity of derivatives of ouabain, digoxin and proscillaridin A in human MCF-7 and MDA-MB-231 breast cancer cells.
K. Winnicka (2008)
10.1016/J.JBIOTEC.2007.05.032
Cloning and characterization of a caspase gene from black tiger shrimp (Penaeus monodon)-infected with white spot syndrome virus (WSSV).
K. Wongprasert (2007)
10.1006/EXCR.2000.4923
Specific inhibition of rRNA transcription and dynamic relocation of fibrillarin induced by mercury.
M. Chen (2000)
10.1016/S1388-1981(00)00100-1
Preferential externalization of newly synthesized phosphatidylserine in apoptotic U937 cells is dependent on caspase-mediated pathways.
A. Yu (2000)
10.1111/j.1349-7006.2003.tb01358.x
Evodiamine, a constituent of Evodiae Fructus, induces anti‐proliferating effects in tumor cells
Xiao Fei (2003)
10.1016/J.VIRUSRES.2006.03.003
Caspase 3 activation during herpes simplex virus 1 infection.
Rachel M Kraft (2006)
10.1038/sj.onc.1204155
Cellular and viral Fos proteins are degraded by different proteolytic systems
C. Acquaviva (2001)
10.1016/B978-012492543-4/50015-5
Transferring Groups by Displacement Reactions
David E. Metzler (2001)
10.1042/0264-6021:3540397
Nitric oxide-dependent pro-oxidant and pro-apoptotic effect of metallothioneins in HL-60 cells challenged with cupric nitrilotriacetate.
S. Liu (2001)
10.1517/14728214.6.1.81
Caspase inhibitors as neuroprotective agents
J. Legos (2001)
10.1038/sj.cdd.4400873
Establishment of okadaic acid resistant cell clones using a cDNA expression library
T. Sandal (2001)
10.1091/MBC.12.6.1569
Involvement of p38 in apoptosis-associated membrane blebbing and nuclear condensation.
R. Deschesnes (2001)
10.1007/978-1-4614-9099-9_3
Involvement of Caspases in the Pathophysiology of Neurodegeneration and Stroke
A. Goswami (2014)
10.1177/026765910101600609
Apoptosis in the ischemic reperfused myocardium
C. Holleyman (2001)
10.1074/JBC.M104810200
Differential Involvement of Initiator Caspases in Apoptotic Volume Decrease and Potassium Efflux during Fas- and UV-induced Cell Death*
C. C. Vu (2001)
10.1016/S0079-6468(08)70068-7
Caspase inhibitors as anti-inflammatory and antiapoptotic agents.
Piotr P. Graczyk (2002)
10.1515/CCLM.2001.046
Caspase-3 Apoptotic Signaling Following Injury to the Central Nervous System
J. Springer (2001)
10.2174/1381612053507648
Apoptosis following photodynamic tumor therapy: induction, mechanisms and detection.
K. Plaetzer (2005)
10.1016/j.phytochem.2010.08.015
Neurocytoprotective effects of the bioactive constituents of Pueraria thomsonii in 6-hydroxydopamine (6-OHDA)-treated nerve growth factor (NGF)-differentiated PC12 cells.
Chien-Min Lin (2010)
10.1210/EN.141.5.1846
Caspase-3 activation is required for Leydig cell apoptosis induced by ethane dimethanesulfonate.
J. Kim (2000)
10.1016/S0014-5793(98)01640-8
Non‐specific effects of methyl ketone peptide inhibitors of caspases
P. Schotte (1999)
10.1073/PNAS.96.6.2885
A cloning method to identify caspases and their regulators in yeast: identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1.
C. Hawkins (1999)
10.1002/(SICI)1097-4644(19990701)74:1<99::AID-JCB11>3.0.CO;2-E
Biochemical and morphological changes in the nuclear matrix prepared from apoptotic HL‐60 cells: Effect of different stabilizing procedures
A. Martelli (1999)
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