Online citations, reference lists, and bibliographies.
← Back to Search

6-Sulfo LacNAc, A Novel Carbohydrate Modification Of PSGL-1, Defines An Inflammatory Type Of Human Dendritic Cells.

K. Schäkel, R. Kannagi, B. Kniep, Y. Goto, C. Mitsuoka, J. Zwirner, A. Soruri, M. von Kietzell, E. Rieber
Published 2002 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
The monoclonal antibody M-DC8 defines a major subset of human blood dendritic cells (DCs). Here we identify the M-DC8 structure as 6-sulfo LacNAc, a novel carbohydrate modification of the P selectin glycoprotein ligand 1 (PSGL-1). In contrast to previously described blood DCs, M-DC8+ DCs lack the cutaneous lymphocyte antigen (CLA) on PSGL-1 and fail to bind P and E selectin. Yet they express anaphylatoxin receptors (C5aR and C3aR) and the Fcgamma receptor III (CD16), which recruit cells to inflammatory sites. While sharing with DC1 the expression of myeloid markers and a potent capacity to prime T cells in vitro, M-DC8+ DCs produce far more TNF-alpha in response to the bacterial endotoxin lipopolysaccharide (LPS). Thus, 6-sulfo LacNAc-expressing DCs appear as a novel proinflammatory DC subset.
This paper references
Systematic purification of five glycosidases from Streptococcus (Diplococcus) pneumoniae.
L. R. Glasgow (1977)
Human T cell differentiation antigens characterizing a cytotoxic/suppressor T cell subset.
P. Rieber (1981)
Direct monoclonal antibody rosetting. An effective method for weak antigen detection and large scale separation of human mononuclear cells.
M. Wilhelm (1986)
The dendritic cell system and its role in immunogenicity.
R. Steinman (1991)
Total synthesis of sialyl Lewis X.
A. Kameyama (1991)
Binding of fluorescein-labeled anaphylatoxin C5a to human peripheral blood, spleen, and bone marrow leukocytes.
T. Werfel (1992)
Expression cloning of a functional glycoprotein ligand for P-selectin
D. Sako (1993)
The novel subset of CD14+/CD16+ blood monocytes is expanded in sepsis patients
G. Fingerle (1993)
Structure-function studies on selectin carbohydrate ligands. Modifications to fucose, sialic acid and sulphate as a sialic acid replacement.
B. Brandley (1993)
Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature.
U. O’Doherty (1994)
Synthesis of sialyl Le(x) ganglioside analogues sulfated at C-6 of either the galactose or N-acetylglucosamine residues, and at both of the galactose and N-acetylglucosamine residues: probes for clarifying the real carbohydrate ligand of L-selectin.
S. Komba (1996)
Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells
R. Fuhlbrigge (1997)
Preparative two‐dimensional gel electrophoresis of membrane proteins
C. Pasquali (1997)
A cell surface antigen that cross-reacts with My4, a monoclonal antibody to CD14, is expressed on human monoblastic cell line U937, B-lymphoma cells, and polymorphonuclear leukocytes.
T. Ikemoto (1997)
Nucleotide and corrected amino acid sequence of the functional recombinant rat anaphylatoxin C5a.
E. Rothermel (1997)
Identification of a Major Carbohydrate Capping Group of the L-selectin Ligand on High Endothelial Venules in Human Lymph Nodes as 6-Sulfo Sialyl Lewis X*
C. Mitsuoka (1998)
A novel dendritic cell population in human blood: one‐step immunomagnetic isolation by a specific mAb (M‐DC8) and in vitro priming of cytotoxic T lymphocytes
Knut Schäkel (1998)
A novel P-selectin glycoprotein ligand-1 monoclonal antibody recognizes an epitope within the tyrosine sulfate motif of human PSGL-1 and blocks recognition of both P- and L-selectin.
K. Snapp (1998)
Molecular Cloning and Characterization of anN-Acetylglucosamine-6-O-sulfotransferase*
K. Uchimura (1998)
Survival, maturation, and function of CD11c- and CD11c+ peripheral blood dendritic cells are differentially regulated by cytokines.
N. Kohrgruber (1999)
Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of alpha1-->3 fucosyltransferase VII and newly cloned GlcNAcbeta:6-sulfotransferase cDNA.
N. Kimura (1999)
Reciprocal control of T helper cell and dendritic cell differentiation.
M. Rissoan (1999)
8B4/20, a private CD43 epitope on developing human thymocytes, is involved in thymocyte maturation.
M. Fabbi (1999)
Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus.
H. Vallin (1999)
Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
M. Cella (1999)
The nature of the principal type 1 interferon-producing cells in human blood.
F. Siegal (1999)
Correction of leukocyte adhesion deficiency type II with oral fucose.
T. Marquardt (1999)
Interaction of Dendritic Cells with Skin Endothelium: A New Perspective on Immunosurveillance
C. Robert (1999)
Structure and function of the selectin ligand PSGL-1.
R. Cummings (1999)
A CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells.
T. Ito (1999)
Evaluation of C3a receptor expression on human leucocytes by the use of novel monoclonal antibodies
Zwirner (1999)
Dendritic cells in cancer immunotherapy.
L. Fong (2000)
GalNAc-α-O-benzyl Inhibits Sialylation ofde Novo Synthesized Apical but Not Basolateral Sialoglycoproteins and Blocks Lysosomal Enzyme Processing in a Post-trans-Golgi Network Compartment*
F. Ulloa (2000)
Macrophages, smooth muscle cells, endothelial cells, and T-cells express CD40 and CD40L in fatty streaks and more advanced human atherosclerotic lesions
T. Häkkinen (2000)
The M-DC8-positive leukocytes are a subpopulation of the CD14+ CD16+ monocytes.
M. Siedlar (2000)
Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization
M. Cella (2000)
BDCA-2, BDCA-3, and BDCA-4: Three Markers for Distinct Subsets of Dendritic Cells in Human Peripheral Blood
A. Dzionek (2000)
Immunobiology of dendritic cells.
J. Banchereau (2000)
Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity
N. Kadowaki (2000)
Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens
N. Kadowaki (2001)
Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation.
A. Coxon (2001)
Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells
M. Dhodapkar (2001)

This paper is referenced by
PSGL-1 Immune Checkpoint Inhibition for CD4+ T Cell Cancer Immunotherapy
Julia M. DeRogatis (2021)
Reduced frequencies and functional impairment of dendritic cell subsets and non-classical monocytes in myelodysplastic syndromes.
Nathalie van Leeuwen-Kerkhoff (2021)
Increased sCD163 and sCD14 Plasmatic Levels and Depletion of Peripheral Blood Pro-Inflammatory Monocytes, Myeloid and Plasmacytoid Dendritic Cells in Patients With Severe COVID-19 Pneumonia
M. Zingaropoli (2021)
Monocyte and macrophage heterogeneity in Giant Cell Arteritis and Polymyalgia Rheumatica: central in Pathology and a Source of Clinically Relevant Biomarkers
Y. V. Sleen (2020)
Human innate immune cell crosstalk induces melanoma cell senescence
Felix Funck (2020)
Interplay of Monocytes and T Lymphocytes in COVID-19 Severity
Lindsey E Padgett (2020)
Epigenetics in non-classical monocytes support their pro-inflammatory gene expression.
Lu Zhang (2020)
Plasticity of Paneth cells and their ability to regulate intestinal stem cells
Xianglin Mei (2020)
Conventional Dendritic Cells and Slan+ Monocytes During HIV-2 Infection
M. Iannetta (2020)
Deciphering the fate of slan+‐monocytes in human tonsils by gene expression profiling
Francisco Bianchetto-Aguilera (2020)
Human Monocyte Heterogeneity as Revealed by High-Dimensional Mass Cytometry
A. Hamers (2019)
Mind the Map: Technology Shapes the Myeloid Cell Space
P. Günther (2019)
Platelets and IgE: Shaping the Innate Immune Response in Systemic Lupus Erythematosus
Benoit Brilland (2019)
Neoadjuvant Radiochemotherapy Significantly Alters the Phenotype of Plasmacytoid Dendritic Cells and 6-Sulfo LacNAc+ Monocytes in Rectal Cancer
F. Wagner (2019)
6-Sulfo LacNAc (Slan) as a Marker for Non-classical Monocytes
Thomas P. J. Hofer (2019)
RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-4
T. Sekiya (2019)
Differential effects of anaphylatoxin C5a on antigen presenting cells, roles for C5aR1 and C5aR2.
A. Zaal (2019)
Myeloid and lymphoid activation markers in AIDS and non-AIDS presenters.
M. Iannetta (2019)
Human in vivo-differentiated monocyte-derived dendritic cells.
T. Tang-Huau (2019)
Current Concepts on 6-sulfo LacNAc Expressing Monocytes (slanMo)
F. Ahmad (2019)
Autologous tumor cell vaccination combined with systemic CpG-B and IFN-α promotes immune activation and induces clinical responses in patients with metastatic renal cell carcinoma: a phase II trial
Bas D Koster (2019)
A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer
H. Rammensee (2019)
The Biology of Monocytes and Dendritic Cells: Contribution to HIV Pathogenesis
V. Wacleche (2018)
Potential contribution of tumor‐associated slan+ cells as anti‐CSF‐1R targets in human carcinoma
S. Lonardi (2018)
Human Bone Marrow-Derived Myeloid Dendritic Cells Show an Immature Transcriptional and Functional Profile Compared to Their Peripheral Blood Counterparts and Separate from Slan+ Non-Classical Monocytes
Nathalie van Leeuwen-Kerkhoff (2018)
Innate immune memory in fibroblasts
T. Crowley (2018)
Extracellular vesicles from mature dendritic cells (DC) differentiate monocytes into immature DC
Stefan Schierer (2018)
CD16+ monocytes give rise to CD103+RALDH2+TCF4+ dendritic cells with unique transcriptional and immunological features.
V. Wacleche (2018)
Cenicriviroc inhibits trans‐endothelial passage of monocytes and is associated with impaired E‐selectin expression
Michelle L. D’Antoni (2018)
C5aR and TLR crosstalk: Regulatory effect of anaphylatoxin C5a on human dendritic cells
A. Zaal (2018)
Les cellules dendritiques inflammatoires humaines utilisent une voie non-cytosolique pour la présentation croisée
Tsing-Lee Tang-Huau (2018)
Quantitative and functional alterations of 6-sulfo LacNac dendritic cells in multiple myeloma
B. Lamarthée (2018)
See more
Semantic Scholar Logo Some data provided by SemanticScholar