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Identification Of Paracaspases And Metacaspases: Two Ancient Families Of Caspase-like Proteins, One Of Which Plays A Key Role In MALT Lymphoma.
A. Uren, K. O'Rourke, L. Aravind, M. T. Pisabarro, S. Seshagiri, E. Koonin, V. Dixit
Published 2000 · Medicine, Biology
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Caspases are cysteine proteases essential to apoptosis. We have identified two families of caspase-like proteins, Paracaspases (found in metazoans and Dictyostelium) and metacaspases (found in plants, fungi, and protozoa). Metazoan paracaspase prodomains contain a death domain and immunoglobulin domains. Several plant metacaspase prodomains contain zinc finger motifs resembling those in the plant hypersensitive response/cell death protein Isd-1. The human paracaspase prodomain binds Bcl10, a protein involved in the t(1;14)(p22;q32) translocation of mucosa-associated lymphoid tissue (MALT) lymphoma. Another MALT lymphoma translocation, t(11;18)(q21;q21), fuses the IAP-2 gene to the MLT1/MALT1 locus, which encodes the human paracaspase. We find that this fusion activates NF-kappaB and that the caspase domain is required for this function, since mutation of the conserved catalytic cysteine attenuates NF-kappaB activation.
This paper references
[The Dictyostelium developmental cDNA project].
T. Morio (2001)
The domains of death: evolution of the apoptosis machinery.
L. Aravind (1999)
Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases
J. M. Chen (1998)
A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue
T. Akagi (1999)
Aberrant rel/nfkb genes and activity in human cancer
B. Rayet (1999)
The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas.
J. Dierlamm (1999)
Crystal structure of gingipain R: an Arg‐specific bacterial cysteine proteinase with a caspase‐like fold
A. Eichinger (1999)
Aggressive mucosa associated lymphoid tissue lymphomas are associated with mutations inBcl10
J. Spencer (1999)
Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18.
J. A. Morgan (1999)
Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control.
Z. Chu (1997)
The inhibitors of apoptosis (IAPs) and their emerging role in cancer
Eric C LaCasse (1998)
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.
J. Thompson (1994)
Diverse agents act at multiple levels to inhibit the Rel/NF-κB signal transduction pathway
J. Epinat (1999)
Bcl10 Is Involved in t(1;14)(p22;q32) of MALT B Cell Lymphoma and Mutated in Multiple Tumor Types
T. Willis (1999)
Gapped BLAST and PSI-BLAST: A new
D. Lipman (1997)
Caspases: the executioners of apoptosis.
G. Cohen (1997)
mE10, a Novel Caspase Recruitment Domain-containing Proapoptotic Molecule*
M. Yan (1999)
The Dictyostelium developmental cDNA project: generation and analysis of expressed sequence tags from the first-finger stage of development.
T. Morio (1998)
Caspases and programmed cell death in the hypersensitive response of plants to pathogens
Olga María del Pozo (1998)
This paper is referenced by
More than one way to go.
A. Wyllie (2001)
Three-dimensional progression of programmed death in the rice coleoptile.
N. Inada (2002)
Multiple mediators of plant programmed cell death: Interplay of conserved cell death mechanisms and plant‐specific regulators
F. Hoeberichts (2003)
Bax-induced cell death of Arabidopsisis meditated through reactive oxygen-dependent and -independent processes
Dongwon Baek (2004)
Interactions between malaria and mosquitoes: the role of apoptosis in parasite establishment and vector response to infection.
H. Hurd (2005)
Role of Polyamines in Apoptosis and Other Recent Advances in Plant Polyamines
G. Kuehn (2005)
p16/INK4a gene methylation is a frequent finding in pulmonary MALT lymphomas at diagnosis
Hisashi Takino (2005)
Mutations of the act promoter in Myxococcus xanthus.
T. M. Gronewold (2007)
What happened to plant caspases?
L. Bonneau (2008)
Calnexin is involved in apoptosis induced by endoplasmic reticulum stress in the fission yeast.
R. Guérin (2008)
The antimicrobial peptide, psacotheasin induces reactive oxygen species and triggers apoptosis in Candida albicans.
Bomi Hwang (2011)
Chlamydia psittaci in ocular adnexa MALT lymphoma: a possible role in lymphomagenesis and a different geographical distribution
F. Collina (2012)
Tumor Necrosis Factor Alpha Induced Protein 3 (TNFAIP3)
Ingrid E. Wertz (2013)
Ocular and Adnexal Lymphoma: Molecular Pathology
Alia Rashid (2014)
Endoplasmic reticulum stress-induced PCD and caspase-like activities involved
Yaomin Cai (2014)
Primary Cutaneous Marginal Zone B-Cell Lymphoma: A Molecular and Clinicopathologic Study of 24 Asian Cases
C. Li (2003)
DNA Damage, Response, and Repair in Plants Under Genotoxic Stress
Uzma Fatima (2017)
Tracing the ancient origins of plant innate immunity.
J. Staal (2007)
Are protozoan metacaspases potential parasite killers?
B. Meslin (2010)
Oikopleura dioica: An Emergent Chordate Model to Study the Impact of Gene Loss on the Evolution of the Mechanisms of Development.
Alfonso Ferrández-Roldán (2019)
The CBM signalosome: potential therapeutic target for aggressive lymphoma?
Chenghua Yang (2014)
NF‐ĸB activation pathways induced by T cell costimulation
M. Schmitz (2003)
Mammalian initiator apoptotic caspases
P. Ho (2005)
Review/ Derleme Evidences for the presence of caspase-like activities in plants
N. Palavan-Unsal (2011)
Further characterization of metacaspase expression and activity in marine phytoplankton
W. Liao (2010)
MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma.
D. Sánchez-Izquierdo (2003)
GALIG : UN NOUVEAU GÈNE HUMAIN INDUCTEUR DE LA MORT CELLULAIRE
M. Duneau (2005)
Evasion of phagotrophic predation by protist hosts and innate immunity of metazoan hosts by Legionella pneumophila
Ashley Best (2019)
Structural Insights into Separase Architecture and Substrate Recognition through Computational Modelling of Caspase-Like and Death Domains
Anja Winter (2015)
Processing of metacaspase 2 from Trypanosoma brucei (TbMCA2) broadens its substrate specificity.
J. M. Gilio (2017)
Molecular basis of lysophosphatidic acid-induced NF-κB activation.
W. Sun (2010)
THE ORIGIN AND EVOLUTION OF CELL DEATH
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