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New Graphical Method To Measure Silent Periods Evoked By Transcranial Magnetic Stimulation
M. Garvey, U. Ziemann, D. A. Becker, C. Barker, J. Bartko
Published 2001 · Psychology, Medicine
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OBJECTIVES Manual methods of measuring duration of cortical silent periods (CSP) evoked by transcranial magnetic stimulation (TMS) depend upon subjective visual estimation of onset and offset. Because of this, the measurements are susceptible to poor rater reliability. We describe a graphical method to measure silent periods with greater precision. The statistical process underlying this new method is simple and particularly suited to signal detection in serially dependent data. METHODS TMS-evoked silent periods were recorded in 13 healthy subjects. Two investigators subjectively measured silent period duration on each subject to estimate rater reliability. Using the graphical method, the mean and 99.76% variation limits of pre-stimulus electromyogram (EMG) activity were computed. Each averaged trial was displayed and CSP onset and offset detected when post-stimulus EMG activity moved outside the 99.76% limits. RESULTS Maximum variation in silent period duration was 21.8 ms between the two investigators' subjective measurements. Silent period duration measured with the graphical method closely approximated measurements obtained using the manual method. It was possible to automate the procedure. CONCLUSIONS This graphical method allowed precise measurement of CSP duration, independent of subjective estimations of onset or offset points. Further studies are necessary to determine if this method can provide a framework for other physiologic measures.
This paper references
Understanding Variation: The Key to Managing Chaos
D. Wheeler (2000)
Computer-aided determination of the silent period.
J. Nilsson (1997)
Motor cortical inhibition and the dopaminergic system. Pharmacological changes in the silent period after transcranial brain stimulation in normal subjects, patients with Parkinson's disease and drug-induced parkinsonism.
A. Priori (1994)
Signal detection in averaged evoked potentials: Monte Carlo comparison of the sensitivity of different methods.
A. Achim (1995)
Parkinson's disease rigidity
R. Cantello (1991)
On the inter- and intra-subject variability of the electromyographic signal in isometric contractions.
R. Araújo (2000)
Changes in excitability of motor cortical circuitry in patients with parkinson's disease
M. C. Ridding (1995)
Using statistical process control to make data-based clinical decisions.
A. Pfadt (1995)
Cortical inhibition in Parkinson's disease. A study with paired magnetic stimulation.
A. Berardelli (1996)
Calculation of the electromyographic jitter 1
J. Ekstedt (1974)
Stereotactic pallidotomy lengthens the transcranial magnetic cortical stimulation silent period in Parkinson's disease
M. Young (1997)
AAEM minimonograph #16: Instrumentation and measurement in electrodiagnostic medicine–part I
A. Gitter (1995)
Transcranial magnetic stimulation. Negative effects.
M. Hallett (1995)
Applying statistical process control to clinical data: an illustration.
A. Pfadt (1992)
Deficient motor control in children with tic disorder: evidence from transcranial magnetic stimulation
Gunther H Moll (1999)
Decreased motor inhibition in Tourette's disorder: evidence from transcranial magnetic stimulation.
U. Ziemann (1997)
Statistical method from the viewpoint of quality control
W. A. Shewhart (1939)
Silent period evoked by transcranial stimulation of the human cortex and cervicomedullary junction.
M. Inghilleri (1993)
Significance testing of difference potentials.
D. Guthrie (1991)
Visual Inspection of Data Revisited: Do the Eyes Still Have It?
G. Fisch (1998)
Inhibitory and excitatory interhemispheric transfers between motor cortical areas in normal humans and patients with abnormalities of the corpus callosum.
B. Meyer (1995)
Pediatric Clinical Electromyography
H. Jones (1996)
Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans
K. Werhahn (1999)
ON THE METHODS AND THEORY OF RELIABILITY
J. Bartko (1976)
Using statistical process control charts for the continual improvement of asthma care.
P. Boggs (1999)
Silent period induced by cutaneous stimulation.
A. Uncini (1991)
Magnetic brain stimulation: the silent period after the motor evoked potential.
R. Cantello (1992)
The muscle silent period following transcranial magnetic cortical stimulation
S. Wilson (1993)
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F. Vacherot (2010)
Differential contributions of transcallosal sensorimotor fiber tract structure and neurophysiologic function to manual motor control in young and older adults
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Direct and crossed effects of somatosensory electrical stimulation on motor learning and neuronal plasticity in humans
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A. Thompson (2011)
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Y. Sohn (2004)
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S. Pallanti (2010)
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P. Jung (2006)
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