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Cortico-motor Excitability Of The Lower Limb Motor Representation: A Comparative Study In Parkinson's Disease And Healthy Controls

F. Tremblay, L. Tremblay
Published 2002 · Psychology, Medicine

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OBJECTIVE To compare indices of cortico-motor excitability derived from transcranial magnetic stimulation (TMS) of the lower limb motor representation in patients with Parkinson's diseases (PD) and healthy controls. METHODS The cortico-motor excitability of the lower limb motor area was studied both at rest (motor threshold, amplitude of motor evoked potentials (MEPs)) and during active contraction of the quadriceps (Quad) muscle (MEPs facilitation and silent period) in 10 PD patients (11 legs) and 11 healthy controls using single pulse TMS. RESULTS At rest, the motor threshold was found to be significantly lower and the amplitude of MEPs larger in patients than in controls. During active knee contraction, patients produced lower levels of MEP facilitation with respect to baseline values and the silent period was lengthened in comparison to controls. CONCLUSIONS The present results provide further evidence from the lower limb motor area that enhanced cortico-spinal excitability is an important feature in the pathophysiology of PD.
This paper references
10.1111/j.1469-7793.1998.191bi.x
Does a C3‐C4 propriospinal system transmit corticospinal excitation in the primate? An investigation in the macaque monkey
M. A. Maier (1998)
10.1093/BRAIN/117.2.317
Motor cortical inhibition and the dopaminergic system. Pharmacological changes in the silent period after transcranial brain stimulation in normal subjects, patients with Parkinson's disease and drug-induced parkinsonism.
A. Priori (1994)
10.1016/S0165-0173(01)00158-8
Transcranial magnetic stimulation and Parkinson’s disease
R. Cantello (2002)
10.1152/JAPPL.2001.91.5.2224
Long-term activity in upper- and lower-limb muscles of humans.
D. S. Kern (2001)
10.1152/JN.1998.80.6.2870
Intracortical inhibition and facilitation in different representations of the human motor cortex.
R. Chen (1998)
10.1007/s002210100839
Effect of apomorphine on cortical inhibition in Parkinson's disease patients: a transcranial magnetic stimulation study
M. Pierantozzi (2001)
10.1212/WNL.44.4.735
Abnormal facilitation of the response to transcranial magnetic stimulation in patients with Parkinson's disease
J. Valls-Solé (1994)
10.1002/ANA.410370208
Changes in excitability of motor cortical circuitry in patients with parkinson's disease
M. C. Ridding (1995)
10.1002/MUS.880170604
Association between muscle architecture and quadriceps femoris H‐reflex
S. J. Garland (1994)
10.1136/jnnp.64.2.166
Overactivity of cervical premotor neurons in Parkinson’s disease
S. Pol (1998)
10.1016/0304-3940(96)12575-1
Enhancement of human motor cortex inhibition by the dopamine receptor agonist pergolide: evidence from transcranial magnetic stimulation
U. Ziemann (1996)
10.1002/(SICI)1097-4598(199705)20:5<570::AID-MUS5>3.0.CO;2-6
Corticomotor threshold to magnetic stimulation: Normal values and repeatability
K. Mills (1997)
10.1016/S0987-7053(00)00236-7
Neurophysiological characterization of parkinsonian syndromes
J. Valls-Solé (2000)
10.1016/S1388-2457(00)00316-3
Effects of chronic levodopa and pergolide treatment on cortical excitability in patients with Parkinson's disease: a transcranial magnetic stimulation study
A. Strafella (2000)
10.1212/WNL.41.9.1449
Parkinson's disease rigidity
R. Cantello (1991)
10.1111/j.1469-7793.1999.0301z.x
Cortical control of spinal pathways mediating group II excitation to human thigh motoneurones
V. Marchand-Pauvert (1999)
10.1212/WNL.56.6.716
Effects of internal globus pallidus stimulation on motor cortex excitability
R. Chen (2001)
Pathophysiology of the motor cortex in patients with Parkinson's disease.
J. Rothwell (1999)



This paper is referenced by
10.1016/j.clinph.2003.10.013
Impact of different stimulation types on orthostatic tremor
J. Spiegel (2004)
10.1007/s00221-007-1150-6
Corticomotor facilitation associated with observation and imagery of hand actions is impaired in Parkinson’s disease
F. Tremblay (2007)
10.1016/j.jocn.2009.09.038
Pallidotomy does not ameliorate abnormal intracortical inhibition in Parkinson’s disease
M. V. Sale (2010)
10.1017/CBO9780511545047.007
The Circuitry of the Human Spinal Cord: Ib Pathways
E. Pierrot-Deseilligny (2005)
10.1155/2016/8764238
Mirror Visual Feedback to Improve Bradykinesia in Parkinson's Disease
G. Bonassi (2016)
Project title: Effects of combined repetitive transcranial magnetic stimulation and treadmill training on gait performance in Parkinson’s disease – a randomised controlled trial
(2019)
Contributions of the cerebral cortex and basal ganglia to human anticipatory postural control in healthy and Parkinsons Disease subjects
J. Jacobs (2006)
10.1016/j.neuroscience.2009.08.002
The supplementary motor area contributes to the timing of the anticipatory postural adjustment during step initiation in participants with and without Parkinson's disease
J. Jacobs (2009)
10.3109/00207450903411141
Premovement Facilitation of Corticospinal Excitability in Patients with Parkinson's Disease
K. Hiraoka (2010)
10.3389/fnhum.2020.00190
Corticomotor Excitability Changes Associated With Freezing of Gait in People With Parkinson Disease
Ya-Yun Lee (2020)
10.1002/mds.27870
Sex differences in Parkinson's disease: A transcranial magnetic stimulation study
Kaja Kolmančič (2019)
10.3233/JPD-130212
Corticomotor excitability in Parkinson's disease during observation, imagery and imitation of action: effects of rehabilitation using wii fit and comparison to healthy controls.
J. Esculier (2014)
10.5535/arm.2016.40.1.81
Usefulness of Transcranial Magnetic Stimulation to Assess Motor Function in Patients With Parkinsonism
Jaechan Park (2016)
10.1002/mds.22284
Subthalamic nucleus stimulation restores corticospinal facilitation in Parkinson's disease
M. Poetter-Nerger (2008)
10.1002/mds.23378
A motor cortex excitability and gait analysis on Parkinsonian patients
F. Vacherot (2010)
Historia badania ruchowych potencjałów wywołanych drażnieniem zmiennym polem magnetycznym przez powierzchnię czaszki. Pionierzy i kontynuatorzy
Jacek Bojakowski (2015)
10.1002/mds.21565
Asymmetric corticomotor excitability correlations in early Parkinson's disease
A. Wu (2007)
10.1016/S0035-3787(05)84971-9
Stimulation du cortex moteur, Parkinson et dystonie : que nous enseigne la stimulation magnétique transcrânienne? revue de la littérature
J. P. Lefaucheur (2005)
10.1146/annurev-neuro-061010-113749
Three-dimensional transformations for goal-directed action.
J. Crawford (2011)
10.1016/j.clinph.2010.07.016
Neurophysiological evaluation of motor corticospinal pathways by TMS in idiopathic early-onset Parkinson’s disease
A. Perretti (2011)
10.1016/j.neucli.2010.04.002
Excitability of the lower-limb area of the motor cortex in Parkinson's disease
F. Vacherot (2010)
10.1016/j.clinph.2004.11.017
Motor cortex dysfunction revealed by cortical excitability studies in Parkinson's disease: influence of antiparkinsonian treatment and cortical stimulation
Jean-Pascal Lefaucheur (2005)
10.1016/j.clinph.2012.09.016
History of exposure to dopaminergic medication does not affect motor cortex plasticity and excitability in Parkinson’s disease
A. Kacar (2013)
10.1016/j.parkreldis.2013.01.007
Safety of transcranial magnetic stimulation in Parkinson's disease: a review of the literature.
Matthew Vonloh (2013)
Transformations for Goal-Directed Action
J. Crawford (2011)
10.1002/mus.24584
Reliability of single and paired‐pulse transcranial magnetic stimulation in the vastus lateralis muscle
T. J. O’Leary (2015)
10.1007/s00221-004-2170-0
Excitability of the motor cortical representation of the external anal sphincter
Jean-Pascal Lefaucheur (2004)
10.1016/S1567-424X(09)70205-3
TMS and threshold hunting.
F. Awiszus (2003)
10.1016/j.clinph.2013.09.004
Modulation of corticomotor excitability after maximal or sustainable-rate repetitive finger movement is impaired in Parkinson’s disease and is reversed by levodopa
W. Teo (2014)
10.1371/journal.pone.0110004
Age and Muscle-Dependent Variations in Corticospinal Excitability during Standing Tasks
A. Remaud (2014)
Corticospinal and peripheral conductions to proximal lower limb muscles: a combined neurophysiological study
Miglė Ališauskienė (2008)
Plastische Veränderungen des motorischen Kortex nach BIG-Physiotherapie bei Patienten mit idiopathischem Parkinson-Syndrom
Florian Restle (2015)
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