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Hyperthermia In Combined Treatment Of Cancer.

P. Wust, B. Hildebrandt, G. Sreenivasa, B. Rau, J. Gellermann, H. Riess, R. Felix, P. Schlag
Published 2002 · Medicine

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Hyperthermia, the procedure of raising the temperature of tumour-loaded tissue to 40-43 degrees C, is applied as an adjunctive therapy with various established cancer treatments such as radiotherapy and chemotherapy. The potential to control power distributions in vivo has been significantly improved lately by the development of planning systems and other modelling tools. This increased understanding has led to the design of multiantenna applicators (including their transforming networks) and implementation of systems for monitoring of E-fields (eg, electro-optical sensors) and temperature (particularly, on-line magnetic resonance tomography). Several phase III trials comparing radiotherapy alone or with hyperthermia have shown a beneficial effect of hyperthermia (with existing standard equipment) in terms of local control (eg, recurrent breast cancer and malignant melanoma) and survival (eg, head and neck lymph-node metastases, glioblastoma, cervical carcinoma). Therefore, further development of existing technology and elucidation of molecular mechanisms are justified. In recent molecular and biological investigations there have been novel applications such as gene therapy or immunotherapy (vaccination) with temperature acting as an enhancer, to trigger or to switch mechanisms on and off. However, for every particular temperature-dependent interaction exploited for clinical purposes, sophisticated control of temperature, spatially as well as temporally, in deep body regions will further improve the potential.
This paper references
Heat shock protein 72 on tumor cells: a recognition structure for natural killer cells.
G. Multhoff (1997)
10.1016/0360-3016(93)90314-L
Cumulative minutes with T90 greater than Tempindex is predictive of response of superficial malignancies to hyperthermia and radiation.
K. Leopold (1993)
10.1016/S0360-3016(97)00731-1
Survival benefit of hyperthermia in a prospective randomized trial of brachytherapy boost +/- hyperthermia for glioblastoma multiforme.
P. Sneed (1998)
Intratumoral pO 2 predicts survival in advanced cancer of the uterine cervix
M. Hockel (2003)
10.1016/S0360-3016(97)00109-0
Combined external beam irradiation and external regional hyperthermia for locally advanced adenocarcinoma of the prostate.
M. Anscher (1997)
10.1080/02656730150201552
Hyperthermia in oncology.
M. H. Falk (2001)
10.1016/0360-3016(94)90571-1
Influence of elevated temperature on natural killer cell activity, lymphokine-activated killer cell activity and lectin-dependent cytotoxicity of human umbilical cord blood and adult blood cells.
R. N. Shen (1994)
10.1002/(SICI)1097-0142(19970301)79:5<935::AID-CNCR10>3.0.CO;2-3
Phase II trial of weekly locoregional hyperthermia and cisplatin in patients with a previously irradiated recurrent carcinoma of the uterine cervix
Ron C. Rietbroek (1997)
Immunological and physiological responses to whole-body hyperthermia.
J. Bull (1982)
Report of a long-term follow-up in a randomized trial comparing radiation therapy and radiation plus hyperthermia to metastatic lymph nodes in stage IV head and neck cancer patients
R Valdagni (1993)
10.1016/0360-3016(96)00154-X
Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group.
C. Vernon (1996)
10.1016/0360-3016(90)90361-M
Two or six hyperthermia treatments as an adjunct to radiation therapy yield similar tumor responses: results of a randomized trial.
D. Kapp (1990)
Fast 3 D monitoring of small temperature changes for hyperthermia using magnetic resonance
W Wlodarczyk (1998)
10.1097/00000658-199803000-00010
Preoperative hyperthermia combined with radiochemotherapy in locally advanced rectal cancer: a phase II clinical trial.
B. Rau (1998)
10.1016/S0360-3016(97)00855-9
Magnetic resonance thermometry during hyperthermia for human high-grade sarcoma.
D. Carter (1998)
10.1088/0031-9155/41/3/007
Dose uniformity in MECS interstitial hyperthermia: the impact of longitudinal control in model anatomies.
J. F. van der Koijk (1996)
10.1056/NEJM199904153401501
Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer.
M. Morris (1999)
10.1002/JMRI.1880080129
Three‐dimensional monitoring of small temperature changes for therapeutic hyperthermia using MR
W. Wlodarczyk (1998)
10.1080/09553009214550851
Effect of heat on induction and repair of DNA strand breaks in X-irradiated CHO cells.
E. Dikomey (1992)
10.1126/SCIENCE.7545313
A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides.
R. Suto (1995)
10.1080/02656730118651
Electromagnetic phased arrays for regional hyperthermia: optimal frequency and antenna arrangement.
M. Seebass (2001)
10.1016/S0959-8049(01)00191-5
Treatment of primary, recurrent or inadequately resected high-risk soft-tissue sarcomas (STS) of adults: results of a phase II pilot study (RHT-95) of neoadjuvant chemotherapy combined with regional hyperthermia.
C. Wendtner (2001)
Apoptosis in tumors and normal tissues induced by whole body hyperthermia in rats.
Y. Sakaguchi (1995)
10.3109/02656739009140970
Thermoradiotherapy of patients with locally advanced carcinoma of the rectum.
B. Berdov (1990)
10.1200/JCO.1998.16.9.2906
Prophylactic isolated limb perfusion for localized, high-risk limb melanoma: results of a multicenter randomized phase III trial. European Organization for Research and Treatment of Cancer Malignant Melanoma Cooperative Group Protocol 18832, the World Health Organization Melanoma Program Trial 15, a
H. S. Koops (1998)
10.1016/S0959-8049(01)00183-6
Neoadjuvant chemotherapy combined with regional hyperthermia (RHT) for locally advanced primary or recurrent high-risk adult soft-tissue sarcomas (STS) of adults: long-term results of a phase II study.
R. D. Issels (2001)
10.1080/02656730118511
Hyperthermia in oncology.
M. Falk (2001)
10.1200/JCO.1991.9.12.2091
Regional hyperthermic perfusion with melphalan after surgery for recurrent malignant melanoma of the extremities. Swedish Melanoma Study Group.
L. Hafström (1991)
10.1002/1097-0142(19940415)73:8<2048::AID-CNCR2820730806>3.0.CO;2-Q
Intraperitoneal thermochemotherapy for prevention of peritoneal recurrence of gastric cancer. Final results of a randomized controlled study
R. Hamazoe (1994)
10.1080/02656730117458
Whole-body hyperthermia with water-filtered infrared radiation: technical-physical aspects and clinical experiences.
H. Wehner (2001)
10.1118/1.1388220
Antenna arrays in the SIGMA-eye applicator: interactions and transforming networks.
P. Wust (2001)
10.1080/02656730150502323
Temperature data and specific absorption rates in pelvic tumours: predictive factors and correlations.
W. Tilly (2001)
Fast 3D monitoring of small temperature changes for hyperthermia using magnetic resonance
W Wlodarczyk (1998)
Phase III study of interstitial thermoradiotherapy compared with interstitial radiotherapy alone in the treatment of recurrent or persistent human tumors. A prospectively controlled randomized study by the Radiation Therapy Group.
B. Emami (1996)
10.1016/S0140-6736(00)02059-6
Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial
J. Zee (2000)
10.1016/0304-3835(95)03976-4
Cytokine induction by 41.8 °C whole body hyperthermia
H. Robins (1995)
10.1080/02656730050074096
Feasibility and analysis of thermal parameters for the whole-bodyhyperthermia system IRATHERM-2000
P. Wust (2000)
10.1002/(SICI)1097-0215(19990105)80:1<5::AID-IJC2>3.0.CO;2-F
Hyperthermia for treatment of rectal cancer: evaluation for induction of multidrug resistance gene (mdr1) expression.
U. Stein (1999)
10.3109/02656738909140469
Quality assurance guidelines for ESHO protocols.
J. Hand (1989)
Final Results of a Randomized Controlled Study of the Ibritumomab Tiuxetan Radioimmunotherapy Regimen vs a Standard Course of Rituximab Immunotherapy for B-Cell Non-Hodgkin’s Lymphoma
T. Witzig (2001)
Radiologe
M Peller (1999)
10.3109/02656739009140944
Head and neck cancers: results of thermoradiotherapy versus radiotherapy.
N. R. Datta (1990)
10.1016/S1359-6101(99)00006-4
Whole body hyperthermia cytokine induction: a review, and unifying hypothesis for myeloprotection in the setting of cytotoxic therapy.
D. Katschinski (1999)
Time-temperature relationship th hyperthermic treatment of malignant and normal tissue in vivo.
J. Overgaard (1979)
10.1016/S0360-3016(00)00650-7
Preoperative radiochemotherapy in locally advanced or recurrent rectal cancer: regional radiofrequency hyperthermia correlates with clinical parameters.
B. Rau (2000)
10.1148/RADIOLOGY.137.3.7003650
Will hyperthermia conquer the elusive hypoxic cell? Implications of heat effects on tumor and normal-tissue microcirculation.
M. Dewhirst (1980)
10.1200/JCO.1990.8.11.1818
Ifosfamide plus etoposide combined with regional hyperthermia in patients with locally advanced sarcomas: a phase II study.
R. Issels (1990)
10.1097/00000421-199104000-00008
Randomized Phase III Study Comparing Irradiation and Hyperthermia with Irradiation Alone in Superficial Measurable Tumors: Final Report by the Radiation Therapy Oncology Group
C. Perez (1991)
10.1016/0360-3016(92)91034-K
Combined hyperthermia and irradiation in the treatment of superficial tumors: results of a prospective randomized trial of hyperthermia fractionation (1/wk vs 2/wk).
B. Emami (1992)
10.1016/0360-3016(94)90154-6
Report of long-term follow-up in a randomized trial comparing radiation therapy and radiation therapy plus hyperthermia to metastatic lymph nodes in stage IV head and neck patients.
R. Valdagni (1994)
A Nontoxic System for 41.8°C Whole-Body Hyperthermia: Results of a Phase I Study Using a Radiant Heat Device
H. Robins (1985)
10.1080/02656730010001333
A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma.
Y. Harima (2001)
Hyperthermia in cancer therapy.
M. R. Manning (1981)
10.3109/02656739609022525
Tumour oxygenation is increased by hyperthermia at mild temperatures.
C. Song (1996)
10.1007/s001340050989
Whole body hyperthermia: a secure procedure for patients with various malignancies?
T. Kerner (1999)
A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage III cervical carcinoma
B Emami (2001)
10.3109/02656739409009351
Arrhenius relationships from the molecule and cell to the clinic.
W. Dewey (1994)
10.1002/JSO.2930600111
Prospective randomized study of hyperthermia combined with chemoradiotherapy for esophageal carcinoma
K. Kitamura (1995)
10.1016/S0360-3016(00)00425-9
Clinical evaluation and verification of the hyperthermia treatment planning system hyperplan.
J. Gellermann (2000)
10.1016/0360-3016(95)02137-X
Phase III study of interstitial thermoradiotherapy compared with interstitial radiotherapy alone in the treatment of recurrent or persistent human tumors: A prospectively controlled randomized study by the radiation therapy oncology group
B. Emami (1993)
10.1007/978-3-642-83260-4_23
Interaction of hyperthermia and chemotherapy.
O. Dahl (1988)
10.1016/S0360-3016(98)00165-5
Rationale for using invasive thermometry for regional hyperthermia of pelvic tumors.
P. Wust (1998)
10.1097/00000658-199612000-00011
Isolated limb perfusion with tumor necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas. The cumulative multicenter European experience.
A. Eggermont (1996)
10.1016/S0360-3016(99)00272-2
The treatment of high-grade soft tissue sarcomas with preoperative thermoradiotherapy.
L. Prosnitz (1999)
10.1007/s001170050572
MRT-gesteuerte regionale Tiefenhyperthermie
M. Peller (1999)
10.1002/1097-0142(19890615)63:12<2551::AID-CNCR2820631233>3.0.CO;2-7
Prognostic variables in recurrent limb melanoma treated with hyperthermic antiblastic perfusion
Franco Di Filippo (1989)
10.3109/02656739509022483
Heat shock proteins, thermotolerance, and their relevance to clinical hyperthermia.
G. Li (1995)
10.1097/00000658-198412000-00016
A Prospective Randomized Study of Regional Extremity Perfusion in Patients with Malignant Melanoma
F. Ghussen (1984)
10.1080/026567399285765
For the clinical application of thermochemotherapy given at mild temperatures.
M. Urano (1999)
10.1016/S0140-6736(95)90463-8
Randomised trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma
J. Overgaard (1995)
Thermoradiotherapy in the management of superficial malignant tumors.
K. Engin (1995)
10.1002/MRM.1910320311
Modeling and observation of temperature changes in Vivo using MRI
I. Young (1994)
Report of a long - term follow - up in a randomized trial comparing radiation therapy and radiation plus hyperthermia to metastatic lymph nodes in stage IV head and neck cancer patients
C Vernon (1993)
10.1379/1466-1268(1998)003<0245:NMAATF>2.3.CO;2
Nuclear matrix as a target for hyperthermic killing of cancer cells.
J. R. Roti Roti (1998)
Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.
P. Vaupel (1989)
An update on the anticancer effects of a combination of chemotherapy and hyperthermia.
J. Bull (1984)
A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage III cervical carcinoma
Y Harima (2001)
Matched - pair analysis of response to local hyperthermia and megavoltage electron therapy for superficial human tumors
RA Steeves (1986)
10.1016/S0140-6736(05)73674-6
Regional hyperthermia for rectal cancer
B. Hildebrandt (2000)
10.3109/02656739409009352
Chemotherapy combined with or without hyperthermia for patients with oesophageal carcinoma: a prospective randomized trial.
K. Sugimachi (1994)
10.1016/0167-8140(93)90025-4
Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix.
M. Höckel (1993)



This paper is referenced by
10.1088/0022-3727/43/47/474011
Ferromagnetic nanoparticles for magnetic hyperthermia and thermoablation therapy
E. Kita (2010)
10.1049/IP-NBT:20055018
Use of magnetic nanoparticle heating in the treatment of breast cancer.
I. Hilger (2005)
10.1098/rsif.2013.0134
Controlled cobalt doping in biogenic magnetite nanoparticles
J. Byrne (2013)
10.1109/TMAG.2014.2363108
Temperature Field Optimization and Magnetic Nanoparticles Optimal Approximation of MFH for Cancer Therapy
Guanzhong Hu (2015)
Microwave-based temperature monitoring: Sensitivity to temperature changes
Yousef Gouda (2014)
10.1007/978-3-319-14160-2_6
Noninvasive Radio Frequency for Early Diagnosis of Prostate Cancer
Carlo Bellorofonte (2015)
10.1186/1476-4598-4-12
Heat shock protein 72 expression allows permissive replication of oncolytic adenovirus dl1520 (ONYX-015) in rat glioblastoma cells
Jonathan Madara (2004)
10.1080/02656730500069559
Editorial
Olav Dahl (2005)
10.1038/s41598-017-09116-1
Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers
Y. Liu (2017)
10.1117/12.706302
Intratumoral iron oxide nanoparticle hyperthermia and radiation cancer treatment
P. Hoopes (2007)
10.1080/02656730410001711664
Optimization of the sources in local hyperthermia using a combined finite element-genetic algorithm method
N. Siauve (2004)
10.1007/s10147-006-0647-5
Regional hyperthermia combined with radiotherapy for locally advanced non-small cell lung cancers: a multi-institutional prospective randomized trial of the International Atomic Energy Agency
M. Mitsumori (2006)
10.1089/cbr.2007.0455
Hyperthermia and fibrinolytic therapy do not improve the beneficial effect of radioimmunotherapy following cytoreductive surgery in rats with peritoneal carcinomatosis of colorectal origin.
F. Aarts (2008)
10.1039/c1cs15237h
The golden age: gold nanoparticles for biomedicine.
Erik C Dreaden (2012)
10.3892/ijmm.2013.1366
Identification of common gene networks responsive to mild hyperthermia in human cancer cells.
Ayako Kariya (2013)
10.1109/TAP.2009.2027040
Compact Patch Antenna for Electromagnetic Interaction With Human Tissue at 434 MHz
S. Curto (2009)
10.1016/j.canlet.2008.04.026
Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice.
E. Dickerson (2008)
10.3109/02656730903341332
Optimisation-based thermal treatment planning for catheter-based ultrasound hyperthermia
X. Chen (2010)
CYLINDRICAL PHASED DIPOLES ARRAY FOR HYPERTHERMIA OF DEEP-SITUATED TUMORS
S. Polozov (2012)
10.5772/28184
Fiber Optics for Thermometry in Hyperthermia Therapy
M. Rubio (2012)
10.7150/ntno.31164
Magnetic Heating Stimulated Cargo Release with Dose Control using Multifunctional MR and Thermosensitive Liposome
Sayoni Ray (2019)
10.1002/ADOM.201500726
Neodymium-Based Stoichiometric Ultrasmall Nanoparticles for Multifunctional Deep-Tissue Photothermal Therapy
B. D. Rosal (2016)
10.1038/s41598-020-65823-2
Relationship between Energy Dosage and Apoptotic Cell Death by Modulated Electro-Hyperthermia
Patrick Hung-Ju Kao (2020)
10.3164/jcbn.14-8
The inhibitory effect of heat treatment against epithelial-mesenchymal transition (EMT) in human pancreatic adenocarcinoma cell lines
Reiko Kimura-Tsuchiya (2014)
10.1098/rsos.191139
The cell uptake properties and hyperthermia performance of Zn0.5Fe2.5O4/SiO2 nanoparticles as magnetic hyperthermia agents
R. Wang (2020)
10.1002/mrm.27194
High peak and high average radiofrequency power transmit/receive switch for thermal magnetic resonance
Yiyi Ji (2018)
10.1016/j.semcancer.2019.12.004
Glyco-Nanoparticles: New drug delivery systems in cancer therapy.
H. Khan (2019)
10.1080/02656736.2019.1579371
Modified-FOLFIRINOX combined with deep regional hyperthermia in pancreatic cancer: a retrospective study in Chinese patients
M. He (2019)
10.1159/000509039
Targeting Stem Cells with Hyperthermia: Translational Relevance in Cancer Patients
M. Ammendola (2020)
10.3390/s20102946
The Potential of Adjusting Water Bolus Liquid Properties for Economic and Precise MR Thermometry Guided Radiofrequency Hyperthermia
K. Sumser (2020)
10.1016/J.EURPOLYMJ.2018.12.005
Highly stable photosensitive supramolecular micelles for tunable, efficient controlled drug release
Belete Tewabe Gebeyehu (2019)
10.1039/d0bm00222d
Overview of the application of inorganic nanomaterials in cancer photothermal therapy.
Natanael Fernandes (2020)
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