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Emerging Use Of Nanoparticles In Diagnosis And Treatment Of Breast Cancer.

M. Yezhelyev, X. Gao, Y. Xing, A. Al-Hajj, S. Nie, R. O'Regan
Published 2006 · Medicine
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The biological application of nanoparticles is a rapidly developing area of nanotechnology that raises new possibilities in the diagnosis and treatment of human cancers. In cancer diagnostics, fluorescent nanoparticles can be used for multiplex simultaneous profiling of tumour biomarkers and for detection of multiple genes and matrix RNA with fluorescent in-situ hybridisation. In breast cancer, three crucial biomarkers can be detected and accurately quantified in single tumour sections by use of nanoparticles conjugated to antibodies. In the near future, the use of conjugated nanoparticles will allow at least ten cancer-related proteins to be detected on tiny tumour sections, providing a new method of analysing the proteome of an individual tumour. Supermagnetic nanoparticles have exciting possibilities as contrast agents for cancer detection in vivo, and for monitoring the response to treatment. Several chemotherapy agents are available as nanoparticle formulations, and have at least equivalent efficacy and fewer toxic effects compared with conventional formulations. Ultimately, the use of nanoparticles will allow simultaneous tumour targeting and drug delivery in a unique manner. In this review, we give an overview of the use of clinically applicable nanoparticles in oncology, with particular focus on the diagnosis and treatment of breast cancer.
This paper references
10.1200/JCO.2001.19.14.3422
Cationic liposome-mediated E1A gene transfer to human breast and ovarian cancer cells and its biologic effects: a phase I clinical trial.
G. Hortobagyi (2001)
10.1111/j.1075-122X.2005.21574.x
Allergic reactions to isosulfan blue in sentinel lymph node mapping.
Ian K. Komenaka (2005)
10.1038/nmeth791
Correlated light and electron microscopic imaging of multiple endogenous proteins using Quantum dots
B. Giepmans (2005)
10.1634/theoncologist.9-4-361
Oncogenes and tumor suppressor genes in breast cancer: potential diagnostic and therapeutic applications.
C. Osborne (2004)
Effi cacy and safety of trastuzumab as a single agent in fi rstline treatment of HER 2overexpressing metastatic breast cancer
G Konecny (2002)
10.1186/bcr432
Liposome-based drug delivery in breast cancer treatment
J. Park (2002)
10.1038/nbt1003
Rapid and ultra-sensitive determination of enzyme activities using surface-enhanced resonance Raman scattering
B. Moore (2004)
10.1038/nbt764
Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots
X. Wu (2003)
Poly(ethylene oxide)-modified poly(epsilon-caprolactone) nanoparticles for targeted delivery of tamoxifen in breast cancer.
D. Shenoy (2005)
Multiplex molecular diagnostic of tumor tissue using quantum dots
M Yezhelyev (2005)
Dendrimers in biomedical applicationsreflections on the field
S. Svenson (2005)
10.1038/nmeth1005-723
Semiconductor nanocrystal conjugates, FISH and pH
Y. Xiao (2005)
10.1200/JCO.2005.04.937
Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer.
W. Gradishar (2005)
Simultaneous and quantitative detection of multiple biomarkers in human breast cancers using semiconductor multicolor quantum dots breast cancer research and treatment
M Yezhelyev (2005)
10.1038/90228
Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules
M. Han (2001)
10.1148/radiology.169.2.3174987
Superparamagnetic iron oxide: enhanced detection of focal splenic tumors with MR imaging.
R. Weissleder (1988)
10.1038/nbt929
Quantum dot ligands provide new insights into erbB/HER receptor–mediated signal transduction
D. Lidke (2004)
10.1056/NEJMoa052122
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer.
E. H. Romond (2005)
10.1073/pnas.2232479100
Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
L. R. Hirsch (2003)
10.1097/01.cad.0000167902.53039.5a
Liposomal encapsulated anti-cancer drugs.
R. Hofheinz (2005)
10.1002/mrm.10406
MR molecular imaging of the Her-2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles.
D. Artemov (2003)
10.1038/nmat1390
Quantum dot bioconjugates for imaging, labelling and sensing
Igor L. Medintz (2005)
10.1038/nrc1566
Cancer nanotechnology: opportunities and challenges
M. Ferrari (2005)
10.1016/j.cccn.2005.03.014
Nanotechnology in clinical laboratory diagnostics.
K. Jain (2005)
10.1158/1078-0432.CCR-04-2291
Comparative Preclinical and Clinical Pharmacokinetics of a Cremophor-Free, Nanoparticle Albumin-Bound Paclitaxel (ABI-007) and Paclitaxel Formulated in Cremophor (Taxol)
A. Sparreboom (2005)
10.1038/nm1096
Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy
E. B. Voura (2004)
10.1038/nmat1571
An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles
Oded Rabin (2006)
10.1038/nm1247
Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo
M. Stroh (2005)
10.1038/nrd1088
The dawning era of polymer therapeutics
R. Duncan (2003)
10.1038/sj.gt.3302699
Genospheres: self-assembling nucleic acid-lipid nanoparticles suitable for targeted gene delivery
M. E. Hayes (2006)
10.1200/jco.2001.19.5.1444
Reduced cardiotoxicity and preserved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin and cyclophosphamide in a randomized, multicenter trial of metastatic breast cancer.
G. Batist (2001)
10.1038/sj.gt.3302425
RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
B. Urban-Klein (2005)
10.1038/nbt767
Long-term multiple color imaging of live cells using quantum dot bioconjugates
Jyoti K. Jaiswal (2003)
10.1016/j.tcb.2004.07.012
Potentials and pitfalls of fluorescent quantum dots for biological imaging.
Jyoti K. Jaiswal (2004)
10.1002/ijc.11497
Small interfering RNA (siRNA) inhibits the expression of the Her2/neu gene, upregulates HLA class I and induces apoptosis of Her2/neu positive tumor cell lines.
A. Choudhury (2004)
10.1016/S0959-8049(01)00171-X
Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation.
H. Gelderblom (2001)
10.1056/nejm200103153441101
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.
D. Slamon (2001)
10.1073/pnas.152463399
Nanocrystal targeting in vivo
M. Akerman (2002)
10.1038/nbt920
Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping
S. Kim (2004)
Multiple profi ling of human breast cancer cell lines with quantum dots–Ab conjugates
M Yezhelyev (2005)
10.1002/(SICI)1097-0215(20000320)89:2<111::AID-IJC2>3.0.CO;2-W
Estrogen receptor (ER) and progesterone receptor (PgR), by ligand-binding assay compared with ER, PgR and pS2, by immuno-histochemistry in predicting response to tamoxifen in metastatic breast cancer: a Southwest Oncology Group Study.
R. Elledge (2000)
10.1263/jbb.100.1
Medical application of functionalized magnetic nanoparticles.
A. Ito (2005)
A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation.
M. Kircher (2003)
10.1200/JCO.1990.8.7.1263
Hypersensitivity reactions from taxol.
R. Weiss (1990)
10.1016/S1470-2045(05)70537-4
Diagnostic precision of nanoparticle-enhanced MRI for lymph-node metastases: a meta-analysis.
O. Will (2006)
10.1016/j.copbio.2004.11.003
In vivo molecular and cellular imaging with quantum dots.
X. Gao (2005)
10.1517/14656566.6.9.1463
Personalised medicine for cancer: from drug development into clinical practice
K. Jain (2005)
10.1136/bmj.329.7458.170-b
Sentinel lymph node biopsy: Sentinel node technique has drawbacks
Stefano Ciatto (2004)
TLC D99 (Myocet) and Herceptin is safe in advanced breast cancer: fi nal cardiac safety and effi cacy analysis
M Theodoulou (2002)
Simultaneous, quantitative detection of multiple biomarkers in breast cancers using semiconductor multicolor quantum dots
Ahmad H. Al-Hajj (2006)
10.1073/pnas.91.22.10460
Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice.
G. Schwab (1994)
10.1021/mp049970+
Nanoparticle-mediated wild-type p53 gene delivery results in sustained antiproliferative activity in breast cancer cells.
S. Prabha (2004)
10.1289/ehp.8284
A Toxicologic Review of Quantum Dots: Toxicity Depends on Physicochemical and Environmental Factors
R. Hardman (2006)
10.1186/bcr280
Clinical aspects of sentinel node biopsy
H. Cody (2001)
10.1039/b107318b
Assessment of silver and gold substrates for the detection of amphetamine sulfate by surface enhanced Raman scattering (SERS).
K. Faulds (2002)
10.1038/nbt0202-155
Simultaneous measurement of multiple active kinase states using polychromatic flow cytometry
O. Perez (2002)
Repressed expression of the HER-2/c-erbB-2 proto-oncogene by the adenovirus E1a gene products.
D. Yan (1991)
10.1021/cr050569o
Chemistry of carbon nanotubes.
D. Tasis (2006)
Analysis of the reliability of manual and automated immunohistochemical staining procedures. A pilot study.
Stefan Biesterfeld (2003)
10.1093/jnci/95.2.142
Quantitative association between HER-2/neu and steroid hormone receptors in hormone receptor-positive primary breast cancer.
G. Konecny (2003)
10.1002/ijc.20754
Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity.
J. Menéndez (2005)
10.1093/nar/gnh024
Semiconductor nanocrystal probes for human metaphase chromosomes.
Y. Xiao (2004)
10.1200/JCO.2005.11.013
Multicenter phase II trial of ABI-007, an albumin-bound paclitaxel, in women with metastatic breast cancer.
N. Ibrahim (2005)
Weekly nanoparticle albumin paclitaxel (Abraxane) results in long-term disease control in patients with taxane-refractory metastatic breast cancer
JA O’Shaughnessy (2004)
Eff ects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15 - year survival : an overview of the randomised trials
CL Vogel (2005)
10.2325/jbcs.13.8
Gene therapy for breast cancer. — review of clinical gene therapy trials for breast cancer and mdr1 gene therapy trial in cancer institute hospital
S. Takahashi (2006)
10.1016/j.cbpa.2005.10.005
Applications of carbon nanotubes in drug delivery.
A. Bianco (2005)
10.1038/nm1101-1241
Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent
M. Zhao (2001)
10.1038/nbt994
In vivo cancer targeting and imaging with semiconductor quantum dots
X. Gao (2004)
10.1016/j.tibtech.2005.02.007
Nanobiotechnology: the promise and reality of new approaches to molecular recognition.
P. Fortina (2005)
10.1038/nbt1171
Designing dendrimers for biological applications
C. C. Lee (2005)
10.1021/ac034672u
Spectroscopic tags using dye-embedded nanoparticles and surface-enhanced Raman scattering.
W. Doering (2003)
10.1093/annonc/mdh097
Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer.
M. O'Brien (2004)
10.1093/nar/gni162
Method for multiplex cellular detection of mRNAs using quantum dot fluorescent in situ hybridization
P. Chan (2005)



This paper is referenced by
10.1088/0957-4484/22/11/115101
The effects of particle size, density and shape on margination of nanoparticles in microcirculation.
Randall Toy (2011)
10.1088/0031-8949/86/05/055702
Optical properties of single silver triangular nanoprism
François Kossi Guédjé (2012)
10.5772/61791
Active-targeted Nanotherapy as Smart Cancer Treatment
Katayoun Derakhshandeh (2016)
10.1016/j.msec.2016.06.051
Multifunctional nanocrystalline calcium phosphates loaded with Tetracycline antibiotic combined with human adipose derived mesenchymal stromal stem cells (hASCs).
K. Marycz (2016)
10.1007/S13204-019-01098-Y
Investigation of the potential of using TiO 2 nanoparticles as a contrast agent in computed tomography and magnetic resonance imaging
Hiroaki Akasaka (2019)
10.3390/ijms12074395
Enabling Anticancer Therapeutics by Nanoparticle Carriers: The Delivery of Paclitaxel
Yongjin Liu (2011)
10.1021/nn201570n
HER2 expression in breast cancer cells is downregulated upon active targeting by antibody-engineered multifunctional nanoparticles in mice.
Fabio Corsi (2011)
10.1142/9789814472869_0015
Nanoparticles for Imaging and Therapy: Functionalization, Endocytosis and Characterization
Yu Zhang (2013)
10.1039/C6RA07380H
Amphiphilic peptide coated superparamagnetic iron oxide nanoparticles for in vivo MR tumor imaging
Ayse Daut Ozdemir (2016)
10.1016/j.biopha.2017.03.098
Knockdown of PEBP4 suppresses proliferation, migration and invasion of human breast cancer cells.
S. Wang (2017)
10.1007/s12033-009-9161-0
Cancer Detection and Treatment: The Role of Nanomedicines
Justin LaRocque (2009)
10.1039/C4RA06863G
Characteristics of three sizes of silica nanoparticles in the osteoblastic cell line, MC3T3-E1
X. Xu (2014)
10.4028/WWW.SCIENTIFIC.NET/AMR.1132.72
The Role of Adhesion in Gold Nanoparticles for Cancer Detection and Treatment
Y. Oni (2015)
10.1002/tcr.201700061
Advanced Inorganic Nanosystems for Skin Drug Delivery.
Esperanza Carazo (2018)
10.1146/ANNUREV.MED.59.061506.185523
Nanotechnology and cancer.
J. Heath (2008)
10.1134/S1995078019030030
Preparation of stabilized silver nanoparticles and study of their antimicrobial and cytotoxic activity on the human hepatoma HepG2 cell line
M. A. Ananyan (2019)
10.1016/j.nano.2014.10.005
Biodistribution and in vivo toxicity of aptamer-loaded gold nanostars.
D. H. M. Dam (2015)
10.1186/s40580-016-0084-8
Priming nanoparticle-guided diagnostics and therapeutics towards human organs-on-chips microphysiological system
Jin-Ha Choi (2016)
10.2147/IJN.S173424
Vascular targeted nanotherapeutic approach for obesity treatment
N. Sibuyi (2018)
10.1016/j.tibtech.2009.02.010
Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment.
J. Phan (2009)
Lanthanide Chelates as Donors in Fluorescence Resonance Energy Transfer: Exciting Prospects for Bioaffinity Assay Detection
Tiina Kokko (2009)
10.1016/j.chemphyslip.2014.03.006
Drug targeting using solid lipid nanoparticles.
E. Rostami (2014)
10.1504/IJMEI.2016.073664
Tuberculosis diagnosis - an overview to the conventional diagnostic methodology and need for nanodiagnosis
S. Sudha (2016)
10.1186/s12951-019-0554-3
Nanotechnology advances towards development of targeted-treatment for obesity
N. Sibuyi (2019)
10.1186/s40824-020-00187-2
Synthesizing efficacious genistein in conjugation with superparamagnetic Fe3O4 decorated with bio-compatible carboxymethylated chitosan against acute leukemia lymphoma
Rachel Ghasemi Goorbandi (2020)
10.3109/17435390.2011.562328
Impact of dietary gold nanoparticles in zebrafish at very low contamination pressure: The role of size, concentration and exposure time
Benjamin Geffroy (2012)
10.1016/j.jmr.2018.07.019
Molecular oxygen loading in candidate theranostic droplets stabilized with biocompatible fluorinated surfactants: Particle size effect and application to in situ19F MRI mapping of oxygen partial pressure.
Orane Lorton (2018)
10.2174/157016309787581066
Development of multifunctional nanoparticles for targeted drug delivery and noninvasive imaging of therapeutic effect.
Hari Krishna Sajja (2009)
Gold nanoparticles: novel radiobiological dose enhancement studies for radiation therapy, synchrotron based microbeam and stereotactic radiotherapy
Wan Aizan Wan Abd Rahman (2010)
Development of nanoscale delivery systems for breast cancer treatment
Yuning Zhang (2015)
TARGETED THERAPY FOR BREAST CANCER CELLS BY HERBAL DRUG FORMULATIONS OF IRON OXIDE NANOPARTICLES
K PraseethaP (2016)
10.1021/nn400728t
Monitoring controlled release of payload from gold nanocages using surface enhanced Raman scattering.
Limei Tian (2013)
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