Online citations, reference lists, and bibliographies.
← Back to Search

Proteomics: An Holistic Analysis Of Nature's Proteins.

H. F. Hebestreit
Published 2001 · Medicine, Biology

Cite This
Download PDF
Analyze on Scholarcy
Share
Proteomics has matured to a technology platform way beyond two-dimensional gel electrophoresis, delivering on its promise to identify structure, function and cellular localization of all proteins expressed in a cell at a given time. Major achievements in the past year include mapping the proteome of human and microbial cells, improvements in two-dimensional gel electrophoresis and mass spectrometric analysis, and the development of protein arrays and biochips.
This paper references
10.1038/45350
A post-genomic challenge: learning to read patterns of protein synthesis
A. Abbott (1999)
10.1002/(SICI)1522-2683(20000501)21:9<1823::AID-ELPS1823>3.0.CO;2-3
Comprehensive analyses of prostate gene expression: Convergence of expressed sequence tag databases, transcript profiling and proteomics
P. Nelson (2000)
10.1038/76126
Gene Index analysis of the human genome estimates approximately 120,000 genes
Feng Liang (2000)
10.1002/(SICI)1522-2683(20000401)21:6<1164::AID-ELPS1164>3.0.CO;2-0
Recent advancements in surface‐enhanced laser desorption/ionization‐time of flight‐mass spectrometry
M. Merchant (2000)
10.1038/76115
Analysis of expressed sequence tags indicates 35,000 human genes
Brent Ewing (2000)
10.1126/SCIENCE.1058040
The Sequence of the Human Genome
J. Venter (2001)
10.1002/1522-2683(200011)21:17<3639::AID-ELPS3639>3.0.CO;2-V
A turning point in proteome analysis: Sample prefractionation via multicompartment electrolyzers with isoelectric membranes
B. Herbert (2000)
10.1002/1522-2683(200011)21:17<3673::AID-ELPS3673>3.0.CO;2-M
A comparison of silver stain and SYPRO Ruby Protein Gel Stain with respect to protein detection in two‐dimensional gels and identification by peptide mass profiling
M. Lopez (2000)
10.1006/ABIO.1999.4363
Protein microchips: use for immunoassay and enzymatic reactions.
P. Arenkov (2000)
10.1073/PNAS.97.22.11996
Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: coral red (dsRed) and yellow (Citrine).
A. Heikal (2000)
10.1002/ELPS.1150180341
Analysis of polypeptide expression in benign and malignant human breast lesions
B. Franzén (1997)
10.1002/1615-9861(200101)1:1<13::AID-PROT13>3.0.CO;2-J
Arrays for protein expression profiling: Towards a viable alternative to two‐dimensional gel electrophoresis?
R. Jenkins (2001)
10.1002/1615-9861(200101)1:1<54::AID-PROT54>3.0.CO;2-5
Comparison of three different fluorescent visualization strategies for detecting Escherichia coli ATP synthase subunits after sodium dodecyl sulfate‐polyacrylamide gel electrophoresis
K. Berggren (2001)
10.1038/35051615
The protein–protein interaction map of Helicobacter pylori
J. Rain (2001)
10.1016/S0956-5663(99)00070-6
Patterning multiple antibodies on polystyrene.
R. Brizzolara (2000)
10.1002/1615-9861(200102)1:2<285::AID-PROT285>3.0.CO;2-G
A high‐performance liquid chromatography based strategy for rapid, sensitive sequencing of N‐linked oligosaccharide modifications to proteins in sodium dodecyl sulphate polyacrylamide electrophoresis gel bands
P. Rudd (2001)
10.1385/MB:14:2:109
Principles of affinity-based biosensors
K. Rogers (2000)
10.1385/1-59259-584-7:147
Large-gel 2-D electrophoresis.
J. Klose (1999)
10.1002/(SICI)1522-2683(20000401)21:6<1155::AID-ELPS1155>3.0.CO;2-X
Biosensor chip mass spectrometry: A chip‐based proteomics approach
R. Nelson (2000)
10.1002/1615-9861(200101)1:1<3::AID-PROT3>3.0.CO;2-T
Back to the future: The human protein index (HPI) and the agenda for post‐proteomic biology
N. Anderson (2001)
10.1006/ABIO.2000.4595
A fiber-optic microarray biosensor using aptamers as receptors.
M. Lee (2000)
10.1046/J.1432-1327.2000.01183.X
The proteome of Mycoplasma genitalium. Chaps-soluble component.
V. Wasinger (2000)
10.1002/1522-2683(200011)21:17<3740::AID-ELPS3740>3.0.CO;2-3
Towards the proteome of Mycobacterium tuberculosis
I. Rosenkrands (2000)
10.1016/S0168-1656(00)00258-3
High-throughput protein expression of cDNA products as a tool in functional genomics.
M. Larsson (2000)
10.1002/ELPS.1150180333
A comparison of selected mRNA and protein abundances in human liver
L. Anderson (1997)
10.1002/1522-2683(200011)21:17<3649::AID-ELPS3649>3.0.CO;2-T
An Immobiline DryStrip application method enabling high‐capacity two‐dimensional gel electrophoresis
F. Sabounchi-Schütt (2000)
10.1016/S0956-5663(99)00052-4
Array biosensor for detection of biohazards.
C. A. Rowe-Taitt (2000)
10.1002/(SICI)1521-1878(199904)21:4<339::AID-BIES11>3.0.CO;2-C
Instrumental biosensors: new perspectives for the analysis of biomolecular interactions.
E. Nice (1999)
10.1002/(SICI)1522-2683(20000401)21:6<1116::AID-ELPS1116>3.0.CO;2-Z
Combination of electrophoretic techniques for comprehensive analysis of complex protein systems
T. Manabe (2000)
10.1021/BI992513S
Partial IGF affinity of circulating N- and C-terminal fragments of human insulin-like growth factor binding protein-4 (IGFBP-4) and the disulfide bonding pattern of the C-terminal IGFBP-4 domain.
L. Ständker (2000)
10.1002/1522-2683(200105)22:9<1652::AID-ELPS1652>3.0.CO;2-E
Rapid quantitative measurements of proteomes by Fourier transform ion cyclotron resonance mass spectrometry
R. Smith (2001)
10.1002/1522-2683(200011)21:17<3765::AID-ELPS3765>3.0.CO;2-6
Towards a two‐dimensional proteome map of Mycoplasma pneumoniae
J. T. Regula (2000)
10.1038/13690
Quantitative analysis of complex protein mixtures using isotope-coded affinity tags
Steven P. Gygi (1999)
10.1002/1615-9861(200104)1:4<550::AID-PROT550>3.0.CO;2-W
Analysis of the serologic response to systemic Candida albicans infection in a murine model
A. Pitarch (2001)
10.1002/1097-0231(20000630)14:12<1047::AID-RCM990>3.0.CO;2-E
A tandem quadrupole/time-of-flight mass spectrometer with a matrix-assisted laser desorption/ionization source: design and performance
Loboda (2000)
10.1021/BI992488Q
Posttranslationally processed forms of the human chemokine HCC-1.
R. Richter (2000)
10.1021/AC9912754
Identification of protein vaccine candidates from Helicobacter pylori using a preparative two-dimensional electrophoretic procedure and mass spectrometry.
C. Nilsson (2000)
10.1002/1522-2683(200101)22:2<208::AID-ELPS208>3.0.CO;2-O
Proteomics on a chip: Promising developments
D. Figeys (2001)
10.1038/82360
A network of protein–protein interactions in yeast
B. Schwikowski (2000)
10.1038/35057062
Initial sequencing and analysis of the human genome.
E. Lander (2001)
10.1002/1097-0231(20000815)14:15<1377::AID-RCM31>3.0.CO;2-2
Integration of immobilized trypsin bead beds for protein digestion within a microfluidic chip incorporating capillary electrophoresis separations and an electrospray mass spectrometry interface.
C. Wang (2000)
10.1002/ELPS.1150150157
Characterization of gene expression in clinical lung cancer materials by two‐dimensional polyacrylamide gel electrophoresis
K. Okuzawa (1994)
10.1080/02648725.1996.10647923
Progress with proteome projects: why all proteins expressed by a genome should be identified and how to do it.
M. Wilkins (1996)
10.1056/NEJM199609263351303
The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies.
G. Hsich (1996)
10.1073/PNAS.97.22.11990
The structure of the chromophore within DsRed, a red fluorescent protein from coral.
Lydwine Gross (2000)
10.1002/1615-9861(200101)1:1<118::AID-PROT118>3.0.CO;2-1
Matrix‐assisted laser desorption/ionization quadrupole Time‐of‐Flight Mass Spectrometry: An elegant tool for peptidomics
P. Verhaert (2001)
10.1016/0387-7604(94)00099-J
Carbohydrate-deficient glycoprotein syndrome: electrophoretic study of multiple serum glycoproteins
I. Yuasa (1995)
10.1016/S0167-7799(00)01457-8
Bioencapsulation within synthetic polymers (Part 1): sol-gel encapsulated biologicals.
I. Gill (2000)
10.1002/1522-2683(200011)21:17<3797::AID-ELPS3797>3.0.CO;2-P
Complementing genomics with proteomics: The membrane subproteome of Pseudomonas aeruginosa PAO1
A. Nouwens (2000)
10.1073/PNAS.96.22.12589
Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties.
M. Page (1999)
10.1002/ELPS.1150181519
Protein expression profiles in human breast ductal carcinoma and histologically normal tissue
L. Bini (1997)
10.1002/1615-9861(200104)1:4<494::AID-PROT494>3.0.CO;2-4
Identification of acidic, low molecular mass proteins of Mycobacterium tuberculosis strain H37Rv by matrix‐assisted laser desorption/ionization and electrospray ionization mass spectrometry
J. Mattow (2001)
10.1002/1615-9861(200101)1:1<93::AID-PROT93>3.0.CO;2-3
Towards defining the urinary proteome using liquid chromatography‐tandem mass spectrometry I.Profiling an unfractionated tryptic digest
C. Spahr (2001)
10.1002/1522-2683(200011)21:17<3657::AID-ELPS3657>3.0.CO;2-2
Postelectrophoretic staining of proteins separated by two‐dimensional gel electrophoresis using SYPRO dyes
J. Yan (2000)
10.1073/PNAS.97.22.11984
Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral.
G. Baird (2000)
10.1038/79494
Antibody arrays for high-throughput screening of antibody–antigen interactions
R. D. Wildt (2000)
10.1016/S0956-5663(00)00118-4
Optical chip immunoassay for hCG in human whole blood.
B. Schneider (2000)
10.1002/1522-2683(200012)21:18<4046::AID-ELPS4046>3.0.CO;2-5
Capillary electrophoresis of peptides and proteins in isoelectric buffers: An update
P. G. Righetti (2000)
10.1002/(SICI)1098-1128(200005)20:3<212::AID-MED5>3.0.CO;2-F
PROfusion™: Genetically Tagged Proteins for Functional Proteomics and Beyond
B. L. Kreider (2000)
10.1002/(SICI)1522-2683(20000401)21:6<1123::AID-ELPS1123>3.0.CO;2-E
A thousand points of light: The application of fluorescence detection technologies to two‐dimensional gel electrophoresis and proteomics
Wayne F. Patton (2000)
10.1002/(SICI)1522-2683(20000401)21:6<1054::AID-ELPS1054>3.0.CO;2-8
Membrane proteins and proteomics: Un amour impossible?
V. Santoni (2000)
10.1021/AC9913659
MALDI quadrupole time-of-flight mass spectrometry: a powerful tool for proteomic research.
A. Shevchenko (2000)
10.1016/S0968-0004(00)01714-X
Observing proteins in their natural habitat: the living cell.
P. Bastiaens (2000)
Loss of adipocyte-type fatty acid binding protein and other protein biomarkers is associated with progression of human bladder transitional cell carcinomas.
J. Celis (1996)



This paper is referenced by
10.1007/b101875
A Practical Approach to Microarray Data Analysis
D. Berrar (2003)
10.3929/ETHZ-B-000267091
Intracellular Profiling for Biopharmaceutical Cultivation Processes
Vania Bertrand Maroto (2018)
10.1002/MAS.20047
Applying proteomics technology to platelet research.
A. García (2005)
10.1109/mcd.2002.1035346
Prescription chips
Y. Yang (2002)
10.1182/BLOOD-2003-07-2392
Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins.
A. García (2004)
10.1007/0-306-47815-3_19
Microarray Software Review
Y. F. Leung (2003)
10.1201/9780203911129.CH1
Protein Biochips and Array-Based Proteomics
I. Humphery-Smith (2003)
10.1002/ELPS.200600100
Capillary electrophoresis‐based separation techniques for the analysis of proteins
Y. Huang (2006)
10.1016/J.CHROMA.2007.06.015
Use of multidimensional separation protocols for the purification of trace components in complex biological samples for proteomics analysis.
E. Nice (2007)
10.1016/S1043-2760(02)00669-0
Applications of novel resonance energy transfer techniques to study dynamic hormone receptor interactions in living cells
K. Eidne (2002)
Identification of differentially expressed proteins in obese rats fed different high fat diets using proteomics and bioinformatics approaches
K. Gabuza (2013)
10.1007/978-3-319-28368-5_12
Intestinal Microbiota: First Barrier Against Gut-Affecting Pathogens
P. Calo-Mata (2016)
10.1016/B978-044451024-2/50027-8
Affinity-Based Biosensors, Microarrays and Proteomics
E. Nice (2004)
10.1242/jcs.02928
Identification of regulators of germ layer morphogenesis using proteomics in zebrafish
V. Link (2006)
10.1021/pr100204g
Effects of lead and mercury on the blood proteome of children.
Robert E. Birdsall (2010)
10.1016/B978-0-12-394290-6.00011-2
Biochemical genomics for gene discovery in benzylisoquinoline alkaloid biosynthesis in opium poppy and related species.
Thu Thuy T Dang (2012)
10.1201/9780203503430.CH12
Application of Proteomics in Basic Biological Sciences and Cancer
C. Borchers (2005)
Advances for Biomarker Discovery in Neuroproteomics using Mass Spectrometry : From Method Development to Clinical Application
M. Sjödin (2012)
MICROFLUIDIC ELECTROCAPTURE IN PROTEOMIC SAMPLE PREPARATION FOR MASS SPECTROMETRY
S. Vollmer (2007)
10.1182/BLOOD-2003-09-3295
Proteomics techniques and their application to hematology.
I. M. Cristea (2004)
Semantic Scholar Logo Some data provided by SemanticScholar