Online citations, reference lists, and bibliographies.
← Back to Search

Human Immunity To M. Tuberculosis: T Cell Subsets And Antigen Processing.

W. Boom, D. Canaday, S. Fulton, A. Gehring, R. Rojas, M. Torres
Published 2003 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
A hallmark of M. tuberculosis infection is the ability of most (90-95%) healthy adults to control infection through acquired immunity, in which antigen specific T cells and macrophages arrest growth of M. tuberculosis bacilli and maintain control over persistent bacilli. In addition to CD4+ T cells, other T cell subsets such as, gammadelta, CD8+ and CD1-restricted T cells have roles in the immune response to M. tuberculosis. A diverse T cell response allows the host to recognize a wider range of mycobacterial antigens presented by different families of antigen-presenting molecules, and thus greater ability to detect the pathogen. Macrophages are key antigen presenting cells for T cells, and M. tuberculosis survives and persists in this central immune cell. This is likely an important factor in generating this T cell diversity. Furthermore, the slow growth and chronic nature of M. tuberculosis infection results in prolonged exposure to antigens, and hence further T cell sensitization. The effector mechanisms used by T cells to control M. tuberculosis are poorly understood. To survive in macrophages, M. tuberculosis has evolved mechanisms to block immune responses. These include modulation of phagosomes, neutralization of macrophage effector molecules, stimulating the secretion of inhibitory cytokines, and interfering with processing of antigens for T cells. The relative importance of these blocking mechanisms likely depends on the stage of M. tuberculosis infection: primary infection, persistence, reactivation or active tuberculosis. The balance of the host-pathogen interaction in M. tuberculosis infection is determined by the interaction of T cells and infected macrophages. The outcome of this interaction results either in control of M. tuberculosis infection or active disease. A better understanding of this interaction will result in improved approaches to treatment and prevention of tuberculosis.
This paper references
10.1084/JEM.158.1.74
Protection against Mycobacterium tuberculosis infection by adoptive immunotherapy. Requirement for T cell-deficient recipients
I. Orme (1983)
BCG-induced suppressor T cells optimal conditions for in vitro induction and mode of action.
A. S. Mustafa (1985)
10.1128/iai.50.1.1-8.1985
Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria
G. S. Douvas (1985)
10.1111/j.1365-3083.1987.tb01075.x
Cytotoxic Human HLA Class II Restricted Purified Protein Derivative‐Reactive T‐Lymphocyte Clones
P. W. Hansen (1987)
10.1128/iai.55.9.2037-2041.1987
Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells
I. Müller (1987)
Importance of L3T4+ and Lyt-2+ cells in the immunologic control of infection with Mycobacterium bovis strain bacillus Calmette-Guérin in mice. Assessment by elimination of T cell subsets in vivo.
T. Pedrazzini (1987)
10.1084/JEM.168.5.1947
The recombinant 65-kD heat shock protein of Mycobacterium bovis Bacillus Calmette-Guerin/M. tuberculosis is a target molecule for CD4+ cytotoxic T lymphocytes that lyse human monocytes
T. Ottenhoff (1988)
10.1084/JEM.169.3.909
The generation of antigen-specific, major histocompatibility complex- restricted cytotoxic T lymphocytes of the CD4+ phenotype. Enhancement by the cutaneous administration of interleukin 2
G. Hancock (1989)
10.1111/j.1365-2249.1990.tb03287.x
Specific lysis of mycobacterial antigen‐bearing macrophages by class II MHC‐restricted polyclonal T cell lines in healthy donors or patients with tuberculosis
D. S. KUMARARATNE (1990)
10.1084/JEM.171.3.667
A large fraction of human peripheral blood gamma/delta + T cells is activated by Mycobacterium tuberculosis but not by its 65-kD heat shock protein
D. Kabelitz (1990)
10.1172/JCI115053
Selective expansion of human gamma delta T cells by monocytes infected with live Mycobacterium tuberculosis.
D. Havlir (1991)
10.1084/JEM.174.3.583
Selection of a human T helper type 1-like T cell subset by mycobacteria
J. Haanen (1991)
10.1128/iai.59.2.665-670.1991
Human immune response to Mycobacterium tuberculosis antigens
D. Havlir (1991)
10.1128/IAI.59.8.2737-2743.1991
Human Mycobacterium tuberculosis-reactive CD4+ T-cell clones: heterogeneity in antigen recognition, cytokine production, and cytotoxicity for mononuclear phagocytes
W. Boom (1991)
10.1093/INFDIS/165.3.506
γδ T Lymphocytes in Human Tuberculosis
P. F. Barnes (1992)
10.1128/iai.60.4.1717-1720.1992
Heterogeneity of the repertoire of T cells of tuberculosis patients and healthy contacts to Mycobacterium tuberculosis antigens separated by high-resolution techniques
B. Schoel (1992)
10.1093/CLIND/15.3.540
Impact of human immunodeficiency virus infection on the epidemiology, clinical features, management, and control of tuberculosis.
P. Hopewell (1992)
10.1128/MMBR.56.4.648-661.1992
The antigen 85 complex: a major secretion product of Mycobacterium tuberculosis.
H. Wiker (1992)
10.1084/JEM.178.6.2249
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection
J. Flynn (1993)
Genetically permissive recognition of adjacent epitopes from the 19-kDa antigen of Mycobacterium tuberculosis by human and murine T cells.
D. Harris (1993)
10.1084/JEM.178.6.2243
Disseminated tuberculosis in interferon gamma gene-disrupted mice
A. Cooper (1993)
Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens.
H. Surcel (1994)
10.1126/SCIENCE.8303277
Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase.
S. Sturgill-Koszycki (1994)
10.1126/SCIENCE.8146660
Stimulation of human gamma delta T cells by nonpeptidic mycobacterial ligands.
P. Constant (1994)
10.1128/iai.62.8.3472-3478.1994
Defective antigen presentation by Mycobacterium tuberculosis-infected monocytes
J. Gercken (1994)
10.1128/IAI.63.5.1710-1717.1995
Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis.
A. L. Sørensen (1995)
10.1002/EJI.1830250211
Immune response to Mycobacterium bovis bacille Calmette Guérin infection in major histocompatibility complex class I‐ and II‐deficient knock‐out mice: contribution of CD4 and CD8 T cells to acquired resistance
Christoph H. Ladel (1995)
CD4+ alpha beta T cell and gamma delta T cell responses to Mycobacterium tuberculosis. Similarities and differences in Ag recognition, cytotoxic effector function, and cytokine production.
K. Tsukaguchi (1995)
Mapping of T cell epitopes of the 30-kDa alpha antigen of Mycobacterium bovis strain bacillus Calmette-Guérin in purified protein derivative (PPD)-positive individuals.
R. Silver (1995)
10.1016/1074-7613(95)90178-7
Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells
C. T. Morita (1995)
10.1038/375155A0
Natural and synthetic non-peptide antigens recognized by human γδ T cells
Y. Tanaka (1995)
Early activation of human V gamma 9V delta 2 T cell broad cytotoxicity and TNF production by nonpeptidic mycobacterial ligands.
F. Lang (1995)
10.1001/JAMA.1995.03520270054031
Global epidemiology of tuberculosis. Morbidity and mortality of a worldwide epidemic.
M. Raviglione (1995)
10.1056/NEJM199612263352604
Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection.
E. Jouanguy (1996)
10.1046/j.1365-2567.1996.512590.x
Stimulation of human peripheral blood mononuclear cells with live Mycobacterium bovis BCG activates cytolytic CD8+ T cells in vitro
J. Turner (1996)
Disease-specific changes in gammadelta T cell repertoire and function in patients with pulmonary tuberculosis.
B. Li (1996)
10.1016/S0092-8674(00)80412-2
Innate Immunity: The Virtues of a Nonclonal System of Recognition
R. Medzhitov (1997)
10.1172/JCI119810
Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guérin infection and a sibling with clinical tuberculosis.
E. Jouanguy (1997)
IL-6 produced by macrophages infected with Mycobacterium species suppresses T cell responses.
T. Vanheyningen (1997)
Human alveolar T lymphocyte responses to Mycobacterium tuberculosis antigens: role for CD4+ and CD8+ cytotoxic T cells and relative resistance of alveolar macrophages to lysis.
J. S. Tan (1997)
10.1126/SCIENCE.276.5317.1420
Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis.
J. Belisle (1997)
Bacille Calmette-Guérin vaccination enhances human gamma delta T cell responsiveness to mycobacteria suggestive of a memory-like phenotype.
D. Hoft (1998)
10.1073/PNAS.95.1.270
Human cytolytic and interferon gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis.
A. Lalvani (1998)
10.1126/SCIENCE.280.5368.1435
Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients.
R. de Jong (1998)
CTL response to Mycobacterium tuberculosis: identification of an immunogenic epitope in the 19-kDa lipoprotein.
N. Mohagheghpour (1998)
Lymphocyte-dependent inhibition of growth of virulent Mycobacterium tuberculosis H37Rv within human monocytes: requirement for CD4+ T cells in purified protein derivative-positive, but not in purified protein derivative-negative subjects.
R. Silver (1998)
Attenuation of HLA-DR expression by mononuclear phagocytes infected with Mycobacterium tuberculosis is related to intracellular sequestration of immature class II heterodimers.
Z. Hmama (1998)
Activation of human CD8+ alpha beta TCR+ cells by Mycobacterium tuberculosis via an alternate class I MHC antigen-processing pathway.
D. Canaday (1999)
Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis.
T. Means (1999)
10.1128/IAI.67.8.3998-4007.1999
Cloning, Expression, and Immunological Evaluation of Two Putative Secreted Serine Protease Antigens ofMycobacterium tuberculosis
Y. Skeiky (1999)
Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2.
A. Yoshimura (1999)
Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1.
L. Ting (1999)
10.1016/S1074-7613(00)80119-3
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
O. Takeuchi (1999)
Mycobacterium avium Infection of Mouse Macrophages Inhibits IFN-γ Janus Kinase-STAT Signaling and Gene Induction by Down-Regulation of the IFN-γ Receptor
S. Hussain (1999)
10.1086/314667
Apoptosis and T cell hyporesponsiveness in pulmonary tuberculosis.
C. Hirsch (1999)
Attenuation of MHC class II expression in macrophages infected with Mycobacterium bovis bacillus Calmette-Guérin involves class II transactivator and depends on the Nramp1 gene.
W. Wojciechowski (1999)
10.1126/SCIENCE.285.5428.732
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
H. Brightbill (1999)
10.1006/CIMM.1999.1497
Differential Regulation of IFN-γ, TNF-α, and IL-10 Production by CD4+ αβTCR+ T Cells and Vδ2+ γδ T Cells in Response to Monocytes Infected with Mycobacterium tuberculosis-H37Ra
K. Tsukaguchi (1999)
10.1128/IAI.67.6.2941-2950.1999
Molecular Characterization and Human T-Cell Responses to a Member of a Novel Mycobacterium tuberculosis mtb39Gene Family
D. Dillon (1999)
Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis.
A. M. Caruso (1999)
10.1056/nejm199902043400507
Tuberculosis in patients with human immunodeficiency virus infection.
D. Havlir (1999)
10.4049/jimmunol.165.11.6463
Identification of Major Epitopes of Mycobacterium tuberculosis AG85B That Are Recognized by HLA-A*0201-Restricted CD8+ T Cells in HLA-Transgenic Mice and Humans1
A. Geluk (2000)
10.1128/IAI.68.8.4375-4377.2000
Metabolic Routes as Targets for Immunological Discrimination of Host and Parasite
H. Sicard (2000)
10.4049/jimmunol.165.12.7088
Human CD8+ CTL Specific for the Mycobacterial Major Secreted Antigen 85A1
Steven M. Smith (2000)
CD1 proteins: targets of T cell recognition in innate and adaptive immunity.
Timo Ulrichs (2000)
10.1128/JCM.38.9.3285-3290.2000
Molecular and Immunological Characterization ofMycobacterium tuberculosis CFP-10, an Immunodiagnostic Antigen Missing in Mycobacterium bovis BCG
D. Dillon (2000)
10.1086/318817
Augmentation of apoptosis and interferon-gamma production at sites of active Mycobacterium tuberculosis infection in human tuberculosis.
C. Hirsch (2001)
Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vgamma9/Vdelta2 T lymphocytes.
F. Dieli (2001)
10.4049/jimmunol.167.5.2734
CD4+ and CD8+ T Cells Kill Intracellular Mycobacterium tuberculosis by a Perforin and Fas/Fas Ligand-Independent Mechanism1
D. Canaday (2001)
10.1084/JEM.194.10.1421
Processing of Mycobacterium tuberculosis Antigen 85B Involves Intraphagosomal Formation of Peptide–Major Histocompatibility Complex II Complexes and Is Inhibited by Live Bacilli that Decrease Phagosome Maturation
L. Ramachandra (2001)
10.4049/jimmunol.167.2.910
Toll-Like Receptor 2-Dependent Inhibition of Macrophage Class II MHC Expression and Antigen Processing by 19-kDa Lipoprotein of Mycobacterium tuberculosis1
E. Noss (2001)
10.1056/NEJMOA011110
Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent
J. Keane (2001)
10.1086/323600
Granulysin-Dependent Killing of Intracellular and Extracellular Mycobacterium tuberculosis by Vγ9/Vδ2 T Lymphocytes
F. Dieli (2001)
10.1002/047122393X
Cellular aspects of HIV infection.
A. Cossarizza (2001)
10.1126/SCIENCE.1068819
Adaptive Immune Response of Vγ2Vδ2+ T Cells During Mycobacterial Infections
Y. Shen (2002)
10.1128/IAI.70.6.2926-2932.2002
Identification by Mass Spectrometry of CD8+-T-Cell Mycobacterium tuberculosis Epitopes within the Rv0341 Gene Product
D. Flyer (2002)



This paper is referenced by
10.3389/fmicb.2021.692395
Species-Specific Interferon-Gamma Release Assay for the Diagnosis of Mycobacterium abscessus Complex Infection
Mathis Steindor (2021)
10.1016/j.micpath.2021.104996
Mining the Mycobacterium tuberculosis proteome for identification of potential T-cell epitope based vaccine candidates.
Riya Madan (2021)
10.1186/s12865-021-00433-9
Upregulation of PD-1 expression on circulating CD8+ but not CD4+ T cells is associated with tuberculosis infection in health care workers
Cui-lin Shi (2021)
10.3390/jcm9092757
Understanding the Relationship between Glutathione, TGF-β, and Vitamin D in Combating Mycobacterium tuberculosis Infections
Mohkam Singh (2020)
10.1016/j.meegid.2020.104291
Association of TLR2 polymorphisms, Arg753Gln and Arg677Trp, with tuberculosis in Pakhtun population of Pakistan.
Rabia Fatima (2020)
10.15616/bsl.2020.26.1.22
Association of the Genetic Polymorphisms for CD247 Gene and Tuberculosis Case
Yeon-Ji Ju (2020)
10.4103/bbrj.bbrj_78_19
Role of CXCR3+CCR5+ Th1 cells in pulmonary tuberculosis patients: At pathogenic site
Pradip Saha (2019)
10.3389/fimmu.2018.03069
Immunity to the Dual Threat of Silica Exposure and Mycobacterium tuberculosis
P. Konečný (2019)
10.1002/jcb.27452
LOC152742 as a biomarker in the diagnosis of pulmonary tuberculosis infection
L. Wang (2019)
10.1134/S1068162019020067
An Analysis of Adaptive Reactions in Healthy Subjects Who Have Persistent and Prolonged Contact with Tuberculosis Patients
I. Litvinov (2019)
10.1186/s12931-019-1004-3
Prognostic value of serum macrophage migration inhibitory factor levels in pulmonary tuberculosis
Qingjiang Wang (2019)
10.3390/jcm8122219
Type 2 Diabetes Mellitus and Altered Immune System Leading to Susceptibility to Pathogens, Especially Mycobacterium tuberculosis
Steve Ferlita (2019)
10.1016/j.jinf.2019.08.018
QuantiFERON TB Gold Plus for the diagnosis of tuberculosis: a systematic review and meta-analysis.
G. Sotgiu (2019)
10.3390/jcm8020232
Investigating the Role of Everolimus in mTOR Inhibition and Autophagy Promotion as a Potential Host-Directed Therapeutic Target in Mycobacterium tuberculosis Infection
Stephen Cerni (2019)
10.1007/978-3-319-97367-8_2
Recent Advances in Tuberculosis Immunodiagnostics
I. Khan (2018)
10.1038/s41419-018-0640-8
Clinical isolates of the modern Mycobacterium tuberculosis lineage 4 evade host defense in human macrophages through eluding IL-1β-induced autophagy
A. Romagnoli (2018)
10.1097/CPM.0000000000000247
Diagnostic Utility of CD4/CD8 Ratio in Bronchoalveolar Lavage
Sean A. Marco (2018)
10.1016/j.cyto.2018.03.009
Cytokine and soluble adhesion molecule profiles and biomarkers for treatment monitoring in Re‐treated smear‐positive patients with pulmonary tuberculosis
Xue-juan Bai (2018)
10.3343/alm.2018.38.1.9
Serum Macrophage Migration Inhibitory Factor as a Biomarker of Active Pulmonary Tuberculosis
Zhong-bo Shang (2018)
10.1016/j.tube.2018.06.005
Evaluation of IP-10 in Quantiferon-Plus as biomarker for the diagnosis of latent tuberculosis infection.
L. Petrone (2018)
10.3389/fimmu.2018.02069
The Synergistic Effects of the Glutathione Precursor, NAC and First-Line Antibiotics in the Granulomatous Response Against Mycobacterium tuberculosis
Garrett Teskey (2018)
10.3855/JIDC.10171
Immunophenotyping of circulating mononuclear cells in active pulmonary tuberculosis.
Amany Elkholy (2018)
Mycobacterial antigens accumulation in foamy macrophages of tuberculosis lesions plays a central role in tuberculosis pathogenesis and tissue destruction in chronic murine pulmonary tuberculosis
Syeda Mariam Riaz (2018)
10.1016/B978-0-12-812475-8.00007-X
Can Medicinal Plants Provide an Adjuvant for Tuberculosis Patients
Carel Basson Oosthuizen (2018)
Rôle et mécanismes moléculaires d'action des lipides de l'enveloppe de Mycobacterium tuberculosis dans la virulence
Jacques Augenstreich (2018)
10.4103/ijmy.ijmy_98_17
Humoral immune responses in mice immunized with region of difference DNA vaccine constructs of pUMVC6 and pUMVC7
S. Hanif (2017)
10.3109/9780203908464-15
Diagnosis of Latent Tuberculosis Infection
C. Whalen (2017)
10.5588/ijtld.16.0764
The sensitivity of the QuantiFERON®-TB Gold Plus assay in Zambian adults with active tuberculosis
L. Telisinghe (2017)
Membrane vesicle trafficking of immune modulatory stimuli during Mycobacterium tuberculosis infection
Jaffre J Athman (2017)
10.1080/21505594.2016.1256536
Early diagnosis and effective treatment regimens are the keys to tackle antimicrobial resistance in tuberculosis (TB): A report from Euroscicon's international TB Summit 2016
Arundhati Maitra (2017)
10.1016/J.GENREP.2017.07.005
WITHDRAWN: Rs4073 single nucleotide polymorphism of interleukin-8 (CXCL8/IL-8) and susceptibility to pulmonary tuberculosis in Gilan, northern Iran
Sahar Zarifi Roodposhti (2017)
10.2147/ITT.S81892
Immunotherapy for tuberculosis: future prospects
G. Abate (2016)
See more
Semantic Scholar Logo Some data provided by SemanticScholar