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Protein-based Nanoparticles As A Drug Delivery System: Chances, Risks, Perspectives
S. Fuchs, C. Coester
Published 2010 · Medicine
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Abstract This review aims to provide a broad overview of the development of drug delivery nanoparticulate systems, their classification by basic material, preparation method and administration route while focusing on recent trends in the field of protein-based nanoparticles. Literature on drug delivery by nanotechnology was reviewed in the light of previous and ongoing research. Potentials and challenges including regulatory issues are discussed in the context of possible applications of the miscellaneous nanoparticle devices. Over the past years homogeneous and clearly size-defined nanoparticles have been successfully designed from a large variety of starting materials. These nanoparticles offered diverse targeting or imaging properties in order to either enhance pharmacodynamic efficiency or reduce side effects of the delivered drug substance or to monitor the system’s fate in vivo. The latter is considered especially crucial when it comes to finally guiding nanoparticulate formulations through the clinical phase and its use for the patient’s benefit in the end. If the clinical requirements can be met, the main promises of the new nanoparticulate formulations and associated new routes of drug delivery can be met (a) to enable new types of medicines to be carried to previously inaccessible sites within the body or (b) to reduce risks in delivering already established drugs.
This paper references
Adsorption of antineoplastic drugs to polyalkylcyanoacrylate nanoparticles and their release in calf serum.
P. Couvreur (1979)
Microencapsulated chitosan nanoparticles for lung protein delivery.
A. Grenha (2005)
Effect of trastuzumab-modified antisense oligonucleotide-loaded human serum albumin nanoparticles prepared by heat denaturation.
I. Steinhauser (2008)
Gelatin nanoparticles by two step desolvation--a new preparation method, surface modifications and cell uptake.
C. Coester (2000)
Gastrointestinal distribution and in vivo gene transfection studies with nanoparticles-in-microsphere oral system (NiMOS).
M. Bhavsar (2007)
Drug delivery of siRNA therapeutics: potentials and limits of nanosystems.
D. Reischl (2009)
Ultrasonic bubbles in medicine: influence of the shell.
M. Postema (2007)
A numerical investigation of the resonance of gas-filled microbubbles: resonance dependence on acoustic pressure amplitude.
C. A. Macdonald (2004)
Protein Separation via Polyelectrolyte Coacervation: Selectivity and Efficiency
Y. Wang (1996)
Liposome–nucleic acid immunotherapeutics
S. Dow (2008)
Recent advances with liposomes as pharmaceutical carriers
V. Torchilin (2005)
Matrix-loaded biodegradable gelatin nanoparticles as new approach to improve drug loading and delivery.
Kenneth Ofokansi (2010)
The effect of static magnetic fields and tat peptides on cellular and nuclear uptake of magnetic nanoparticles.
Carol-Anne Smith (2010)
Use of A‐type CpG oligodeoxynucleotides as an adjuvant in allergen‐specific immunotherapy in humans: a phase I/IIa clinical trial
G. Senti (2009)
In vitro uptake of gelatin nanoparticles by murine dendritic cells and their intracellular localisation.
C. Coester (2006)
Preparation of insulin nanoparticles and their encapsulation with biodegradable polyelectrolytes via the layer-by-layer adsorption.
Y. Fan (2006)
Pulmonary targeting with biodegradable salbutamol-loaded nanoparticles.
M. Beck-Broichsitter (2010)
Nanomedicine: sizing up targets with nanoparticles.
Rod minchin (2008)
Nanotechnology applications for improved delivery of antiretroviral drugs to the brain.
H. L. Wong (2010)
Characteristics of Albunex: air-filled albumin microspheres for echocardiography contrast enhancement.
J. Barnhart (1990)
Single-step process to produce surface-functionalized polymeric nanoparticles.
Eric M. Sussman (2007)
Preparation and characterization of low-molecular-weight heparin/protamine nanoparticles (LMW-H/P NPs) as FGF-2 carrier
Y. Mori (2010)
Targeting CpG Oligonucleotides to the Lymph Node by Nanoparticles Elicits Efficient Antitumoral Immunity1
C. Bourquin (2008)
Drug delivery and nanoparticles: Applications and hazards
W. D. de Jong (2008)
Macromolecular Drugs: Novel Strategy In Target Specific Drug Delivery
R. Sharma (2008)
Nanotechnology solutions for mucosal immunization.
S. Chadwick (2010)
A comparison of the effectiveness of cationic polymers poly-L-lysine (PLL) and polyethylenimine (PEI) for non-viral delivery of plasmid DNA to bone marrow stromal cells (BMSC).
L. Farrell (2007)
Recent developments in nanoparticle-based drug delivery and targeting systems with emphasis on protein-based nanoparticles
Guilin Wang (2008)
Chitosan nanoparticles as delivery systems for doxorubicin.
K. Janes (2001)
Drug release study of large hollow nanoparticulate aggregates carrier particles for pulmonary delivery.
Kunn Hadinoto (2007)
The potential for nanoparticle-based drug delivery to the brain: overcoming the blood–brain barrier
E. Barbu, (2009)
Development of gelatin nanoparticles with biotinylated EGF conjugation for lung cancer targeting.
Ching-Li Tseng (2007)
Development and validation of an indirect enzyme-linked immunosorbent assay (ELISA) for the nonsteroidal anti-inflammatory drug S-ibuprofen.
K. Gräfe (2000)
Complex formation of protein with different water-soluble synthetic polymers.
T. Matsudo (2003)
Small animal PET in preclinical studies: opportunities and challenges.
B. Riemann (2008)
A novel technique for selective NF-κB inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia–reperfusion
F. Hoffmann (2009)
Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer.
W. Gradishar (2005)
Therapeutic potential of Toll-like receptor 9 activation
Arthur M. Krieg (2006)
Drug Delivery Systems: Entering the Mainstream
T. Allen (2004)
BIODEGRADABLE POLY (E-CAPROLACTONE) NANOPARTICLES FOR TUMOR-TARGETED DELIVERY OF TAMOXIFEN
J. S. Chawla (2002)
Targeted Delivery of Protein Drugs by Nanocarriers
R. Solaro (2010)
Preparation and characterisation of antibody modified gelatin nanoparticles as drug carrier system for uptake in lymphocytes.
S. Balthasar (2005)
Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system.
M. Amidi (2006)
Towards the use of nanoparticles in cancer therapy and imaging.
E. Pauwels (2007)
Nanoparticles for detection and diagnosis.
Sarit S Agasti (2010)
Comparison of protein-polysaccharide nanoparticle fabrication methods: impact of biopolymer complexation before or after particle formation.
O. G. Jones (2010)
A dimethylmaleic acid–melittin‐polylysine conjugate with reduced toxicity, pH‐triggered endosomolytic activity and enhanced gene transfer potential
M. Meyer (2007)
A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.
O. Boussif (1995)
Lack of an immune response to Albunex, a new ultrasound contrast agent based on air-filled albumin microspheres.
C. Christiansen (1994)
Liposomes: From the Bench to the Bed
D. J. Crommelin (2003)
Delivery of antisense oligodeoxyribonucleotide lipopolyplex nanoparticles assembled by microfluidic hydrodynamic focusing.
C. G. Koh (2010)
Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity.
A. Zintchenko (2008)
Distribution of poly-hexyl-2-cyano-[3-14C]acrylate nanoparticles in healthy and chronically inflamed rabbit eyes
R. Diepold (1989)
Oligonucleotide-protamine-albumin nanoparticles: Protamine sulfate causes drastic size reduction.
G. Mayer (2005)
Tissue-specific gene delivery via nanoparticle coating.
T. Harris (2010)
Targeted drugs and nanomedicine: present and future.
P. Debbage (2009)
Gold Nanoparticles for the Improved Anticancer Drug Delivery of the Active Component of Oxaliplatin
S. D. Brown (2010)
The physiology of the lymphatic system.
M. Swartz (2001)
Silk fibroin nanoparticles for cellular uptake and control release.
J. Kundu (2010)
PEGylation of therapeutic proteins
S. Jevševar (2010)
Protein-based nanomedicine platforms for drug delivery.
A. Maham (2009)
Small-Animal SPECT and SPECT/CT: Important Tools for Preclinical Investigation*
B. Franc (2008)
Biodistribution and Targeting Potential of Poly(ethylene glycol)-modified Gelatin Nanoparticles in Subcutaneous Murine Tumor Model
Goldie Kaul (2004)
Neovasculature induced by vascular endothelial growth factor is fenestrated.
W. Roberts (1997)
Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones.
Anja Zensi (2009)
Nanoparticles for Applications in Cellular Imaging
K. Thurn (2007)
Encapsulation of Nucleic Acids and Opportunities for Cancer Treatment
L. Brannon-Peppas (2006)
Strategies for Optimized Radiolabeling of Nanoparticles for in vivo PET Imaging
G. Sun (2007)
Clinical setbacks for toll-like receptor 9 agonists in cancer
C. Schmidt (2007)
Innovations and perspectives of metered dose inhalers in pulmonary drug delivery.
M. Keller (1999)
Gelatin Nanoparticles for Targeted Oligonucleotide Delivery to Kupffer Cells - Analytics, Formulation Development, Practical Application
J. Zillies (2007)
Parameters influencing the stealthiness of colloidal drug delivery systems.
A. Vonarbourg (2006)
Imaging in the era of molecular oncology
R. Weissleder (2008)
Nanomedicine based approaches for the delivery of siRNA in cancer
B. Ozpolat (2010)
Polymeric micelles as nanocarriers for drug delivery
Liyan Qiu (2007)
Single dose and multiple dose studies of itraconazole nanoparticles.
J. M. Vaughn (2006)
Long-term inhalation toxicity studies with multiwalled carbon nanotubes: closing the gaps or initiating the debate?
D. Warheit (2009)
Development of a novel method for the preparation of submicron particles based on thiolated chitosan.
A. Bernkop-Schnürch (2006)
In vivo tumor targeting and radionuclide imaging with self-assembled nanoparticles: mechanisms, key factors, and their implications.
Yong Woo Cho (2007)
Dynamic 18F-fluoride small animal PET to noninvasively assess renal function in rats
U. Schnoeckel (2008)
Insulin-loaded nanoparticles are prepared by alginate ionotropic pre-gelation followed by chitosan polyelectrolyte complexation.
B. Sarmento (2007)
Evaluation of nanoparticles as drug-delivery systems. III: materials, stability, toxicity, possibilities of targeting, and use.
J. Kreuter (1983)
PEGylation: Camouflage of Proteins, Cells, and Nanoparticles Against Recognition by the Body's Defense Mechanism
Yong Woo Cho (2010)
Targeted brain delivery of AZT via transferrin anchored pegylated albumin nanoparticles
V. Mishra (2006)
Dynavax trial halted.
L. Defrancesco (2008)
Nanoparticle albumin-bound (NAB) technology is a promising method for anti-cancer drug delivery.
Q. Fu (2009)
Advanced nebulizer designs employing vibrating mesh/aperture plate technologies for aerosol generation.
J. Waldrep (2008)
Sheddable Coatings for Long-Circulating Nanoparticles
B. Romberg (2007)
Nanoparticles for RNA interference : novel preclinical formulations for SIRNA mediated gene therapy
S. Schultes (2009)
Evaluation of gliadins nanoparticles as drug delivery systems: a study of three different drugs.
C. Duclairoir (2003)
Nanoparticle albumin-bound paclitaxel (ABI-007): a newer taxane alternative in breast cancer.
A. Moreno-Aspitia (2005)
Nanoparticles--a new colloidal drug delivery system.
J. Marty (1978)
Orally administered OVA/CpG‐ODN induces specific mucosal and systemic immune response in young and aged mice
D. Alignani (2005)
New approaches for imaging tumour responses to treatment
K. Brindle (2008)
Cellular interactions and in vitro DNA transfection studies with poly(ethylene glycol)-modified gelatin nanoparticles.
Goldie Kaul (2005)
A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.
Y. Matsumura (1986)
A self-assembling nanoparticle for paclitaxel delivery in ovarian cancer.
K. Xiao (2009)
Stealth Me.PEG-PLA nanoparticles avoid uptake by the mononuclear phagocytes system.
D. Bazile (1995)
'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption.
The role of specific and non-specific interactions in receptor-mediated endocytosis of nanoparticles.
P. Decuzzi (2007)
Biosynthesis of insulin-silk fibroin nanoparticles conjugates and in vitro evaluation of a drug delivery system
Haibo Yan (2008)
Formulation and characterization of spray-dried powders containing nanoparticles for aerosol delivery to the lung.
Jeffrey O-H Sham (2004)
Selective targeting of antibody-conjugated nanoparticles to leukemic cells and primary T-lymphocytes.
N. Dinauer (2005)
Chitosan and Chitosan/Ethylene Oxide-Propylene Oxide Block Copolymer Nanoparticles as Novel Carriers for Proteins and Vaccines
P. Calvo (2004)
Cancer nanotechnology: opportunities and challenges
M. Ferrari (2005)
The Role of Molecular Imaging in Drug Discovery and Development
R. Hargreaves (2008)
The use of biotinylated-EGF-modified gelatin nanoparticle carrier to enhance cisplatin accumulation in cancerous lungs via inhalation.
Ching-Li Tseng (2009)
Decoy gelatin nanoparticles as a novel tool to elucidate the role of NF-kB in Kupffer cells on hepatic ischemia/reperfusion injury
F. Hoffmann (2007)
Biodistribution of fluoresceinated dextran using novel nanoparticles evading reticuloendothelial system.
U. Gaur (2000)
Oral IL-10 gene delivery in a microsphere-based formulation for local transfection and therapeutic efficacy in inflammatory bowel disease
M. Bhavsar (2008)
Desolvation process and surface characterisation of protein nanoparticles.
C. Weber (2000)
Nonviral vectors for gene delivery.
Meredith A. Mintzer (2009)
DNA-based therapeutics and DNA delivery systems: A comprehensive review
S. Patil (2008)
Covalent Linkage of Apolipoprotein E to Albumin Nanoparticles Strongly Enhances Drug Transport into the Brain
K. Michaelis (2006)
Gelatin Nanoparticles as a modern platform for drug delivery
S. Fuchs (2010)
Biodistribution and pharmacokinetic analysis of long-circulating thiolated gelatin nanoparticles following systemic administration in breast cancer-bearing mice.
S. Kommareddy (2007)
PEGylated PLGA nanoparticles for the improved delivery of doxorubicin.
J. Park (2009)
Bioengineered silk protein-based gene delivery systems.
K. Numata (2009)
Delivery by Cationic Gelatin Nanoparticles Strongly Increases the Immunostimulatory Effects of CpG Oligonucleotides
Klaus Zwiorek (2007)
Nanocarriers’ entry into the cell: relevance to drug delivery
H. Hillaireau (2009)
Targeted pharmaceutical nanocarriers for cancer therapy and imaging
V. Torchilin (2008)
Preparation of nanoparticles from denatured whey protein by pH-cycling treatment
H. J. Giroux (2010)
Optimization of the preparation process for human serum albumin (HSA) nanoparticles.
K. Langer (2003)
Gelatin Nanoparticles as Delivery System for Nucleotide-Based Drugs
Klaus Zwiorek (2006)
Nanoparticle-mediated cellular response is size-dependent.
W. Jiang (2008)
Lipid nanoparticles for parenteral delivery of actives.
Medha D. Joshi (2009)
Formulating protein therapeutics into particulate forms
Sixing Yang (2009)
Formation of silk fibroin nanoparticles in water-miscible organic solvent and their characterization
Yu-Qing Zhang (2007)
Shape effects of filaments versus spherical particles in flow and drug delivery.
Y. Geng (2007)
Method for quantifying the PEGylation of gelatin nanoparticle drug carrier systems using asymmetrical flow field-flow fractionation and refractive index detection.
J. Zillies (2007)
Nanogeometry: beyond drug delivery.
M. Ferrari (2008)
Preparation of human serum albumin microspheres by a novel acetone-heat denaturation method.
C. Chen (1994)
Preparation of sub-100-nm β-lactoglobulin (BLG) nanoparticles
Sanghoon Ko (2006)
Preparation and cytotoxicity comparison of type a gelatin nanoparticles with recombinant human gelatin nanoparticles
Young-Wook Won (2009)
Nanoparticles for drug delivery to the lungs.
Jean Sung (2007)
Seven challenges for nanomedicine.
W. Sanhai (2008)
Nanoparticle albumin-bound paclitaxel for metastatic breast cancer.
M. Harries (2005)
Preparation of Sterically Stabilized Human Serum Albumin Nanospheres Using a Novel Dextranox-MPEG Crosslinking Agent
W. Lin (2004)
Tumor accumulation, degradation and pharmacokinetics of elastin-like polypeptides in nude mice.
W. Liu (2006)
Construction of nanoscale protein particle using temperature-sensitive elastin-like peptide and polyaspartic acid chain.
Y. Fujita (2009)
Topical delivery of liposomally encapsulated interferon evaluated in a cutaneous herpes guinea pig model.
N. Weiner (1989)
This paper is referenced by
Updated but not outdated "Gliadin": A plant protein in advanced pharmaceutical nanotechnologies.
M. Mehanna (2020)
Polysaccharide Based Nanoparticles
Wahid Khan (2018)
Nanomedicines for cancer therapy: state-of-the-art and limitations to pre-clinical studies that hinder future developments
Charlene M. Dawidczyk (2014)
Biopolymers for gene delivery applications
L. G. L. Torre (2017)
Nanomaterials as Therapeutic/Imaging Agent Delivery Vehicles for Tumor Targeting Theranostics
Mingqian Tan (2016)
Layer-by-layer Polyelectrolytes Coating of Alginate Microgels for Sustained Release of Sodium Benzoate and Zosteric Acid.
Q. Wang (2018)
Functionalizing nanoparticles with biological molecules: developing chemistries that facilitate nanotechnology.
K. Sapsford (2013)
Cereal protein-based nanoparticles as agents stabilizing air–water and oil–water interfaces in food systems
A. Wouters (2019)
Zein-casein-lysine multicomposite nanoparticles are effective in modulate the intestinal permeability of ferulic acid.
G. Heep (2019)
Bioprotein Based IPN Nanoparticles as Potential Vehicles for Anticancer Drug Delivery: Fabrication Technology
Md Mehedi Hasan (2020)
Silk for pharmaceutical and cosmeceutical applications
J. Wong (2014)
Synthesis of protein nanoparticles for drug delivery
D. Cheng (2016)
Understanding Cancer Cell Behavior Through 3D Printed Bone Microenvironments
Yangyang Luo (2019)
Nanobiotechnology and nanostructured therapeutic delivery systems
N. Castro (2012)
The effects of radiation and experimental conditions over papain nanoparticle formation: Towards a new generation synthesis
G. N. Fazolin (2020)
A review on pH and temperature responsive gels and other less explored drug delivery systems
P. Bolla (2018)
Synthesis of papain nanoparticles by electron beam irradiation - A pathway for controlled enzyme crosslinking.
G. C. Varca (2016)
Modelling transport of layered double hydroxide nanoparticles in axons and dendrites of cortical neurons
A. Kuznetsov (2012)
Precise nanomedicine for intelligent therapy of cancer
Huabing Chen (2018)
Exploring a new jellyfish collagen in the production of microparticles for protein delivery
M. Calejo (2012)