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What Are Parameters Affecting Leu-enkephalin Loading And Release From Poly(isobutylcyanoacrylate) Nanoparticles Coated With Thiolated Chitosan?

Silvia Mazzaferro, K. Bouchemal, C. Vauthier, C. Gueutin, G. Palmieri, G. Ponchel
Published 2011 · Materials Science

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This work aimed to investigate the loading and the release of Leu-enkephalin from chitosan and thiolated chitosan-coated poly(isobutylcyanoacrylate) nanoparticles by modifying different parameters : chitosan molecular weight (Mw 30, 85 and 145 kg/mol), its degree of thiolation and incorporation of poly(methylmethacrylate) in the nanoparticle core. According to the results, the main parameter controlling the loading and the release of Leu-enkephalin was the composition of the nanoparticle shell. Indeed, it was found that loading was higher and the release was most delayed when chitosan Mw was low. Furthermore, there was a clear trend to a better control of Leu-enkephalin release with low thiolated-chitosan proportion. As demonstrated by using isothermal titration microcalorimetry (ITC) experiments, low thiolated-chitosan proportion corresponds to a higher amount of functional amino-groups able to interact with the negative charge found on Leu-enkephalin. In contrast, the incorporation of poly(methylmethacrylate) in the nanoparticle core did not slow-down the release of Leu-enkephalin but enhanced the burst release effect.
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