Online citations, reference lists, and bibliographies.
← Back to Search

Imprinted ZnO Nanostructure-based Electrochemical Sensing Of Calcitonin: A Clinical Marker For Medullary Thyroid Carcinoma.

S. Patra, E. Roy, R. Madhuri, P. Sharma
Published 2015 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The present work describes an exciting method for the selective and sensitive determination of calcitonin in human blood serum samples. Adopting the surface molecular imprinting technique, a calcitonin-imprinted polymer was prepared on the surface of the zinc oxide nanostructure. Firstly, a biocompatible tyrosine derivative as a monomer was grafted onto the surface of zinc oxide nanostructure followed by their polymerization on vinyl functionalized electrode surface by activator regenerated by electron transfer-atom transfer radical polymerization (ARGET-ATRP) technique. Such sensor can predict the small change in the concentration of calcitonin in the human body and it may also consider to be as cost-effective, renewable, disposable, and reliable for clinical studies having no such cross-reactivity and matrix effect from real samples. The morphologies and properties of the proposed sensor were characterized by scanning electron microscopy, cyclic voltammetry, difference pulse voltammetry and chronocoulometry. The linear working range was found to be 9.99 ng L(-1) to 7.919 mg L(-1) and the detection limit as low as 3.09±0.01 ng L(-1) (standard deviation for three replicate measurements) (S/N=3).
This paper references
10.1016/J.SNB.2010.02.032
Potentiometric sensors based on surface molecular imprinting: Detection of cancer biomarkers and viruses
Y. Wang (2010)
10.1007/S10008-008-0567-6
Electrochemical oxidation and determination of ceftriaxone on a glassy carbon and carbon-nanotube-modified glassy carbon electrodes
S. Majdi (2009)
10.1373/clinchem.2007.100636
Analytical quality of calcitonin determination and its effect on the adequacy of screening for medullary carcinoma of the thyroid.
E. Cavalier (2008)
10.1093/CLINCHEM/38.11.2284
Two-site immunoradiometric assay of intact salmon calcitonin.
L. Deftos (1992)
10.1590/S1807-59322009000700015
Hypercalcitoninemia is not Pathognomonic of Medullary Thyroid Carcinoma
Sergio P. A. Toledo (2009)
10.1039/C1JM12414E
Preparation and characterization of uniformly sized molecularly imprinted polymers functionalized with core–shell magnetic nanoparticles for the recognition and enrichment of protein
Ruixia Gao (2011)
World Cancer Report 2008
P. Boyle (2009)
10.1038/nature04165
Colloidal nanocrystal synthesis and the organic–inorganic interface
Y. Yin (2004)
10.1038/19267
Template-imprinted nanostructured surfaces for protein recognition
H. Shi (1999)
10.1016/j.aca.2012.07.017
A specific Tween-80-Rhodamine S-MWNTs phosphorescent reagent for the detection of trace calcitonin.
J. Liu (2012)
Voltammetric, UV Absorption and Viscometric Studies of the Interaction of Norepinephrine with DNA
M. Aslanoğlu (2005)
10.1016/j.bios.2012.02.053
Detection of p53 gene point mutation using sequence-specific molecularly imprinted PoPD electrode.
A. Tiwari (2012)
10.3762/bjnano.4.87
Structural, optical and photocatalytic properties of flower-like ZnO nanostructures prepared by a facile wet chemical method
S. Kuriakose (2013)
10.1021/ed060pa25.1
Electrochemical Methods: Fundamentals and Applications
Allen J. Bard (1980)
10.1021/MA980558F
Synthesis and Characterization of Zwitterionic Block Copolymers
A. B. Lowe (1998)
10.3390/ijms12095908
Molecularly Imprinted Polymers: Present and Future Prospective
G. Vasapollo (2011)
10.1016/j.talanta.2013.11.074
Gold nanoparticle mediated designing of non-hydrolytic sol-gel cross-linked metformin imprinted polymer network: a theoretical and experimental study.
E. Roy (2014)
10.1093/CLINCHEM/40.9.1774
Sensitive time-resolved fluoroimmunoassay of salmon calcitonin.
H. Rong (1994)
10.5185/AMLETT.2013.3440
ZnO quantum dots for biomedical applications
Sunita Gulia (2013)
Electro-oxidation of some non-steroidal anti-inflammatory drugs on an alumina nanoparticle-modified glassy carbon electrode
M. Tabeshnia (2010)
10.3390/s100201216
ZnO-Based Amperometric Enzyme Biosensors
Zhiwei Zhao (2010)
10.1039/b810248a
Surface molecularly imprinted nanowire for protein specific recognition.
R. Ouyang (2008)
10.1002/ANIE.200503760
Selective protein capture by epitope imprinting.
H. Nishino (2006)
10.1039/C4RA04868G
A metronidazole-probe sensor based on imprinted biocompatible nanofilm for rapid and sensitive detection of anaerobic protozoan
E. Roy (2014)
10.1007/BF02491825
Some studies of the chromatographic properties of gels (‘Artificial antibodies/receptors’) for selective adsorption of proteins
D. Tong (2001)
10.1093/clinchem/43.1.71
Two-site immunofluorometric assay of intact salmon calcitonin with improved sensitivity.
H. Rong (1997)
10.1016/S0003-2670(97)00356-5
Determination of salmon calcitonin by square wave adsorptive stripping voltammetry
J. Osteryoung (1997)
10.1021/ac1029924
Enhanced lysozyme imprinting over nanoparticles functionalized with carboxyl groups for noncovalent template sorption.
Guoqi Fu (2011)
10.1021/JA00125A035
Controlled/"living" radical polymerization. atom transfer radical polymerization in the presence of transition-metal complexes
J. Wang (1995)
10.1016/j.bios.2010.11.004
Composite of CdTe quantum dots and molecularly imprinted polymer as a sensing material for cytochrome c.
W. Zhang (2011)
10.1016/j.bios.2013.07.013
An ultrasensitive molecularly-imprinted human cardiac troponin sensor.
N. Karimian (2013)
10.1016/j.aca.2012.05.048
Recent advances in ZnO nanostructures and thin films for biosensor applications: review.
S. Arya (2012)
10.1016/J.ELECOM.2013.09.014
On/off-switchable electrochemical folic acid sensor based on molecularly imprinted polymer electrode
Najmeh Karimian (2013)
10.1016/j.bios.2014.03.013
Electrochemical evaluation of troponin T imprinted polymer receptor.
N. Karimian (2014)
10.5185/AMLETT.INDIAS.202
Double imprinting in a single molecularly imprinted polymer format for the determination of ascorbic acid and dopamine
Mahavir Prasad Tiwari (2011)
10.1002/(SICI)1097-0231(19960131)10:2<151::AID-RCM434>3.0.CO;2-C
High-performance liquid chromatography/tandem mass spectrometry identification of salmon calcitonin degradation products in aqueous solution preparations.
L. Silvestro (1996)
10.1159/000048138
Multiple Endocrine Neoplasia
R. Thakker (2001)
10.1039/c0nr00439a
The nucleation kinetics of ZnO nanoparticles from ZnCl2 in ethanol solutions.
A. Vega-Poot (2010)
10.1021/JA070975K
A surface functional monomer-directing strategy for highly dense imprinting of TNT at surface of silica nanoparticles.
D. Gao (2007)
10.5185/AMLETT.2010.4110
A pH-responsive, low crosslinked, molecularly imprinted insulin delivery system
S. Li (2010)
10.1002/cncr.28509
Annual Report to the Nation on the status of cancer, 1975‐2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer
B. Edwards (2014)
10.2307/1505543
Principles of Instrumental Analysis
D. Skoog (1971)
10.1080/15321818808057039
Calcitonin determination by a fast and highly sensitive enzyme amplified immunoassay.
C. Lynch (1988)
10.1016/j.bios.2008.06.025
Electrochemical synthesis of polyaniline nano-networks on p-aminobenzene sulfonic acid functionalized glassy carbon electrode Its use for the simultaneous determination of ascorbic acid and uric acid.
L. Zhang (2008)
10.1016/j.jinorgbio.2013.10.004
The synergetic antibacterial activity of Ag islands on ZnO (Ag/ZnO) heterostructure nanoparticles and its mode of action.
Y. Zhang (2014)
10.1016/j.jpba.2010.06.028
Quality analysis of salmon calcitonin in a polymeric bioadhesive pharmaceutical formulation: sample preparation optimization by DOE.
Matthias D'Hondt (2010)
10.1016/0731-7085(90)80118-9
A validated HPLC assay for salmon calcitonin analysis. Comparison of HPLC and biological assay.
R. H. Buck (1990)
10.1016/J.JCHROMB.2004.02.013
Molecularly imprinted polymers: synthesis and characterisation.
P. Cormack (2004)
10.1063/1.1342050
Ultraviolet-emitting ZnO nanowires synthesized by a physical vapor deposition approach
Yunchuan Kong (2001)
10.1038/ncpendmet1023
Determination of calcitonin levels in C-cell disease: clinical interest and potential pitfalls
G. Costante (2009)
10.1016/J.BIOMATERIALS.2005.02.007
A method for the molecular imprinting of hemoglobin on silica surfaces using silanes.
T. Shiomi (2005)
10.5185/AMLETT.INDIAS.207
Molecularly imprinted polymer-modified electrochemical sensor for simultaneous determination of copper and zinc
D. Kumar (2011)



This paper is referenced by
10.3390/ma10070795
A Highly-Sensitive Picric Acid Chemical Sensor Based on ZnO Nanopeanuts
Ahmed A. Ibrahim (2017)
Applications of Metallic nanostructures in electrochemical sensors
Mahsa Azami (2015)
10.1039/C7NJ01541K
A label-free electrochemical immunosensor based on gold nanoparticles and graphene oxide for the detection of tumor marker calcitonin
N. Alarfaj (2017)
10.1016/j.bios.2017.06.003
RETRACTED: Anisotropic (spherical/hexagon/cube) silver nanoparticle embedded magnetic carbon nanosphere as platform for designing of tramadol imprinted polymer.
S. Patra (2017)
10.1016/j.bios.2017.10.050
A ratiometric electrochemical biosensor for the exosomal microRNAs detection based on bipedal DNA walkers propelled by locked nucleic acid modified toehold mediate strand displacement reaction.
J. Zhang (2018)
10.1016/J.JPCS.2018.01.038
Designing of fluorescent and magnetic imprinted polymer for rapid, selective and sensitive detection of imidacloprid via activators regenerated by the electron transfer-atom transfer radical polymerization (ARGET-ATRP) technique
S. Kumar (2018)
10.3390/s17040718
MIP-Based Sensors: Promising New Tools for Cancer Biomarker Determination
Giulia Selvolini (2017)
10.1007/s00604-020-4143-9
Strand displacement-triggered G-quadruplex/rolling circle amplification strategy for the ultra-sensitive electrochemical sensing of exosomal microRNAs
Xiaoqi Tang (2020)
10.1016/j.seppur.2019.116453
Molecularly imprinted poly(methyl methacrylate)-nickel sulfide hybrid membranes for adsorptive desulfurization of dibenzothiophene
A. Mujahid (2020)
Semiconductor nanomaterials for environmental applications
Ahmed Mohamed (2018)
10.1016/j.bios.2015.12.053
RETRACTED: Graphene quantum dots decorated CdS doped graphene oxide sheets in dual action mode: As initiator and platform for designing of nimesulide imprinted polymer.
S. Patra (2017)
10.1016/j.bios.2017.08.058
Recent advances and future prospects in molecularly imprinted polymers-based electrochemical biosensors.
R. Gui (2018)
10.3390/nano8040257
Imprinted Oxide and MIP/Oxide Hybrid Nanomaterials for Chemical Sensors †
A. Afzal (2018)
10.1016/j.msec.2016.06.006
Novel alkaline-reduced cuprous oxide/graphene nanocomposites for non-enzymatic amperometric glucose sensor application.
Siti Nur Akmar Mohd Yazid (2016)
10.1016/j.bios.2016.05.003
A signal amplification electrochemical aptasensor for the detection of breast cancer cell via free-running DNA walker.
Shuxian Cai (2016)
10.1016/j.bios.2016.02.067
2-Dimensional graphene as a route for emergence of additional dimension nanomaterials.
S. Patra (2017)
10.1007/978-3-319-60630-9_9
Role of Nanomaterials as an Emerging Trend Towards the Detection of Winged Contaminants
S. Patra (2018)
10.1016/j.bios.2015.06.005
RETRACTED: Bimetallic magnetic nanoparticle as a new platform for fabrication of pyridoxine and pyridoxal-5'-phosphate imprinted polymer modified high throughput electrochemical sensor.
S. Patra (2015)
10.1002/9781119336181.CH5
Imprinted Carbonaceous Nanomaterials: A Tiny Looking Big Thing in the Field of Selective and Specific Analysis
E. Roy (2016)
10.1016/j.colsurfb.2016.02.053
Stimuli-responsive poly(N-isopropyl acrylamide)-co-tyrosine@gadolinium: Iron oxide nanoparticle-based nanotheranostic for cancer diagnosis and treatment.
E. Roy (2016)
10.1021/acs.chemrev.6b00220
Electrochemical Methods for the Analysis of Clinically Relevant Biomolecules.
Mahmoud Labib (2016)
10.1016/J.JALLCOM.2019.05.174
Tailored assembly of vinylbenzyl N-halamine with end-activated ZnO to form hybrid nanoparticles for quick antibacterial response and enhanced UV stability
W. Ma (2019)
10.1021/ACSSUSCHEMENG.7B01124
Removal and Recycling of Precious Rare Earth Element from Wastewater Samples Using Imprinted Magnetic Ordered Mesoporous Carbon
S. Patra (2017)
10.1002/9783527694396.CH11
Molecular Imprinting Technique for Biomimetic Sensing and Diagnostics
Huiqi Zhang (2016)
10.1016/J.ELECTACTA.2018.02.038
Porous reduced graphene oxide modified electrodes for the analysis of protein aggregation. Part 2: Application to the analysis of calcitonin containing pharmaceutical formulation
Alina Vasilescu (2018)
10.1016/j.bios.2015.12.085
Single cell imprinting on the surface of Ag-ZnO bimetallic nanoparticle modified graphene oxide sheets for targeted detection, removal and photothermal killing of E. Coli.
E. Roy (2017)
10.1002/9781119336181.CH2
A Genuine Combination of Solvent‐free Sample Preparation Technique and Molecularly Imprinted Nanomaterials
Santanu Kumar Patra (2016)
Photophysical and Optoelectronic Properties of Pristine, Doped and Surface-Functionalized Two-Dimensional Zinc Oxide Nanostructures
Jung-soo Kang (2016)
10.1016/j.aca.2016.02.046
Nanocomposite of bimetallic nanodendrite and reduced graphene oxide as a novel platform for molecular imprinting technology.
S. Patra (2016)
10.1016/j.bios.2016.07.084
Size-specific imprinted polymer embedded carbon nanodots modified magnetic nanoparticle for specific recognition of titanium nanoparticle: The round versus round.
S. Patra (2016)
10.5772/60781
Molecularly Imprinted Sensors — New Sensing Technologies
Z. O. Uygun (2015)
10.1021/acsami.5b01786
Dual-responsive polymer coated superparamagnetic nanoparticle for targeted drug delivery and hyperthermia treatment.
S. Patra (2015)
See more
Semantic Scholar Logo Some data provided by SemanticScholar