Online citations, reference lists, and bibliographies.
← Back to Search

Chemical Template-assisted Synthesis Of Monodisperse Rattle-type Fe3O4@C Hollow Microspheres As Drug Carrier.

L. Cheng, Weimin Ruan, Bingfang Zou, Y. Liu, Y. Wang
Published 2017 · Materials Science, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
A chemical template strategy was put forward to synthesize monodisperse rattle-type magnetic carbon (Fe3O4@C) hollow microspheres. During the synthesis procedure, monodisperse Fe2O3 microspheres were used as chemical template, which released Fe3+ ions in acidic solution and initiated the in-situ polymerization of pyrrole into polypyrrole (PPy) shell. With the continual acidic etching of Fe2O3 microspheres, rattle-type Fe2O3@PPy microspheres were generated with the cavity appearing between the PPy shell and left Fe2O3 core, which were then transformed into Fe3O4@C hollow microspheres through calcination in nitrogen atmosphere. Compared with traditional physical template, the shell and cavity of rattle-type hollow microspheres were generated in one step using the chemical template method, which obviously saved the complex procedures including the coating and removal of middle shells. The experimental results exhibited that the rattle-type Fe3O4@C hollow microspheres with different parameters could be regulated through controlled synthesis of the intermediate Fe2O3@PPy product. Moreover, when the rattle-type Fe3O4@C hollow microspheres were investigated as drug carrier, they manifested sustained-release behaviour of doxorubicin, justifying their promising applications as carriers in drug delivery. STATEMENT OF SIGNIFICANCE The aim of the present study was first to synthesize rattle-type Fe3O4@C hollow microspheres through a simple synthesis method as a drug carrier. Here a chemical template synthesis of rattle-type hollow microspheres was developed, which saved the complex procedures including the coating and removal of middle shells in traditional physical template. Second, all the influence factors in the reaction processes were systematically investigated to obtain rattle-type Fe3O4@C hollow microspheres with controlled parameters. Third, the rattle-type Fe3O4@C hollow microspheres were studied as drug carriers and the influences of their structural parameters on drug loading and releasing performance were investigated.
This paper references
10.1016/J.ACTBIO.2007.05.011
Magnetic drug-targeting carrier encapsulated with thermosensitive smart polymer: core-shell nanoparticle carrier and drug release response.
J. Zhang (2007)
10.1039/c3nr02932h
Facile synthesis of yolk-shell magnetic mesoporous carbon microspheres for efficient enrichment of low abundance peptides.
H. Wan (2013)
10.1039/c5nr04729c
Yolk/shell nanoparticles: classifications, synthesis, properties, and applications.
Rahul Purbia (2015)
10.1016/J.ACTBIO.2006.10.006
On the suitability of nanocrystalline ferrites as a magnetic carrier for drug delivery: functionalization, conjugation and drug release kinetics.
S. Rana (2007)
10.1021/jacs.5b05619
An Interface Coassembly in Biliquid Phase: Toward Core-Shell Magnetic Mesoporous Silica Microspheres with Tunable Pore Size.
Q. Yue (2015)
10.1021/am503421z
Movable magnetic porous cores enclosed within carbon microcapsules: structure-controlled synthesis and promoted carbon-based applications.
Lijun You (2014)
10.1039/c3dt50789k
Yolk-type Au@Fe3O4@C nanospheres for drug delivery, MRI and two-photon fluorescence imaging.
Y. Zhou (2013)
10.1039/C3TB20238K
Biocompatible hollow magnetic supraparticles: ultrafast microwave-assisted synthesis, casein-micelle-mediated cavity formation and controlled drug delivery.
S. Xu (2013)
10.1039/C1JM12263K
Fabrication of novel rattle-type magnetic mesoporous carbon microspheres for removal of microcystins
X. Zhang (2011)
10.1002/anie.201001252
Monodisperse yolk-shell nanoparticles with a hierarchical porous structure for delivery vehicles and nanoreactors.
J. Liu (2010)
10.2147/IJN.S34773
pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release
Wen-Yu Qian (2012)
10.1021/JP106685Q
Folate-Conjugated Fe3O4@SiO2 Hollow Mesoporous Spheres for Targeted Anticancer Drug Delivery
Y. Zhu (2010)
10.1039/c1cs15103g
Fabrication and application of inorganic hollow spheres.
J. Hu (2011)
10.1039/C3TA14046F
A versatile designed synthesis of magnetically separable nano-catalysts with well-defined core–shell nanostructures
Z. Sun (2014)
10.1021/ja107697s
Functional hollow carbon nanospheres by latex templating.
R. White (2010)
10.1016/J.MICROMESO.2011.04.033
Novel synthesis of Fe-containing mesoporous carbons and their release of ibuprofen
X. Wang (2011)
10.1039/C3BM60087D
Preparation and biological characterization of hollow magnetic Fe3O4@C nanoparticles as drug carriers with high drug loading capability, pH-control drug release and MRI properties.
K. Cheng (2013)
10.1039/C4TA06967F
Magnetic yolk–shell mesoporous silica microspheres with supported Au nanoparticles as recyclable high-performance nanocatalysts
Q. Yue (2015)
10.1021/ja1025744
Multifunctional mesoporous composite microspheres with well-designed nanostructure: a highly integrated catalyst system.
Y. Deng (2010)
10.1016/j.jcis.2011.05.014
Preparation of rattle-type magnetic mesoporous carbon spheres and their highly efficient adsorption and separation.
Yuyong Yin (2011)
10.1039/C3RA42716A
Facile synthesis of highly water-dispersible and monodispersed Fe3O4 hollow microspheres and their application in water treatment
Bingfang Zou (2013)
10.1039/C3RA47490A
Synthesis of porous iron oxide microspheres by a double hydrophilic block copolymer
B. P. Bastakoti (2014)
10.1021/nn1015117
Core/shell structured hollow mesoporous nanocapsules: a potential platform for simultaneous cell imaging and anticancer drug delivery.
Y. Chen (2010)
10.1002/asia.201500232
Prussian Blue Derived Nanoporous Iron Oxides as Anticancer Drug Carriers for Magnetic-Guided Chemotherapy.
Mohamed B Zakaria (2015)
10.1007/s12274-014-0647-0
Magnetic yolk-shell structured anatase-based microspheres loaded with Au nanoparticles for heterogeneous catalysis
C. Wang (2014)
10.1016/j.actbio.2008.02.002
A stimulus-responsive magnetic nanoparticle drug carrier: magnetite encapsulated by chitosan-grafted-copolymer.
Q. Yuan (2008)
10.1021/la501381v
Magnetic MSP@ZrO₂ microspheres with yolk-shell structure: designed synthesis and application in highly selective enrichment of phosphopeptides.
Wan-Fu Ma (2014)
10.1002/EJIC.201301307
Thermal Conversion of Hollow Prussian Blue Nanoparticles into Nanoporous Iron Oxides with Crystallized Hematite Phase
Mohamed Barakat Zakaria (2014)
10.1039/c1cc13658e
Yolk/shell nanoparticles: new platforms for nanoreactors, drug delivery and lithium-ion batteries.
J. Liu (2011)
10.1016/S1369-7021(11)70161-4
Carbon materials for drug delivery & cancer therapy
Z. Liu (2011)
10.1039/C2JM31891A
Multifunctional polymer vesicles for ultrasensitive magnetic resonance imaging and drug delivery
Tianbin Ren (2012)
10.1002/smll.200901403
Rattle-type Fe(3)O(4)@SiO(2) hollow mesoporous spheres as carriers for drug delivery.
Y. Zhu (2010)
10.1039/C2JM30440F
Synthesis of orange-like Fe3O4/PPy composite microspheres and their excellent Cr(VI) ion removal properties
Yongqiang Wang (2012)
10.1002/asia.201201050
Synthesis of monodisperse hollow carbon nanocapsules by using protective silica shells.
Bo Quan (2013)
10.1002/smll.201200962
Pd nanosheet-covered hollow mesoporous silica nanoparticles as a platform for the chemo-photothermal treatment of cancer cells.
Weijun Fang (2012)
10.1002/anie.201105486
Synthesis of discrete and dispersible hollow carbon nanospheres with high uniformity by using confined nanospace pyrolysis.
A. Lu (2011)
10.1039/C1EE02426D
Recent advances in micro-/nano-structured hollow spheres for energy applications: From simple to complex systems
Xiaoyong Lai (2012)
10.1002/ADMA.200800854
Hollow Micro-/Nanostructures: Synthesis and Applications**
X. D. Lou (2008)
10.2147/IJN.S68719
Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia
Shih-Hsiang Liao (2015)
10.1039/B404734F
Sandwich Fe2O3@SiO2@PPy ellipsoidal spheres and four types of hollow capsules by hematite olivary particles
Lingyun Hao (2004)
10.1021/CM900956J
An Efficient Route to Rattle-Type Fe3O4@SiO2 Hollow Mesoporous Spheres Using Colloidal Carbon Spheres Templates
Y. Zhu (2009)
10.1002/anie.201102070
Dopamine as a carbon source: the controlled synthesis of hollow carbon spheres and yolk-structured carbon nanocomposites.
Rui Liu (2011)
10.1016/j.biomaterials.2012.10.002
Multifunctional Fe3O4@C@Ag hybrid nanoparticles as dual modal imaging probes and near-infrared light-responsive drug delivery platform.
J. Chen (2013)
10.1021/ar200001m
Functional micro/nanostructures: simple synthesis and application in sensors, fuel cells, and gene delivery.
S. Guo (2011)
10.1002/ADFM.200701317
Uniform Rattle-type Hollow Magnetic Mesoporous Spheres as Drug Delivery Carriers and their Sustained-Release Property†
Wenru Zhao (2008)



This paper is referenced by
10.1149/2162-8777/ab8c1b
Carbon Pseudocubes from Iron Oxide Templates for Capacitive Energy Storage
Neriman Sinan (2020)
10.1016/J.APMT.2018.06.008
Mechanically enhanced lipo-hydrogel with controlled release of multi-type drugs for bone regeneration
R. Cheng (2018)
10.1016/j.msec.2018.11.067
Porous aerogel and core/shell nanoparticles for controlled drug delivery: A review.
T. A. Esquivel-Castro (2019)
10.3390/nano9091255
Synthesis, Characterization and Dye Removal Behavior of Core–Shell–Shell Fe3O4/Ag/Polyoxometalates Ternary Nanocomposites
Shixia Zhan (2019)
10.1007/S10971-018-4909-2
The influence of grain size on the magnetic properties of Fe3O4 nanocrystals synthesized by solvothermal method
Zhang Shao-qiang (2018)
10.1016/j.msec.2020.111455
A dual-targeting Fe3O4@C/ZnO-DOX-FA nanoplatform with pH-responsive drug release and synergetic chemo-photothermal antitumor in vitro and in vivo
X. Liu (2021)
10.1016/J.APSUSC.2017.12.229
Fabrication and characterization of morphology-tuned single-crystal monodisperse Fe3O4 nanocrystals
Xuegang Yu (2018)
10.1016/j.micromeso.2020.110041
Triethylenetetramine-modified hollow Fe3O4/SiO2/chitosan magnetic nanocomposites for removal of Cr(VI) ions with high adsorption capacity and rapid rate
Wang Xiang (2020)
10.1016/j.addr.2018.12.008
Design strategies for shape‐controlled magnetic iron oxide nanoparticles
A. G. Roca (2019)
10.1007/s10853-020-05184-3
A novel high doxorubicin-loaded Fe3O4@void@ZnO nanocomposite: pH-controlled drug release and targeted antitumor activity
C. Wang (2020)
10.1002/asia.202000045
Recent Advances in the Synthesis, Surface Modifications and Applications of Core-shell Magnetic Mesoporous Silica Nanospheres.
Bin Zuo (2020)
Semantic Scholar Logo Some data provided by SemanticScholar