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Seeds In The Liver.
Hongjie Ji, Y. Lu, Yujun Shi
Published 2017 · Biology, Medicine
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The liver is a crucial organ for homeostasis and has a tremendous self-renewal and regenerative capacity. It has long been believed that the self-renewal and repair of the liver within a given physiological condition or its repopulation in chronic liver diseases, when hepatocyte proliferation is impaired, will primarily be conducted by the proliferating duct cells, termed "oval cells" or hepatic progenitor cells (HPCs). In addition, numerous studies have revealed that HPCs are the initial tumor cells of liver cancer under certain micro-environments. However, benefit from the extensive application of lineage tracing strategies using the Cre/LoxP system, researchers have redefined the fate of these bipotential cells, raising obvious controversies regarding the capacity of liver cells to control their own biology and differentiation. Here, we review the relevant articles, focusing on cell-lineage tracing to better understanding seed cells and their distinct fate in the liver.
This paper references
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Apoptosis differently affects lineage tracing of Lgr5 and Bmi1 intestinal stem cell populations.
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Robust cellular reprogramming occurs spontaneously during liver regeneration.
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Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver
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Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes.
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The biliary epithelium gives rise to liver progenitor cells
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Liya Pi (2005)
Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury
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Sry HMG Box Protein 9-positive (Sox9+) Epithelial Cell Adhesion Molecule-negative (EpCAM−) Biphenotypic Cells Derived from Hepatocytes Are Involved in Mouse Liver Regeneration*
Naoki Tanimizu (2014)
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