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Nanotechnology As A Therapeutic Tool To Combat Microbial Resistance.
Robert Y. Pelgrift, A. Friedman
Published 2013 · Chemistry, Medicine
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Use of nanoparticles is among the most promising strategies to overcome microbial drug resistance. This review article consists of three parts. The first part discusses the epidemiology of microbial drug resistance. The second part describes mechanisms of drug resistance used by microbes. The third part explains how nanoparticles can overcome this resistance, including the following: Nitric oxide-releasing nanoparticles (NO NPs), chitosan-containing nanoparticles (chitosan NPs), and metal-containing nanoparticles all use multiple mechanisms simultaneously to combat microbes, thereby making development of resistance to these nanoparticles unlikely. Packaging multiple antimicrobial agents within the same nanoparticle also makes development of resistance unlikely. Nanoparticles can overcome existing drug resistance mechanisms, including decreased uptake and increased efflux of drug from the microbial cell, biofilm formation, and intracellular bacteria. Finally, nanoparticles can target antimicrobial agents to the site of infection, so that higher doses of drug are given at the infected site, thereby overcoming resistance.
This paper references
In vitro antimicrobial studies of silver carbene complexes: activity of free and nanoparticle carbene formulations against clinical isolates of pathogenic bacteria.
J. Leid (2012)
The potential of nitric oxide releasing therapies as antimicrobial agents
David O Schairer (2012)
Updated Functional Classification of β-Lactamases
K. Bush (2009)
Resistance to antibiotics: are we in the post-antibiotic era?
A. Alanis (2005)
Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
K. Kumarasamy (2010)
Antimicrobial and anti-inflammatory activity of chitosan-alginate nanoparticles: a targeted therapy for cutaneous pathogens
A. Friedman (2013)
Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase
A. Robicsek (2006)
Recent advances in materials for extended-release antibiotic delivery system
Ping Gao (2011)
Fluoroquinolones: structure and target sites.
P. Higgins (2003)
Nitric oxide releasing nanoparticle synthesis and characterization.
George Han (2011)
The molecular evolution of hospital- and community-associated methicillin-resistant Staphylococcus aureus.
R. H. Deurenberg (2009)
Development of nanoparticles for antimicrobial drug delivery.
L. Zhang (2010)
The antimicrobial efficacy of sustained release silver-carbene complex-loaded L-tyrosine polyphosphate nanoparticles: characterization, in vitro and in vivo studies.
Khadijah M. Hindi (2009)
Saskia Bonjour (1824)
Zerovalent bismuth nanoparticles inhibit Streptococcus mutans growth and formation of biofilm
René Hernández-Delgadillo (2012)
Isothermal Amplification and Molecular Typing of the Obligate Intracellular Pathogen Mycobacterium leprae Isolated from Tissues of Unknown Origins
Nathan A. Groathouse (2006)
The macrolide–ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA
L. H. Hansen (1999)
The use of nitric oxide releasing nanoparticles as a treatment against Acinetobacter baumannii in wound infections
M. R. Mihu (2010)
Mechanisms of bacterial biocide and antibiotic resistance.
K. Poole (2002)
New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles
M. Knetsch (2011)
Nitric oxide-releasing nanoparticles: challenges and future prospects.
Luis R Martinez (2012)
M. Sankar (1824)
Using pharmacodynamic and pharmacokinetic concepts to optimize treatment of infectious diseases
R. Quintiliani (2004)
Examination of bacterial resistance to exogenous nitric oxide.
Benjamin J. Privett (2012)
Transmission of Bartonella henselae by Ixodes ricinus
Violaine Cotté (2008)
The emerging problem of linezolid-resistant Staphylococcus.
B. Gu (2013)
Nanoalumina promotes the horizontal transfer of multiresistance genes mediated by plasmids across genera
Zhigang Qiu (2012)
Antibiofilm surface functionalization of catheters by magnesium fluoride nanoparticles
J. Lellouche (2012)
Medicine at nanoscale: a new horizon
A. Khan (2012)
The Delivery of Benzyl Penicillin to Staphylococcus aureus Biofilms by Use of Liposomes
H. Kim (2004)
Nitric Oxide Releasing Nanoparticles Are Therapeutic for Staphylococcus aureus Abscesses in a Murine Model of Infection
G. Han (2009)
Magnetite nanoparticles for functionalized textile dressing to prevent fungal biofilms development
I. Anghel (2012)
Anti-biofilm efficacy of nitric oxide-releasing silica nanoparticles.
Evan M. Hetrick (2009)
Bactericidal effect of silver nanoparticles against multidrug-resistant bacteria
H. H. Lara (2010)
The antimicrobial ef fi cacy of sustained release silver – carbene complex - loaded L - tyrosine polyphosphate nanoparticles : characterization , in vitro and in vivo studies
K. M. Hindi (2009)
Origins and Evolution of Antibiotic Resistance
J. Davies (2010)
Targeted nanoparticles for enhanced X-ray radiation killing of multidrug-resistant bacteria.
Yang Luo (2013)
Antimicrobial surface functionalization of plastic catheters by silver nanoparticles.
D. Roe (2008)
Eradication of drug resistant Staphylococcus aureus by liposomal oleic acids.
Chun-Ming Huang (2011)
Antibacterial properties of nanoparticles.
M. Hajipour (2012)
Improved antimicrobial efficacy with nitric oxide releasing nanoparticle generated S-nitrosoglutathione.
A. Friedman (2011)
Mutational analysis of quinolone resistance in the plasmid-encoded pentapeptide repeat proteins QnrA, QnrB and QnrS.
J. Rodríguez-Martínez (2009)
Prevalence in the United States of aac(6′)-Ib-cr Encoding a Ciprofloxacin-Modifying Enzyme
C. Park (2006)
D. H. Walker (1996)
Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum.
T. Triglia (1997)
Effects of Salt Stress on the Antimicrobial Drug Resistance and Protein Profile of Staphylococcus aureus
Ganjian Haleh (2012)
Penicillin-binding protein-mediated resistance in pneumococci and staphylococci.
H. Chambers (1999)
Advances in industrial biofilm control with micro-nanotechnology
Nitric oxide nanoparticles
David O Schairer (2012)
Dihydropteroate Synthase Mutations in Pneumocystis jiroveci Can Affect Sulfamethoxazole Resistance in a Saccharomyces cerevisiae Model
P. Iliades (2004)
"Nanoantibiotics": a new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era.
Ae Jung Huh (2011)
Synergistic Combination of Chitosan Acetate with Nanoparticle Silver as a Topical Antimicrobial: Efficacy against Bacterial Burn Infections
L. Huang (2011)
The diverse habitats of obligate intracellular parasites.
T. Hackstadt (1998)
fi cacy of nitric oxide - releasing silica nanoparticles
E. M. Hetrick (2009)
Role of folate antagonists in the treatment of methicillin-resistant Staphylococcus aureus infection.
R. Proctor (2008)
Seguin Hen (1824)
The growing role of nanotechnology in combating infectious disease
Karin Blecher (2011)
Susceptibility of Gram-positive and -negative bacteria to novel nitric oxide-releasing nanoparticle technology
A. Friedman (2011)
Sustained release nitric oxide releasing nanoparticles: characterization of a novel delivery platform based on nitrite containing hydrogel/glass composites.
A. Friedman (2008)
Antibiotic resistance: an overview of mechanisms and a paradigm shift
R. Jayaraman (2009)
VanA-Type Vancomycin-Resistant Staphylococcus aureus
B. Périchon (2009)
Nanoparticles Functionalized with Ampicillin Destroy Multiple-Antibiotic-Resistant Isolates of Pseudomonas aeruginosa and Enterobacter aerogenes and Methicillin-Resistant Staphylococcus aureus
A. N. Brown (2012)
Resistance is futile: the bacteriocin model for addressing the antibiotic resistance challenge.
M. Riley (2012)
A review of current and emergent biofilm control strategies
M. Simões (2010)
Antibacterial resistance worldwide: causes, challenges and responses
S. Levy (2004)
Bioinspired implant materials befuddle bacteria
J. Bryers (2004)
Antimicrobial and healing efficacy of sustained release nitric oxide nanoparticles against Staphylococcus aureus skin infection.
L. Martinez (2009)
Hybrid magnetite nanoparticles/Rosmarinus officinalis essential oil nanobiosystem with antibiofilm activity
C. Chifiriuc (2012)
Nanodrugs: optimism for emerging trend of multidrug resistance
A. Khan (2012)
This paper is referenced by
Antibiotic delivery by liposomes from prokaryotic microorganisms: Similia cum similis works better.
I. Colzi (2015)
A charge-adaptive nanosystem for prolonged and enhanced in vivo antibiotic delivery.
L. Chu (2016)
Microbial Pathogenesis and Antimicrobial Drug Resistance
Indranil Chattopadhyay (2020)
Effect of silica on the ZnS nanoparticles for stable and sustainable antibacterial application
S. Kumar (2019)
Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs
F. Chiodo (2014)
Tocopherol polyethylene glycol succinate-modified hollow silver nanoparticles for combating bacteria-resistance.
Xu-Qi Kang (2019)
Hyaluronic acid microneedles‐laden collagen cryogel plugs for ocular drug delivery
K. Saraswathy (2020)
Does nanobiotechnology create new tools to combat microorganisms?
M. Zielińska-Górska (2016)
Silver nanoparticles: the immediate benefits of low bacterial resistance and the long-term risk of persistent stress in mammalian cells
D. Ellis (2015)
Toward an optimized treatment of intracellular bacterial infections: input of nanoparticulate drug delivery systems.
C. Ladavière (2015)
S-nitrosocaptopril nanoparticles as nitric oxide-liberating and transnitrosylating anti-infective technology.
B. Mordorski (2015)
Nanomaterials and molecular transporters to overcome the bacterial envelope barrier: Towards advanced delivery of antibiotics
Rita S Santos (2018)
Synthesis and characterization of phytochemical fabricated zinc oxide nanoparticles with enhanced antibacterial and catalytic applications.
Jawad Ali (2018)
Three Phoma spp. synthesised novel silver nanoparticles that possess excellent antimicrobial efficacy.
M. Rai (2015)
Mechanism of Controlled Release of Vancomycin from Crumpled Graphene Oxides
X. He (2019)
Study of antimicrobial effects of several antibiotics and iron oxide nanoparticles on biofilm producing pseudomonas aeruginosa
Khadijeh Akbari (2017)
The Potential Application of Antimicrobial Silver Polyvinyl Chloride Nanocomposite Films to Extend the Shelf-Life of Chicken Breast Fillets
S. Azlin-Hasim (2016)
Antimicrobial nanomaterials against biofilms: an alternative strategy
Chunhua Liu (2017)
Antimicrobial Activity and pH of Calcium Hydroxide and Zinc Oxide Nanoparticles Intracanal Medication and Association with Chlorhexidine.
A. S. Aguiar (2015)
The Effect of Cu-BPDCA-Ty on Antibacterial Activity and The Expression of mecA Gene in Clinical and Standard Strains of Methicillin-Resistant Staphylococcus aureus
Marzieh Askarinia (2018)
Fluorescent lactose-derived catanionic aggregates: synthesis, characterisation and potential use as antibacterial agents
Alexandre Bettoschi (2016)
Synthesis of silver nanoparticles using gallic acid-conjugated chitosan derivatives.
Alexey Lunkov (2020)
Modulation of antibiotic effect by Fe2(MoO4)3 microstrutures
Thiago Sampaio de Freitas (2018)
Shape engineering boosts antibacterial activity of chitosan coated mesoporous silica nanoparticle doped with silver: a mechanistic investigation.
D. Şen Karaman (2016)
Synthesis and optimization of ceftriaxone-loaded solid lipid nanocarriers.
S. Kumar (2016)
Antibacterial polyamide obtained by the incorporation of glass microparticles doped with ionic zinc and by zinc oxide nanoparticle: Evaluation with salmonella typhimurium and staphylococcus aureus
M. Kirschner (2017)
Surface-Adaptive, Antimicrobially Loaded, Micellar Nanocarriers with Enhanced Penetration and Killing Efficiency in Staphylococcal Biofilms.
Y. Liu (2016)
Fungal diseases: could nanostructured drug delivery systems be a novel paradigm for therapy?
A. R. Voltan (2016)
Escherichia coli and Pseudomonas aeruginosa eradication by nano-penicillin G.
M. M. Fernandes (2016)
Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells.
A. Wongrakpanich (2016)
In Vitro Assessment of the Antibacterial Potential of Silver Nano-Coatings on Cotton Gauzes for Prevention of Wound Infections
F. Paladini (2016)
Improvement of the antibacterial activity of daptomycin-loaded polymeric microparticles by Eudragit RL 100: an assessment by isothermal microcalorimetry.
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