Online citations, reference lists, and bibliographies.
← Back to Search

Nanotechnology As A Therapeutic Tool To Combat Microbial Resistance.

Robert Y. Pelgrift, A. Friedman
Published 2013 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Use of nanoparticles is among the most promising strategies to overcome microbial drug resistance. This review article consists of three parts. The first part discusses the epidemiology of microbial drug resistance. The second part describes mechanisms of drug resistance used by microbes. The third part explains how nanoparticles can overcome this resistance, including the following: Nitric oxide-releasing nanoparticles (NO NPs), chitosan-containing nanoparticles (chitosan NPs), and metal-containing nanoparticles all use multiple mechanisms simultaneously to combat microbes, thereby making development of resistance to these nanoparticles unlikely. Packaging multiple antimicrobial agents within the same nanoparticle also makes development of resistance unlikely. Nanoparticles can overcome existing drug resistance mechanisms, including decreased uptake and increased efflux of drug from the microbial cell, biofilm formation, and intracellular bacteria. Finally, nanoparticles can target antimicrobial agents to the site of infection, so that higher doses of drug are given at the infected site, thereby overcoming resistance.
This paper references
10.1093/jac/dkr408
In vitro antimicrobial studies of silver carbene complexes: activity of free and nanoparticle carbene formulations against clinical isolates of pathogenic bacteria.
J. Leid (2012)
10.4161/viru.20328
The potential of nitric oxide releasing therapies as antimicrobial agents
David O Schairer (2012)
10.1128/AAC.01009-09
Updated Functional Classification of β-Lactamases
K. Bush (2009)
10.1016/J.ARCMED.2005.06.009
Resistance to antibiotics: are we in the post-antibiotic era?
A. Alanis (2005)
10.1016/S1473-3099(10)70143-2
Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
K. Kumarasamy (2010)
10.1038/jid.2012.399
Antimicrobial and anti-inflammatory activity of chitosan-alginate nanoparticles: a targeted therapy for cutaneous pathogens
A. Friedman (2013)
10.1038/nm1347
Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase
A. Robicsek (2006)
10.1038/ja.2011.58
Recent advances in materials for extended-release antibiotic delivery system
Ping Gao (2011)
10.2174/1389450033346920
Fluoroquinolones: structure and target sites.
P. Higgins (2003)
10.1007/978-1-61737-964-2_14
Nitric oxide releasing nanoparticle synthesis and characterization.
George Han (2011)
10.2174/156652409787581637
The molecular evolution of hospital- and community-associated methicillin-resistant Staphylococcus aureus.
R. H. Deurenberg (2009)
10.2174/092986710790416290
Development of nanoparticles for antimicrobial drug delivery.
L. Zhang (2010)
10.1016/j.biomaterials.2009.03.044
The antimicrobial efficacy of sustained release silver-carbene complex-loaded L-tyrosine polyphosphate nanoparticles: characterization, in vitro and in vivo studies.
Khadijah M. Hindi (2009)
10.1515/9783111576855-009
D
Saskia Bonjour (1824)
10.2147/IJN.S29854
Zerovalent bismuth nanoparticles inhibit Streptococcus mutans growth and formation of biofilm
René Hernández-Delgadillo (2012)
10.1128/JCM.44.4.1502-1508.2006
Isothermal Amplification and Molecular Typing of the Obligate Intracellular Pathogen Mycobacterium leprae Isolated from Tissues of Unknown Origins
Nathan A. Groathouse (2006)
10.1046/j.1365-2958.1999.01202.x
The macrolide–ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA
L. H. Hansen (1999)
10.4161/viru.1.2.10038
The use of nitric oxide releasing nanoparticles as a treatment against Acinetobacter baumannii in wound infections
M. R. Mihu (2010)
Mechanisms of bacterial biocide and antibiotic resistance.
K. Poole (2002)
10.3390/POLYM3010340
New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles
M. Knetsch (2011)
10.4155/TDE.12.97
Nitric oxide-releasing nanoparticles: challenges and future prospects.
Luis R Martinez (2012)
10.1515/9783111548050-024
M
M. Sankar (1824)
Using pharmacodynamic and pharmacokinetic concepts to optimize treatment of infectious diseases
R. Quintiliani (2004)
10.1016/j.niox.2012.02.002
Examination of bacterial resistance to exogenous nitric oxide.
Benjamin J. Privett (2012)
10.3201/eid1407.071110
Transmission of Bartonella henselae by Ixodes ricinus
Violaine Cotté (2008)
10.1093/jac/dks354
The emerging problem of linezolid-resistant Staphylococcus.
B. Gu (2013)
10.1073/pnas.1107254109
Nanoalumina promotes the horizontal transfer of multiresistance genes mediated by plasmids across genera
Zhigang Qiu (2012)
10.2147/IJN.S26770
Antibiofilm surface functionalization of catheters by magnesium fluoride nanoparticles
J. Lellouche (2012)
10.2147/IJN.S33238
Medicine at nanoscale: a new horizon
A. Khan (2012)
10.1081/LPR-200029887
The Delivery of Benzyl Penicillin to Staphylococcus aureus Biofilms by Use of Liposomes
H. Kim (2004)
10.1371/journal.pone.0007804
Nitric Oxide Releasing Nanoparticles Are Therapeutic for Staphylococcus aureus Abscesses in a Murine Model of Infection
G. Han (2009)
10.1186/1556-276X-7-501
Magnetite nanoparticles for functionalized textile dressing to prevent fungal biofilms development
I. Anghel (2012)
10.1016/j.biomaterials.2009.01.052
Anti-biofilm efficacy of nitric oxide-releasing silica nanoparticles.
Evan M. Hetrick (2009)
10.1007/S11274-009-0211-3
Bactericidal effect of silver nanoparticles against multidrug-resistant bacteria
H. H. Lara (2010)
The antimicrobial ef fi cacy of sustained release silver – carbene complex - loaded L - tyrosine polyphosphate nanoparticles : characterization , in vitro and in vivo studies
K. M. Hindi (2009)
10.1128/MMBR.00016-10
Origins and Evolution of Antibiotic Resistance
J. Davies (2010)
10.1039/c2nr33154c
Targeted nanoparticles for enhanced X-ray radiation killing of multidrug-resistant bacteria.
Yang Luo (2013)
10.1093/jac/dkn034
Antimicrobial surface functionalization of plastic catheters by silver nanoparticles.
D. Roe (2008)
10.1016/j.biomaterials.2010.08.076
Eradication of drug resistant Staphylococcus aureus by liposomal oleic acids.
Chun-Ming Huang (2011)
10.1016/j.tibtech.2012.06.004
Antibacterial properties of nanoparticles.
M. Hajipour (2012)
10.1016/j.niox.2011.09.001
Improved antimicrobial efficacy with nitric oxide releasing nanoparticle generated S-nitrosoglutathione.
A. Friedman (2011)
10.1093/jac/dkp111
Mutational analysis of quinolone resistance in the plasmid-encoded pentapeptide repeat proteins QnrA, QnrB and QnrS.
J. Rodríguez-Martínez (2009)
10.1128/AAC.00915-06
Prevalence in the United States of aac(6′)-Ib-cr Encoding a Ciprofloxacin-Modifying Enzyme
C. Park (2006)
Rickettsiae
D. H. Walker (1996)
10.1073/PNAS.94.25.13944
Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum.
T. Triglia (1997)
Effects of Salt Stress on the Antimicrobial Drug Resistance and Protein Profile of Staphylococcus aureus
Ganjian Haleh (2012)
10.1086/513854
Penicillin-binding protein-mediated resistance in pneumococci and staphylococci.
H. Chambers (1999)
Advances in industrial biofilm control with micro-nanotechnology
(2011)
10.4161/viru.3.1.18816
Nitric oxide nanoparticles
David O Schairer (2012)
10.1128/AAC.48.7.2617-2623.2004
Dihydropteroate Synthase Mutations in Pneumocystis jiroveci Can Affect Sulfamethoxazole Resistance in a Saccharomyces cerevisiae Model
P. Iliades (2004)
10.1016/j.jconrel.2011.07.002
"Nanoantibiotics": a new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era.
Ae Jung Huh (2011)
10.1128/AAC.01803-10
Synergistic Combination of Chitosan Acetate with Nanoparticle Silver as a Topical Antimicrobial: Efficacy against Bacterial Burn Infections
L. Huang (2011)
10.1016/S1369-5274(98)80146-X
The diverse habitats of obligate intracellular parasites.
T. Hackstadt (1998)
fi cacy of nitric oxide - releasing silica nanoparticles
E. M. Hetrick (2009)
10.1086/525536
Role of folate antagonists in the treatment of methicillin-resistant Staphylococcus aureus infection.
R. Proctor (2008)
10.1515/9783111576855-015
J
Seguin Hen (1824)
10.4161/viru.2.5.17035
The growing role of nanotechnology in combating infectious disease
Karin Blecher (2011)
10.4161/viru.2.3.16161
Susceptibility of Gram-positive and -negative bacteria to novel nitric oxide-releasing nanoparticle technology
A. Friedman (2011)
10.1016/j.niox.2008.04.003
Sustained release nitric oxide releasing nanoparticles: characterization of a novel delivery platform based on nitrite containing hydrogel/glass composites.
A. Friedman (2008)
Antibiotic resistance: an overview of mechanisms and a paradigm shift
R. Jayaraman (2009)
10.1128/AAC.00346-09
VanA-Type Vancomycin-Resistant Staphylococcus aureus
B. Périchon (2009)
10.1128/AEM.06513-11
Nanoparticles Functionalized with Ampicillin Destroy Multiple-Antibiotic-Resistant Isolates of Pseudomonas aeruginosa and Enterobacter aerogenes and Methicillin-Resistant Staphylococcus aureus
A. N. Brown (2012)
10.1042/BST20120179
Resistance is futile: the bacteriocin model for addressing the antibiotic resistance challenge.
M. Riley (2012)
10.1016/J.LWT.2009.12.008
A review of current and emergent biofilm control strategies
M. Simões (2010)
10.1038/nm1145
Antibacterial resistance worldwide: causes, challenges and responses
S. Levy (2004)
Bioinspired implant materials befuddle bacteria
J. Bryers (2004)
10.1038/jid.2009.95
Antimicrobial and healing efficacy of sustained release nitric oxide nanoparticles against Staphylococcus aureus skin infection.
L. Martinez (2009)
10.1186/1556-276X-7-209
Hybrid magnetite nanoparticles/Rosmarinus officinalis essential oil nanobiosystem with antibiofilm activity
C. Chifiriuc (2012)
10.2147/IJN.S35288
Nanodrugs: optimism for emerging trend of multidrug resistance
A. Khan (2012)



This paper is referenced by
10.1016/j.ejpb.2015.06.013
Antibiotic delivery by liposomes from prokaryotic microorganisms: Similia cum similis works better.
I. Colzi (2015)
10.1039/c6cc01269h
A charge-adaptive nanosystem for prolonged and enhanced in vivo antibiotic delivery.
L. Chu (2016)
10.1007/978-981-15-1695-5_6
Microbial Pathogenesis and Antimicrobial Drug Resistance
Indranil Chattopadhyay (2020)
10.1111/IJAC.13145
Effect of silica on the ZnS nanoparticles for stable and sustainable antibacterial application
S. Kumar (2019)
10.3762/bjoc.10.136
Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs
F. Chiodo (2014)
10.1039/c9bm00343f
Tocopherol polyethylene glycol succinate-modified hollow silver nanoparticles for combating bacteria-resistance.
Xu-Qi Kang (2019)
10.1002/app.49285
Hyaluronic acid microneedles‐laden collagen cryogel plugs for ocular drug delivery
K. Saraswathy (2020)
10.1515/ntrev-2016-0042
Does nanobiotechnology create new tools to combat microorganisms?
M. Zielińska-Górska (2016)
Silver nanoparticles: the immediate benefits of low bacterial resistance and the long-term risk of persistent stress in mammalian cells
D. Ellis (2015)
10.2217/nnm.15.128
Toward an optimized treatment of intracellular bacterial infections: input of nanoparticulate drug delivery systems.
C. Ladavière (2015)
10.1016/j.nano.2014.09.017
S-nitrosocaptopril nanoparticles as nitric oxide-liberating and transnitrosylating anti-infective technology.
B. Mordorski (2015)
10.1016/j.addr.2017.12.010
Nanomaterials and molecular transporters to overcome the bacterial envelope barrier: Towards advanced delivery of antibiotics
Rita S Santos (2018)
10.1016/j.jphotobiol.2018.05.006
Synthesis and characterization of phytochemical fabricated zinc oxide nanoparticles with enhanced antibacterial and catalytic applications.
Jawad Ali (2018)
10.1049/iet-nbt.2014.0068
Three Phoma spp. synthesised novel silver nanoparticles that possess excellent antimicrobial efficacy.
M. Rai (2015)
10.1021/acsomega.9b00873
Mechanism of Controlled Release of Vancomycin from Crumpled Graphene Oxides
X. He (2019)
10.22038/NMJ.2017.8051
Study of antimicrobial effects of several antibiotics and iron oxide nanoparticles on biofilm producing pseudomonas aeruginosa
Khadijeh Akbari (2017)
10.1007/s11947-016-1745-7
The Potential Application of Antimicrobial Silver Polyvinyl Chloride Nanocomposite Films to Extend the Shelf-Life of Chicken Breast Fillets
S. Azlin-Hasim (2016)
10.1139/ER-2016-0046
Antimicrobial nanomaterials against biofilms: an alternative strategy
Chunhua Liu (2017)
10.5005/JP-JOURNALS-10024-1732
Antimicrobial Activity and pH of Calcium Hydroxide and Zinc Oxide Nanoparticles Intracanal Medication and Association with Chlorhexidine.
A. S. Aguiar (2015)
10.5812/JJM.60680
The Effect of Cu-BPDCA-Ty on Antibacterial Activity and The Expression of mecA Gene in Clinical and Standard Strains of Methicillin-Resistant Staphylococcus aureus
Marzieh Askarinia (2018)
10.1039/C6RA02511K
Fluorescent lactose-derived catanionic aggregates: synthesis, characterisation and potential use as antibacterial agents
Alexandre Bettoschi (2016)
10.1016/j.carbpol.2020.115916
Synthesis of silver nanoparticles using gallic acid-conjugated chitosan derivatives.
Alexey Lunkov (2020)
10.1016/j.ejps.2018.07.033
Modulation of antibiotic effect by Fe2(MoO4)3 microstrutures
Thiago Sampaio de Freitas (2018)
10.1039/C5TB02526E
Shape engineering boosts antibacterial activity of chitosan coated mesoporous silica nanoparticle doped with silver: a mechanistic investigation.
D. Şen Karaman (2016)
10.1016/j.chemphyslip.2016.09.002
Synthesis and optimization of ceftriaxone-loaded solid lipid nanocarriers.
S. Kumar (2016)
10.1002/APP.45005
Antibacterial polyamide obtained by the incorporation of glass microparticles doped with ionic zinc and by zinc oxide nanoparticle: Evaluation with salmonella typhimurium and staphylococcus aureus
M. Kirschner (2017)
10.1021/acsnano.6b01370
Surface-Adaptive, Antimicrobially Loaded, Micellar Nanocarriers with Enhanced Penetration and Killing Efficiency in Staphylococcal Biofilms.
Y. Liu (2016)
10.2147/IJN.S93105
Fungal diseases: could nanostructured drug delivery systems be a novel paradigm for therapy?
A. R. Voltan (2016)
10.1016/j.nano.2016.05.018
Escherichia coli and Pseudomonas aeruginosa eradication by nano-penicillin G.
M. M. Fernandes (2016)
10.1039/C5EN00271K
Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells.
A. Wongrakpanich (2016)
10.3390/ma9060411
In Vitro Assessment of the Antibacterial Potential of Silver Nano-Coatings on Cotton Gauzes for Prevention of Wound Infections
F. Paladini (2016)
10.1016/j.ijpharm.2015.03.016
Improvement of the antibacterial activity of daptomycin-loaded polymeric microparticles by Eudragit RL 100: an assessment by isothermal microcalorimetry.
I. Ferreira (2015)
See more
Semantic Scholar Logo Some data provided by SemanticScholar