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Polysaccharide-based Nanoparticles For Theranostic Nanomedicine.

M. Swierczewska, H. Han, K. Kim, J. Park, S. Lee
Published 2016 · Chemistry, Medicine

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Polysaccharides are natural biological molecules that have numerous advantages for theranostics, the integrated approach of therapeutics and diagnostics. Their derivable reactive groups can be leveraged for functionalization with a nanoparticle-enabling conjugate, therapeutics (small molecules, proteins, peptides, photosensitizers) and/or diagnostic agents (imaging agents, sensors). In addition, polysaccharides are diverse in size and charge, biodegradable and abundant and show low toxicity in vivo. Polysaccharide-based nanoparticles are increasingly being used as platforms for simultaneous drug delivery and imaging and are therefore becoming popular theranostic nanoparticles. The review focuses on the method of nanoparticle formation (self-assembled, physical or chemical cross-linked) when engineering polysaccharide-based nanoparticles for theranostic nanomedicine. We highlight recent examples of polysaccharide-based theranostic systems from literature and their potential for use in the clinic, particularly chitosan- and hyaluronic acid-based NPs.
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10.1002/wnan.1558
Carbohydrate-based nanomaterials for biomedical applications.
Soeun Gim (2019)
10.1007/s12274-017-1590-7
Construction of highly stable selenium nanoparticles embedded in hollow nanofibers of polysaccharide and their antitumor activities
Zhaohua Ping (2017)
10.1002/mabi.201600335
Identification of a Glypican-3-Binding Peptide for In Vivo Non-Invasive Human Hepatocellular Carcinoma Detection.
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Two-photon AIE luminogen labeled multifunctional polymeric micelles for theranostics
W. Zhuang (2019)
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Antitumor Activity of Furanoallocolchicinoid-Chitosan Conjugate
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10.1016/j.ijbiomac.2020.06.113
Composite materials based on chitosan/gold nanoparticles: From synthesis to biomedical applications.
A. B. D. da Silva (2020)
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Development of pH‐responsive cyclodextrin nanoparticles for tumor‐specific photodynamic therapy
Seonyoung Yoon (2020)
10.1016/j.intimp.2019.05.025
Immunostimulatory plant polysaccharides impede cancer progression and metastasis by avoiding off-target effects.
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Nano based drug delivery systems: recent developments and future prospects
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Oxygen-generating hybrid nanoparticles to enhance fluorescent/photoacoustic/ultrasound imaging guided tumor photodynamic therapy.
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Targeted Nanoparticles for the Treatment of Alzheimer's Disease.
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Vectorisation cellulaire et adressage mitochondrial de photosensibilisateurs par des nanoparticules formées de xylane de bois de feuillus : nouvelle voie de valorisation d'hémicellulose pour une application en PDT
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Electrospinning of hyaluronan/polyvinyl alcohol in presence of in-situ silver nanoparticles: Preparation and characterization.
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Fluorescence Cancer Imaging
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Non-thermal acoustic treatment as a safe alternative to thermosensitive liposome-involved hyperthermia for cancer therapy
W. Um (2017)
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