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Tumor Targeting Via EPR: Strategies To Enhance Patient Responses.
Susanne K Golombek, Jan-Niklas May, B. Theek, Lia Appold, N. Drude, F. Kiessling, T. Lammers
Published 2018 · Medicine
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The tumor accumulation of nanomedicines relies on the enhanced permeability and retention (EPR) effect. In the last 5-10 years, it has been increasingly recognized that there is a large inter- and intra-individual heterogeneity in EPR-mediated tumor targeting, explaining the heterogeneous outcomes of clinical trials in which nanomedicine formulations have been evaluated. To address this heterogeneity, as in other areas of oncology drug development, we have to move away from a one-size-fits-all tumor targeting approach, towards methods that can be employed to individualize and improve nanomedicine treatments. To this end, efforts have to be invested in better understanding the nature, the complexity and the heterogeneity of the EPR effect, and in establishing systems and strategies to enhance, combine, bypass and image EPR-based tumor targeting. In the present manuscript, we summarize key studies in which these strategies are explored, and we discuss how these approaches can be employed to enhance patient responses.
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Riboflavin-Targeted Drug Delivery
Milita Darguzyte (2020)
Controlled Drug Release and Cytotoxicity Studies of Beta-Lapachone and Doxorubicin Loaded into Cyclodextrins Attached to a Polyethyleneimine Matrix
A. Kowalczyk (2020)
Critical considerations for targeting colorectal liver metastases with nanotechnology
Usman Arshad (2019)
Norepinephrine transporter-derived homing peptides enable rapid endocytosis of drug delivery nanovehicles into neuroblastoma cells
Yazan Haddad (2020)
The evolution of polymer conjugation and drug targeting for the delivery of proteins and bioactive molecules.
Antonella Grigoletto (2020)
Tumor-responsive dynamic nanoassemblies for targeted imaging, therapy and microenvironment manipulation.
L. Low (2020)
Reactive-ester derived polymer nanogels for cancer immunotherapy
Judith Stickdorn (2020)
Hollow mesoporous silica nanoparticles as nanocarriers employed in cancer therapy: A review
Yimin Zhou (2020)
Nanomedicine for the Treatment of Advanced Prostate Cancer
Sonia Vicente-Ruiz (2020)
Fe/Mg-Modified Carbonate Apatite with Uniform Particle Size and Unique Transport Protein-Related Protein Corona Efficiently Delivers Doxorubicin into Breast Cancer Cells
Sheikh Tanzina Haque (2020)
Composition design and medical application of liposomes.
Mingyuan Li (2019)
A physiologically-based nanocarrier biopharmaceutics model to reverse-engineer the in vivo drug release.
Shakti Nagpal (2020)
In vivo efficacy of bevacizumab-loaded albumin nanoparticles in the treatment of colorectal cancer
Inés Luis de Redín (2020)
A HMCuS@MnO2 nanocomplex responsive to multiple tumor environmental clues for photoacoustic/fluorescence/magnetic resonance trimodal imaging-guided and enhanced photothermal/photodynamic therapy.
Q. Li (2020)See more