Iron Oxide Nanoparticles: Diagnostic, Therapeutic And Theranostic Applications
Seyed Mohammadali Dadfar, Karolin Roemhild, Natascha Drude, Saskia von Stillfried, Ruth Knuechel, Fabian Kiessling, Twan Lammers
Published 2019 · Biology, Medicine
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&NA; Many different iron oxide nanoparticles have been evaluated over the years, for a wide variety of biomedical applications. We here summarize the synthesis, surface functionalization and characterization of iron oxide nanoparticles, as well as their (pre‐) clinical use in diagnostic, therapeutic and theranostic settings. Diagnostic applications include liver, lymph node, inflammation and vascular imaging, employing mostly magnetic resonance imaging but recently also magnetic particle imaging. Therapeutic applications encompass iron supplementation in anemia and advanced cancer treatments, such as modulation of macrophage polarization, magnetic fluid hyperthermia and magnetic drug targeting. Because of their properties, iron oxide nanoparticles are particularly useful for theranostic purposes. Examples of such setups, in which diagnosis and therapy are intimately combined and in which iron oxide nanoparticles are used, are image‐guided drug delivery, image‐guided and microbubble‐mediated opening of the blood‐brain barrier, and theranostic tissue engineering. Together, these directions highlight the versatility and the broad applicability of iron oxide nanoparticles, and indicate the integration in future medical practice of multiple iron oxide nanoparticle‐based materials.
This paper references
Impact of Amino-Acid Coating on the Synthesis and Characteristics of Iron-Oxide Nanoparticles (IONs)
Alireza Ebrahiminezhad (2012)
Applications and potential toxicity of magnetic iron oxide nanoparticles.
Gang Liu (2013)
Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast
Bo Zheng (2015)
Physicochemical characteristics of Sonazoid, a new contrast agent for ultrasound imaging.
Per Christian Sontum (2008)
Current and potential imaging applications of ferumoxytol for magnetic resonance imaging.
Gerda B Tóth (2017)
PBCA‐based polymeric microbubbles for molecular imaging and drug delivery
Patrick Koczera (2017)
Redox control of inflammation in macrophages.
Bernhard Brüne (2013)
Thermally-Sensitive and Magnetic Poly(N-Vinylcaprolactam)-Based Nanogels by Inverse Miniemulsion Polymerization
Simone de Fátima Medeiros (2012)
Quantitative Magnetic Particle Imaging Monitors the Transplantation, Biodistribution, and Clearance of Stem Cells In Vivo
Bo Zheng (2016)
Pseudoprogression of glioblastoma after chemo- and radiation therapy: diagnosis by using dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging with ferumoxytol versus gadoteridol and correlation with survival.
Seymur Gahramanov (2013)
Thermo-and pH-sensitive hydrogel membranes composed of poly(N-isopropylacrylamide)-hyaluronan for biomedical applications: Influence of hyaluronan incorporation on the membrane properties.
Elbadawy A. Kamoun (2018)
Nanoparticles for imaging: top or flop?
Fabian Kiessling (2014)
Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications.
Ajay Kumar Gupta (2007)
One minute synthesis of amino-silane functionalized superparamagnetic iron oxide nanoparticles by sonochemical method.
Bashiru Kayode Sodipo (2018)
Labeling of cells with ferumoxides-protamine sulfate complexes does not inhibit function or differentiation capacity of hematopoietic or mesenchymal stem cells.
A. Arbab (2005)
Improvement of image quality of non-invasive coronary artery imaging with magnetic resonance by the use of the intravascular contrast agent Clariscan (NC100150 injection) in patients with coronary artery disease.
Christoph Thomas Klein (2003)
Phenyl alanine & Tyrosine Amino acids Coated Magnetic Nanoparticles: Preparation and Toxicity study.
Hamed Nosrati (2019)
Design of iron oxide-based nanoparticles for MRI and magnetic hyperthermia.
Cristina Blanco-Andujar (2016)
High-resolution MR lymphography using ultrasmall superparamagnetic iron oxide (USPIO) in the evaluation of axillary lymph nodes in patients with early stage breast cancer: preliminary results
Kosei Kimura (2010)
Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications.
Sophie Laurent (2008)
Clinical applications of magnetic nanoparticles for hyperthermia
Burghard Thiesen (2008)
In Vivo Nanotoxicity Testing using the Zebrafish Embryo Assay.
Larissa Yokota Rizzo (2013)
Synthesizing cysteine-coated magnetite nanoparticles as MRI contrast agent: Effect of pH and cysteine addition on particles size distribution
Reza Ahmadi (2012)
Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy.
Carlos Tassa (2011)
Easy Synthesis and Magnetic Properties of Iron Oxide Nanoparticles
Kyoungja Woo (2004)
Yu-Qin Cao (1824)
Synthesis and characterization of a novel pH-thermo dual responsive hydrogel based on salecan and poly(N,N-diethylacrylamide-co-methacrylic acid).
Wei Wei (2015)
Progress in Electrochemical Synthesis of Magnetic Iron Oxide Nanoparticles
Donya Ramimoghadam (2014)
Dextran and Polymer Polyethylene Glycol (PEG) Coating Reduce Both 5 and 30 nm Iron Oxide Nanoparticle Cytotoxicity in 2D and 3D Cell Culture
Miao Yu (2012)
Magnetic resonance imaging enhanced by superparamagnetic iron oxide particles: usefulness for distinguishing between focused ultrasound-induced blood-brain barrier disruption and brain hemorrhage.
Hao-Li Liu (2009)
Resovist enhanced MR imaging of the liver: does quantitative assessment help in focal lesion classification and characterization?
Lucia Santoro (2009)
Effects of nanoparticle size on cellular uptake and liver MRI with polyvinylpyrrolidone-coated iron oxide nanoparticles.
Jing Hui Huang (2010)
An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice.
Anca Sindrilaru (2011)
Accumulation of Ultrasmall Superparamagnetic Particles of Iron Oxide in Human Atherosclerotic Plaques Can Be Detected by In Vivo Magnetic Resonance Imaging
M. Eline Kooi (2003)
Blood pool MR angiography of aortic stent-graft endoleak.
Hale Ersoy (2004)
Polyethylene glycol modified, cross-linked starch-coated iron oxide nanoparticles for enhanced magnetic tumor targeting.
Adam J. Cole (2011)
Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease.
Francesca Vinchi (2016)
Detection of liver metastases with superparamagnetic iron oxide in 15 patients: results of MR imaging at 1.5 T.
Gilles Marchal (1989)
High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents
Boris Polyak (2008)
Saskia Bonjour (1824)
Biocom - patibility of Fe 3 O 4 nanoparticles evaluated by in vitro cytotoxicity assays using normal , glia and breast cancer cells
G. J. Jenkins N. Singh (2010)
Biogenic Fabrication of Iron/Iron Oxide Nanoparticles and Their Application
Khwaja Salahuddin Siddiqi (2016)
Image-guided breast tumor therapy using a small interfering RNA nanodrug.
Mohanraja Kumar (2010)
Pluriformity of inflammation in multiple sclerosis shown by ultra-small iron oxide particle enhancement.
Machteld M. Vellinga (2008)
Human serum albumin coated iron oxide nanoparticles for efficient cell labeling.
Jin Y. Xie (2010)
Versatile ferrofluids based on polyethylene glycol coated iron oxide nanoparticles
Ward Brullot (2012)
Superparamagnetic MFe2O4 (M = Fe, Co, Mn) Nanoparticles: Tuning the Particle Size and Magnetic Properties through a Novel One-Step Coprecipitation Route
Clara Pereira (2012)
Mark Voorneveld (2004)
Y.-C. Chen (2011)
Monocyte Subset Dynamics in Human Atherosclerosis Can Be Profiled with Magnetic Nano-Sensors
Moritz Wildgruber (2009)
Dendrimer-based magnetic iron oxide nanoparticles: their synthesis and biomedical applications.
Wenjie Sun (2016)
Assessing the in vivo efficacy of doxorubicin loaded hyaluronan nanoparticles.
Mohammad H. El-Dakdouki (2014)
Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues.
Saeid Zanganeh (2016)
Three-dimensional magnetic resonance coronary angiography using a new blood pool contrast agent: initial experience.
Willemijn L F Bedaux (2002)
A Phase I Dosing Study of Ferumoxytol for MR Lymphography at 3 T in Patients With Prostate Cancer.
B. Turkbey (2015)
SPION primes THP1 derived M2 macrophages towards M1-like macrophages.
Amit Laskar (2013)
Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations
Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy.
Morteza Mahmoudi (2011)
Labeling of mesenchymal stromal cells with iron oxide-poly(l-lactide) nanoparticles for magnetic resonance imaging: uptake, persistence, effects on cellular function and magnetic resonance imaging properties
Gerlinde Schmidtke-Schrezenmeier (2011)
Chitosan (or alginate)-coated iron oxide nanoparticles: A comparative study
Julia Castello (2015)
Chip–NMR biosensor for detection and molecular analysis of cells
Hakho Lee (2008)
Magnetic Drug Targeting: Preclinical in Vivo Studies, Mathematical Modeling, and Extrapolation to Humans.
Khuloud T. Al-Jamal (2016)
Iron Oxide-labeled Collagen Scaffolds for Non-invasive MR Imaging in Tissue Engineering.
Marianne E. Mertens (2014)
Superparamagnetic Iron Oxide Nanoparticles: Diagnostic Magnetic Resonance Imaging and Potential Therapeutic Applications in Neurooncology and Central Nervous System Inflammatory Pathologies, a Review
Jason S Weinstein (2010)
Magnetic Particle Imaging With Tailored Iron Oxide Nanoparticle Tracers
R. M. Ferguson (2015)
Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle.
Daniel L. J. Thorek (2014)
MR angiography with blood pool contrast agents
Jens Bremerich (2007)
Superparamagnetic iron oxide nanoparticles for MR imaging and therapy: design considerations and clinical applications.
Rongrong Jin (2014)
Current concepts in lymph node imaging.
Maha Torabi (2004)
Donatus Cyron (2012)
Ultra-small superparamagnetic iron oxide enhancement is associated with higher loss of brain tissue structure in clinically isolated syndrome
Adil Maarouf (2016)
Polyethylenimine-coated SPIONs trigger macrophage activation through TLR-4 signaling and ROS production and modulate podosome dynamics.
Vladimir Mulens-Arias (2015)
Small Angle X-ray Scattering for Nanoparticle Research.
Tao Li (2016)
Ferucarbotran (Resovist): a new clinically approved RESspecific contrast agent for contrast-enhanced MRI of the liver: properties
P. Reimer (2003)
Superparamagnetic iron oxide nanoparticles encapsulated in biodegradable thermosensitive polymeric micelles: toward a targeted nanomedicine suitable for image-guided drug delivery.
Marina Talelli (2009)
Fundamentals and advances in magnetic hyperthermia
E. A. Périgo (2015)
Advances in magnetofection—magnetically guided nucleic acid delivery
Ulrike Schillinger (2005)
Synthesis optimization and characterization of chitosan-coated iron oxide nanoparticles produced for biomedical applications
Gozde Unsoy (2012)
Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs.
Tian Xia (2009)
Comparison of active, passive and magnetic targeting to tumors of multifunctional paclitaxel/SPIO-loaded nanoparticles for tumor imaging and therapy.
Nathalie Schleich (2014)
The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases
Hor-Yue Tan (2016)
USPIO-labeled textile materials for non-invasive MR imaging of tissue-engineered vascular grafts.
Marianne E. Mertens (2015)
In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors.
Moritz F Kircher (2003)
Ultrasmall superparamagnetic particles of iron oxide allow for the detection of metastases in normal sized pelvic lymph nodes of patients with bladder and/or prostate cancer.
Maria Triantafyllou (2013)
Systematic Review of the Preparation Techniques of Iron Oxide Magnetic Nanoparticles
S. F. Hasany (2013)
Recent advances in molecular, multimodal and theranostic ultrasound imaging.
Fabian Kiessling (2014)
The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma
Andreas Jordan (2005)
Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme
Klaus Maier-Hauff (2010)
Synthesis and characterization of a novel pH-thermo dual responsive hydrogel based on salecan and poly (N
W. Wei (2015)
Toxicity, toxicokinetics and biodistribution of dextran stabilized Iron oxide Nanoparticles for biomedical applications.
N Remya (2016)
Casein-coated iron oxide nanoparticles for high MRI contrast enhancement and efficient cell targeting.
Jing Huang (2013)
Synthesis, self-assembly, and characterization of PEG-coated iron oxide nanoparticles as potential MRI contrast agent
Chen Yuejian (2010)
Iron oxide-enhanced MR imaging of the liver and spleen: review of the first 5 years.
Joseph T. Jr. Ferrucci (1990)
Magnetic relaxation switches capable of sensing molecular interactions
José Manuel Pérez (2002)
USPIO-enhanced MR angiography of arteriovenous fistulas in patients with renal failure.
Monica Sigovan (2012)
J. Koda (2002)
Redox control of in fl ammation in macrophages
Drug-loaded and superparamagnetic iron oxide nanoparticle surface-embedded amphiphilic block copolymer micelles for integrated chemotherapeutic drug delivery and MR imaging.
Jinming Hu (2012)
Magnetic Field-Induced T Cell Receptor Clustering by Nanoparticles Enhances T Cell Activation and Stimulates Antitumor Activity
Karlo Perica (2014)
Multifunctional poly(aspartic acid) nanoparticles containing iron oxide nanocrystals and doxorubicin for simultaneous cancer diagnosis and therapy
Hee-Man Yang (2011)
Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery.
Challa S. S. R. Kumar (2011)
Theranostic USPIO-Loaded Microbubbles for Mediating and Monitoring Blood-Brain Barrier Permeation.
Twan Lammers (2015)
AMI-227-enhanced MR lymphography: usefulness for differentiating reactive from tumor-bearing lymph nodes.
Pierre Vassallo (1994)
Multifunctional magnetic nanoparticles for targeted imaging and therapy.
Jason Mccarthy (2008)
Imagingmacrophages with nanoparticles
Polymer encapsulated upconversion nanoparticle/iron oxide nanocomposites for multimodal imaging and magnetic targeted drug delivery.
Haipeng Xu (2011)
Recent advances in molecular
F. Kiessling (2014)
Endothelial biocompatibility and accumulation of SPION under flow conditions
Jasmin Matuszak (2015)
Magnetic resonance imaging of pancreatic islets transplanted into the liver in humans.
František Saudek (2010)
MRI study of atherosclerotic plaque progression using ultrasmall superparamagnetic iron oxide in Watanabe heritable hyperlipidemic rabbits.
Chiyuki Kaneko (2015)
Water-soluble iron oxide nanocubes with high values of specific absorption rate for cancer cell hyperthermia treatment.
Pablo Guardia (2012)
John B. Shoven (1824)
Cancer related inflammation: the macrophage connection.
Antonio Sica (2008)
Stem cell tracking using iron oxide nanoparticles
Elizabeth Bull (2014)
MRI with a lymph-node-specific contrast agent as an alternative to CT scan and lymph-node dissection in patients with prostate cancer: a prospective multicohort study.
Roel AM Heesakkers (2008)
Magnetic nanoparticle biosensors.
Jered B. Haun (2010)
Martin P. Catherwood (1824)
Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Roger Stupp (2005)
Thermosensitive liposomes entrapping iron oxide nanoparticles for controllable drug release.
Lin-Ai Tai (2009)
Marina Azevedo (1986)
Gadoxetate Acid-Enhanced MR Imaging for HCC: A Review for Clinicians
Jendana Chanyaputhipong (2011)
New forms of superparamagnetic nanoparticles for biomedical applications.
Chenjie Xu (2013)
Synthesis of phase-pure and monodisperse iron oxide nanoparticles by thermal decomposition.
Ryan Hufschmid (2015)
Critical Evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the Measurement of Nanoparticles and Protein Aggregates
Vasco Filipe (2010)
Liver MR imaging with iron oxides: toward consensus and clinical practice.
Ralph Weissleder (1994)
Magnetic Tagging of Therapeutic Cells for MRI
Matthew Budde (2009)
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial.
Roger Stupp (2009)
Intracranial Gadolinium Deposition after Contrast-enhanced MR Imaging.
Robert J. McDonald (2015)
Preparation and in vitro evaluation of folate-receptor-targeted SPION-polymer micelle hybrids for MRI contrast enhancement in cancer imaging.
Shveta Mahajan (2013)
Silver-coated engineered magnetic nanoparticles are promising for the success in the fight against antibacterial resistance threat.
Morteza Mahmoudi (2012)
Herceptin functionalized polyhedral oligomeric silsesquioxane - conjugated oligomers - silica/iron oxide nanoparticles for tumor cell sorting and detection.
Yu Mi (2011)
Low molecular weight alkyl-polycation wrapped magnetite nanoparticle clusters as MRI probes for stem cell labeling and in vivo imaging.
Gang Liu (2011)
Ultrasmall superparamagnetic iron oxides (USPIOs): a future alternative magnetic resonance (MR) contrast agent for patients at risk for nephrogenic systemic fibrosis (NSF)?
E. Neuwelt (2009)
Ashish Kumar (1824)
Microemulsion-assisted synthesis of tunable superparamagnetic composites
Pedro Tartaj (2002)
Assessment of disease activity in multiple sclerosis phenotypes with combined gadolinium- and superparamagnetic iron oxide-enhanced MR imaging.
Thomas Tourdias (2012)
MR imaging of the liver and spleen: a comparison of the effects on signal intensity of two superparamagnetic iron oxide agents.
F Chen (1999)
Nanocluster of superparamagnetic iron oxide nanoparticles coated with poly (dopamine) for magnetic field-targeting, highly sensitive MRI and photothermal cancer therapy.
Ming Wu (2015)
Ferucarbotran (Resovist): a new clinically approved RES-specific contrast agent for contrast-enhanced MRI of the liver: properties, clinical development, and applications
Peter Reimer (2002)
Muckenthaler, Iron induces anti-tumor activity in tumorassociated macrophages
M. Costa da Silva (2017)
The use of magnetic nanoparticles in cancer theranostics: Toward handheld diagnostic devices.
László Hajba (2016)
Gadofosveset-enhanced magnetic resonance angiography
Mathias Goyen (2008)
Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors.
Esben Kjær Unmack Larsen (2012)
Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications
Elena Vismara (2017)
Effect of synthesis conditions on the properties of citric-acid coated iron oxide nanoparticles
Lanfen Li (2013)
Microbubbles as a novel contrast agent for brain MRI
Jerry S. Cheung (2009)
Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)
Neenu Singh (2010)
T1–T2 Dual-modal MRI contrast agents based on superparamagnetic iron oxide nanoparticles with surface attached gadolinium complexes
Agnieszka Szpak (2014)
MR Angiography of Renal Transplant Vasculature with Ferumoxytol:: Comparison of High-Resolution Steady-State and First-Pass Acquisitions.
Michael T. Corwin (2016)
Magnetic nanoparticles for environmental and biomedical applications: A review
Leena Mohammed (2017)
A multicenter , phase I / II trial of hepatic intra - arterial delivery of doxorubicin hydrochloride adsorbed to magnetic targeted carriers in patients with hepatocellular carcinoma
A. Venook Koda (2004)
Michel Millodot (2018)
Safety and Tolerability of Ultrasmall Superparamagnetic Iron Oxide Contrast Agent: Comprehensive Analysis of a Clinical Development Program
Hamm Bernd (2009)
Detection of hepatic metastasis: manganese- and ferucarbotran-enhanced MR imaging.
Jin-Young Choi (2006)
Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo
Friedrich Scherer (2002)
Enhancing and targeting nucleic acid delivery by magnetic force
Christian Plank (2003)
Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy
I. Jolanda M. Vries (2005)
Combined Preclinical Magnetic Particle Imaging and Magnetic Resonance Imaging: Initial Results in Mice.
Michael G. Kaul (2015)
Iron oxide-silica nanocomposites yielded by chemical route and sol–gel method
Emil Puscasu (2016)
In vivo imaging of siRNA delivery and silencing in tumors
Zdravka Medarova (2007)
Magnetic particle imaging: current developments and future directions
Nikolaos Panagiotopoulos (2015)
A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy.
Nam-Hyuk Cho (2011)
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer.
Mukesh G Harisinghani (2003)
Current status of gadolinium toxicity in patients with kidney disease.
Mark A Perazella (2009)
Neural stem cell transplantation in central nervous system disorders: from cell replacement to neuroprotection.
Donatella De Feo (2012)
S. C. Tan (2009)
Iron Oxide Silica Derived from Sol-Gel Synthesis
Adi Darmawan (2011)
Characterization of aqueous dispersions of Fe(3)O(4) nanoparticles and their biomedical applications.
Fong-Yu Cheng (2005)
Recent Advances in Synthesis and Surface Modification of Superparamagnetic Iron Oxide Nanoparticles with Silica
Bashiru Kayode Sodipo (2016)
The competing effect of ammonia in the synthesis of iron oxide/silica nanoparticles in microemulsion/sol–gel system
Maria Tereza Cortez Fernandes (2013)
Synthesis of nonspherical superparamagnetic particles: in situ coprecipitation of magnetic nanoparticles in microgels prepared by stop-flow lithography.
Su Kyung Suh (2012)
Magnetic iron oxide nanoparticles: synthesis and applications
Chengyin Fu (2012)
Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients.
J. Gaglia (2011)
Magnetic particle imaging: visualization of instruments for cardiovascular intervention.
J. Haegele (2012)
Expression of transferrin receptor and ferritin following ferumoxides-protamine sulfate labeling of cells: implications for cellular magnetic resonance imaging.
Edyta Pawelczyk (2006)
Silica-coated super paramagnetic iron oxide nanoparticles (SPION) as biocompatible contrast agent in biomedical photoacoustics
Rudolf Alwi (2012)
Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging
Yi-Xiang J. Wang (2014)
Comparison of passive, active and magnetic targeting of tumors by theranostic nanoparticles
Nathalie Schleich (2014)
First in vivo traveling wave magnetic particle imaging of a beating mouse heart.
Patrick Vogel (2016)
Review on magnetic nanoparticles for magnetic nanofluid hyperthermia application
Ziba Hedayatnasab (2017)
Daniel Davies (1998)
C.-H. Fan (2013)
Targetable Clinical Nanoparticles for Precision Cancer Therapy Based on Disease-Specific Molecular Inflection Points.
Charalambos Kaittanis (2017)
pH-responsive poly(aspartic acid) hydrogel-coated magnetite nanoparticles for biomedical applications.
Jaime Vega-Chacón (2017)
Synthesis, characterization, applications, and challenges of iron oxide nanoparticles
Attarad Ali (2016)
Ferrofluid based on polyethylene glycol-coated iron oxide nanoparticles: Characterization and properties
Sonia García-Jimeno (2013)
Iron oxide-based superparamagnetic polymeric nanomaterials: Design, preparation, and biomedical application
Jung Kwon Oh (2011)
Nanotheranostics and image-guided drug delivery: current concepts and future directions.
Twan Lammers (2010)
Controlled release of Fe3O4 nanoparticles in encapsulated microbubbles to tumor cells via sonoporation and associated cellular bioeffects.
Fang Yang (2011)
A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging.
Yì Xiáng J Wáng (2017)
Iron oxide MR contrast agents for molecular and cellular imaging.
Jeff W. M. Bulte (2004)
Metastases in normal-sized pelvic lymph nodes: detection with diffusion-weighted MR imaging.
Harriet C. Thoeny (2014)
Iron-based superparamagnetic nanoparticle contrast agents for MRI of infection and inflammation.
Alexander J. Neuwelt (2015)
Effect of surface charge on the colloidal stability and in vitro uptake of carboxymethyl dextran-coated iron oxide nanoparticles
Vanessa Ayala (2013)
Adam S. Opalski (1824)
In vitro and in vivo experiments with iron oxide nanoparticles functionalized with DEXTRAN or polyethylene glycol for medical applications: magnetic targeting.
M L Mojica Pisciotti (2014)
LETTER TO THE EDITOR: Three-dimensional real-time in vivo magnetic particle imaging
Jürgen Weizenecker (2009)
Thermotherapy of prostate cancer using magnetic nanoparticles: feasibility, imaging, and three-dimensional temperature distribution.
M Johannsen (2007)
Triggered release from liposomes through magnetic actuation of iron oxide nanoparticle containing membranes.
E. Amstad (2011)
Local hyperthermia treatment of tumors induces CD8(+) T cell-mediated resistance against distal and secondary tumors.
Seiko Toraya-Brown (2014)
Comparison of the Iron Oxide-Based Blood-Pool Contrast Medium VSOP-C184 With Gadopentetate Dimeglumine for First-Pass Magnetic Resonance Angiography of the Aorta and Renal Arteries in Pigs
Jörg Schnorr (2004)
Gelatin-coated magnetic iron oxide nanoparticles as carrier system: drug loading and in vitro drug release study.
Babita Gaihre (2009)
Imaging macrophages with nanoparticles.
Ralph Weissleder (2014)
Contrast-enhanced MR imaging of liver and spleen: first experience in humans with a new superparamagnetic iron oxide.
Bernd A. Hamm (1994)
Synthe - sis , self - assembly , and characterization of PEG - coated iron oxide nanoparticles as potential MRI contrast agent
Nanocluster of superparamagnetic iron oxide nanoparticles coated with poly (dopamine) for magnetic fieldtargeting
M. Wu (2015)
Designed Synthesis of Uniformly Sized Iron Oxide Nanoparticles for Efficient Magnetic Resonance Imaging Contrast Agents
Nohyun Lee (2012)
Studies of Fe3O4-chitosan nanoparticles prepared by co-precipitation under the magnetic field for lipase immobilization
Yong Liu (2011)
Doxorubicin loaded PVA coated iron oxide nanoparticles for targeted drug delivery
Sibnath Kayal (2010)
Magnetite-Loaded Polymeric Micelles as Ultrasensitive Magnetic-Resonance Probes†
Hua Ai (2005)
Detection of lymph node metastases with ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance imaging in oesophageal cancer: a feasibility study
B.B. Pultrum (2009)
Detection of malignant hepatic tumors with ferumoxides-enhanced MRI: comparison of five gradient-recalled echo sequences with different TEs.
Masayuki Matsuo (2004)
Magnetofection--a highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo.
Florian Kroetz (2003)
Contrast agents used in MR imaging of the liver.
Nevzat Karabulut (2006)
SPIO-conjugated, doxorubicin-loaded microbubbles for concurrent MRI and focused-ultrasound enhanced brain-tumor drug delivery.
Ching-Hsiang Fan (2013)
DNA-based magnetic nanoparticle assembly acts as a magnetic relaxation nanoswitch allowing screening of DNA-cleaving agents.
José Manuel Pérez (2002)
Diagnostic accuracy of MR colonography with fecal tagging
Michael Patrick Achiam (2008)
Ultrasound Contrast Agents in Cancer Therapy
Rounak Nande and Pier Paolo Claudio (2014)
Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery.
Ru Cheng (2013)
Fe3O4 magnetic nanoparticles synthesis from tailings by ultrasonic chemical co-precipitation
Shen Rong Wu (2011)
Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications
Maarten Bloemen (2012)
DNA, RNA, and Protein Extraction: The Past and The Present
Siun Chee Tan (2009)
Superparamagnetic iron oxide based MRI contrast agents: Current status of clinical application.
Yì Xiáng J Wáng (2011)
Superparamagnetic iron oxide-enhanced MR imaging of head and neck lymph nodes.
Martin G. Mack (2002)
Citric-acid-coated magnetite nanoparticles for biological applications
Mihaela Răcuciu (2006)
Preparation, relaxometry, and biokinetics of PEGylated magnetoliposomes as MR contrast agent
Jeff W. M. Bulte (1999)
Low molecular weight alkyl-polycation wrapped magnetite nanoparticle clusters as MRI probes for stem cell labeling and in vivo
G. Liu (2011)
Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications
Wei Wu (2015)
Magnetic targeting for site-specific drug delivery: applications and clinical potential.
Boris Polyak (2009)
Comparative analysis of ferumoxytol and gadoteridol enhancement using T1- and T2-weighted MRI in neuroimaging.
B E Hamilton (2011)
Perspectives and opportunities for nanomedicine in the management of atherosclerosis
Mark E Lobatto (2011)
Clinical applications of iron oxide nanoparticles for magnetic resonance imaging of brain tumors.
Michael Iv (2015)
Philip R. Wakeley (2013)
Value of PET/CT and MR lymphography in treatment of prostate cancer patients with lymph node metastases.
Ansje S Fortuin (2012)
Monodisperse magnetite nanoparticle tracers for in vivo magnetic particle imaging.
A. Khandhar (2013)
Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle
Miles A. Miller (2015)
MR venography using an intravascular contrast agent: results from a multicenter phase 2 study of dosage.
Elna-Marie Larsson (2003)
A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxide nanoparticles.
Morteza Mahmoudi (2010)
Synthesis and characterization of Fe3O4–TiO2 core-shell nanoparticles
Mundt Stefan (2014)
Large‐Scale Synthesis of Uniform and Crystalline Magnetite Nanoparticles Using Reverse Micelles as Nanoreactors under Reflux Conditions
You Jin Lee (2005)
Preparation and characterization of superparamagnetic iron oxide nanoparticles stabilized by alginate.
Hui-li Ma (2007)
Ferroptosis: Role of lipid peroxidation, iron and ferritinophagy.
Gladys O Latunde-Dada (2017)
From iron oxide nanoparticles towards advanced iron-based inorganic materials designed for biomedical applications.
Albert Figuerola (2010)
Magnetoliposomes for controlled drug release in the presence of low-frequency magnetic field
Silvia Nappini (2010)
Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems.
Norased Nasongkla (2006)
J. M. Lackie (2013)
Magnetic nanoparticle hyperthermia enhances radiation therapy: A study in mouse models of human prostate cancer
Anilchandra Attaluri (2015)
Uniform mesoporous silica coated iron oxide nanoparticles as a highly efficient, nontoxic MRI T(2) contrast agent with tunable proton relaxivities.
Fei Ye (2012)
Cancer theranostics: the rise of targeted magnetic nanoparticles.
Adam J. Cole (2011)
Correlation between Ferumoxytol Uptake in Tumor Lesions by MRI and Response to Nanoliposomal Irinotecan in Patients with Advanced Solid Tumors: A Pilot Study
R. Ramanathan (2017)
Multifunctional Fe₃O₄@polydopamine core-shell nanocomposites for intracellular mRNA detection and imaging-guided photothermal therapy.
Lisen Lin (2014)
Magnetic Particle Imaging-Guided Heating in Vivo Using Gradient Fields for Arbitrary Localization of Magnetic Hyperthermia Therapy.
Zhi Wei Tay (2018)
Oleic acid coating on the monodisperse magnetite nanoparticles
Ling Tao Zhang (2006)
Iron oxide-loaded nanotheranostics: major obstacles to in vivo studies and clinical translation.
Nathalie Schleich (2015)
Ultra‐small superparamagnetic iron oxides for metastatic lymph node detection: back on the block
Ansje S. Fortuin (2018)
Facile synthesis of ultrasmall PEGylated iron oxide nanoparticles for dual-contrast T1- and T2-weighted magnetic resonance imaging.
Fengqin Hu (2011)
Polyethylene glycol modified
A. J. Cole (2011)
Superparamagnetic iron oxide nanoparticles: from preparations to in vivo MRI applications
Ruirui Qiao (2009)
Point Spread Function Analysis of Magnetic Particles
Ingo Schmale (2012)
Design of Superparamagnetic Nanoparticles for Magnetic Particle Imaging (MPI)
Yimeng Du (2013)
Ferumoxytol for treatment of iron deficiency anemia in patients with chronic kidney disease
Daniel W Coyne (2009)
Imaging macrophage development and fate in atherosclerosis and myocardial infarction.
Filip K Swirski (2013)
Fundamentals and application of magnetic particles in cell isolation and enrichment: a review.
Brian D. Plouffe (2015)
Biomedical nanoparticles modulate specific CD4+ T cell stimulation by inhibition of antigen processing in dendritic cells
Fabian Blank (2011)
Ultrasound molecular imaging with targeted microbubble contrast agents
Alexander L. Klibanov (2007)
Three-dimensional real-time in vivo magnetic particle imaging.
Jürgen Weizenecker (2009)
Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles.
Sophie Laurent (2011)
Synthesis and characterization of magnetite nanoparticles coated with lauric acid
Javier Bustamante Mamani (2013)
Antibody conjugated magnetic iron oxide nanoparticles for cancer cell separation in fresh whole blood.
Hengyi Xu (2011)
Ferrite-based magnetic nanofluids used in hyperthermia applications
Ibrahim Sharifi (2012)
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.
Ajay Kumar Gupta (2005)
Next-generation superparamagnetic iron oxide nanoparticles for cancer theranostics.
Kai Li (2017)
Biomedical applications of superparamagnetic iron oxide nanoparticles encapsulated within chitosan
Eun Hee Kim (2007)
Prediction of Anti-cancer Nanotherapy Efficacy by Imaging
Miles A. Miller (2017)
Novel magnetic multicore nanoparticles designed for MPI and other biomedical applications: From synthesis to first in vivo studies
Harald Kratz (2018)
Use of magnetic nanoparticles as nanosensors to probe for molecular interactions.
José Manuel Pérez (2004)
Ultra-large-scale syntheses of monodisperse nanocrystals
Jongnam Park (2004)
Hepatocellular carcinoma: regional therapy with a magnetic targeted carrier bound to doxorubicin in a dual MR imaging/ conventional angiography suite--initial experience with four patients.
Mark Wilson (2004)
Phase I Clinical Evaluation of Citrate-coated Monocrystalline Very Small Superparamagnetic Iron Oxide Particles as a New Contrast Medium for Magnetic Resonance Imaging
Matthias Taupitz (2004)
Coronary CT versus MR angiography: the role of MR angiography.
Hajime Sakuma (2011)
Synthesis and characterization of magnetite nanoparticles via the chemical co-precipitation method
Karat Petcharoen (2012)
Liver-specific agents for contrast-enhanced MRI: role in oncological imaging
Yee Liang Thian (2013)
Identifying Inflamed Carotid Plaques Using In Vivo USPIO-Enhanced MR Imaging to Label Plaque Macrophages
Rikin Trivedi (2006)
MR of carcinoma-specific monoclonal antibody conjugated to monocrystalline iron oxide nanoparticles: the potential for noninvasive diagnosis.
L G Remsen (1996)
Magnetic targeting of magnetoliposomes to solid tumors with MR imaging monitoring in mice: feasibility.
Jean-Paul Fortin-Ripoche (2006)
G.V.T.V. Weerasooriya (1824)
Conolly, Quantitative magnetic particle imaging monitors the transplantation, biodistribution, and clearance of stem cells
B. Zheng (2016)
Ferroptosis: role of lipid peroxidation
G. O. Latunde-Dada (2017)
Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages
Milene Costa da Silva (2017)
In vivo MRI cell tracking: clinical studies.
Jeff W. M. Bulte (2009)
Stimuli-responsive poly(N-isopropyl acrylamide)-co-tyrosine@gadolinium: Iron oxide nanoparticle-based nanotheranostic for cancer diagnosis and treatment.
Ekta Roy (2016)
P85, Optison microbubbles and ultrasound cooperate in mediating plasmid DNA transfection in mouse skeletal muscles in vivo.
Yunchao Chen (2011)
Magnetic Iron Oxide Nanoparticles: Synthesis and Surface Functionalization Strategies
Wei Chen Wu (2009)
Scaling laws at the nanosize
Eric D. Smolensky (2013)
Gold coated magnetic nanoparticles: from preparation to surface modification for analytical and biomedical applications.
Saimon Moraes Silva (2016)
Biocompatibility of Fe(3)O(4) nanoparticles evaluated by in vitro cytotoxicity assays using normal, glia and breast cancer cells.
Balaprasad Ankamwar (2010)
Dual anticancer drug/superparamagnetic iron oxide-loaded PLGA-based nanoparticles for cancer therapy and magnetic resonance imaging.
Nathalie Schleich (2013)
Magnetic particle imaging: advancements and perspectives for real-time in vivo monitoring and image-guided therapy.
Michele H Pablico-Lansigan (2013)
A highly effective, nontoxic T1 MR contrast agent based on ultrasmall PEGylated iron oxide nanoparticles.
Ulrich I. Tromsdorf (2009)
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Seyed Mohammadali Dadfar (2020)
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O. I. Vernaya (2019)
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Advances in the Application of Magnetic Nanoparticles for Sensing.
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Adam Aron Mieloch (2020)
Biogenic synthesis of iron oxide nanorods using Moringa oleifera leaf extract for antibacterial applications
Samson O. Aisida (2019)
Rapid colorimetric and spectroscopy based sensing of mercury by surface functionalized silver nanoparticles in the presence of tyrosine
S. Balasurya (2020)
Influence of Magnetic Micelles on Assembly and Deposition of Porphyrin J-Aggregates
Maria Angela Castriciano (2020)
State-of-the-art iron-based nanozymes for biocatalytic tumor therapy
Meng-Huan Li (2020)
Nanopharmaceuticals: A focus on their clinical translatability.
Sofia Bisso (2020)
Development of Superparamagnetic Nanoparticles Coated with Polyacrylic Acid and Aluminum Hydroxide as an Efficient Contrast Agent for Multimodal Imaging
Manuel Antonio González-Gómez (2019)
PEGlatyon-SPION surface functionalization with folic acid for magnetic hyperthermia applications
Rodolfo Debone Piazza (2020)
Combustion and friction-derived nanoparticles and industrial-sourced nanoparticles: The culprit of Alzheimer and Parkinson's diseases.
Lilian Calderón-Garcidueñas (2019)
Small Dimension–Big Impact! Nanoparticle-Enhanced Non-Invasive and Intravascular Molecular Imaging of Atherosclerosis In Vivo
Tobias Lenz (2020)
Synthesis and characterization of magnetite nanoparticles for photocatalysis of nitrobenzene
Victor Alfredo Reyes Villegas (2020)
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Prospective Protective Effect of Ellagic Acid as a SIRT1 Activator in Iron Oxide Nanoparticle-Induced Renal Damage in Rats
Eman Taha Mohammed (2020)
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Juan A. Ramos-Guivar (2020)
Synthesis, characterization and in vitro toxicity evaluation of doxorubicin-loaded magnetoliposomes on MCF-7 breast cancer cell line
Alireza Askari (2020)
Maghemite nanoparticles stabilize the protein corona formed with transferrin presenting different iron-saturation levels.
Ulrike Martens (2019)
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