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Solvent Effects On Composition And Structure Of Thiolipid Molecular Anchors For Tethering Phospholipid Bilayers

Saulius Tumenas, Tadas Ragaliauskas, Tadas Penkauskas, Audronė Valančiūtė, Filipas Ambrulevicius, Gintaras Valincius
Published 2020 · Materials Science

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Abstract This article reports the effects of solvent polarity on the formation and properties of multi-component self-assembled monolayers (SAMs) for surface immobilization of tethered bilayer membranes (tBLMs). Monolayers were formed on polycrystalline gold using a synthetic 1-thiahexa(ethylene oxide) thiolipid serving as molecular anchor mixed with the β-mercaptoethanol backfiller. The properties of SAMs and tBLMs prepared in different solvents were monitored by the electrochemical impedance spectroscopy, spectroscopic ellipsometry and polarization modulation infrared reflection absorption spectroscopy. We found that the solvent polarity allows controlling the surface concentration of molecular anchors on a surface in the range from 9% to 57% while keeping constant adsorbate concentration in solution. A solvent polarity also determines the structural arrangement of the molecular components. A low polarity environment favours sparser accommodation of molecular anchors and a more compact arrangement of backfillers, while the high polarity solvent favours clustering of the hydrophobic polymethylene parts, which adopt more vertical orientation tilted ~25° to a surface normal. Both composition and structure affect both the physical and functional properties of tBLMs. In general, the nature of the solvents used in the assembly of SAMs used in tBLM technologies should be taken into account if specific functional features of tBLMs are being sought.
This paper references
10.1116/1.2709308
Molecular-scale structural and functional characterization of sparsely tethered bilayer lipid membranes
D. McGillivray (2007)
10.1016/J.ELECTACTA.2018.12.148
Electrochemical impedance of randomly distributed defects in tethered phospholipid bilayers: Finite element analysis
Tomas Raila (2019)
10.1021/acs.langmuir.7b00929
Formation Kinetics of Mixed Self-Assembled Monolayers of Alkanethiols on GaAs(100).
Vivien Lacour (2019)
10.1021/la204054g
Electrochemical impedance spectroscopy of tethered bilayer membranes.
G. Valincius (2012)
10.1021/ja00227a044
Formation of two-component surfaces by the spontaneous assembly of monolayers on gold from solutions containing mixtures of organic thiols
C. Bain (1988)
10.1021/j100364a009
Quantitative evaluation of molecular orientation in thin Langmuir-Blodgett films by FT-IR transmission and reflection-absorption spectroscopy
J. Umemura (1990)
10.1126/science.240.4848.62
Molecular-Level Control over Surface Order in Self-Assembled Monolayer Films of Thiols on Gold
C. Bain (1988)
10.1021/ja00005a004
Concentration-Driven Surface Transition in the Wetting of Mixed Alkanethiol Monolayers on Gold
A. Ulman (1991)
10.1021/JA981187L
Mixed Self-assembled Monolayers of Rigid Biphenyl Thiols: Impact of Solvent and Dipole Moment
J. Kang (1998)
10.1002/cphc.200900917
Effect of the structure of cholesterol-based tethered bilayer lipid membranes on ionophore activity.
James R. Kendall (2010)
10.1021/la00060a041
Comparisons of self-assembled monolayers on silver and gold: mixed monolayers derived from HS(CH2)21X and HS(CH2)10Y (X, Y = CH3, CH2OH) have similar properties
P. E. Laibinis (1991)
10.1366/0003702924444498
Optical Considerations for Infrared Reflection Spectroscopic Analysis in the C-H Stretching Region of Monolayer Films at an Aqueous/Metal Interface
D. Popenoe (1992)
10.1021/ACS.JPCC.6B07686
Water-Induced Structural Changes in the Membrane-Anchoring Monolayers Revealed by Isotope-Edited SERS
Martynas Talaikis (2016)
10.1021/ja00019a011
Comparison of the Structures and Wetting Properties of Self-Assembled Monolayers of n- Alkanethiols on the Coinage Metal Surfaces, Cu, Ag, Au'
P. E. Laibinis (1991)
10.1016/J.APSUSC.2014.09.070
Solvent polarity effect on quality of n-octadecanethiol self-assembled monolayers on copper and oxidized copper
Y. Zhang (2014)
10.1021/j100053a035
Phase behavior of two-component self-assembled monolayers of alkanethiolates on gold
J. P. Folkers (1994)
10.1002/andp.19354160705
Berechnung verschiedener physikalischer Konstanten von heterogenen Substanzen. I. Dielektrizitätskonstanten und Leitfähigkeiten der Mischkörper aus isotropen Substanzen
D. A. G. Bruggeman (1935)
10.1021/la401132c
Structure and properties of tethered bilayer lipid membranes with unsaturated anchor molecules.
R. Budvytytė (2013)
10.1021/la00041a015
Self-assembled monolayers of alkanethiols on gold: comparisons of monolayers containing mixtures of short- and long-chain constituents with methyl and hydroxymethyl terminal groups
J. P. Folkers (1992)
10.1016/j.bpj.2008.11.020
Structure of functional Staphylococcus aureus alpha-hemolysin channels in tethered bilayer lipid membranes.
D. McGillivray (2009)
10.1016/J.ELECTACTA.2016.11.056
Electrochemical Impedance Spectroscopy of Tethered Bilayer Membranes: An Effect of Heterogeneous Distribution of Defects in Membranes
G. Valincius (2016)
10.1016/J.APSUSC.2017.03.126
Optical constants of electroplated gold from spectroscopic ellipsometry
Ron A. Synowicki (2017)
10.1039/C0SM00618A
Hydrogel-supported protein-tethered bilayer lipid membranes: a new approach toward polymer-supported lipid membranes
A. Kibrom (2011)
10.1021/la00049a028
Contact angle stability. Reorganization of monolayer surfaces
S. D. Evans (1991)
10.1038/42432
A biosensor that uses ion-channel switches
B. Cornell (1997)
10.1002/pol.1961.1205516121
Molecular vibrations and structure of high polymers. II. Helical parameters of infinite polymer chains as functions of bond lengths, bond angles, and internal rotation angles
T. Miyazawa (1961)
10.1021/ma60035a005
Structural Studies of Polyethers, (-(CH2)m-O-)n. X. Crystal Structure of Poly(ethylene oxide)
Y. Takahashi (1973)
10.1021/j100211a029
An infrared reflection spectroscopy study of oriented cadmium arachidate monolayer films on evaporated silver
D. Allara (1982)
10.1021/j100191a065
Structure of monolayers formed by coadsorption of two n-alkanethiols of different chain lengths on gold and its relation to wetting
P. E. Laibinis (1992)
10.1021/ja00200a040
Formation of Monolayers by the Coadsorption of Thiols on Gold: Variation in the Length of the Alkyl Chain
C. Bain (1989)
10.1021/ja00200a039
Formation of monolayers by the coadsorption of thiols on gold: variation in the head group, tail group, and solvent
C. Bain (1989)
10.1021/la503715b
Structure and function of the membrane anchoring self-assembled monolayers.
Bozena Rakovska (2015)
10.1021/la1021802
Formation and finite element analysis of tethered bilayer lipid structures.
K. J. Kwak (2010)
10.1529/biophysj.108.130997
Soluble amyloid beta-oligomers affect dielectric membrane properties by bilayer insertion and domain formation: implications for cell toxicity.
G. Valincius (2008)
10.1021/JA056972U
Redox enzymes in tethered membranes.
L. Jeuken (2006)
10.1002/pol.1969.160071009
Vibrational analysis of molten poly(ethylene glycol)
H. Matsuura (1969)
10.1016/J.JELECHEM.2008.07.001
Study of the solvent effect on the quality of dodecanethiol self-assembled monolayers on polycrystalline gold
J. Dai (2008)
10.1021/la3051725
A PM-IRRAS investigation of monorhamnolipid orientation at the air-water interface.
Hongsen Wang (2013)
10.1143/JJAP.44.1052
Growth Processes and Control of Two-Dimensional Structure of Carboxylic Acid-Terminated Self-Assembled Monolayers on Au(111)
J. Noh (2005)
10.1139/v73-169
Vibrational Spectra and Rotational Isomerism in 2-Mercaptoethanol
S. K. Nandy (1973)
10.1021/la991590l
Phase separation of alkanethiol self-assembled monolayers during the replacement of adsorbed thiolates on Au(111) with thiols in solution
T. Kakiuchi (2000)
10.1016/S0022-0728(97)00553-6
Phase separation of binary self-assembled thiol monolayers composed of 1-hexadecanethiol and 3-mercaptopropionic acid on Au(111) studied by scanning tunneling microscopy and cyclic voltammetry
D. Hobara (1998)
10.1021/la00061a008
Spontaneously Organized Molecular Assemblies. 2. Quantitative Infrared Spectroscopic Determination of Equilibrium Structures of Solution-Adsorbed n-Alkanoic Acids on an Oxidized Aluminum Surface
D. Allara (1985)
10.1021/ja00219a055
Correlations between wettability and structure in monolayers of alkanethiols adsorbed on gold
C. Bain (1988)
10.1021/la900907d
In situ PM-IRRAS studies of an archaea analogue thiolipid assembled on a au(111) electrode surface.
Jay A. Leitch (2009)
10.1063/1.462460
Morphology dependent anomalous frequency shifts of infrared absorption bands of polymer crystals: Interpretation in terms of transition dipole–dipole coupling theory
M. Kobayashi (1992)
10.1063/1.464613
Molecular ordering of organosulfur compounds on Au(111) and Au(100): Adsorption from solution and in ultrahigh vacuum
L. Dubois (1993)
10.1021/LA970447U
Selective Replacement of Adsorbed Alkanethiols in Phase-Separated Binary Self-Assembled Monolayers by Electrochemical Partial Desorption
S. Imabayashi (1997)
10.1021/JP972635Z
Molecular Conformation in Oligo(ethylene glycol)-Terminated Self-Assembled Monolayers on Gold and Silver Surfaces Determines Their Ability To Resist Protein Adsorption
P. Harder (1998)



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