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Prevalence And Pattern Of Lymph Node Metastasis In Malignant Pleural Mesothelioma.

A. Abdel Rahman, Rabab M. Gaafar, Hoda A. Baki, Hesham M. El Hosieny, Fatma Aboulkasem, Eman G. Farahat, Akram M. Nouh, Kamal A. Mansour
Published 2008 · Medicine

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BACKGROUND The incidence and pattern of nodal metastases in mesothelioma are not well understood. This study was conducted to evaluate the prevalence and pattern of nodal metastasis in mesothelioma patients. METHODS The study included 53 patients with mesothelioma. The first 37 patients (group I) underwent combined modality treatment without preoperative mediastinoscopy. The second group included 16 patients (group II) with pretreatment mediastinoscopy. RESULTS A total of 18 patients had positive lymph nodes, 12 in group I and 6 in group II; of the latter, 4 had positive mediastinoscopy and 2 had positive nodes on final pathology. Postoperatively, a mean of 14 nodes were dissected (range, 5 to 34). In the post-pleuropneumonectomy group, 6 of 14 patients had positive hilar node metastases in addition to positive mediastinal lymph nodes. One patient had positive hilar nodes only. Of the 49 patients operated on, only 7 had no lung invasion by pathologic evaluation, and none had positive hilar nodes. The mechanism of spread of the disease to hilar nodes may be through lung invasion and not due to direct spread from the pleura. This observation raises the possibility that mediastinal nodes should be considered the primary station in patients with mesothelioma, whereas hilar node metastasis necessitated lung invasion first. CONCLUSIONS The pattern of nodal metastases may be different from that of lung cancer, and multicenter studies are needed to evaluate this observation.
This paper references
Impact of lymph metastasis on outcome after extrapleural pneumonectom for malignant pleural mesothelioma
Perrot (2007)
10.1016/S1010-7940(01)00594-2
Trimodality management of malignant pleural mesothelioma.
G. Maggi (2001)
10.1053/J.OPTECHSTCVS.2006.02.002
Treatment of Malignant Pleural Mesothelioma: Pleurectomy with Adjuvant Therapy
R. Flores (2006)
Resec margins , extrapleural nodal status and cell type determ postoperative long - term survival in trimodality therapy malignant pleural mesothelioma : results in 183 patien
DJ Sugarbaker (1999)
10.1016/S0022-5223(99)70469-1
Resection margins, extrapleural nodal status, and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural mesothelioma: results in 183 patients.
D. Sugarbaker (1999)
10.1378/CHEST.130.3.710
Comparison of endobronchial ultrasound, positron emission tomography, and CT for lymph node staging of lung cancer.
K. Yasufuku (2006)
10.5555/URI:PII:0093775481900403
Clinical presentation and natural history of benign and malignant mesothelioma.
K. Antman (1981)
10.1016/J.EJCTS.2003.12.001
The case for routine cervical mediastinoscopy prior to radical surgery for malignant pleural mesothelioma.
J. Pilling (2004)
10.1016/S1010-7940(02)00273-7
The management of malignant pleural mesothelioma; single centre experience in 10 years.
T. Aziz (2002)
Real endobronchial ultrasound - guided transbronchial lymp node aspiration
BU Vincent (2008)
10.1016/S0003-4975(99)01038-3
Important prognostic factors in patients with malignant pleural mesothelioma, managed surgically.
V. Rusch (1999)
10.1378/CHEST.93.1.159
Prognostic factors in diffuse malignant pleural mesothelioma. A study of 167 patients.
E. Chailleux (1988)
10.1016/J.ATHORACSUR.2004.01.034
The effect of extent of local resection on patterns of disease progression in malignant pleural mesothelioma.
D. Stewart (2004)
Prevalence and pattern of lymph node metastasis in malignant pleural mesothelioma: P1-105
M. A. Rahman (2007)
10.1200/JCO.1993.11.6.1172
Node status has prognostic significance in the multimodality therapy of diffuse, malignant mesothelioma.
D. Sugarbaker (1993)
10.1016/S0003-4975(03)00010-9
The value of chest computer tomography and cervical mediastinoscopy in the preoperative assessment of patients with malignant pleural mesothelioma.
J. H. Schouwink (2003)
10.1378/CHEST.108.4.1122
A proposed new international TNM staging system for malignant pleural mesothelioma. From the International Mesothelioma Interest Group.
V. Rusch (1995)
10.1016/S0022-5223(96)70342-2
The importance of surgical staging in the treatment of malignant pleural mesothelioma.
V. Rusch (1996)
Prognostic factors in diffuse ma nant mesothelioma . A study of 167 patients
E Chailleux (1998)
10.1016/J.JTCVS.2006.06.044
Impact of lymph node metastasis on outcome after extrapleural pneumonectomy for malignant pleural mesothelioma.
M. D. de Perrot (2007)
10.1016/S1010-7940(02)00735-2
The management of malignant pleural mesothelioma.
G. Maggi (2003)
10.1053/SONC.2002.30299
Prognostic factors in mesothelioma.
J. Steele (2005)
10.1016/S0022-5223(03)00207-1
Positron emission tomography defines metastatic disease but not locoregional disease in patients with malignant pleural mesothelioma.
R. Flores (2003)
10.1016/J.ATHORACSUR.2007.07.023
Real-time endobronchial ultrasound-guided transbronchial lymph node aspiration.
Brad D. Vincent (2008)
Extended sur staging for potentially resectable malignant pleural m sothelioma
DC Rice (2005)
10.1016/S0003-4975(96)01228-3
Patterns of failure after trimodality therapy for malignant pleural mesothelioma.
E. Baldini (1997)
10.1016/J.ATHORACSUR.2005.06.014
Extended surgical staging for potentially resectable malignant pleural mesothelioma.
D. Rice (2005)
10.1016/J.HOC.2005.09.009
Prognostic factors for mesothelioma.
J. Steele (2005)



This paper is referenced by
10.21037/shc.2018.09.02
What are the implications of the revised N staging system for surgery
Hasan Fevzi Batırel (2018)
10.1016/j.athoracsur.2008.05.067
Invited commentary.
M. Liptay (2008)
10.1017/9781316402009.004
Multi-modality Imaging of Pleural and Peritoneal Disease
J. Cunningham (2018)
10.3892/ol.2013.1461
Primary intrahepatic malignant mesothelioma with multiple lymphadenopathies due to non-tuberculous mycobacteria: A case report and review of the literature
Noriko Inagaki (2013)
10.3348/kjr.2016.17.4.545
Multidetector CT Findings and Differential Diagnoses of Malignant Pleural Mesothelioma and Metastatic Pleural Diseases in Korea
Y. Kim (2016)
10.1200/JCO.2008.19.8523
Malignant pleural mesothelioma.
A. Tsao (2009)
10.1016/j.cllc.2020.01.002
Impact of Detecting Occult Pathologic Nodal Disease During Resection for Malignant Pleural Mesothelioma.
Vivek Verma (2020)
10.1016/j.suronc.2019.10.018
Intra-abdominal recurrence from colorectal carcinoma: Differences and similarities between local and peritoneal recurrence.
F. Dumont (2019)
10.3892/or.2013.2800
Lymph node involvement and metastatic lymph node ratio influence the survival of malignant pleural mesothelioma: a French multicenter retrospective study.
I. Hysi (2014)
10.1016/j.rmed.2017.11.015
Progress and challenges in Mesothelioma: From bench to bedside.
K. Blyth (2018)
10.1053/j.semtcvs.2019.06.004
Management of Clinically Lymph Node-Positive Malignant Pleural Mesothelioma.
V. Verma (2019)
10.1556/MASEB.63.2010.2.3
A mellhártya elsődleges daganatainak sebészi kezelése osztályunk anyagában
Tibor Németh (2010)
10.1016/j.jtho.2016.09.121
The IASLC Mesothelioma Staging Project: Proposals for Revisions of the N Descriptors in the Forthcoming Eighth Edition of the TNM Classification for Pleural Mesothelioma
D. Rice (2016)
10.1097/COC.0b013e3181d31f02
Expert Opinions of the First Italian Consensus Conference on the Management of Malignant Pleural Mesothelioma
C. Pinto (2011)
10.1055/a-0879-1758
Internal Mammary Lymph Node Visualization as a Sentinel Sonographic Sign of Tuberculous Pleurisy.
L. Messineo (2019)
10.1016/j.lungcan.2012.03.021
Perineal and colonic metastases in two cases of malignant mesothelioma.
Bhajneek Grewal (2012)
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