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Post-translational Modifications Of S1PR1 And Endothelial Barrier Regulation.

Mumtaz Anwar, D. Mehta
Published 2020 · Medicine

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Sphingosine-1-phosphate receptor-1 (S1PR1), a G-protein coupled receptor that is expressed in endothelium and activated upon ligation by the bioactive lipid sphingosine-1-phosphate (S1P), is an important vascular-barrier protective mechanism at the level of adherens junctions (AJ). Loss of endothelial barrier function is a central factor in the pathogenesis of various inflammatory conditions characterized by protein-rich lung edema formation, such as acute respiratory distress syndrome (ARDS). While several S1PR1 agonists are available, the challenge of arresting the progression of protein-rich edema formation remains to be met. In this review, we discuss the role of S1PRs, especially S1PR1, in regulating endothelial barrier function. We review recent findings showing that replenishment of the pool of cell-surface S1PR1 may be crucial to the effectiveness of S1P in repairing the endothelial barrier. In this context, we discuss the S1P generating machinery and mechanisms that regulate S1PR1 at the cell surface and their impact on endothelial barrier function.
This paper references
10.1016/S0021-9258(19)38849-0
An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.
T. Hla (1990)
10.1152/AJPHEART.1993.265.2.H725
Plasmalemmal vesicles represent the large pore system of continuous microvascular endothelium.
D. Predescu (1993)
10.1172/JCI118345
Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures.
B. V. Van Lenten (1995)
10.1093/OXFORDJOURNALS.JBCHEM.A021681
Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum.
Y. Yatomi (1997)
10.1126/SCIENCE.279.5356.1552
Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.
M. J. Lee (1998)
10.1083/JCB.147.3.545
Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival
A. Olivera (1999)
10.1074/jbc.274.45.32248
Association of β-Arrestin with G Protein-coupled Receptors during Clathrin-mediated Endocytosis Dictates the Profile of Receptor Resensitization*
R. Oakley (1999)
10.1074/jbc.274.39.27351
Differential Coupling of the Sphingosine 1-Phosphate Receptors Edg-1, Edg-3, and H218/Edg-5 to the Gi, Gq, and G12 Families of Heterotrimeric G Proteins*
R. Windh (1999)
10.1042/bj3400677
Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters.
R. Jasinská (1999)
10.1074/JBC.M910348199
Differential Affinities of Visual Arrestin, βArrestin1, and βArrestin2 for G Protein-coupled Receptors Delineate Two Major Classes of Receptors*
R. Oakley (2000)
10.1083/JCB.150.5.1057
Endothelial Cell-Surface Gp60 Activates Vesicle Formation and Trafficking via Gi-Coupled Src Kinase Signaling Pathway
R. Minshall (2000)
10.1146/ANNUREV.PHARMTOX.40.1.97
Sequencing the entire genomes of free-living organisms: the foundation of pharmacology in the new millennium.
S. Broder (2000)
10.1074/JBC.M002759200
Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform*
Hong Liu (2000)
10.1161/01.HYP.35.6.1237
Interactions between nitric oxide and endothelin in the regulation of vascular tone of human resistance vessels in vivo.
C. Cardillo (2000)
10.1172/JCI10905
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.
Y. Liu (2000)
10.1042/BJ3520809
Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions.
N. Murata (2000)
10.1074/JBC.M101450200
Molecular Determinants Underlying the Formation of Stable Intracellular G Protein-coupled Receptor-β-Arrestin Complexes after Receptor Endocytosis*
R. Oakley (2001)
10.1161/01.ATV.21.1.115
Simvastatin Has Anti-Inflammatory and Antiatherosclerotic Activities Independent of Plasma Cholesterol Lowering
C. Sparrow (2001)
10.1172/JCI12450
Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement.
J. Garcia (2001)
10.1124/pr.54.2.265
International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature
J. Chun (2002)
10.1074/JBC.M109968200
Characterization of Murine Sphingosine-1-phosphate Phosphohydrolase*
H. Le Stunff (2002)
10.1016/S0014-5793(02)03409-9
Tandem genomic arrangement of a G protein (Gna15) and G protein‐coupled receptor (s1p4 /lpC1 /Edg6) gene
J. Contos (2002)
10.1074/jbc.M203033200
PKC-dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane
Korey R. Johnson (2002)
10.1126/SCIENCE.1070238
Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists
S. Mandala (2002)
10.1016/S1388-1981(02)00175-0
Sphingosine-1-phosphate receptors and the development of the vascular system.
M. L. Allende (2002)
10.1096/fj.02-0548com
Activation‐regulated expression and chemotactic function of sphingosine 1‐phosphate receptors in mouse splenic T cells
M. Graeler (2002)
10.1016/S0014-5793(03)01168-2
The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2
S. Paugh (2003)
10.1182/BLOOD-2003-02-0460
G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation.
M. L. Allende (2003)
10.1093/emboj/cdg540
Activation of sphingosine kinase 1 by ERK1/2‐mediated phosphorylation
S. Pitson (2003)
10.1002/jcb.20127
Structural and functional characteristics of S1P receptors
T. Sanchez (2004)
10.1016/J.SEMCDB.2004.05.002
Physiological and pathological actions of sphingosine 1-phosphate.
T. Hla (2004)
10.1074/JBC.M313969200
Pulmonary Endothelial Cell Barrier Enhancement by Sphingosine 1-Phosphate
S. Dudek (2004)
10.1016/J.BBRC.2004.10.036
Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5'-phosphate binding domain exposed to the cytosol.
M. Ikeda (2004)
10.1002/jcb.20088
Endothelial cell barrier regulation by sphingosine 1‐phosphate
B. McVerry (2004)
10.1074/JBC.M311743200
Sphingosine 1-Phosphate (S1P) Receptor Subtypes S1P1 and S1P3, Respectively, Regulate Lymphocyte Recirculation and Heart Rate*
M. Sanna (2004)
10.1038/nature02284
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
M. Matloubian (2004)
10.1161/01.RES.0000122383.60368.24
Point-Counterpoint of Sphingosine 1-Phosphate Metabolism
J. Saba (2004)
10.1074/jbc.M502207200
SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism*
M. Maceyka (2005)
10.1128/MCB.25.24.11113-11121.2005
Essential Role for Sphingosine Kinases in Neural and Vascular Development
K. Mizugishi (2005)
10.1016/J.CELLSIG.2004.07.011
c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells.
C. Waters (2005)
10.1084/jem.20040559
Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling
S. Pitson (2005)
10.1161/CIRCULATIONAHA.104.525774
Kruppel-Like Factor 2 as a Novel Mediator of Statin Effects in Endothelial Cells
S. Sen-Banerjee (2005)
10.1074/jbc.M411674200
Sphingosine 1-Phosphate-induced Mobilization of Intracellular Ca2+ Mediates Rac Activation and Adherens Junction Assembly in Endothelial Cells*
D. Mehta (2005)
10.1096/fj.05-3730fje
Type 4 sphingosine 1‐phosphate G protein‐coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration
Wengang Wang (2005)
10.1523/JNEUROSCI.4645-04.2005
Edg8/S1P5: An Oligodendroglial Receptor with Dual Function on Process Retraction and Cell Survival
C. Jaillard (2005)
10.1016/J.BBAMEM.2006.08.007
Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases.
N. Hait (2006)
10.1158/0008-5472.CAN-05-2001
Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization.
K. Lamontagne (2006)
10.1038/nature04882
Kruppel-like factor 2 regulates thymocyte and T-cell migration
Corey M. Carlson (2006)
10.1161/CIRCULATIONAHA.105.607135
High-Density Lipoproteins and Their Constituent, Sphingosine-1-Phosphate, Directly Protect the Heart Against Ischemia/Reperfusion Injury In Vivo via the S1P3 Lysophospholipid Receptor
G. Theilmeier (2006)
10.1172/JCI24787
Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2.
K. Parmar (2006)
10.1152/PHYSREV.00012.2005
Signaling mechanisms regulating endothelial permeability.
D. Mehta (2006)
10.1016/J.PROSTAGLANDINS.2006.05.001
The functional PDGFβ receptor–S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor
J. Long (2006)
10.1042/BJ20060251
Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient.
K. Venkataraman (2006)
10.1161/ATVBAHA.107.152322
Involvement of Rho Kinase in Endothelial Barrier Maintenance
G. P. van Nieuw Amerongen (2007)
10.1016/j.tem.2007.07.005
Autocrine and paracrine roles of sphingosine-1-phosphate
Sergio E Alvarez (2007)
10.1161/ATVBAHA.107.143735
Induction of Vascular Permeability by the Sphingosine-1-Phosphate Receptor–2 (S1P2R) and its Downstream Effectors ROCK and PTEN
T. Sanchez (2007)
10.1152/AJPREGU.00085.2006
Vascular dysfunction in S1P2 sphingosine 1-phosphate receptor knockout mice.
J. Lorenz (2007)
10.1096/fj.06-7420com
Activation of sphingosine‐1‐phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration
Alexander S. Novgorodov (2007)
10.1074/jbc.M610318200
Immunosuppressive and Anti-angiogenic Sphingosine 1-Phosphate Receptor-1 Agonists Induce Ubiquitinylation and Proteasomal Degradation of the Receptor*
M. Oo (2007)
10.1038/ni1523
Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor
T. Walzer (2007)
10.1152/ajplung.00428.2007
Endothelial cell barrier protection by simvastatin: GTPase regulation and NADPH oxidase inhibition.
Weiguo Chen (2008)
10.1038/nri2400
The alliance of sphingosine-1-phosphate and its receptors in immunity
J. Rivera (2008)
10.1038/sj.bjp.0707662
G‐protein‐coupled receptor phosphorylation: where, when and by whom
A. Tobin (2008)
10.1016/j.cub.2008.10.061
The Spinster Homolog, Two of Hearts, Is Required for Sphingosine 1-Phosphate Signaling in Zebrafish
N. Osborne (2008)
10.1038/nature06663
Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation
F. Niessen (2008)
10.1124/pr.107.07113
“Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets
K. Takabe (2008)
10.1161/01.RES.0000338501.84810.51
Activation of Sphingosine Kinase-1 Reverses the Increase in Lung Vascular Permeability Through Sphingosine-1-Phosphate Receptor Signaling in Endothelial Cells
Mohammad Tauseef (2008)
10.1084/jem.20080406
VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF
A. Nottebaum (2008)
10.1371/journal.pone.0004112
Incomplete Inhibition of Sphingosine 1-Phosphate Lyase Modulates Immune System Function yet Prevents Early Lethality and Non-Lymphoid Lesions
P. Vogel (2009)
10.1126/science.1176709
Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate
N. Hait (2009)
10.1038/nature08144
The structure and function of G-protein-coupled receptors
D. Rosenbaum (2009)
10.1161/CIRCRESAHA.108.193367
Akt-Mediated Transactivation of the S1P1 Receptor in Caveolin-Enriched Microdomains Regulates Endothelial Barrier Enhancement by Oxidized Phospholipids
P. Singleton (2009)
10.1158/0008-5472.CAN-09-1110
Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation.
G. Cattoretti (2009)
10.1146/annurev.biochem.78.072407.103733
Sphingosine 1-phosphate receptor signaling.
H. Rosen (2009)
10.1074/jbc.M806819200
Constitutive Internalization of G Protein-coupled Receptors and G Proteins via Clathrin-independent Endocytosis*
M. Scarselli (2009)
10.1074/jbc.M807336200
Subcellular Origin of Sphingosine 1-Phosphate Is Essential for Its Toxic Effect in Lyase-deficient Neurons*
N. Hagen (2009)
10.1242/jcs.033951
Molecular mechanisms of clathrin-independent endocytosis
C. G. Hansen (2009)
10.1126/science.1167449
The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors
A. Kawahara (2009)
10.1007/978-1-4419-6741-1_10
Extracellular and intracellular actions of sphingosine-1-phosphate.
G. Strub (2010)
10.1161/CIRCRESAHA.110.219592
Krüppel-Like Factor-4 Transcriptionally Regulates VE-Cadherin Expression and Endothelial Barrier Function
Colleen E. Cowan (2010)
10.1074/jbc.M110.171116
The Sphingosine 1-Phosphate Transporter, SPNS2, Functions as a Transporter of the Phosphorylated Form of the Immunomodulating Agent FTY720*
Yu 野悠 Hisano 久 (2010)
10.1210//en.2009-1387
S1P1 and VEGFR-2 form a signaling complex with extracellularly regulated kinase 1/2 and protein kinase C-alpha regulating ML-1 thyroid carcinoma cell migration.
N. Bergelin (2010)
10.1194/jlr.M004374
Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate[S]
D. Siow (2010)
10.1074/jbc.M110.171819
Sphingosine-1-phosphate Lyase Deficiency Produces a Pro-inflammatory Response While Impairing Neutrophil Trafficking*
M. L. Allende (2010)
10.1074/jbc.M109.081489
Sphingosine 1-Phosphate Lyase Deficiency Disrupts Lipid Homeostasis in Liver*
M. Bektas (2010)
10.1038/nm.2250
Stat3-induced S1PR1 expression is critical for persistent Stat3 activation in tumors
Heehyoung Lee (2010)
10.1210/EN.2009-1387
S1P1 and VEGFR-2 Form a Signaling Complex with Extracellularly Regulated Kinase 1/2 and Protein Kinase C-α Regulating ML-1 Thyroid Carcinoma Cell Migration
N. Bergelin (2010)
10.1038/nchembio.392
An update on sphingosine-1-phosphate and other sphingolipid mediators.
H. Fyrst (2010)
10.1038/nrd3248
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
V. Brinkmann (2010)
10.1096/fj.09-141473
Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine-1-phosphate receptor S1P4.
S. Golfier (2010)
10.1007/978-1-4419-6741-1_1
An overview of sphingolipid metabolism: from synthesis to breakdown.
Christopher R. Gault (2010)
10.1016/j.tips.2011.04.002
Receptor tyrosine kinase-G-protein-coupled receptor signalling platforms: out of the shadow?
N. Pyne (2011)
10.1083/jcb.201012129
Caveolin-1–eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability
M. Siddiqui (2011)
10.1111/j.1476-5381.2011.01364.x
Endocannabinoid tone versus constitutive activity of cannabinoid receptors
A. Howlett (2011)
10.1161/CIRCRESAHA.110.235028
Sphingosine-1-Phosphate Receptor 3 Promotes Recruitment of Monocyte/Macrophages in Inflammation and Atherosclerosis
P. Keul (2011)
10.1038/nri2974
The outs and the ins of sphingosine-1-phosphate in immunity
S. Spiegel (2011)
10.1172/JCI45403
Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice.
M. Oo (2011)
10.1073/pnas.1103187108
Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
C. Christoffersen (2011)
10.1177/0022034510389178
Dissecting the Role of the S1P/S1PR Axis in Health and Disease
J. J. Aarthi (2011)
10.1038/nrm3151
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
H. McMahon (2011)
10.1165/rcmb.2010-0422OC
Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression.
Yutong Zhao (2011)
10.4103/2045-8932.87309
S1P4 receptor mediates S1P-induced vasoconstriction in normotensive and hypertensive rat lungs
H. Ota (2011)
10.1016/j.tibs.2010.08.001
Regulation of sphingosine kinase and sphingolipid signaling.
S. Pitson (2011)
10.1016/j.mvr.2011.05.004
Heterotrimeric G proteins, focal adhesion kinase, and endothelial barrier function.
Tracy Thennes (2012)
10.1016/j.tcb.2011.09.003
Sphingosine-1-phosphate signaling and its role in disease.
M. Maceyka (2012)
10.1146/annurev-nutr-071811-150709
New roles of HDL in inflammation and hematopoiesis.
Xuewei Zhu (2012)
10.1016/j.devcel.2012.07.015
Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development.
B. Jung (2012)
10.1172/JCI60746
The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice.
S. Fukuhara (2012)
10.1165/rcmb.2012-0048OC
Sphingosine-1-phosphate receptor-3 is a novel biomarker in acute lung injury.
Xiaoguang Sun (2012)
10.1371/journal.pone.0038941
Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells
Yu Hisano (2012)
10.1016/j.devcel.2012.08.005
The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2.
K. Gaengel (2012)
10.1016/j.cell.2011.12.022
Visualizing neuromodulation in vivo: TANGO-mapping of dopamine signaling reveals appetite control of sugar sensing.
Hidehiko K. Inagaki (2012)
10.1186/1742-2094-9-133
Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier
R. van Doorn (2012)
10.1074/jbc.M112.427344
Sphingosine 1-Phosphate Receptor Signaling Regulates Proper Embryonic Vascular Patterning*
Karen Mendelson (2012)
10.1161/ATVBAHA.111.241034
Sphingosine-1-Phosphate Receptor 3 Promotes Neointimal Hyperplasia in Mouse Iliac-Femoral Arteries
Takuya Shimizu (2012)
10.1016/j.mvr.2011.08.012
Role of FAK in S1P-regulated endothelial permeability.
P. Belvitch (2012)
10.1091/mbc.E12-01-0038
The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation
Ilse Timmerman (2012)
10.1165/rcmb.2012-0411TR
Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury.
V. Natarajan (2013)
10.1111/febs.12446
Sphingosine‐1‐phosphate receptor 2
M. Adada (2013)
10.1038/nrd4099
Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond
Gregory T Kunkel (2013)
10.1152/ajplung.00094.2013
Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities.
T. Schmidt (2013)
10.1146/annurev-biochem-062411-130916
Sphingosine-1-phosphate and its receptors: structure, signaling, and influence.
H. Rosen (2013)
10.1038/ni.2745
Transcriptional downregulation of S1pr1 is required for establishment of resident memory CD8+ T cells
Cara N. Skon (2013)
10.1371/journal.pone.0082590
Moesin Controls Clathrin-Mediated S1PR1 Internalization in T Cells
Akira Nomachi (2013)
10.1242/dev.085340
S1pr2/Gα13 signaling controls myocardial migration by regulating endoderm convergence
Ding Ye (2013)
10.1182/blood-2012-11-467191
Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation.
Guoqi Zhang (2013)
10.1016/j.bbalip.2012.07.005
Post-translational regulation of sphingosine kinases.
Huasheng Chan (2013)
10.1096/fj.12-219618
Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network
M. Nagahashi (2013)
10.1038/nature13765
Loss of signaling via Gα13 in germinal center B cell-derived lymphoma
J. Muppidi (2014)
10.1038/ncb2987
Coupling between endocytosis and sphingosine kinase I recruitment
Hongying Shen (2014)
10.1007/978-3-642-41199-1_9
β-arrestins and G protein-coupled receptor trafficking.
X. Tian (2014)
10.1172/JCI71194
Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo.
M. Kono (2014)
10.1194/jlr.R046300
An update on the biology of sphingosine 1-phosphate receptors
V. Blaho (2014)
10.1111/bph.12678
Lysophospholipid receptor nomenclature review: IUPHAR Review 8
Y. Kihara (2014)
10.1242/dev.094805
Sphingosine 1-phosphate signalling
Karen Mendelson (2014)
10.1016/j.phrs.2014.02.009
Cardiovascular effects of statins, beyond lipid-lowering properties.
Christos G Mihos (2014)
10.1002/JCB.24770
Interaction of Integrin β4 With S1P Receptors in S1P‐ and HGF‐Induced Endothelial Barrier Enhancement
Xiuqin Ni (2014)
10.1172/JCI77685
Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development.
Yuquan Xiong (2014)
Endothelial Focal Adhesion Kinase Transcriptionally Regulates S1P1 to Maintain Lung Vascular Barrier Function
Pascal Yazbeck (2015)
10.1113/expphysiol.2014.082149
Differential activation of receptors and signal pathways upon stimulation by different doses of sphingosine‐1‐phosphate in endothelial cells
Q. Li (2015)
10.1194/jlr.R058362
Lipid phosphate phosphatases and their roles in mammalian physiology and pathology
Xiaoyun Tang (2015)
10.1083/jcb.201409108
Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interaction
N. Daneshjou (2015)
10.1038/ncomms8893
Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke
Gab Seok Kim (2015)
10.1126/scisignal.aaa2581
HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation
S. Galvani (2015)
10.1242/jcs.154476
S1PR1 Tyr143 phosphorylation downregulates endothelial cell surface S1PR1 expression and responsiveness
Alejandra Chavez (2015)
10.1126/scisignal.aaa4998
Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation
S. Panneer Selvam (2015)
10.1096/fj.15-274936
Spinster 2, a sphingosine‐1‐phosphate transporter, plays a critical role in inflammatory and autoimmune diseases
M. Donoviel (2015)
10.1016/j.it.2015.10.005
Exit Strategies: S1P Signaling and T Cell Migration.
A. Baeyens (2015)
10.1161/CIRCRESAHA.116.308929
Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock.
Salomé L Gazit (2016)
10.1038/nature19107
Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region
A. Venkatakrishnan (2016)
10.1111/tra.12343
Endocytosis of Ligand‐Activated Sphingosine 1‐Phosphate Receptor 1 Mediated by the Clathrin‐Pathway
P. Reeves (2016)
10.1016/j.ajhg.2015.12.004
Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2.
R. Santos-Cortez (2016)
10.1096/fj.201500064
Impaired endothelial barrier function in apolipoprotein M‐deficient mice is dependent on sphingosine‐1‐phosphate receptor 1
Pernille M. Christensen (2016)
10.1126/scisignal.aad1899
FOXF1 maintains endothelial barrier function and prevents edema after lung injury
Yuqi Cai (2016)
10.1016/j.pharmthera.2016.09.008
Targeting sphingosine-1-phosphate signaling in lung diseases.
D. Ebenezer (2016)
10.1038/nature24053
Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets
T. M. Vu (2017)
10.1124/pr.116.013367
The Diverse Roles of Arrestin Scaffolds in G Protein–Coupled Receptor Signaling
Y. Peterson (2017)
10.1038/s41467-017-02373-8
Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis
Jiahui Cao (2017)
10.1016/bs.mie.2017.05.005
Methods for the Development of In Silico GPCR Models.
P. Morales (2017)
10.1038/s41467-017-01340-7
Bioluminescence imaging of G protein-coupled receptor activation in living mice
M. Kono (2017)
10.1091/mbc.E17-03-0136
The balance between Gαi-Cdc42/Rac and Gα12/13-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate
N. R. Reinhard (2017)
10.1161/CIRCRESAHA.116.306534
Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability.
Y. Komarova (2017)
10.3390/molecules22030344
Sphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells
N. Pyne (2017)
10.1155/2017/6059203
Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation
Catherine Olesch (2017)
10.1177/2045893217701162
Simvastatin-induced sphingosine 1−phosphate receptor 1 expression is KLF2-dependent in human lung endothelial cells
Xiaoguang Sun (2017)
10.1038/ncomms15054
A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling
Alexandre Beautrait (2017)
10.1126/scisignal.aal2722
An engineered S1P chaperone attenuates hypertension and ischemic injury
S. Swendeman (2017)
10.1172/jci.insight.91700
KLF2 and KLF4 control endothelial identity and vascular integrity.
Panjamaporn Sangwung (2017)
10.1111/bph.13820
A sphingosine‐1‐phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration
R. Yamamoto (2017)
10.1186/s12944-017-0556-9
Characteristics of lipid metabolism including serum apolipoprotein M levels in patients with primary nephrotic syndrome
Lagu He (2017)
10.1016/bs.ctm.2018.08.007
Sphingolipids Signaling in Lamellipodia Formation and Enhancement of Endothelial Barrier Function.
P. Fu (2018)
10.1097/CCM.0000000000002916
Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2
B. Gutbier (2018)
10.1097/SHK.0000000000000908
Sphingosine-1-Phosphate Receptor-1 Agonist Sew2871 Causes Severe Cardiac Side Effects and Does Not Improve Microvascular Barrier Breakdown in Sepsis
Sven Flemming (2018)
10.1093/hmg/ddy153
Stimulation of S1PR5 with A-971432, a selective agonist, preserves blood–brain barrier integrity and exerts therapeutic effect in an animal model of Huntington’s disease
A. di Pardo (2018)
10.3390/ijms19020420
Expansion of Sphingosine Kinase and Sphingosine-1-Phosphate Receptor Function in Normal and Cancer Cells: From Membrane Restructuring to Mediation of Estrogen Signaling and Stem Cell Programming
O. Sukocheva (2018)
10.3389/fcvm.2018.00006
Krüppel-Like Factors in Vascular Inflammation: Mechanistic Insights and Therapeutic Potential
David R Sweet (2018)
10.3390/molecules23112730
Current Therapies Focused on High-Density Lipoproteins Associated with Cardiovascular Disease
D. Estrada-Luna (2018)
10.1124/mol.117.109140
S1P1 Modulator-Induced Gαi Signaling and β-Arrestin Recruitment Are Both Necessary to Induce Rapid and Efficient Reduction of Blood Lymphocyte Count In Vivo
Magdalena Birker-Robaczewska (2018)
10.1016/bs.acr.2018.04.015
Targeting Sphingosine Kinases for the Treatment of Cancer: CHAPTER ELEVEN
C. S. Lewis (2018)
10.1002/art.40558
Sphingosine 1‐Phosphate Receptor 1 Signaling Maintains Endothelial Cell Barrier Function and Protects Against Immune Complex–Induced Vascular Injury
N. Burg (2018)
FAK maintenance of endothelial mechanotransduction controls epigenetic repression of KLF2 and S1PR1 transcription
Akhter (2018)
Dynamin internalizes tyrosine phosphorylated sphingosine 1 phosphate receptor 1 and impair downstream signaling
Anwar (2018)
10.1083/jcb.201807210
VE-PTP stabilizes VE-cadherin junctions and the endothelial barrier via a phosphatase-independent mechanism
V. Juettner (2019)
10.3892/mmr.2018.9747
Apolipoprotein M induces inhibition of inflammatory responses via the S1PR1 and DHCR24 pathways.
M. Wang (2019)
10.1136/thoraxjnl-2018-212378
Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury
D. Ebenezer (2019)
10.1016/j.phrs.2019.02.009
Targeting the S1P receptor signaling pathways as a promising approach for treatment of autoimmune and inflammatory diseases.
Bisera Stepanovska (2019)
10.1093/intimm/dxz037
Sphingosine 1-phosphate and inflammation.
Hideru Obinata (2019)
10.1016/j.celrep.2019.11.036
Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling
Vijay Avin Balaji Ragunathrao (2019)
10.3389/fphar.2019.00125
GPCR Signaling Regulation: The Role of GRKs and Arrestins
V. Gurevich (2019)
10.1016/j.celrep.2020.02.112
SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages
J. Joshi (2020)
10.7554/eLife.52690
Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta
Eric Engelbrecht (2020)
Engelbrecht (2020)



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