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Recent Advances In SCF Ubiquitin Ligase Complex: Clinical Implications.
Nana Zheng, Q. Zhou, Z. Wang, W. Wei
Published 2016 · Biology, Medicine
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F-box proteins, which are subunit recruiting modules of SCF (SKP1-Cullin 1-F-box protein) E3 ligase complexes, play critical roles in the development and progression of human malignancies through governing multiple cellular processes including cell proliferation, apoptosis, invasion and metastasis. Moreover, there are emerging studies that lead to the development of F-box proteins inhibitors with promising therapeutic potential. In this article, we describe how F-box proteins including but not restricted to well-established Fbw7, Skp2 and β-TRCP, are involved in tumorigenesis. However, in-depth investigation is required to further explore the mechanism and the physiological contribution of undetermined F-box proteins in carcinogenesis. Lastly, we suggest that targeting F-box proteins could possibly open new avenues for the treatment and prevention of human cancers.
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β-TRCP-mediated AEBP2 ubiquitination and destruction controls cisplatin resistance in ovarian cancer.
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Reduced RBX1 expression induces chromosome instability and promotes cellular transformation in high-grade serous ovarian cancer precursor cells.
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ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation
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The SCFβ-TrCP E3 Ubiquitin Ligase Regulates Immune Receptor Signaling by Targeting the Negative Regulatory Protein TIPE2
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WNT pathway signaling is associated with microvascular injury and predicts kidney transplant failure
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F-box protein FBXO30 mediates retinoic acid receptor γ ubiquitination and regulates BMP signaling in neural tube defects
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Cdh1-mediated Skp2 degradation by dioscin reprogrammes aerobic glycolysis and inhibits colorectal cancer cells growth
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Skp2 Expression Is Inhibited by Arsenic Trioxide through the Upregulation of miRNA-330-5p in Pancreatic Cancer Cells
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A patent review of the ubiquitin ligase system: 2015–2018
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FBXW8-dependent degradation of MRFAP1 in anaphase controls mitotic cell death
Duan-zhuo Li (2017)
Hepatic F-Box Protein FBXW7 Maintains Glucose Homeostasis Through Degradation of Fetuin-A
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CSNAP, the smallest CSN subunit, modulates proteostasis through cullin-RING ubiquitin ligases
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