Online citations, reference lists, and bibliographies.
← Back to Search

Investigation Of Archaeosomes As Carriers For Oral Delivery Of Peptides.

Z. Li, Jian Chen, W. Sun, Yuhong Xu
Published 2010 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Oral administration of peptide and protein drugs faces a big challenge partly due to the hostile gastrointestinal (GI) environment. Lipid-based delivery systems are attractive because they offer some protection for peptides and proteins. In this context, we prepared a special lipid-based oral delivery system: archaeosomes, made of the polar lipid fraction E (PLFE) extracted from Sulfolobus acidocaldarius, and explored its potential as an oral drug delivery vehicle. Our study demonstrates that archaeosomes have superior stability in simulated GI fluids, and enable fluorescent labeled peptides to reside for longer periods in the GI tract after oral administration. Although archaeosomes have little effect on the transport of insulin across the Caco-2 cell monolayers, the in vivo experiments indicated that archaeosomes containing insulin induced lower levels of blood glucose than a conventional liposome formulation. These data indicate that archaeosomes could be a potential carrier for effective oral delivery of peptide drugs.
This paper references
10.1016/S0378-5173(99)00331-2
In vitro assessment of archaeosome stability for developing oral delivery systems.
G. B. Patel (2000)
10.1002/JBM.A.10128
Novel complexation hydrogels for oral peptide delivery: in vitro evaluation of their cytocompatibility and insulin-transport enhancing effects using Caco-2 cell monolayers.
H. Ichikawa (2003)
Liposomes for oral administration of drugs.
Woodley Jf (1985)
10.1023/A:1016245711557
Characterization of Drug Transport Through Tight-Junctional Pathway in Caco-2 Monolayer: Comparison with Isolated Rat Jejunum and Colon
Y. Tanaka (2004)
10.1128/IAI.68.1.54-63.2000
Archaeosome Vaccine Adjuvants Induce Strong Humoral, Cell-Mediated, and Memory Responses: Comparison to Conventional Liposomes and Alum
L. Krishnan (2000)
10.1080/0738-859991229170
Archaeobacterial ether lipid liposomes (archaeosomes) as novel vaccine and drug delivery systems.
Patel Gb (1999)
10.4049/jimmunol.165.9.5177
Archaeosomes Induce Long-Term CD8+ Cytotoxic T Cell Response to Entrapped Soluble Protein by the Exogenous Cytosolic Pathway, in the Absence of CD4+ T Cell Help1
L. Krishnan (2000)
10.1016/S0167-7799(98)01220-7
Novel applications of liposomes.
D. Lasic (1998)
10.1016/J.JCONREL.2007.04.004
Vesicles from Pluronic/poly(lactic acid) block copolymers as new carriers for oral insulin delivery.
X. Y. Xiong (2007)
Functional reconstitution of membrane proteins in monolayer liposomes from bipolar lipids of Sulfolobus acidocaldarius.
M. Elferink (1992)
10.1080/10915810305080
Short-Term Repeated-Dose Toxicity Profile of Archaeosomes Administered to Mice via Intravenous and Oral Routes
Abdelwahab Omri (2003)
10.1081/LPR-120016712
SAFETY OF ARCHAEOSOME ADJUVANTS EVALUATED IN A MOUSE MODEL*
G. B. Patel (2002)
10.1021/MA060230J
Formation of New Glucomannan−Chitosan Nanoparticles and Study of Their Ability To Associate and Deliver Proteins
M. Alonso-Sande (2006)
10.1016/S0006-3495(96)79379-7
Effect of physical constraints on the mechanisms of membrane fusion: bolaform lipid vesicles as model systems.
A. Relini (1996)
10.1016/S0376-7388(01)00771-2
Structure and permeability properties of biomimetic membranes of bolaform archaeal tetraether lipids
A. Gliozzi (2002)
10.1615/CRITREVTHERDRUGCARRIERSYST.V20.I23.30
Emerging trends in oral delivery of peptide and protein drugs.
R. Mahato (2003)
10.2174/156720105774370285
Archaeosome immunostimulatory vaccine delivery system.
G. B. Patel (2005)
10.1016/S0378-5173(98)00408-6
Pharmacodynamics of insulin in polyethylene glycol-coated liposomes.
A. Kim (1999)
10.1016/S0264-410X(01)00041-X
Immunization of mice with lipopeptide antigens encapsulated in novel liposomes prepared from the polar lipids of various Archaeobacteria elicits rapid and prolonged specific protective immunity against infection with the facultative intracellular pathogen, Listeria monocytogenes.
J. Conlan (2001)
10.1016/J.DRUDIS.2006.08.005
Is the oral route possible for peptide and protein drug delivery?
M. Morishita (2006)
10.1016/j.ijpharm.2008.07.012
Peptide ligand-mediated liposome distribution and targeting to EGFR expressing tumor in vivo.
S. Song (2008)
10.1016/j.biomaterials.2008.12.066
In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery.
K. Sonaje (2009)
10.1016/j.ijpharm.2007.12.014
Confocal microscopic analysis of transport mechanisms of insulin across the cell monolayer.
Nikhil J. Kavimandan (2008)
10.1016/S0378-5173(01)00579-8
Liposomes with phosphatidylethanol as a carrier for oral delivery of insulin: studies in the rat.
M. Kisel (2001)
10.1007/BF00762348
Structures of archaebacterial membrane lipids
G. Sprott (1992)
10.1016/0006-291X(90)91756-I
Purification and characterization of a liposomal-forming tetraether lipid fraction.
S. L. Lo (1990)
10.1016/0031-9384(90)90361-7
Plasma catecholamine, corticosterone and glucose responses to repeated stress in rats: Effect of interstressor interval length
S. F. Boer (1990)
10.1023/A:1016113117851
Preparation and Characterization of Mono-PEGylated Epidermal Growth Factor: Evaluation of in Vitro Biologic Activity
H. Lee (2004)
10.1016/S0168-3659(03)00093-2
Application of polyethyleneglycol (PEG)-modified liposomes for oral vaccine: effect of lipid dose on systemic and mucosal immunity.
Seiichiro Minato (2003)
10.1016/S0378-5173(97)00237-8
Oral delivery of insulin by using surface coating liposomes improvement of stability of insulin in GI tract
K. Iwanaga (1997)
10.1016/0005-2736(94)90198-8
Calcium-induced interaction and fusion of archaeobacterial lipid vesicles: a fluorescence study.
A. Relini (1994)
10.1016/J.IJPHARM.2005.01.018
Investigation of lectin-modified insulin liposomes as carriers for oral administration.
N. Zhang (2005)
10.1016/0005-2736(95)00157-X
Stability against temperature and external agents of vesicles composed of archael bolaform lipids and egg PC.
Q. Fan (1995)
10.1007/BF00902745
Stability of pressure-extruded liposomes made from archaeobacterial ether lipids
C. Choquet (2004)
10.1016/S0378-5173(03)00158-3
Polyethylene glycol-coated liposomes for oral delivery of recombinant human epidermal growth factor.
H. Li (2003)
10.1016/S0169-409X(98)00047-7
Oral particulate delivery: status and future trends.
Chen (1998)
10.1615/CRITREVTHERDRUGCARRIERSYST.V15.I5.10
The potential of liposomes in oral drug delivery.
J. Rogers (1998)
10.1016/S0016-5085(89)80072-1
Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability.
I. Hidalgo (1989)
10.1016/0005-2736(94)90160-0
Stability and proton-permeability of liposomes composed of archaeal tetraether lipids.
M. Elferink (1994)



This paper is referenced by
10.1016/j.ijpharm.2018.07.041
Recent advancements in oral administration of insulin‐loaded liposomal drug delivery systems for diabetes mellitus
Chun Y Wong (2018)
10.1002/9780470015902.A0000385.PUB3
Archaeal Membrane Lipids and Applications
G. Dennis Sprott (2011)
10.1208/s12249-019-1293-3
Lipid-Based Nanocarriers for Lymphatic Transportation
Nikhar Vishwakarma (2019)
10.29252/QUMS.12.10.16
The Effect of Synthesis of Pegylated Nanoliposome Containing DNAi on Reduction of BCL-2 Gene Expression in DLCL2 Cell Line
Farahnaz Boozari Saravani (2018)
10.1016/j.ijpharm.2013.02.030
Approaches for enhancing oral bioavailability of peptides and proteins.
J. Renukuntla (2013)
10.3109/10717544.2013.819611
Oral delivery of therapeutic proteins and peptides: a review on recent developments
S. Gupta (2013)
10.3109/21691401.2014.975239
Proteins and peptides: The need to improve them as promising therapeutics for ulcerative colitis
Kantrol Kumar Sahu (2016)
10.1016/j.csbj.2019.09.004
Recent Advancements in Non-Invasive Formulations for Protein Drug Delivery
Rajiv Bajracharya (2019)
10.3934/BIOPHY.2017.2.316
Monte Carlo simulations of the distributions of intra- and extra-vesicular ions and membrane associated charges in hybrid liposomes composed of negatively charged tetraether and zwitterionic diester phospholipids
I. Sugár (2017)
10.1080/17425247.2017.1395853
Strategies and industrial perspectives to improve oral absorption of biological macromolecules
Chang Liu (2018)
10.29252/jorjanibiomedj.6.2.21
Preparing Nanoarchaeosome Containing Triptorelin Acetate and Evaluation of Its Cellular Toxic Effect on PC3 Prostate Cancer Cell Line
Zeynab Mohammadi (2018)
10.1016/J.JDDST.2017.06.018
Advances on the formulation of proteins using nanotechnologies
Irene Santalices (2017)
10.26689/par.v2i3.357
99mTc radiolabeled archaeosomes as a potential melanoma imaging agent
Pablo Cabral (2018)
10.4155/TDE.15.47
Why most oral insulin formulations do not reach clinical trials.
M. Lopes (2015)
10.1016/j.addr.2016.04.001
Lipid-based nanocarriers for oral peptide delivery.
Zhigao Niu (2016)
10.3109/21691401.2014.982800
The potential of archaeosomes as carriers of pDNA into mammalian cells
A. Attar (2016)
10.4155/tde-2015-0012
Nanocarrier fabrication and macromolecule drug delivery: challenges and opportunities.
Vibhuti Agrahari (2016)
10.1097/MRM.0000000000000000
Archaeosomes as means of nano-drug delivery
E. Moghimipour (2014)
10.1016/S2221-1691(12)60381-5
Recent advances in various emerging vescicular systems: An overview
M. Gangwar (2012)
Study of the efficacy pegylated Cisplatin loaded nano archaeosome on breast cancer in vitro
Masoumeh Kasiri (2015)
10.5772/58459
Liposomes as Potential Drug Carrier Systems for Drug Delivery
Melis Çağdaş (2014)
10.1016/J.COLSURFB.2020.111389
Phytochemical delivery through nanocarriers: a review.
Razi Ahmad (2020)
10.3109/10717544.2015.1019653
Archaeosomes: an excellent carrier for drug and cell delivery
G. Kaur (2016)
10.2147/IJN.S218101
Preparation And Antibacterial Effects Of Carboxymethyl Chitosan-Modified Photo-Responsive Camellia Sapogenin Derivative Cationic Liposomes
Jingcheng Zhang (2019)
Nanotechnology in Drug Delivery 52 3 Nanotechnology systems for oral drug delivery : challenges and opportunities
Alberto Berardi (2016)
10.1111/cbdd.13066
Preparation, characterization, and in vitro evaluation of isoniazid and rifampicin‐loaded archaeosomes
A. Attar (2018)
10.1016/j.biotechadv.2014.07.006
A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules.
Bibi F Choonara (2014)
10.1016/j.vaccine.2011.05.015
Archaeosomes with encapsulated antigens for oral vaccine delivery.
Z. Li (2011)
10.5101/nbe.v9i4.p324-332
Enhanced Peptide Delivery and Sustainable Release of Pleurocidin Using N-Succinyl Chitosan Nanoparticle
G. Bupesh (2017)
Post-genomic characterization of metabolic pathways in Sulfolobus solfataricus
J. Walther (2012)
10.1016/B978-0-323-47720-8.00016-X
Recent advancements in oral delivery of insulin: from challenges to solutions
Raje Chouhan (2017)
10.1016/j.jconrel.2017.09.025
Animal models for evaluation of oral delivery of biopharmaceuticals
Stine Harloff-Helleberg (2017)
See more
Semantic Scholar Logo Some data provided by SemanticScholar