Online citations, reference lists, and bibliographies.
← Back to Search

Genipin-cross-linked Fucose-chitosan/heparin Nanoparticles For The Eradication Of Helicobacter Pylori.

Y. Lin, S. Tsai, C. Lai, Che-Hsin Lee, Zih Sian He, G. Tseng
Published 2013 · Materials Science, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Helicobacter pylori is a significant human pathogen that recognizes specific carbohydrate receptors, such as the fucose receptor, and produces the vacuolating cytotoxin, which induces inflammatory responses and modulates the cell-cell junction integrity of the gastric epithelium. The clinical applicability of topical antimicrobial agents was needed to complete the eradication of H. pylori in the infected fundal area. In the present study, we combined fucose-conjugated chitosan and genipin-cross-linking technologies in preparing multifunctional genipin-cross-linked fucose-chitosan/heparin nanoparticles to encapsulate amoxicillin of targeting and directly make contact with the region of microorganism on the gastric epithelium. The results show that the nanoparticles effectively reduced drug release at gastric acids and then released amoxicillin in an H. pylori survival situation to inhibit H. pylori growth and reduce disruption of the cell-cell junction protein in areas of H. pylori infection. Furthermore, with amoxicillin-loaded nanoparticles, a more complete H. pylori clearance effect was observed, and H. pylori-associated gastric inflammation in an infected animal model was effectively reduced.
This paper references
10.1016/J.PROCBIO.2012.05.019
Formulation and evaluation of water-in-oil amoxicillin-loaded nanoemulsions using for Helicobacter pylori eradication
Yu-Hsin Lin (2012)
10.3748/WJG.V6.I2.202
Agglutination of Helicobacter pylori coccoids by lectins.
M. M. Khin (2000)
10.1080/10611860310001647771
Receptor Mediated Targeting of Lectin Conjugated Gliadin Nanoparticles in the Treatment of Helicobacter pylori
R. Umamaheshwari (2003)
10.1128/AAC.37.7.1506
Local gastric and serum amoxicillin concentrations after different oral application forms.
M. Cooreman (1993)
10.1016/S0014-2999(00)00278-8
Intragastric administration of heparin enhances gastric ulcer healing through a nitric oxide-dependent mechanism in rats.
Y. Li (2000)
10.1111/j.1523-5378.2008.00625.x
Monocyte and Macrophage Killing of Helicobacter pylori: Relationship to Bacterial Virulence Factors
G. Borlace (2008)
10.1146/ANNUREV.MICRO.54.1.615
The disease spectrum of Helicobacter pylori: the immunopathogenesis of gastroduodenal ulcer and gastric cancer.
P. Ernst (2000)
10.1002/POLA.10960
Mechanism and kinetics of the crosslinking reaction between biopolymers containing primary amine groups and genipin
M. Butler (2003)
10.4254/wjh.v2.i4.151
Fucosylation and gastrointestinal cancer.
K. Moriwaki (2010)
10.1016/S0002-9440(10)64774-8
Helicobacter pylori gastritis in cats with long-term natural infection as a model of human disease.
M. I. Esteves (2000)
Site-specific drug delivery of acetohydroxamic acid for the treatment of H. pylori
R. Umamaheswari (2003)
10.1016/j.canlet.2008.11.016
Helicobacter pylori virulence factors in gastric carcinogenesis.
S. Wen (2009)
Current understandings of Helicobacter pylori, peptic ulcer and gastroesophageal reflux disease.
Y. Liu (2006)
10.1016/j.biomaterials.2009.02.036
Development of pH-responsive chitosan/heparin nanoparticles for stomach-specific anti-Helicobacter pylori therapy.
Y. Lin (2009)
10.1146/ANNUREV.MICRO.53.1.353
Contributions of genome sequencing to understanding the biology of Helicobacter pylori.
Z. Ge (1999)
10.1007/s10856-010-4178-2
Synthesis and characterization of gelatin nanoparticles using CDI/NHS as a non-toxic cross-linking system
Nader Taheri Qazvini (2011)
10.1016/j.ijporl.2010.04.007
Helicobacter pylori colonization of the adenotonsillar tissue: fact or fiction?
S. Vilarinho (2010)
10.1056/NEJM199510123331508
The treatment of Helicobacter pylori infection in the management of peptic ulcer disease.
J. H. Walsh (1995)
10.1056/NEJM199110173251603
Helicobacter pylori infection and the risk of gastric carcinoma.
J. Parsonnet (1991)
10.1021/mp8002539
Polyelectrolyte coated multilayered liposomes (nanocapsules) for the treatment of Helicobacter pylori infection.
P. Jain (2009)
10.1016/J.PROGPOLYMSCI.2004.04.001
Chemically modified chitin and chitosan as biomaterials
H. Sashiwa (2004)
10.1177/002215549804601111
Lectin-Gold Localization of Fucose Residues in Human Gastric Mucosa
J. Madrid (1998)
10.1128/IAI.73.12.7844-7852.2005
Helicobacter pylori Activates Myosin Light-Chain Kinase To Disrupt Claudin-4 and Claudin-5 and Increase Epithelial Permeability
J. Fedwick (2005)
Development of pHresponsive chitosan/heparin nanoparticles for stomach-specific anti-Helicobacter pylori therapy. Biomaterials 2009;30:3332e42
YH Lin (2009)
10.1073/PNAS.90.5.2035
An in vitro adherence assay reveals that Helicobacter pylori exhibits cell lineage-specific tropism in the human gastric epithelium.
P. Falk (1993)
10.1128/CMR.00011-10
Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk
L. E. Wroblewski (2010)
10.1016/S0378-5173(00)00438-5
The degradation pathways of glucagon in acidic solutions.
A. B. Joshi (2000)
10.1046/j.1523-5378.7.s1.7.x
Helicobacter pylori: the challenge in therapy
F. Bazzoli (2002)
10.1016/0016-5085(92)91716-H
Difference in expression of Helicobacter pylori gastritis in antrum and body.
E. Bayerdoerffer (1992)
10.1007/s12272-011-1112-1
Controlled release chitosan microspheres of mirtazapine: In vitro and in vivo evaluation
Om Ranjan (2011)
10.1136/gut.36.5.670
Detection of the intragastric sites at which Helicobacter pylori evades treatment with amoxycillin and cimetidine.
J. Atherton (1995)
cobacter pylori gastritis in cats with long - term natural infection as a model of human disease
MI Esteves (2000)
10.1016/J.FCT.2009.01.037
Gardenia jasminoides Ellis ethanol extract and its constituents reduce the risks of gastritis and reverse gastric lesions in rats.
Je-Hyuk Lee (2009)
10.1016/J.BIOMATERIALS.2004.04.015
The aggregation of pig articular chondrocyte and synthesis of extracellular matrix by a lactose-modified chitosan.
I. Donati (2005)
10.1016/J.PLEFA.2006.04.006
Gastric mucosal cell model for estimating relative gastrointestinal toxicity of non-steroidal anti-inflammatory drugs.
A. Hall (2006)
10.1016/S0378-5173(00)00582-2
Novel pH-sensitive citrate cross-linked chitosan film for drug controlled release.
X. Shu (2001)
10.1016/J.JCONREL.2006.09.016
Hybrid polymer nanocapsules enhance in vitro delivery of azidothymidine-triphosphate to macrophages.
H. Hillaireau (2006)
10.1093/JAC/DKI479
Association of antibiotic resistance and higher internalization activity in resistant Helicobacter pylori isolates.
C. Lai (2006)
10.1016/j.ijbiomac.2011.12.034
Design and characterization of antitumor drug paclitaxel-loaded chitosan nanoparticles by W/O emulsions.
J. Xu (2012)
An overview of pathogenesis and epidemiology of Helicobacter pylori infection
N. F. Tanih (2010)
10.1016/S0003-2670(01)84631-6
A conductometric method for colloid titrations
K. Tǒei (1976)
10.1248/BPB.17.1573
Enzymic studies on the animal and intestinal bacterial metabolism of geniposide.
T. Akao (1994)
10.1136/gut.31.2.134
Bacterial adhesion and disease activity in Helicobacter associated chronic gastritis.
S. J. Hessey (1990)
10.1016/S0140-6736(84)91816-6
UNIDENTIFIED CURVED BACILLI IN THE STOMACH OF PATIENTS WITH GASTRITIS AND PEPTIC ULCERATION
B. Marshall (1984)
10.1016/0277-5379(82)90137-7
Membrane-associated, fucose-containing glycoproteins and glycolipids of cultured epithelial cells from human colonic adenocarcinoma and fetal intestine.
Y. S. Kim (1982)
10.1021/am200416h
Effect of genipin crosslinking on the optical spectral properties and structures of collagen hydrogels.
Yu-Jer Hwang (2011)



This paper is referenced by
10.1016/B978-0-323-46152-8.00007-X
Nanocarriers and Their Potential Application as Antimicrobial Drug Delivery
B. Devrim (2017)
10.4292/wjgpt.v6.i4.183
Antibiotic treatment for Helicobacter pylori: Is the end coming?
S. Kim (2015)
10.1080/14787210.2019.1677464
An overview of nanotechnology-based treatment approaches against Helicobacter Pylori
T. Safarov (2019)
10.1586/14787210.2014.930663
The potential utility of chitosan micro/nanoparticles in the treatment of gastric infection
I. Gonçalves (2014)
10.2217/nnm-2017-0055
Development of genipin-crosslinked fucoidan/chitosan-N-arginine nanogels for preventing Helicobacter infection.
Y. Lin (2017)
10.1016/J.JDDST.2018.10.022
Chitosan-based nanoparticles: An overview of biomedical applications and its preparation
Sweet Naskar (2019)
10.1007/978-3-030-12919-4_3
Chitosan Derivatives and Grafted Adjuncts with Unique Properties
H. Merzendorfer (2019)
Development of novel chitosan nanocomposites as a controlled drug release system for Helicobacter pylori treatment
Suna Seda Güneş (2016)
10.1016/J.MATLET.2016.05.108
Ciprofloxacin loaded genipin cross-linked chitosan/heparin nanoparticles for drug delivery application
G. V. Kumar (2016)
10.4155/fseb2013.13.63
Functionalized nanoparticles for targeting the gastrointestinal apical membrane receptors (Book Chapter)
F. Araújo (2016)
10.1016/j.jconrel.2016.01.008
Current applications of nanoparticles in infectious diseases.
H. Zazo (2016)
10.1016/j.jcis.2020.05.075
Covalently and ionically, dually crosslinked chitosan nanoparticles block quorum sensing and affect bacterial cell growth on a cell-density dependent manner.
C. Vila-Sanjurjo (2020)
10.1021/am403615q
Dual drug-eluting stents coated with multilayers of hydrophobic heparin and sirolimus.
L. Su (2013)
10.1155/2018/9780489
Heparin-Based Nanoparticles: An Overview of Their Applications
M. Rodriguez-Torres (2018)
10.1016/j.nut.2018.05.017
Genipin attenuates hyperoxia-induced lung injury and pulmonary hypertension via targeting glycogen synthase kinase-3 β in neonatal rats.
J. Li (2019)
10.2217/nnm-2019-0329
Eradication of Helicobacter pylori: the power of nanosized formulations.
Q. Zhang (2020)
10.1016/J.FOODHYD.2016.01.021
Polysaccharide-based nanoparticles by chitosan and gum arabic polyelectrolyte complexation as carriers for curcumin
Chen Tan (2016)
10.1016/j.colsurfb.2018.06.008
Real-time imaging tracking of a dual-fluorescent drug delivery system based on doxorubicin-loaded globin- polyethylenimine nanoparticles for visible tumor therapy.
Y. Zhang (2018)
10.18038/BTDA.96384
SYNTHESIS OF CHITOSAN-BASED HYDROGEL BY USING PHOTOPOLYMERIZATION TECHNIQUE
N. Alemdar (2016)
10.1007/978-3-030-16581-9_1
Nutritional and additive uses of chitin and chitosan in the food industry
Carla Harkin (2019)
10.1016/J.SURFCOAT.2018.03.069
Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin
Y. Sun (2018)
10.1016/j.ijpharm.2017.04.050
Cyclodextrin nanosystems in oral drug delivery: A mini review.
Oluwatomide Adeoye (2017)
10.1080/1061186X.2018.1512112
Chitosan-based nanoparticles as drug delivery systems: a review on two decades of research
Sweet Naskar (2019)
10.1016/j.jcis.2019.08.061
Effect of the ultrastructure of chitosan nanoparticles in colloidal stability, quorum quenching and antibacterial activities.
C. Vila-Sanjurjo (2019)
10.4155/fmc-2018-0368
Glycans in nanomedicine, impact and perspectives.
Susanna Sampaolesi (2019)
10.1016/j.biomaterials.2014.03.046
pH-responsive polymer-liposomes for intracellular drug delivery and tumor extracellular matrix switched-on targeted cancer therapy.
Yi-Ting Chiang (2014)
10.1016/j.addr.2019.09.002
Carbohydrate-based nanocarriers and their application to target macrophages and deliver antimicrobial agents.
Tamim Mosaiab (2019)
10.1007/978-981-10-6083-0_2
Polymer Gels: Molecular Design and Practical Application
V. O. S. Neto (2018)
10.1016/j.ijpharm.2013.12.052
A novel gastroretentive porous microparticle for anti-Helicobacter pylori therapy: preparation, in vitro and in vivo evaluation.
S. Hao (2014)
10.1002/mabi.201600534
Innovative Methods and Applications in Mucoadhesion Research.
A. Mackie (2017)
10.1021/acs.biomac.5b00907
Active Targeted Nanoparticles for Oral Administration of Gastric Cancer Therapy.
Y. Lin (2015)
10.1007/978-3-319-28368-5_17
The Use of Nanoparticles for Antimicrobial Delivery
María Moreno-Sastre (2016)
See more
Semantic Scholar Logo Some data provided by SemanticScholar