← Back to Search
The Effect Of Primary Particle Size On Biodistribution Of Inhaled Gold Nano-agglomerates.
S. K. Balasubramanian, Kay-Wee Poh, C. Ong, W. Kreyling, W. Ong, L. Yu
Published 2013 · Materials Science, Medicine
Download PDFAnalyze on Scholarcy
Airborne engineered nanoparticles undergo agglomeration, and careful distinction must be made between primary and agglomerate size of particles, when assessing their health effects. This study compares the effects on rats undergoing 15-day inhalation exposure to airborne agglomerates of gold nanoparticles (AuNPs) of similar size distribution and number concentration (1 × 10(6) particles/cm(3)), but two different primary diameters of 7 nm or 20 nm. Inhalation of agglomerates containing 7-nm AuNPs resulted in highest deposition by mass concentration in the lungs, followed by brain regions including the olfactory bulb, hippocampus, striatum, frontal cortex, entorhinal cortex, septum, cerebellum; aorta, esophagus, and kidney. Eight organs/tissues especially the brain retained greater mass concentration of Au after inhalation exposure to agglomerates of 7-nm than 20-nm AuNPs. Macrophage mediated escalation followed by fecal excretion is the major pathway of clearing inhaled AuNPs in the lungs. Microarray analyses of the hippocampus showed mostly downregulated genes, related to the cytoskeleton and neurite outgrowth. Together, results in this study indicate disintegration of nanosized agglomerates after inhalation and show impact of primary size of particles on subsequent biodistribution.
This paper references
Long-Term Clearance Kinetics of Inhaled Ultrafine Insoluble Iridium Particles from the Rat Lung, Including Transient Translocation into Secondary Organs
M. Semmler (2004)
Characterization, purification, and stability of gold nanoparticles.
S. K. Balasubramanian (2010)
Nanotechnology – Toxicological Issues and Environmental Safety and Environmental Safety
P. Simeonova (2007)
Reference sample method for cardiac output and regional blood flow determinations in the rat.
A. Malik (1976)
microPET-Based Biodistribution of Quantum Dots in Living Mice
M. L. Schipper (2007)
Intratracheal inhalation vs intratracheal instillation: differences in particle effects.
M. Osier (1997)
Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles.
J. F. Hillyer (2001)
Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration.
Jiangxue Wang (2007)
Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients
J. Yan (2005)
Titanium dioxide nanoparticles induce emphysema‐like lung injury in mice
H. Chen (2006)
Inhalation toxicity and lung toxicokinetics of C60 fullerene nanoparticles and microparticles.
G. Baker (2008)
Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats.
Mo-Tao Zhu (2008)
Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma
Y. Song (2009)
Circulation and distribution of gold nanoparticles and induced alterations of tissue morphology at intravenous particle delivery.
G. Terentyuk (2009)
Pulmonary retention of ultrafine and fine particles in rats.
J. Ferin (1992)
Effect of Particles on Mucus and Mucociliary Clearance
M. King (2000)
Particle Deposition in a Multiple-Path Model of the Human Lung
B. Asgharian (2001)
Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
G. Oberdörster (2005)
Principles of soil chemistry
K. H. Tan (1993)
Myelination in the Absence of Galactocerebroside and Sulfatide: Normal Structure with Abnormal Function and Regional Instability
T. Coetzee (1996)
Cancer nanotechnology: opportunities and challenges
M. Ferrari (2005)
Assessment of the In Vivo Toxicity of Gold Nanoparticles
Yangyang Chen (2009)
Rho kinase in the regulation of cell death and survival
J. Shi (2007)
TRANSLOCATION OF ULTRAFINE INSOLUBLE IRIDIUM PARTICLES FROM LUNG EPITHELIUM TO EXTRAPULMONARY ORGANS IS SIZE DEPENDENT BUT VERY LOW
W. Kreyling (2002)
Correlation between particle size, in vivo particle persistence, and lung injury.
G. Oberdörster (1994)
Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types
L. Renwick (2004)
Impact of agglomeration state of nano- and submicron sized gold particles on pulmonary inflammation
I. Gosens (2010)
Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism
S. Jamain (2003)
Translocation and effects of gold nanoparticles after inhalation exposure in rats
L. E. Yu (2007)
Identification of N-WASP homologs in human and rat brain.
M. Fukuoka (1997)
Change in agglomeration status and toxicokinetic fate of various nanoparticles in vivo following lung exposure in rats
O. Creutzenberg (2012)
Persistent Tissue Kinetics and Redistribution of Nanoparticles, Quantum Dot 705, in Mice: ICP-MS Quantitative Assessment
R. Yang (2007)
Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs
W. Kreyling (2009)
Inventory of consumer products containing nanomaterials
S. Dekkers (2007)
Particle size-dependent organ distribution of gold nanoparticles after intravenous administration.
W. D. de Jong (2008)
Deposition and biokinetics of inhaled nanoparticles
M. Geiser (2009)
Estimation of Human Toxicity From Animal Inhalation Toxicity Data: 1. Minute Volume-Body Weight Relationships Between Animals And Man.
R. W. Bide (1997)
The Physics hypertextbook. 1998-2011
G. Elert (2011)
In situ measurement of size and density of submicron aerosol particles
B. Schleicher (1995)
Tissue distribution of inhaled micro- and nano-sized cerium oxide particles in rats: results from a 28-day exposure study.
L. Geraets (2012)
Blood volume in the rat.
H. Lee (1985)
Textbook of Medical Physiology
A. Guyton (1961)
Pulmonary toxicity induced by intratracheal instillation of coarse and fine particles of cerium dioxide in male rats.
T. Toya (2010)
Aggregation and disaggregation of iron oxide nanoparticles: Influence of particle concentration, pH and natural organic matter.
M. Baalousha (2009)
Estimation of pH in individual alveolar macrophage phagolysosomes.
Karl A. Nyberg (1989)
Gold nanoparticles: a new X-ray contrast agent.
M. Geso (2007)
Biokinetics and Effects of Nanoparticles
G. Oberdörster (2007)
Eml5, a novel WD40 domain protein expressed in rat brain.
V. O’Connor (2004)
Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.
W. Liang (2007)
Pulmonary toxicity and fate of agglomerated 10 and 40 nm aluminum oxyhydroxides following 4-week inhalation exposure of rats: toxic effects are determined by agglomerated, not primary particle size.
J. Pauluhn (2009)
Gold for good. Gold and nanotechnology in the age of innovation
T Keel (2010)
Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats.
S. K. Balasubramanian (2010)
Potential neurological lesion after nasal instillation of TiO(2) nanoparticles in the anatase and rutile crystal phases.
Jiang-xue Wang (2008)
Renal clearance of quantum dots
H. Choi (2007)
Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size.
Ganeshchandra Sonavane (2008)
Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles.
E. Bermudez (2004)
A Novel Rat Tetraspan Protein in Cells of the Oligodendrocyte Lineage
M. Birling (1999)
A novel model of in-stent restenosis: rat aortic stenting
H. Lowe (2005)
Clearance of Particles Deposited in the Lungs
W. Kreyling (2000)
Research strategies for safety evaluation of nanomaterials, part V: role of dissolution in biological fate and effects of nanoscale particles.
P. Borm (2006)
Pulmonary toxicity of inhaled nanoscale and fine zinc oxide particles: Mass and surface area as an exposure metric
M. Ho (2011)
Commercial Prospects for Nanomaterials in India
G. Sundararajan (2012)
Nanoparticles – known and unknown health risks
P. Hoet (2004)
Identi fi cation of N - WASP homologs in human and rat brain
M Fukuoka (1997)
Research strategies for safety evaluation of nanomaterials, part II: toxicological and safety evaluation of nanomaterials, current challenges and data needs.
M. Holsapple (2005)
N‐WASP, a novel actin‐depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2‐dependent manner downstream of tyrosine kinases.
H. Miki (1996)
Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines.
D. Brown (2001)
Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2
Alexander A. Chubykin (2007)
Effects of Airway Exposure to Nanoparticles on Lung Inflammation Induced by Bacterial Endotoxin in Mice
K. Inoue (2006)
Physiological role of ROCKs in the cardiovascular system.
K. Noma (2006)
Alveolar distribution of fly ash and of titanium dioxide after long-term inhalation by Wistar rats
S. Takenaka (1986)
Biodistribution of 1.4- and 18-nm gold particles in rats.
Manuela Semmler-Behnke (2008)
The influence of pulmonary surfactant on nanoparticulate drug delivery systems.
C. Schleh (2011)
Pulmonary applications and toxicity of engineered nanoparticles.
J. W. Card (2008)
Survival of Developing Motor Neurons Mediated by Rho GTPase Signaling Pathway through Rho-Kinase
K. Kobayashi (2004)
Translocation of Inhaled Ultrafine Particles to the Brain
G. Oberdörster (2004)
P. Gehr (2000)
Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice.
G. Zhang (2009)
The kinetics of the tissue distribution of silver nanoparticles of different sizes.
D. P. K. Lankveld (2010)
Nanoscale and fine zinc oxide particles: can in vitro assays accurately forecast lung hazards following inhalation exposures?
D. Warheit (2009)
Syndapins integrate N‐WASP in receptor‐mediated endocytosis
M. Kessels (2002)
Translocation of Inhaled Ultrafine Manganese Oxide Particles to the Central Nervous System
A. Elder (2006)
Comparison of gene expression profiles in mice liver following intravenous injection of 4 and 100 nm-sized PEG-coated gold nanoparticles.
W. Cho (2009)
Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation
E. Sadauskas (2009)
Genomics-based screening of differentially expressed genes in the brains of mice exposed to silver nanoparticles via inhalation
Hyeyoung Lee (2010)
Gold nanorod delivery of an ssRNA immune activator inhibits pandemic H1N1 influenza viral replication
Krishnan V Chakravarthy (2010)
New players tip the scales in the balance between excitatory and inhibitory synapses
J. Levinson (2005)
Recommendations for and documentation of biological values for use in risk assessment. U.S. Environmental Protection Agency EPA/600/6e87/ 008 (NTIS PB88179874)
U. S. EPA (1988)
The Interleukin-1 Receptor Accessory Protein (IL-1RAcP) Is Essential for IL-1-induced Activation of Interleukin-1 Receptor-associated Kinase (IRAK) and Stress-activated Protein Kinases (SAP Kinases)*
H. Wesche (1997)
On-line determination of particle size and density in the nanometer size range
S. Hering (1995)
UDP-Galactose:Ceramide Galactosyltransferase Is a Class I Integral Membrane Protein of the Endoplasmic Reticulum*
H. Sprong (1998)
Intracellular particle dissolution in alveolar macrophages.
W. Kreyling (1992)
Genomic organization of a new candidate tumor suppressor gene, LRP1B.
C. Liu (2000)
Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles.
E. Bermudez (2002)
Effects of inhaled nano-TiO2 aerosols showing two distinct agglomeration states on rat lungs.
A. Noël (2012)
Efficient Elimination of Inhaled Nanoparticles from the Alveolar Region: Evidence for Interstitial Uptake and Subsequent Reentrainment onto Airways Epithelium
M. Semmler-Behnke (2007)
Cadherin Regulates Dendritic Spine Morphogenesis
H. Togashi (2002)
Characterization of size, surface charge, and agglomeration state of nanoparticle dispersions for toxicological studies
Jingkun Jiang (2009)
Inflammatory response of mice to manufactured titanium dioxide nanoparticles: Comparison of size effects through different exposure routes
V. Grassian (2007)
This paper is referenced by
Occupational exposure and characterization of aerosol particles
Christof Asbach (2016)
Guidance on the Determination of Potential Health Effects of Nanomaterials Used in Medical Devices
A. Proykova (2014)
Combined effect of titanium dioxide nanoparticles and glucose on the blood glucose homeostasis in young rats after oral administration.
Z. Chen (2020)
Molecular Bases of Nanotoxicology
A. Tino (2014)
Current in vitro approaches to assess nanoparticle interactions with lung cells.
K. Fytianos (2016)
Size-dependent clearance of gold nanoparticles from lungs of Sprague–Dawley rats after short-term inhalation exposure
S. G. Han (2014)
Assessing human exposure risk and lung disease burden posed by airborne silver nanoparticles emitted by consumer spray products
Ying-Fei Yang (2019)
Development of Taiwan’s strategies for regulating nanotechnology-based pharmaceuticals harmonized with international considerations
Jiun-Wen Guo (2014)
Discovery of unique and ENM- specific pathophysiologic pathways: Comparison of the translocation of inhaled iridium nanoparticles from nasal epithelium versus alveolar epithelium towards the brain of rats.
W. Kreyling (2016)
Food-grade titanium dioxide exposure exacerbates tumor formation in colitis associated cancer model.
I. M. Urrutia-Ortega (2016)
High productive and continuous nanoparticle fabrication by laser ablation of a wire-target in a liquid jet
S. Kohsakowski (2017)
A Janus upconverting nanoplatform with biodegradability for glutathione depletion, near-infrared light induced photodynamic therapy and accelerated excretion.
Hang Zhou (2020)
Study of potential transfer of aluminum to the brain via the olfactory pathway.
M. Chalansonnet (2018)
A guide to nanosafety testing: Considerations on cytotoxicity testing in different cell models
C. Riebeling (2018)
The Applications, Neurotoxicity, and Related Mechanism of Gold Nanoparticles
S. Flora (2017)
Comprehensive characterizations of nanoparticle biodistribution following systemic injection in mice.
W. Liao (2013)
Slow lung clearance and limited translocation of four sizes of inhaled iridium nanoparticles
Alison J. Buckley (2017)
Comparative modeling of exposure to airborne nanoparticles released by consumer spray products
C. Riebeling (2016)
From INSTITUTE OF ENVIRONMENTAL MEDICINE (IMM) Karolinska Institutet, Stockholm, Sweden ENGINEERED NANOMATERIALS FOR BIOMEDICAL APPLICATIONS
Neus Feliu Torres (2014)
A systematic electron microscopic study on the uptake of barium sulphate nano-, submicro-, microparticles by bone marrow-derived phagocytosing cells.
V. Sokolova (2018)
Interaction of Nanomaterials with the Immune System
James Calvin Bonner (2020)
Safe Dose of Nanoparticles: A Boon for Consumer Goods and Biomedical Application
Akanksha Raj (2020)
Olfactory deposition of inhaled nanoparticles in humans
G. Garcia (2015)
Neurotoxicity of nanoparticles entering the brain via sensory nerve-to-brain pathways: injuries and mechanisms
Y. Lin (2020)
Air Pollution and Stroke
K. K. Lee (2018)
Toxicity of metallic nanoparticles in the central nervous system
K. Sawicki (2019)
Residual metals in carbon nanotubes suppress the proliferation of neural stem cells
Y. Shigemoto-mogami (2014)
Is Neurotoxicity of Metallic Nanoparticles the Cascades of Oxidative Stress?
B. Song (2016)
In vivo biocompatibility, clearance, and biodistribution of albumin vehicles for pulmonary drug delivery
A. Woods (2015)
Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge
V. Stone (2017)
Evaluation of the dose metric for acute lung inflammogenicity of fast-dissolving metal oxide nanoparticles
Jiyoung Jeong (2016)
Hydrogels for Pulmonary Drug Delivery
Ibrahim M A ElSherbiny (2017)See more