← Back to Search
Increased Neural Processing Of Rewarding And Aversive Food Stimuli In Recovered Anorexia Nervosa
F. Cowdrey, R. Park, C. Harmer, C. McCabe
Published 2011 · Psychology, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
BACKGROUND Recent evidence has shown that individuals with acute anorexia nervosa and those recovered have aberrant physiological responses to rewarding stimuli. We hypothesized that women recovered from anorexia nervosa would show aberrant neural responses to both rewarding and aversive disorder-relevant stimuli. METHODS Using functional magnetic resonance imaging (fMRI), the neural response to the sight and flavor of chocolate, and their combination, in 15 women recovered from restricting-type anorexia nervosa and 16 healthy control subjects matched for age and body mass index was investigated. The neural response to a control aversive condition, consisting of the sight of moldy strawberries and a corresponding unpleasant taste, was also measured. Participants simultaneously recorded subjective ratings of "pleasantness," "intensity," and "wanting." RESULTS Despite no differences between the groups in subjective ratings, individuals recovered from anorexia nervosa showed increased neural response to the pleasant chocolate taste in the ventral striatum and pleasant chocolate sight in the occipital cortex. The recovered participants also showed increased neural response to the aversive strawberry taste in the insula and putamen and to the aversive strawberry sight in the anterior cingulate cortex and caudate. CONCLUSIONS Individuals recovered from anorexia nervosa have increased neural responses to both rewarding and aversive food stimuli. These findings suggest that even after recovery, women with anorexia nervosa have increased salience attribution to food stimuli. These results aid our neurobiological understanding and support the view that the neural response to reward may constitute a neural biomarker for anorexia nervosa.
This paper references
Increased Dopamine D2/D3 Receptor Binding After Recovery from Anorexia Nervosa Measured by Positron Emission Tomography and [11C]Raclopride
G. Frank (2005)
Distinct portions of anterior cingulate cortex and medial prefrontal cortex are activated by reward processing in separable phases of decision-making cognition
R. Rogers (2004)
Cerebral blood flow changes associated with attribution of emotional valence to pleasant, unpleasant, and neutral visual stimuli in a PET study of normal subjects.
S. Paradiso (1999)
Human cortical responses to water in the mouth, and the effects of thirst.
I. D. de Araujo (2003)
Relation of obesity to consummatory and anticipatory food reward
E. Stice (2009)
Influence of Satiety and Subjective Valence Rating on Cerebral Activation Patterns in Response to Visual Stimulation with High-Calorie Stimuli among Restrictive Anorectic and Control Women
E. Gizewski (2010)
Representation in the Human Brain of Food Texture and Oral Fat
I. D. de Araujo (2004)
Representation of umami taste in the human brain.
I. D. de Araujo (2003)
742 BIOL PSYCHIATRY
Weight Gain Is Associated with Reduced Striatal Response to Palatable Food
E. Stice (2010)
Bulimia nervosa treatment: a systematic review of randomized controlled trials.
J. Shapiro (2007)
Reduced neural response to reward following 7 days treatment with the cannabinoid CB1 antagonist rimonabant in healthy volunteers.
J. Horder (2010)
A specific neural substrate for perceiving facial expressions of disgust
M. L. Phillips (1997)
Sensitivity to reward and punishment in eating disorders
A. Harrison (2010)
Classical and Bayesian Inference in Neuroimaging: Applications
Karl J. Friston (2002)
A neural signature of anorexia nervosa in the ventral striatal reward system.
Anne-Katharina Fladung (2010)
Neural representation of reward in recovered depressed patients
C. McCabe (2009)
Structured clinical interview for the DSM-IV (SCID-I/P)
Rl Spitzer (2004)
Neural substrates of anorexia nervosa: a behavioral challenge study with positron emission tomography.
C. Gordon (2001)
Increased amygdala and insula activation during emotion processing in anxiety-prone subjects.
M. Stein (2007)
Anterior cingulate activity during error and autonomic response
H. Critchley (2005)
Theoretical perspective on anorexia nervosa: The conflict of reward
C. Keating (2010)
the Price Foundation Collaborative Group Comorbidity of anxiety disorders with anorexia and bulimia nervosa
Wh Kaye (2004)
Schematic models and modes of mind in anorexia nervosa: A novel process account with treatment implications
Diagnostic and Statistical Manual of Mental Disorders
V. Mittal (2011)
Enhanced affective brain representations of chocolate in cravers vs. non‐cravers
E. Rolls (2007)
Functional anatomy of calorie fear in anorexia nervosa
Zoë Ellison (1998)
Comorbidity of anxiety disorders with anorexia and bulimia nervosa.
W. Kaye (2004)
Altered Insula Response to Taste Stimuli in Individuals Recovered from Restricting-Type Anorexia Nervosa
A. Wagner (2008)
Area-selective neuronal activity in the dorsolateral prefrontal cortex for information retrieval and action planning.
E. Hoshi (2004)
Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens
Brian Knutson (2001)
A scale for the assessment of hedonic tone the Snaith-Hamilton Pleasure Scale.
R. Snaith (1995)
Assessing Anhedonia in Psychiatric Patients: The Pleasure Scale
J. Fawcett (1983)
Neuronal activity changes and body image distortion in anorexia nervosa
Angela Z. Wagner (2003)
Increased dopamine D 2 / D 3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [ 11 C ] raclopride
GK Frank (2005)
Disgust and eating disorder symptomatology in a non-clinical population: the role of trait anxiety and anxiety sensitivity.
G. Davey (2009)
Differential activation of the dorsal striatum by high-calorie visual food stimuli in obese individuals
Yvonne Rothemund (2007)
Schematic models and modes of mind in anorexia nervosa I: A novel process account
R. Park (2011)
Tracking the hemodynamic responses to reward and punishment in the striatum.
M. Delgado (2000)
Diminished Neural Processing of Aversive and Rewarding Stimuli During Selective Serotonin Reuptake Inhibitor Treatment
C. McCabe (2010)
Schematic models and modes of mind in anorexia nervosa : A novel process account with treatment implications
Z Ellison (1998)
Eating Disorder Examination Questionnaire (EDE-Q)
E. Penelo (2012)
The Neural Substrates of Reward Processing in Humans: The Modern Role of fMRI
S. McClure (2004)
Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions.
A. Bechara (2000)
Diagnostic and Statistical Manual of Mental Disorders
J. Williams (2013)
Representation of pleasant and aversive taste in the human brain.
J. O'Doherty (2001)
New insights into symptoms and neurocircuit function of anorexia nervosa
Walter H. Kaye (2009)
Regional brain volume in depression and anxiety disorders.
M. van Tol (2010)
Personality traits after recovery from eating disorders: do subtypes differ?
A. Wagner (2006)
Medial prefrontal cortex activity associated with symptom provocation in eating disorders.
R. Uher (2004)
Amygdala hyperreactivity in restrictive anorexia nervosa
A. Joos (2011)
Recovery and chronicity in anorexia nervosa: brain activity associated with differential outcomes
R. Uher (2003)
F A Cowdrey
A Beck (2002)
Assessing the significance of focal activations using their spatial extent
Karl J. Friston (1994)
Eating Disorder Examination Questionnaire (EDE-Q): norms for young adult women.
J. Mond (2006)
Persistence of abnormal neural responses to a meal in postobese individuals
A. Delparigi (2004)
Disgust and eating disorders
G. Davey (1998)
Altered reward processing in women recovered from anorexia nervosa.
A. Wagner (2007)
Anorexia nervosa treatment: a systematic review of randomized controlled trials.
C. Bulik (2007)
A Role for the Right Anterior Temporal Lobe in Taste Quality Recognition
D. Small (1997)
The long-term course of severe anorexia nervosa in adolescents: survival analysis of recovery, relapse, and outcome predictors over 10-15 years in a prospective study.
M. Strober (1997)
Manual for the State-Trait Anxiety Inventory
C. Spielberger (1970)
Relation of reward from food intake and anticipated food intake to obesity: a functional magnetic resonance imaging study.
E. Stice (2008)
This paper is referenced by
Resting state functional connectivity of networks associated with reward and habit in anorexia nervosa
Ann F Haynos (2019)
Attachment Insecurity Predicts Punishment Sensitivity in Anorexia Nervosa
C. Keating (2016)
The Trajectory of Anhedonic and Depressive Symptoms in Anorexia Nervosa: A Longitudinal and Cross‐Sectional Approach
I. Boehm (2018)
Abnormal relationships between the neural response to high- and low-calorie foods and endogenous acylated ghrelin in women with active and weight-recovered anorexia nervosa
L. Holsen (2014)
Brain parcellation choice affects disease-related topology differences increasingly from global to local network levels
Anton Lord (2016)
Could Dopamine Agonists Aid in Drug Development for Anorexia Nervosa?
G. Frank (2014)
Enhanced Early Neuronal Processing of Food Pictures in Anorexia Nervosa: A Magnetoencephalography Study
Lauren R Godier (2016)
Neurobiological model of the persistence of anorexia nervosa
J. Steinglass (2016)
Thinking about Eating Food Activates Visual Cortex with Reduced Bilateral Cerebellar Activation in Females with Anorexia Nervosa: An fMRI Study
Samantha J. Brooks (2012)
Social reward and social punishment sensitivity in relation to dietary restraint and binge/purge symptoms
L. Fussner (2018)
Evidence of prefrontal hyperactivation to food-cue reversal learning in adolescents with anorexia nervosa.
Tom Hildebrandt (2018)
What can Cognitive Neuroscience Teach us about Anorexia Nervosa?
Amelia Kidd (2012)
Reward processing in anorexia nervosa
C. Keating (2012)
Can age-related CNS taste differences be detected as early as middle age? Evidence from fMRI
E. Green (2013)
Altered insula response to sweet taste processing in recovered anorexia and bulimia nervosa: a matter of disgust sensitivity?
C. Vicario (2013)
Anorexia Nervosa as a Passion
Louis C. Charland (2013)
Anorexia Nervosa and Obesity are Associated with Opposite Brain Reward Response
G. Frank (2012)
The Neurobiology of Eating Disorders.
G. Frank (2019)
Behavioral assessment of activity-based-anorexia: how cognition can become the drive wheel
J. Lamanna (2019)
A systematic and methodological review of attentional biases in eating disorders: Food, body, and perfectionism
Christina Ralph-Nearman (2019)
Altered interoceptive activation before, during, and after aversive breathing load in women remitted from anorexia nervosa.
L. Berner (2018)
Attention allocation to illness-compatible information discriminates women with active versus weight-recovered anorexia nervosa.
K. Giel (2019)
Resting‐state connectivity within and across neural circuits in anorexia nervosa
Blair Uniacke (2019)
Abnormal reward circuitry in anorexia nervosa: A longitudinal, multimodal MRI study
Jiook Cha (2016)
The Neurobiology of Anorexia Nervosa
Ashley Higgins (2018)
Emotions in Eating Disorders: The Interplay of Emotion Regulation and Inhibitory Control in Appetite and Eating Behaviour
I. Wolz (2016)
Sensory modulation disorder symptoms in anorexia nervosa and bulimia nervosa: A pilot study.
A. Brand-Gothelf (2016)
Decreased feedback learning in anorexia nervosa persists after weight restoration
K. Foerde (2017)
Brain Circuitry Models in Eating Disorders
G. Frank (2011)
Altered brain response to reward and punishment in adolescents with Anorexia nervosa
A. Bischoff-Grethe (2013)
Neural responses to emotional faces in women recovered from anorexia nervosa
F. Cowdrey (2012)
A reward-centred model of anorexia nervosa: A focussed narrative review of the neurological and psychophysiological literature
Caitlin B. O’Hara (2015)See more