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Synthesis And Antiviral Activity Evaluation Of Acyclic 2′-azanucleosides Bearing A Phosphonomethoxy Function In The Side Chain

Mariola Koszytkowska-Stawińska, E. Clercq, J. Balzarini
Published 2009 · Chemistry, Medicine

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Abstract Acyclic 2′-azanucleosides with a phosphonomethoxy function in the side chain were obtained by coupling of diethyl {2-[N-(pivaloyloxymethyl)-N-(p-toluenesulfonyl)amino]ethoxymethyl}phosphonate with the pyrimidine nucleobases via the Vorbrüggen-type protocol. The compounds were evaluated in vitro for activity against a broad variety of RNA and DNA viruses.
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