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Fracture Incidence And Association With Bone Mineral Density In Elderly Men And Women: The Rotterdam Study.

S. C. Schuit, M. van der Klift, A. Weel, C. De laet, H. Burger, E. Seeman, A. Hofman, A. Uitterlinden, J. V. van Leeuwen, H. Pols
Published 2004 · Medicine

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The incidence of all non-vertebral fractures, as well as the relation to bone mineral density (BMD), was quantified in 7806 men and women from the Rotterdam Study, a prospective, population-based cohort study of men and women aged 55 years and older. In addition, the sensitivity of using a T-score at or below -2.5 for identifying subjects at risk for fractures was assessed. At baseline, between 1990 and 1993, femoral neck BMD was measured by dual energy X-ray absorptiometry (DXA). Subsequently, gender-specific T-scores were calculated using the NHANES reference population. During a mean follow-up of 6.8 years, information on incident non-vertebral fractures was gathered. In general, hip, wrist and upper humerus fractures are the most frequent fractures in both men and women. Femoral neck BMD appears to be an equally important risk factor in both genders, and is especially related to hip fractures. For all non-vertebral fractures, the age-adjusted hazard ratio (95% confidence interval) per standard deviation decrease in femoral neck BMD was 1.5 (1.4-1.6) for women and 1.4 (1.2-1.6) for men. For hip fractures, the hazard ratios were 2.1 (1.7-2.5) for women and 2.3 (1.6-3.3) for men. Only 44% of all non-vertebral fractures occurred in women with a T-score below -2.5; in men, this percentage was even lower (21%). Thus, there is a clear need for the development of more sensitive risk assessment tools, using not only BMD, but also other clinical predictors of fractures.
This paper references
10.1007/BF01623186
The apparent incidence of hip fracture in Europe: A study of national register sources
O. Johnel (2005)
10.1007/BF01622200
Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: Synopsis of a WHO report
J. Kanis (2005)
10.1016/S8756-3282(01)00614-7
Epidemiology of fractures in England and Wales.
T. V. van Staa (2001)
10.1007/s001980050093
Updated Data on Proximal Femur Bone Mineral Levels of US Adults
A. Looker (1998)
10.1016/S8756-3282(97)00250-0
Assessment of sex hormones and bone mineral density in relation to occurrence of fracture in men: a prospective population-based study.
F. Nyquist (1998)
10.1016/8756-3282(93)90341-7
Hip fractures: a worldwide problem today and tomorrow.
L. J. Melton (1993)
10.1111/j.1532-5415.1993.tb07307.x
Type of Fall and Risk of Hip and Wrist Fractures: The Study of Osteoporotic Fractures
M. Nevitt (1994)
10.1136/jech.44.3.241
Incidence of fractures in a geographically defined population.
L. Donaldson (1990)
10.1007/s001980170076
Incidence of Distal Forearm Fracture in British Men and Women
T. O'Neill (2001)
10.1136/bmj.s1-3.21.415
A Treatise on Dislocations and Fractures of the Joints
Astley Cooper (1823)
10.1016/0140-6736(93)92555-8
Bone density at various sites for prediction of hip fractures
S. Cummings (1993)
10.1007/PL00004168
Osteoporosis in Men
E. Seeman (1997)
10.1111/j.1532-5415.1994.tb06576.x
TYPE OF FALL AND RISK OF HIP AND WRIST FRACTURES: THE STUDY OF OSTEOPOROTIC FRACTURES
M. Nevitt (1993)
10.1007/BF01627079
Screening for vertebral osteoporosis using individual risk factors
C. Cooper (2005)
10.1016/S0169-6009(08)80203-6
The association between age and bone mineral density in men and women aged 55 years and over: the Rotterdam Study.
H. Burger (1994)
10.1136/bmj.315.7102.221
Bone density and risk of hip fracture in men and women: cross sectional analysis
C. De laet (1997)
10.1302/0301-620X.80B2.7762
Epidemiology of fractures in 15 000 adults: The influence of age and gender
B. Singer (1998)
10.1016/8756-3282(90)90074-9
The predictive value of forearm bone mineral content measurements in men.
P. Gärdsell (1990)
10.1007/BF01623349
The variable incidence of hip fracture in Southern Europe: The MEDOS study
I. Elffors (2005)
10.1007/s001980050073
Long-Term Trends in the Incidence of Distal Forearm Fractures
L. Melton Iii (1998)
10.7326/0003-4819-115-11-837
Which Fractures Are Associated with Low Appendicular Bone Mass in Elderly Women
D. Seeley (1991)
10.1359/jbmr.2005.20.5.886
How Many Women Have Osteoporosis?
L. J. Melton (2005)
10.1007/BF01626541
International comparison of hip fracture rates in 1988–89
W. E. Bacon1 (2005)
10.1007/s001980050113
Fracture Incidence in Olmsted County, Minnesota: Comparison of Urban with Rural Rates and Changes in Urban Rates Over time
L. Melton Iii (1999)
10.1136/bmj.307.6912.1111
Prediction of osteoporotic fractures by postural instability and bone density.
T. Nguyen (1993)
10.1007/s001980200074
Incidence of Limb Fracture across Europe: Results from the European Prospective Osteoporosis Study (EPOS)
A. A. Ismail (2002)
10.1136/bmj.312.7041.1254
Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures
D. Marshall (1996)
10.3109/17453678508994345
Increasing incidence of forearm fractures. A comparison of epidemiologic patterns 25 years apart.
U. Bengnér (1985)
10.1007/BF01623184
Hip fractures in the elderly: A world-wide projection
C. Cooper (2005)
10.1093/oxfordjournals.aje.a116314
Risk factors for fractures of the distal forearm and proximal humerus. The Study of Osteoporotic Fractures Research Group.
J. Kelsey (1992)
10.1007/s001980200069
A New Approach to the Development of Assessment Guidelines for Osteoporosis
J. Kanis (2002)
10.1093/ije/30.3.427
Sick individuals and sick populations.
G. Rose (1985)
10.1002/JBMR.5650070902
Perspective how many women have osteoporosis?
L. J. Melton (1992)
10.1359/jbmr.1997.12.1.24
Medical Expenditures for the Treatment of Osteoporotic Fractures in the United States in 1995: Report from the National Osteoporosis Foundation
N. F. Ray (1997)
10.1007/BF00145007
Determinants of disease and disability in the elderly: The Rotterdam elderly study
A. Hofman (2004)
10.1007/s00223-001-1057-3
The Assessment of Bone Mass in Men
A. Lombardi (2001)
10.1007/BF02352261
Bone density of the calcaneus and fractures in 75- and 80-year-old men and women
S. Cheng (1994)



This paper is referenced by
10.1007/s00198-009-0904-3
Is bone quality associated with collagen age?
D. Leeming (2009)
10.1007/s00062-018-0722-0
MDCT-based Finite Element Analysis of Vertebral Fracture Risk: What Dose is Needed?
D. Anitha (2018)
10.4168/aair.2019.11.3.302
Is Trabecular Bone Score a More Sensitive Marker for Osteoporosis in Asthmatics?
C. Kim (2019)
10.1016/j.mri.2010.06.003
Interrelationships between 3-T-MRI-derived cortical and trabecular bone structure parameters and quantitative-computed-tomography-derivedbone mineral density.
A. Issever (2010)
10.5040/9781492595700.ch-0011
arthritis and osteoporosis
C. Jochems (2008)
10.1016/j.jbiomech.2009.04.017
Validation of an anatomy specific finite element model of Colles' fracture.
P. Varga (2009)
10.1016/j.archger.2008.07.014
Predicting osteoporosis in patients with a low-energy fracture.
Monique H M Timmer (2009)
10.1016/B978-0-12-374602-3.00043-2
Dual-Energy X-ray Absorptiometry (DXA) in Men
N Binkley (2010)
10.1007/s00393-011-0753-2
Radiologische Diagnostik der Osteoporose
Ahi Sema Issever (2011)
10.1016/j.bone.2013.05.023
Biomechanical properties and microarchitecture parameters of trabecular bone are correlated with stochastic measures of 2D projection images.
X. Dong (2013)
10.1016/j.jocd.2015.05.067
Sarcopenia, the Next Frontier in Fracture Prevention: Introduction From the Guest Editors.
N Binkley (2015)
10.2147/CIA.S101078
Validation of three tools for identifying painful new osteoporotic vertebral fractures in older Chinese men: bone mineral density, Osteoporosis Self-Assessment Tool for Asians, and fracture risk assessment tool
Jisheng Lin (2016)
10.1007/s10334-016-0577-9
Magnetization transfer imaging of cortical bone in vivo using a zero echo time sequence in mice at 4.7 T: a feasibility study
M. Marcon (2016)
10.1371/journal.pone.0196536
Bone mineral density and bone remodeling markers in chronic low back pain patients with active discopathy: A case-control exploratory study
Stéphanie Teboul-Coré (2018)
Bone Mineral Density in Prostate Cancer Patients with Drug Induced Hypogonadism
Bruno Lopes Cançado (2014)
10.1007/s00198-017-4293-8
Characterization of trabecular bone microstructure in premenopausal women with distal radius fractures
T. D. Rozental (2017)
10.21767/2471-8173.100009
Predictive Value of Native Computed Tomography in Low Energy Vertebra Fracture Risk Assessment
Andrey Bokov (2016)
10.1016/j.bone.2012.09.023
Systematic vertebral fracture assessment in asymptomatic postmenopausal women.
Abdellah El Maghraoui (2013)
10.1007/s12018-018-9255-y
Fourier Transform Infrared Spectroscopy of Bone Tissue: Bone Quality Assessment in Preclinical and Clinical Applications of Osteoporosis and Fragility Fracture
Nikolaos Kourkoumelis (2019)
10.1016/j.bone.2016.06.006
Study of sex differences in the association between hip fracture risk and body parameters by DXA-based biomechanical modeling.
M. Nasiri (2016)
10.1258/175404507781605668
Risk factors for clinical fractures among postmenopausal women: a 10-year prospective study
T. van Geel (2007)
10.1007/s40200-020-00537-w
The reference value of trabecular bone score (TBS) in the Iranian population
G. Shafiee (2020)
10.1007/978-3-030-03706-2_2
State-of-the-Art of Sensing Technologies for Monitoring of Bone-Health
Nasrin Afsarimanesh (2019)
10.1007/s00198-005-0061-2
A comparison between peripheral BMD and central BMD measurements in the prediction of spine fractures in men
N. Hongsdusit (2005)
10.5606/tftrd.2016.33407
The role of quantitative computed tomography and magnetic resonance imaging in diagnosis and follow-up of osteoporosis: A review
Derya Demirbağ Kabayel (2016)
10.5812/atr.10687
Utility of the Cortical Thickness of the Distal Radius as a Predictor of Distal-Radius Bone Density
S. Rausch (2013)
10.1007/s00223-015-0011-8
Erratum to: The Role of Collagen Organization on the Properties of Bone
P. Garnero (2015)
10.2217/14622416.10.3.417
Update on the pharmacogenetics of the vitamin D receptor and osteoporosis.
L. Gennari (2009)
10.1002/jbmr.171
Age‐related patterns of trabecular and cortical bone loss differ between sexes and skeletal sites: A population‐based HR‐pQCT study
H. Macdonald (2011)
Doeltreffende opsporing van osteoporose in de fractuur- en osteoporosepolikliniek in Groningen; analyse na de eerste 100 patiënten
J. Hegeman (2004)
10.1007/s12024-018-9964-z
Fatal falls involving stairs: an anthropological analysis of skeletal trauma
Samantha K. Rowbotham (2018)
10.1016/j.bone.2015.10.012
Age-related changes in bone strength from HR-pQCT derived microarchitectural parameters with an emphasis on the role of cortical porosity.
N. Vilayphiou (2016)
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