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Distribution Of Cortical Bone In The Femoral Neck And Hip Fracture: A Prospective Case-control Analysis Of 143 Incident Hip Fractures; The AGES-REYKJAVIK Study.

F. Johannesdottir, K. Poole, J. Reeve, K. Siggeirsdottir, T. Aspelund, B. Mogensen, B. Jónsson, S. Sigurdsson, T. Harris, V. Gudnason, Gunnar Sigurdsson
Published 2011 · Medicine

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In this prospective nested case-control study we analyzed the circumferential differences in estimated cortical thickness (Est CTh) of the mid femoral neck as a risk factor for osteoporotic hip fractures in elderly women and men. Segmental QCT analysis of the mid femoral neck was applied to assess cortical thickness in anatomical quadrants. The superior region of the femoral neck was a stronger predictor for hip fracture than the inferior region, particularly in men. There were significant gender differences in Est CTh measurements in the control group but not in the case group. In multivariable analysis for risk of femoral neck (FN) fracture, Est CTh in the supero-anterior (SA) quadrant was significant in both women and men, and remained a significant predictor after adjustment for FN areal BMD (aBMD, dimensions g/cm², DXA-like), (p=0.05 and p<0.0001, respectively). In conclusion, Est CTh in the SA quadrant best discriminated cases (n=143) from controls (n=298), especially in men. Cortical thinning superiorly in the hip might be of importance in determining resistance to fracture.
This paper references
10.1016/8756-3282(93)90209-S
Cortical aging differences and fracture implications for the human femoral neck.
T. M. Boyce (1993)
10.1016/S0140-6736(05)66870-5
Relation between age, femoral neck cortical stability, and hip fracture risk
Paul M. Mayhew (2005)
10.1016/j.jbiomech.2009.05.001
During sideways falls proximal femur fractures initiate in the superolateral cortex: evidence from high-speed video of simulated fractures.
P. D. de Bakker (2009)
10.2106/00004623-199308000-00009
Age-related changes in the tensile properties of cortical bone. The relative importance of changes in porosity, mineralization, and microstructure.
R. Mccalden (1993)
10.1016/S1078-1439(03)00140-6
Osteoporosis: a rapid review of risk factors and screening methods.
M. Moyad (2003)
10.1016/S8756-3282(00)00300-8
Hip geometry, bone mineral distribution, and bone strength in European men and women: the EPOS study.
N. Crabtree (2000)
10.1016/S0140-6736(05)66842-0
The biomechanics of hip fracture
C. H. Turner (2005)
10.1093/AJE/KWK115
Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics.
T. Harris (2007)
10.1007/s001980070046
Bone Mineral Density, Hip Axis Length and Risk of Hip Fracture in Men: Results from the Cornwall Hip Fracture Study
I. Pande (2000)
10.1359/jbmr.1999.14.1.111
Structure of the Femoral Neck in Hip Fracture: Cortical Bone Loss in the Inferoanterior to Superoposterior Axis
K. L. Bell (1999)
10.1359/jbmr.080802
Prediction of Incident Hip Fracture Risk by Femur Geometry Variables Measured by Hip Structural Analysis in the Study of Osteoporotic Fractures
S. Kaptoge (2008)
10.1118/1.1521940
Accuracy of CT-based thickness measurement of thin structures: modeling of limited spatial resolution in all three dimensions.
S. Prevrhal (2003)
10.1359/jbmr.090504
Femoral Neck Trabecular Bone: Loss With Aging and Role in Preventing Fracture
C. Thomas (2009)
10.1016/8756-3282(95)00448-3
Interleukin-6 and tumor necrosis factor alpha levels after bisphosphonates treatment in vitro and in patients with malignancy.
A. Sauty (1996)
10.1007/s00223-007-9076-3
The Effects of Geometric and Threshold Definitions on Cortical Bone Metrics Assessed by In Vivo High-Resolution Peripheral Quantitative Computed Tomography
Kevin A Davis (2007)
10.1038/SCIENTIFICAMERICAN1188-118
Evolution of Human Walking
L. Co (1988)
10.1359/jbmr.081108
Hip Fractures and the Contribution of Cortical Versus Trabecular Bone to Femoral Neck Strength
G. Holzer (2009)
10.1359/jbmr.080316
Proximal Femoral Structure and the Prediction of Hip Fracture in Men: A Large Prospective Study Using QCT
D. Black (2008)
10.1016/j.bone.2009.08.059
Analysis of hip geometry by clinical CT for the assessment of hip fracture risk in elderly Japanese women.
M. Ito (2010)
10.1359/jbmr.2003.18.10.1775
Bone Remodeling at the Endocortical Surface of the Human Femoral Neck: A Mechanism for Regional Cortical Thinning in Cases of Hip Fracture
J. Power (2003)
10.1007/s00198-004-1702-6
Epidemiology of osteoporotic fractures
O. Johnell (2004)
10.1016/J.BONE.2007.08.039
Load distribution in the healthy and osteoporotic human proximal femur during a fall to the side.
E. Verhulp (2008)
10.1359/jbmr.090529
Differences in Macro‐ and Microarchitecture of the Appendicular Skeleton in Young Chinese and White Women
X. Wang (2009)
10.1016/J.JBIOMECH.2003.12.011
The dependence of transversely isotropic elasticity of human femoral cortical bone on porosity.
X. N. Dong (2004)
10.1007/s00198-005-0019-4
Femur strength index predicts hip fracture independent of bone density and hip axis length
K. Faulkner (2005)
10.1359/jbmr.070712
Femoral Neck BMD Is a Strong Predictor of Hip Fracture Susceptibility in Elderly Men and Women Because It Detects Cortical Bone Instability: The Rotterdam Study
F. Rivadeneira (2007)
10.1359/jbmr.090734
Changing structure of the femoral neck across the adult female lifespan
K. Poole (2010)
10.1016/8756-3282(95)00490-4
Are the etiologies of cervical and trochanteric hip fractures different?
C. Mautalen (1996)
10.1111/j.1469-7580.2007.00694.x
Variation in mammalian proximal femoral development: comparative analysis of two distinct ossification patterns
Maria A. Serrat (2007)
10.1007/s001980050144
International Variation in the Incidence of Hip Fractures: Cross-National Project on Osteoporosis for the World Health Organization Program for Research on Aging
A. Schwartz (1999)
10.1359/jbmr.090528
Application of High‐Resolution Skeletal Imaging to Measurements of Volumetric BMD and Skeletal Microarchitecture in Chinese‐American and White Women: Explanation of a Paradox
M. Walker (2009)
10.1016/0021-9290(88)90006-1
The effect of porosity and mineral content on the Young's modulus of elasticity of compact bone.
J. Currey (1988)
10.1016/j.media.2010.01.003
High resolution cortical bone thickness measurement from clinical CT data
Graham M. Treece (2010)
10.1007/BF02508641
Impact direction from a fall influences the failure load of the proximal femur as much as age-related bone loss
T. Pinilla (2006)
10.1359/jbmr.2001.16.7.1318
Intracapsular Hip Fracture and the Region‐Specific Loss of Cortical Bone: Analysis by Peripheral Quantitative Computed Tomography
N. Crabtree (2001)
10.1359/jbmr.1997.12.11.1895
Different Morphometric and Densitometric Parameters Predict Cervical and Trochanteric Hip Fracture: The EPIDOS Study
F. Duboeuf (1997)
10.1007/BF01621853
The incidence of hip fracture in Europe
J. Kanis (2005)
10.1016/S8756-3282(02)00779-2
Correlation of bone mineral density with strength and microstructural parameters of cortical bone in vitro.
N. Wachter (2002)
10.1016/J.BONE.2005.03.007
In vivo short-term precision of hip structure analysis variables in comparison with bone mineral density using paired dual-energy X-ray absorptiometry scans from multi-center clinical trials.
B. C. C. Khoo (2005)
10.1359/JBMR.050510
New QCT Analysis Approach Shows the Importance of Fall Orientation on Femoral Neck Strength
R. D. Carpenter (2005)
10.1016/J.BONE.2006.03.020
Increasing sex difference in bone strength in old age: The Age, Gene/Environment Susceptibility-Reykjavik study (AGES-REYKJAVIK).
G. Sigurdsson (2006)
Osteoporosis. Current techniques and recent developments in quantitative bone densitometry.
P. Lang (1991)
[Radiologic diagnosis of osteoporosis. Current methods and outlook].
M. Jergas (1992)
10.1359/jbmr.060814
Leptin Is a Negative Independent Predictor of Areal BMD and Cortical Bone Size in Young Adult Swedish Men
M. Lorentzon (2006)
10.1007/s00198-008-0675-2
Cortical and trabecular bone in the femoral neck both contribute to proximal femur failure load prediction
S. Manske (2008)
10.1007/BF01774015
Stress distributions within the proximal femur during gait and falls: Implications for osteoporotic fracture
J. C. Lotz (2005)
10.1016/J.BONE.2004.05.025
Bone mineralization density and femoral neck fragility.
N. Loveridge (2004)
10.1172/JCI110667
Changes in bone mineral density of the proximal femur and spine with aging. Differences between the postmenopausal and senile osteoporosis syndromes.
B. Riggs (1982)



This paper is referenced by
Vers la mesure d’ondes circonférentielles guidées par la coque corticale du col du fémur
P. Nauleau (2013)
10.1016/B978-0-12-801238-3.65815-4
X-Ray Based Imaging Methods to Assess Bone Quality
Klaus Engelke (2014)
10.1007/978-1-59745-459-9_7
Biomechanics of Bone
J. Cole (2010)
10.1016/j.jocd.2018.11.004
DXA-Based 3D Analysis of the Cortical and Trabecular Bone of Hip Fracture Postmenopausal Women: A Case-Control Study.
L. Humbert (2018)
10.1007/978-3-319-43504-6_19
Use Case V: Imaging Biomarkers in Musculoskeletal Disorders
J. Carballido-Gamio (2017)
10.1002/jbmr.3939
Heterogeneous Spatial and Strength Adaptation of the Proximal Femur to Physical Activity: A Within‐Subject Controlled Cross‐Sectional Study
S. Warden (2019)
10.1016/j.jmbbm.2020.104046
An experimental procedure to perform mechanical characterization of small-sized bone specimens from thin femoral cortical wall.
D. Gastaldi (2020)
10.1016/j.bone.2018.05.016
Sex differences in the spatial distribution of bone in relation to incident hip fracture: Findings from the AGES-Reykjavik study.
E. Marques (2018)
10.1016/j.jbiomech.2013.06.031
Femoral neck bone adaptation to weight-bearing physical activity by computational analysis.
M. Machado (2013)
10.1016/j.jocd.2017.01.005
Quadrant Analysis of Quantitative Computed Tomography Scans of the Femoral Neck Reveals Superior Region-Specific Weakness in Young and Middle-Aged Men With Type 1 Diabetes Mellitus.
T. Kuroda (2018)
10.1007/s11914-013-0147-2
Advanced CT based In Vivo Methods for the Assessment of Bone Density, Structure, and Strength
K. Engelke (2013)
10.1007/s12018-015-9201-1
FEA to Measure Bone Strength: A Review
K. Engelke (2016)
10.1097/MED.0b013e32835a2609
Assessment of bone quality and strength with new technologies
K. Engelke (2012)
10.3978/j.issn.2223-4292.2015.08.02
Automatic multi-parametric quantification of the proximal femur with quantitative computed tomography.
J. Carballido-Gamio (2015)
10.1016/j.bone.2017.07.023
Comparison of non-invasive assessments of strength of the proximal femur.
F. Johannesdottir (2017)
10.5278/VBN.PHD.MED.00101
Thiazide diuretics and hyponatremia in relation to osteoporosis
Christian Kruse (2017)
Osteoporotic fracture risk
José de Jesús Garduño-García (2014)
10.1016/j.actbio.2019.03.020
Hypermineralization in the femoral neck of the elderly.
Tengteng Tang (2019)
10.1371/journal.pone.0195463
Ranking of osteogenic potential of physical exercises in postmenopausal women based on femoral neck strains
P. Pellikaan (2018)
10.1007/s00198-015-3324-6
QCT of the proximal femur—which parameters should be measured to discriminate hip fracture?
O. Museyko (2015)
10.1186/s12891-017-1669-z
Cortical thickness in the intertrochanteric region may be relevant to hip fracture type
Huafeng Zhuang (2017)
10.1002/jbmr.2499
The Influence of High‐Impact Exercise on Cortical and Trabecular Bone Mineral Content and 3D Distribution Across the Proximal Femur in Older Men: A Randomized Controlled Unilateral Intervention
Sarah J. Allison (2015)
10.1007/s11657-020-00780-x
Anatomical factors associated with femoral neck fractures of elderly Beijing women
B. C. C. Khoo (2020)
10.1016/B978-0-12-804182-6.00012-5
Chapter 12 – Overview of Bone Structure and Strength
F. Johannesdottir (2018)
10.4103/0366-6999.244118
Comparison of Proximal Femoral Geometry and Risk Factors between Femoral Neck Fractures and Femoral Intertrochanteric Fractures in an Elderly Chinese Population
Zu-Sheng Hu (2018)
10.1002/jbmr.1693
Distribution of bone density in the proximal femur and its association with hip fracture risk in older men: The osteoporotic fractures in men (MrOS) study
L. Yang (2012)
10.1016/j.bone.2013.12.034
The fragile elderly hip: Mechanisms associated with age-related loss of strength and toughness☆
J. Reeve (2014)
10.1016/j.bone.2013.08.017
Structural patterns of the proximal femur in relation to age and hip fracture risk in women.
J. Carballido-Gamio (2013)
Extended Discrete Element Method forsubject specific modelling and analysis ofthe ankle joint contact mechanics
Ivan Benemerito (2018)
Afdrif og horfur sjúklinga með mjaðmarbrot á Landspítala
G. Sigurðsson (2012)
10.3389/fendo.2014.00020
Physical Activity and Bone: May the Force be with You
J. Tobias (2014)
10.1371/journal.pgen.1002745
WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk
H. Zheng (2012)
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