Online citations, reference lists, and bibliographies.
← Back to Search

Structural Patterns Of The Proximal Femur In Relation To Age And Hip Fracture Risk In Women.

J. Carballido-Gamio, R. Harnish, I. Saeed, T. Streeper, S. Sigurdsson, S. Amin, E. Atkinson, T. Therneau, K. Siggeirsdottir, X. Cheng, L. J. Melton, J. Keyak, V. Gudnason, S. Khosla, T. Harris, T. Lang
Published 2013 · Medicine, Biology

Cite This
Download PDF
Analyze on Scholarcy
Fractures of the proximal femur are the most devastating outcome of osteoporosis. It is generally understood that age-related changes in hip structure confer increased risk, but there have been few explicit comparisons of such changes in healthy subjects to those with hip fracture. In this study, we used quantitative computed tomography and tensor-based morphometry (TBM) to identify three-dimensional internal structural patterns of the proximal femur associated with age and with incident hip fracture. A population-based cohort of 349 women representing a broad age range (21-97years) was included in this study, along with a cohort of 222 older women (mean age 79±7years) with (n=74) and without (n=148) incident hip fracture. Images were spatially normalized to a standardized space, and age- and fracture-specific morphometric features were identified based on statistical maps of shape features described as local changes of bone volume. Morphometric features were visualized as maps of local contractions and expansions, and significance was displayed as Student's t-test statistical maps. Significant age-related changes included local expansions of regions low in volumetric bone mineral density (vBMD) and local contractions of regions high in vBMD. Some significant fracture-related features resembled an accentuated aging process, including local expansion of the superior aspect of the trabecular bone compartment in the femoral neck, with contraction of the adjoining cortical bone. However, other features were observed only in the comparison of hip fracture subjects with age-matched controls including focal contractions of the cortical bone at the superior aspect of the femoral neck, the lateral cortical bone just inferior to the greater trochanter, and the anterior intertrochanteric region. Results of this study support the idea that the spatial distribution of morphometric features is relevant to age-related changes in bone and independent to fracture risk. In women, the identification by TBM of fracture-specific morphometric alterations of the proximal femur, in conjunction with vBMD and clinical risk factors, may improve hip fracture prediction.
This paper references
Less white matter concentration in autism: 2D voxel-based morphometry
M. Chung (2004)
Relation between age, femoral neck cortical stability, and hip fracture risk
Paul M. Mayhew (2005)
Brain and behaviour in children with 22q11.2 deletion syndrome: a volumetric and voxel-based morphometry MRI study.
L. Campbell (2006)
A Statistical Model of Shape and Bone Mineral Density Distribution of the Proximal Femur for Fracture Risk Assessment
Tristan Whitmarsh (2011)
Local Tissue Growth Patterns Underlying Normal Fetal Human Brain Gyrification Quantified In Utero
V. Rajagopalan (2011)
Increasing sex difference in bone strength in old age: The Age, Gene/Environment Susceptibility-Reykjavik study (AGES-REYKJAVIK).
G. Sigurdsson (2006)
Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: An MRI study of 676 AD, MCI, and normal subjects
X. Hua (2008)
Bone fracture risk estimation based on image similarity.
W. Li (2009)
Male-female differences in the association between incident hip fracture and proximal femoral strength: a finite element analysis study.
J. Keyak (2011)
Proximal femoral density and geometry measurements by quantitative computed tomography: association with hip fracture.
X. Cheng (2007)
Voxel-Based Morphometry—The Methods
J. Ashburner (2000)
Cortical and Trabecular Bone Mineral Loss From the Spine and Hip in Long‐Duration Spaceflight
T. Lang (2004)
Deformable Registration of Prone and Supine Colons for CT Colonography
J.W. Suh (2006)
Population‐Based Study of Age and Sex Differences in Bone Volumetric Density, Size, Geometry, and Structure at Different Skeletal Sites
B. Riggs (2004)
Voxel-based morphometry—the methods. Neuroimage 2000;11:805–21
J Ashburner (2000)
Generalized Tensor-Based Morphometry of HIV/AIDS Using Multivariate Statistics on Deformation Tensors
N. Lepore (2008)
Proximal Femoral Structure and the Prediction of Hip Fracture in Men: A Large Prospective Study Using QCT
D. Black (2008)
Prediction of femoral fracture load using automated finite element modeling.
J. Keyak (1998)
Hip fracture risk estimation based on principal component analysis of QCT atlas: a preliminary study
Wenjun Li (2009)
Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics.
T. Harris (2007)
Age-related loss of proximal femoral strength in elderly men and women: the Age Gene/Environment Susceptibility Study--Reykjavik.
T. Lang (2012)
Mapping the regional influence of genetics on brain structure variability — A Tensor-Based Morphometry study
C. Brun (2009)
Thresholding of Statistical Maps in Functional Neuroimaging Using the False Discovery Rate
C. Genovese (2002)
Active Shape Modeling of the Hip in the Prediction of Incident Hip Fracture
Julie C. BAKER-LePAIN (2011)
Proximal femoral density distribution and structure in relation to age and hip fracture risk in women
J. Carballido-Gamio (2013)
Head size, age and gender adjustment in MRI studies: a necessary nuisance?
J. Barnes (2010)
Inaccuracy in self-report of fractures may underestimate association with health outcomes when compared with medical record based fracture registry
K. Siggeirsdottir (2007)
Multiscale image and multiscale deformation of brain anatomy for building average brain atlases
C. Studholme (2001)
Computerized tomography of proximal femoral trabecular patterns
R. Kerr (1986)
Male – female differences in the association between incident hip fracture and proximal femoral strength : a fi nite element analysis study
JH Keyak (2011)
Three‐dimensional anatomy of the cancellous structures within the proximal femur from computed tomography data
R. P. Elke (1995)
System for the analysis of whole-bone strength from helical CT images
J. Camp (2004)
Identify fracture-critical regions inside the proximal femur using statistical parametric mapping.
W. Li (2009)
Cortical Thickness Mapping to Identify Focal Osteoporosis in Patients with Hip Fracture
K. Poole (2012)
Non-parametric Diffeomorphic Image Registration with the Demons Algorithm
Tom Kamiel Magda Vercauteren (2007)
Detecting brain growth patterns in normal children using tensor‐based morphometry
X. Hua (2009)
Young-elderly differences in bone density, geometry and strength indices depend on proximal femur sub-region: a cross sectional study in Caucasian-American women.
M. Meta (2006)
Voxel-based morphometry of the human brain: Methods and applications
A. Mechelli (2005)
A computerized approach for morphological analysis of the corpus callosum.
C. Davatzikos (1996)
Changing structure of the femoral neck across the adult female lifespan
K. Poole (2010)
Assessment of the individual fracture risk of the proximal femur by using statistical appearance models.
B. Schuler (2010)
Distribution of cortical bone in the femoral neck and hip fracture: a prospective case-control analysis of 143 incident hip fractures; the AGES-REYKJAVIK Study.
F. Johannesdottir (2011)
Analysis of hip geometry by clinical CT for the assessment of hip fracture risk in elderly Japanese women.
M. Ito (2010)
Trabecular Bone Analysis in CT and X-Ray Images of the Proximal Femur for the Assessment of Local Bone Quality
K. Fritscher (2009)
Vessel Driven Correction of Brain Shift
I. Reinertsen (2004)

This paper is referenced by
Proksimal Femur Kırıklarında Demografik Ve Klinik Sonuçlar
A. Albayrak (2017)
Statistical Parametric Mapping of HR-pQCT Images: A Tool for Population-Based Local Comparisons of Micro-Scale Bone Features
J. Carballido-Gamio (2016)
Sex differences in the spatial distribution of bone in relation to incident hip fracture: Findings from the AGES-Reykjavik study.
E. Marques (2018)
Focal osteoporosis defects play a key role in hip fracture
K. Poole (2017)
A cross-sectional study on the age-related cortical and trabecular bone changes at the femoral head in elderly female hip fracture patients
Tristan Whitmarsh (2019)
Early dose-dependent cortical thinning of the femoral neck in anal cancer patients treated with pelvic radiation therapy.
C. Okoukoni (2017)
Automation of a DXA-based finite element tool for clinical assessment of hip fracture risk
Yunhua Luo (2018)
Patient-Specific Phantomless Estimation of Bone Mineral Density and Its Effects on Finite Element Analysis Results: A Feasibility Study
Y. Lee (2019)
Spatial Differences in the Distribution of Bone Between Femoral Neck and Trochanteric Fractures
Ai-hong Yu (2017)
Clinical Use of Quantitative Computed Tomography-Based Advanced Techniques in the Management of Osteoporosis in Adults: the 2015 ISCD Official Positions-Part III.
K. Engelke (2015)
Use Case V: Imaging Biomarkers in Musculoskeletal Disorders
Julio Carballido-Gamio (2017)
Bone fracture risk factors in prevalent hemodialysis patients
P. Matias (2019)
The Association of Vitamin D With Femoral Neck Strength: An Additional Evidence of Vitamin D on Bone Health.
H. Kim (2015)
Automatic multi-parametric quantification of the proximal femur with quantitative computed tomography.
J. Carballido-Gamio (2015)
Fracture Prediction by Computed Tomography and Finite Element Analysis: Current and Future Perspectives
Fjóla Jóhannesdóttir (2018)
Adaptation of Proximal Femur to Mechanical Loading in Young Adults: Standard Vs Localized Regions Evaluated by DXA.
Fátima Baptista (2018)
A two-level subject-specific biomechanical model for improving prediction of hip fracture risk.
Masoud Nasiri Sarvi (2015)
Axial QCT: clinical applications and new developments.
T. Link (2014)
Hip Fracture Discrimination Based on Statistical Multi-parametric Modeling (SMPM)
J. Carballido-Gamio (2019)
Segmentation of the Proximal Femur from MR Images using Deep Convolutional Neural Networks
C. Deniz (2018)
Relationship between Fetuin A, Vascular Calcification and Fracture Risk in Dialysis Patients
H. Y. Chen (2016)
The Association Between BMI and QCT‐Derived Proximal Hip Structure and Strength in Older Men: A Cross‐Sectional Study
J. Shen (2015)
Quantitative Computed Tomography (QCT) derived Bone Mineral Density (BMD) in finite element studies: a review of the literature
N. Knowles (2016)
Fully automated segmentation of a hip joint using the patient-specific optimal thresholding and watershed algorithm
J. Kim (2018)
Regional analysis of age-related local bone loss in the spine of a healthy population using 3D voxel-based modeling.
A. Valentinitsch (2017)
How does the femoral cortex depend on bone shape? A methodology for the joint analysis of surface texture and shape
A. Gee (2018)
Cortical Bone Assessed With Clinical Computed Tomography at the Proximal Femur
F. Johannesdottir (2014)
Cortical Bone Mapping: Measurement and Statistical Analysis of Localised Skeletal Changes
Graham M. Treece (2018)
Semantic Scholar Logo Some data provided by SemanticScholar