Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Primary Sensory Neurons Containing Choline Acetyltransferase Of The Peripheral Type In The Rat Trigeminal Ganglion And Their Relation To Neuropeptides-, Calbindin- And Nitric Oxide Synthase-containing Cells

O. Yasuhara, Y. Aimi, A. Shibano, H. Kimura
Published 2007 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
We have previously demonstrated that a variant form of choline acetyltransferase (pChAT) is expressed in rat trigeminal neurons. To assess the significance of pChAT in sensory functions, we characterized immunohistochemically pChAT-positive trigeminal neurons in the rat. pChAT-immunoreactivity was observed in a rather uniform pattern in about half of all trigeminal neurons throughout the trigeminal ganglion. The majority of pChAT-positive neurons had small to medium-sized cell bodies. Double immunofluorescent study showed that more than 90% of substance P (SP)-positive trigeminal cells and about 80% of calcitonin gene-related peptide (CGRP)-positive cells exhibited pChAT-immunoreactivity. pChAT-positive cells formed a larger population of neurons than SP-positive or CGRP-positive cells, but they were a different population from calbindin-D(28k)-positive neurons. In addition, pChAT-immunoreactivity was present in a subset of neurons positive for neuronal nitric oxide synthase. The present results suggest that pChAT plays roles not only in nociception, but also in other sensory functions such as mechanoreception mediating tactile sensation.
This paper references
Distribution of calcitonin gene-related peptide in the rat peripheral nervous system with reference to its coexistence with substance P
Y. Lee (1985)
Localization of NADPH‐diaphorase‐containing neurons in sensory ganglia of the rat
Y. Aimi (1991)
Calcitonin gene-related peptide coexists with substance P in capsaicin sensitive neurons and sensory ganglia of the rat
G. Skofitsch (1985)
Expression of peptides, nitric oxide synthase and NPY receptor in trigeminal and nodose ganglia after nerve lesions
X. Zhang (2004)
Nitric oxide synthase-containing neurons in rat parasympathetic, sympathetic and sensory ganglia: a comparative study
P. Alm (2004)
Role of nitric oxide in the autonomic innervation of smooth muscle.
P. Sneddon (1992)
Distribution and origin of calcitonin gene‐related peptide (CGRP) immunoreactivity in the sensory innervation of the mammalian eye
G. Terenghi (1985)
Non-myelinated afferent fibres do not originate exclusively from the smallest dorsal root ganglion cells in the cat
U. Hoheisel (1986)
Topographic study of the feline trigeminal ganglion via the horseradish peroxidase tracer method
S. Oyagi (1989)
Partial coexistence of neuropeptide Y and calbindin D28k in the trigeminal ganglion following peripheral axotomy of the inferior alveolar nerve in the rat
S. Wakisaka (1996)
Subpopulations of rat dorsal root ganglion neurons express active vesicular acetylcholine transporter
Ada Maria Tata (2004)
Topographic organization of peripheral trigeminal ganglionic projections in newborn rats.
B. Klein (1986)
VR1-immunoreactive primary sensory neurons in the rat trigeminal ganglion
H. Ichikawa (2001)
Monosynaptic circuitry of trigeminal proprioceptive afferents coordinating jaw movement with visceral and laryngeal activities in rats
J. Zhang (2005)
Parvalbumin, calretinin and carbonic anhydrase in the trigeminal and spinal primary neurons of the rat
H. Ichikawa (1994)
Immunoreactivity for substance P in the gasserian ganglion, ophthalmic nerve and anterior segment of the rabbit eye
K. Tervo (2005)
Acetylcholine synthesis by choline acetyltransferase of a peripheral type as demonstrated in adult rat dorsal root ganglion
J. Bellier (2007)
Two distinct calcitonin gene-related peptide-containing peripheral nervous systems: Distribution and quantitative differences between the iris and cerebral artery with special reference to substance P
T. Matsuyama (1986)
The somatotopic organization of the cat trigeminal ganglion as determined by the horseradish peroxidase technique
C. Marfurt (1981)
Immunohistochemical demonstration of choline acetyltransferase of a peripheral type (pChAT) in the enteric nervous system of rats
Kyoji Nakajima (2000)
Correlation of cell body size, axon size, and signal conduction velocity for individually labelled dorsal root ganglion cells in the cat
K. Lee (1986)
Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat
Z. Wiesenfeld‐Hallin (1984)
Evidence that two forms of choline acetyltransferase are differentially expressed in subclasses of enteric neurons
R. Chiocchetti (2002)
Innervation of rat iris by trigeminal and ciliary neurons expressing pChAT, a novel splice variant of choline acetyltransferase
O. Yasuhara (2004)
Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones.
A. Harper (1985)
Expression of a splice variant of choline acetyltransferase in magnocellular neurons of the tuberomammillary nucleus of rat
H. Kanayama (2003)
Immunohistochemical localization of choline acetyltransferase of a peripheral type in the rat larynx
Y. Nakanishi (1999)
Neuronal NADPH diaphorase is a nitric oxide synthase.
B. Hope (1991)
Calbindin-28k-immunoreactivity in the trigeminal ganglion neurons and molar tooth pulp of the rat
H. Ichikawa (1996)
Innervation of monkey extraocular muscles: Localization of sensory and motor neurons by retrograde transport of horseradish peroxidase
J. Porter (1983)
Calretinin-containing neurons which co-express parvalbumin and calbindin D-28k in the rat spinal and cranial sensory ganglia; triple immunofluorescence study
H. Ichikawa (2005)
Coexistence of calcitonin gene-related peptide and substance P-like peptide in single cells of the trigeminal ganglion of the rat: immunohistochemical analysis
Y. Lee (1985)
Presence of neuronal nitric oxide synthase in autonomic and sensory ganglion neurons innervating the lacrimal glands of the cat: an immunofluorescent and retrograde tracer double-labeling study
Shi-Bin Cheng (2001)
Primary sensory neurons of the rat showing calcitonin gene-related peptide immunoreactivity and their relation to substance P-, somatostatin-, galanin-, vasoactive intestinal polypeptide- and cholecystokinin-immunoreactive ganglion cells
G. Ju. (2004)
A protein encoded by an alternative splice variant of choline acetyltransferase mRNA is localized preferentially in peripheral nerve cells and fibers
I. Tooyama (2000)
Distribution of NADPH-Diaphorase and Nitric Oxide Synthase in the Trigeminal Ganglion and Mesencephalic Trigeminal Nucleus of the Cat
N. Lazarov (1998)
Demonstration of Choline Acetyltransferase of a Peripheral Type in the Rat Heart
O. Yasuhara (2007)
Demonstration of Cholinergic Ganglion Cells in Rat Retina: Expression of an Alternative Splice Variant of Choline Acetyltransferase
O. Yasuhara (2003)
Choline acetyltransferase-like immunoreactivity in small diameter neurones of the rat dorsal root ganglion
H. Sann (1995)

This paper is referenced by
Mechanisms and Treatments of Dry SkinInduced itch
A. Kamo (2017)
Axotomy alters alternative splicing of choline acetyltransferase in the rat dorsal motor nucleus of the vagus nerve
Atsushi Saito (2009)
5‐HT1D Receptor Immunoreactivity in the Sphenopalatine Ganglion: Implications for the Efficacy of Triptans in the Treatment of Autonomic Signs Associated With Cluster Headache
J. Ivanusic (2011)
Expression of choline acetyltransferase of the peripheral type in the primary sensory neurons of the guinea pig trigeminal ganglion.
Mohamed Abdel Aleem Elnasharty (2014)
Peripheral type of choline acetyltransferase: Biological and evolutionary implications for novel mechanisms in cholinergic system
J. Bellier (2011)
Expression and localization of pChAT as a novel method to study cholinergic innervation of rat adrenal gland.
M. A. Elnasharty (2014)
Peripheral choline acetyltransferase in rat skin demonstrated by immunohistochemistry
K. Hanada (2012)
Distinct Localization of Peripheral and Central Types of Choline Acetyltransferase in the Rat Cochlea
T. Kitanishi (2013)
Distribution of a splice variant of choline acetyltransferase in the trigeminal ganglion and brainstem of the rat: Comparison with calcitonin gene‐related peptide and substance P
O. Yasuhara (2008)
Nitroxidergic system in human trigeminal ganglia neurons: a quantitative evaluation.
E. Borsani (2010)
A Novel Antiserum Against a Predicted Human Peripheral Choline Acetyltransferase (hpChAT) for Labeling Neuronal Structures in Human Colon
J. Bellier (2019)
Semantic Scholar Logo Some data provided by SemanticScholar