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Morphological Changes Of The Cerebral Cortex Between Children With Isolated Growth Hormone Deficiency And Idiopathic Short Stature

Zhonghe Zhang, Yu Wang, S. Liu
Published 2020 · Biology, Medicine

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The growth hormone (GH)-insulin-like growth factor-I (IGF-I) axis plays an important role in normal brain development, and GH deficiency inevitably affects the growth of the cerebral cortex. This study was designed to analyze morphological differences in gray matter volume, cortical surface area, and gray matter thickness between children with isolated growth hormone deficiency (IGHD) and children with idiopathic short stature (ISS). Twenty-four children with IGHD (mean age 9.42 years, peak GH < 5 μg/l) and 24 controls with ISS (mean age 9.21 years, peak GH > 10 μg/l) were included. High-resolution three-dimensional T1-weighted MRIs were acquired at participants' first visit. Measurements of gray matter volume, cortical surface area and gray matter thickness were obtained using FreeSurfer. The total and regional differences between groups were statistically analyzed. Correlations between the FreeSurfer results and GH and IGF-I levels were also obtained. The gray matter volume, cortical surface area and gray matter thickness of the total brain and of the bilateral hemispheres of children with IGHD were significantly smaller than those of children with ISS (all P values<0.05). All the measurements had similar cortical distributions between groups but varied across regions. Cortical regions with significant differences in the mean gray matter volume and surface area were mainly distributed around the bilateral central sulci and the lateral and basal parts of the temporal lobes (all P values<0.05). There were negative correlations between gray matter volume, cortical surface area and GH levels, and the right hemispheric and total cortical surface area correlated significantly with GH levels (all P values<0.05) in children with IGHD. There were significant positive correlations between gray matter volume, cortical surface area and IGF-I levels (all P values<0.05) in both groups, except for in left hemispheric gray matter volume in children with ISS. Children with IGHD have significant morphological changes in the cerebral cortex, which were partially influenced by GH and IGF-I levels. These cortical changes may be related to deficits in their relatively slower development in intelligence, motor performance, and other functions.
This paper references
Growth Hormone (GH) Therapy During the Transition Period: Should We Think about Early Retesting in Patients with Idiopathic and Isolated GH Deficiency?
L. Penta (2019)
Differences in the functional connectivity density of the brain between individuals with growth hormone deficiency and idiopathic short stature
Yu-min Hu (2019)
Sexual dimorphism in the growth hormone and insulin-like growth factor axis at birth.
M. Geary (2003)
Treatment of Children With GH in the United States and Europe: Long-Term Follow-Up From NordiNet® IOS and ANSWER Program
L. Sävendahl (2019)
Growth hormone and IGF-I modulate local cerebral glucose utilization and ATP levels in a model of adult-onset growth hormone deficiency.
W. Sonntag (2006)
Patterns of Insulin‐like Growth Factor and IGF Receptor Gene Expression in the Brain: Functional Implications
C. Bondy (1993)
Unique developmental trajectories of cortical thickness and surface area
Lara M. Wierenga (2014)
Effects of Growth Hormone Substitution Therapy on Cognitive Functioning in Growth Hormone Deficient Patients: A Functional MRI Study
L. Arwert (2006)
Unified univariate and multivariate random field theory
K. Worsley (2004)
A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions
Y. Liu (2017)
Serum insulin‐like growth factor‐I and amyloid beta protein in Alzheimer's disease: relationship with cognitive function
Ayako Kimoto (2016)
Measuring the thickness of the human cerebral cortex from magnetic resonance images.
B. Fischl (2000)
The effects of growth hormone (GH) deficiency and GH replacement on cognitive performance in adults: A meta-analysis of the current literature
M. Falleti (2006)
Growth hormone, insulin-like growth factor-1 and the aging brain
N. Ashpole (2015)
Growth hormone is produced within the hippocampus where it responds to age, sex, and stress.
C. Donahue (2006)
Growth Hormone Treatment Improves Cognitive Function in Short Children with Growth Hormone Deficiency
J. Chaplin (2015)
A model of brain morphological changes related to aging and Alzheimer's disease from cross-sectional assessments
R. Sivera (2019)
Normal development of the pituitary gland: assessment with three-dimensional MR volumetry.
K. Takano (1999)
Alterations in Cortical Thickness in Young Male Patients With Childhood-Onset Adult Growth Hormone Deficiency: A Morphometric MRI Study
H. Yang (2019)
Association of Insulin-like Growth Factor I and Insulin-like Growth Factor–Binding Protein-3 With Intelligence Quotient Among 8- to 9-Year-Old Children in the Avon Longitudinal Study of Parents and Children
D. Gunnell (2005)
Psychological Aspects in Children and Adolescents with Hypopituitarism
H. Frisch (1990)
IGF-I specifically enhances axon outgrowth of corticospinal motor neurons
P. H. Özdinler (2006)
Diffusion Tensor Imaging Identifies Deficits in White Matter Microstructure in Subjects With Type 1 Diabetes That Correlate With Reduced Neurocognitive Function
C. Kodl (2008)
Academic achievement and psychological adjustment in short children. The National Cooperative Growth Study.
B. Stabler (1994)
Effect of growth hormone deficiency on brain structure, motor function and cognition.
E. Webb (2012)
Cognitive changes during growth hormone replacement in adult men
J. B. Deijen (1998)
Growth Hormone Deficiency and Memory Functioning in Adults Visualized by Functional Magnetic Resonance Imaging
L. Arwert (2005)
Age-related reduction of human growth hormone-binding sites in the human brain
Z. Lai (1993)
Measures of pituitary gland and stalk: from neonate to adolescence
S. Sari (2014)
MRI features of growth hormone deficiency in children with short stature caused by pituitary lesions
Chao Xu (2017)
Brain structure differences between Chinese and Caucasian cohorts: A comprehensive morphometry study
Y. Tang (2018)
Construction of population-specific Indian MRI brain template: Morphometric comparison with Chinese and Caucasian templates.
Gaurav Vivek Bhalerao (2018)
The pleotrophic effects of insulin-like growth factor-I on human spinal cord neural progenitor cells.
J. Lunn (2010)
Insulin‐like growth factor‐I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats
J. Pardo (2016)
Grey matter differences associated with age and sex hormone levels between premenopausal and perimenopausal women: A voxel‐based morphometry study
W. Lu (2018)
Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene.
K. Woods (1996)
Regional contraction of brain surface area involves three large-scale networks in schizophrenia
L. Palaniyappan (2011)
The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity
A. Dyer (2016)

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