Online citations, reference lists, and bibliographies.
← Back to Search

Task-dependent Differences In Corticobulbar Excitability Of The Submental Motor Projections: Implications For Neural Control Of Swallowing

S. Doeltgen, M. Ridding, J. Dalrymple-Alford, Maggie-Lee Huckabee
Published 2011 · Medicine, Chemistry

Save to my Library
Download PDF
Analyze on Scholarcy
It has been suggested that the primary motor cortex plays a substantial role in the neural circuitry that controls swallowing. Although its role in the voluntary oral phase of swallowing is undisputed, its precise role in motor control of the more reflexive, pharyngeal phase of swallowing is unclear. The contribution of the primary motor cortex to the pharyngeal phase of swallowing was examined using transcranial magnetic stimulation (TMS) to evoke motor evoked potentials (MEPs) in the anterior hyomandibular muscle group during either volitional submental muscle contraction or contraction during the pharyngeal phase of both volitionally, and reflexively, initiated swallowing. For each subject, in all three conditions, TMS was triggered when submental surface EMG (sEMG) reached 75% of the mean maximal submental sEMG amplitude measured during 10 volitional swallows. MEPs recorded during volitional submental muscle contraction were elicited in 22 of the 35 healthy subjects examined (63%). Only 16 of these 22 subjects (45.7%) also displayed MEPs recorded during volitional swallowing, but their MEP amplitudes were larger when triggered by submental muscle contraction than when triggered by volitional swallowing. Additionally, only 7 subjects (of 19 tested) showed MEPs triggered by submental muscle contraction during a reflexively triggered pharyngeal swallow. These differences indicate differing levels of net M1 excitability during execution of the investigated tasks, possibly brought about by task-dependent changes in the balance of excitatory and inhibitory neural activity.
This paper references
Motor-evoked potentials in masseter muscle by electrical and magnetic stimulation in intact alert man.
G. Macaluso (1990)
Dissociation of the pathways mediating ipsilateral and contralateral motor‐evoked potentials in human hand and arm muscles
U. Ziemann (1999)
Brain stem control of swallowing: neuronal network and cellular mechanisms.
A. Jean (2001)
Sensorimotor modulation of human cortical swallowing pathways
S. Hamdy (1998)
Discrete functional contributions of cerebral cortical foci in voluntary swallowing: a functional magnetic resonance (fMRI) " Go, No-Go " study, Exp
J A Toogood (2005)
Driving Plasticity in Human Adult Motor Cortex Is Associated with Improved Motor Function after Brain Injury
C. Fraser (2002)
Cortical Control Mechanisms in Volitional Swallowing: The Bereitschaftspotential
Maggie-Lee Huckabee (2004)
Brain stemcontrol of swallowing : neuronal network and cellularmechanisms
A. Jean (2001)
Significance of sensory inflow to the swallowing reflex.
A. Miller (1972)
Stimulation of the human motor cortex through the scalp
J. Rothwell (1991)
Swallow-related cerebral cortical activity maps are not specific to deglutition.
M. Kern (2001)
Improved reproducibility of magnetic stimulation-evoked motor potentials in the human masseter by a new method for locating stimulation sites on the scalp.
A. McMillan (1998)
Evidence for Direct Connections between the Hand Region of the Supplementary Motor Area and Cervical Motoneurons in the Macaque Monkey
E. Rouiller (1996)
Activation of cerebellumandbasal ganglia onvolitional swallowingdetectedby functionalmagnetic resonance imaging
J. A. Toogood (2003)
Cerebral cortical representation of reflexive and volitional swallowing in humans.
M. Kern (2001)
Facilitation of responses to motor cortex stimulation: Effects of isometric voluntary contraction
A. de Noordhout (1992)
Role of primary sensorimotor cortex and supplementary motor area in volitional swallowing: a movement-related cortical potential study.
T. Satow (2004)
Cerebral areas processing swallowing and tongue movement are overlapping but distinct: a functional magnetic resonance imaging study.
R. Martin (2004)
The assessment and analysis of handedness: the Edinburgh inventory.
R. Oldfield (1971)
Cortical activation during human volitional swallowing: an event-related fMRI study.
S. Hamdy (1999)
Functional organization of the trigeminal motor system in man. A neurophysiological study.
G. Cruccu (1989)
Activation of Cerebellum and Basal Ganglia on Volitional Swallowing Detected by Functional Magnetic Resonance Imaging
M. Suzuki (2003)
Volume accommodation during swallowing
P. Kahrilas (2005)
Cerebral cortical representation of automatic and volitional swallowing in humans.
R. Martin (2001)
Discrete functional contributions of cerebral cortical foci in voluntary swallowing: a functional magnetic resonance imaging (fMRI) “Go, No-Go” study
Jillian A. Toogood (2004)
Test–retest reliability of motor evoked potentials (MEPs) at the submental muscle group during volitional swallowing
S. Doeltgen (2009)
Inhibition in the human motor cortex is reduced just before a voluntary contraction
C. Reynolds (1999)
Reliability of transcranial magnetic stimulation for mapping swallowing musculature in the human motor cortex
E. K. Plowman-Prine (2008)
A safety screening questionnaire for transcranial magnetic stimulation
J. Keel (2001)
Unilateral suppression of pharyngeal motor cortex to repetitive transcranial magnetic stimulation reveals functional asymmetry in the hemispheric projections to human swallowing
S. Mistry (2007)

This paper is referenced by
The effect of swallowing treatments on corticobulbar excitability: A review of transcranial magnetic stimulation induced motor evoked potentials
Phoebe R. Macrae (2014)
Anodal transcranial direct current stimulation and intermittent theta‐burst stimulation improve deglutition and swallowing reproducibility in elderly patients with dysphagia
G. Cosentino (2020)
The role of the primary motor cortex (M1) in volitional and reflexive pharyngeal swallowing.
Aamir K. Al-Toubi (2013)
Electroacupuncture Involved in Motor Cortex and Hypoglossal Neural Control to Improve Voluntary Swallowing of Poststroke Dysphagia Mice
Shuai Cui (2020)
Age and gender effects on submental motor-evoked potentials
Oshrat Sella (2014)
Cerebral Cortical Control of Deglutition
D. Vasant (2013)
Effects of olfactory and gustatory stimuli on the biomechanics of swallowing
Norsila Abdul Wahab (2011)
Transcranial Direct Current Stimulation Enhances Sucking of a Liquid Bolus in Healthy Humans
G. Cosentino (2014)
Pharyngeal pressure differences between four types of swallowing in healthy participants
Aamir K. Al-Toubi (2015)
Modulation of swallowing behaviour by olfactory and gustatory stimulation
Norsila Abdul Wahab (2012)
Skill versus Strength in Swallowing Training: Neurophysiological, Biomechanical, and Structural Assessments
Oshrat Sella (2012)
Influence of CO₂ on upper airway muscles and chest wall/diaphragm corticomotor responses assessed by transcranial magnetic stimulation in awake healthy subjects.
Jean-Christian Borel (2012)
Reliability of surface electromyography measurements from the suprahyoid muscle complex
M. Kothari (2017)
Diaphragm and genioglossus corticomotor excitability in patients with obstructive sleep apnea and control subjects
Jean-Christian Borel (2016)
Change in Excitability of Cortical Projection After Modified Catheter Balloon Dilatation Therapy in Brainstem Stroke Patients with Dysphagia: A Prospective Controlled Study
X. Wei (2017)
Semantic Scholar Logo Some data provided by SemanticScholar