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A Method For Top Down Preparation Of Chitosan Nanoparticles And Nanofibers.
Ruchira N. Wijesena, N. Tissera, Yasun Y. Kannangara, Yuan Lin, Gehan A.J. Amaratunga, K. de Silva
Published 2015 · Medicine, Chemistry
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A method of top down preparation of chitosan nanoparticles and nanofibers is proposed. Chitin nanofibrils (chitin NFs) were prepared using ultrasonic assisted method from crab shells with an average diameter of 5 nm and the length less than 3 μm as analyzed by atomic force microscopy and transmission electron microscopy. These chitin nanofibers were used as the precursor material for the preparation of chitosan nanoparticles and nanofibers. The degree of deacetylation of these prepared chitosan nanostructures were found to be approximately 98%. In addition these chitosan nanostructures showed amorphous crystallinity. Transmission electron microscopic studies revealed that chitosan nanoparticles were roughly spherical in nature and had diameters less than 300 nm. These larger particles formed through self-assembly of much smaller 25 nm particles as evidenced by the TEM imaging. The diameter and the length of the chitosan nanofibers were found to be less than 100 nm and 3 μm respectively. It is envisaged that due to the cavitation effect, the deacetylated chitin nanofibers were broken down to small pieces to form seed particles. These seed particles can then be self-assembled to form larger chitosan nanoparticles.
This paper references
Determination of the degree of deacetylation of chitin and chitosan by X-ray powder diffraction.
Y. Zhang (2005)
Structure and mechanical properties of crab exoskeletons.
P. Chen (2008)
Improved method for i.r. determination of the degree of N-acetylation of chitosan
A. Baxter (1992)
Direct chitosan nanoscaffold formation via chitin whiskers
Sasiprapha Phongying (2007)
Individual chitin nano-whiskers prepared from partially deacetylated α-chitin by fibril surface cationization
Y. Fan (2010)
Genetic toxicity and carcinogenicity studies of Kathon ®
S. L. Longacre (1997)
X-Ray Diffraction Studies of Chitin, Chitosan and Their Derivatives
Waldemar Maniukiewicz (2010)
Improved method for i.r
A. Baxter (1992)
Ultrasonic technique for extracting nanofibers from nature materials
Hong-ping Zhao (2007)
Biomaterials based on chitin and chitosan in wound dressing applications.
R. Jayakumar (2011)
Chitosan-based drug nanocarriers: where do we stand?
M. Garcia-Fuentes (2012)
Fabrication and characterisation of α-chitin nanofibers and highly transparent chitin films by pulsed ultrasonication.
Y. Lu (2013)
Structure and Mechanical Properties
N. Stephens (1987)
Chitosan colloidal suspension composed of mechanically disassembled nanofibers.
D. Liu (2011)
Influence of tip size on AFM roughness measurements
Dana L. Sedin (2001)
Chitosan-sheath and chitin-core nanowhiskers.
A. G. Pereira (2014)
Depolymerization of Chitin and Chitosan under Hydrothermal Conditions.
K. Sato (2003)
Isolation and Characterization of Cellulose Nanofibers from Bambusa rigida
W. He (2013)
The mechanism of cavitation-induced scission of single-walled carbon nanotubes.
F. Hennrich (2007)
Depolymerization of chitin and chitosan in the course of base deacetylation
E. N. Chebotok (2006)
Chitin and chitosan polymers: Chemistry, solubility and fiber formation
C. K. S. Pillai (2009)
Genetic toxicity and carcinogenicity studies of glutaraldehyde--a review.
E. Zeiger (2005)
A novel polyacrylamide nanocomposite hydrogel reinforced with natural chitosan nanofibers.
Chengjun Zhou (2011)
A facile bottom-up route to self-assembled biogenic chitin nanofibers
C. Zhong (2010)
Chitosan-based nanostructures: a delivery platform for ocular therapeutics.
M. de la Fuente (2010)
Heterogeneous N-deacetylation of chitin in alkaline solution
K. Chang (1997)
The crustacean exoskeleton as an example of a structurally and mechanically graded biological nanocomposite material
D. Raabe (2005)
Preparation of chitin nanofibers with a uniform width as alpha-chitin from crab shells.
Shinsuke Ifuku (2009)
Novel Process for Isolating Fibrils from Cellulose Fibers by High-Intensity Ultrasonication. II. Fibril Characterization
Qingzheng Cheng (2010)
Nanotechnology: The “Top‐Down” and “Bottom‐Up” Approaches
Parvez Iqbal (2012)
Scission of electrospun polymer fibres by ultrasonication
M. Sawawi (2013)
Sonofragmentation of molecular crystals.
Brad W. Zeiger (2011)
Biomedical Exploitation of Chitin and Chitosan via Mechano-Chemical Disassembly, Electrospinning, Dissolution in Imidazolium Ionic Liquids, and Supercritical Drying
R. Muzzarelli (2011)
Preparation of chitin nanofibers from squid pen beta-chitin by simple mechanical treatment under acid conditions.
Y. Fan (2008)
10.06 – Nanochitins and Nanochitosans, Paving the Way to Eco-Friendly and Energy-Saving Exploitation of Marine Resources
R.A.A. Muzzarelli (2012)
Chitin characterization by SEM, FTIR, XRD, and 13C cross polarization/mass angle spinning NMR
G. Cárdenas (2004)
Chitosan nanoparticles: a survey of preparation methods
A. Grenha (2012)
Chitosan based nanofibers, review
M. Elsabee (2012)
Effect of the chelating agent sodium tripolyphosphate on cadmium toxicity in mice.
O. Andersen (1982)
Comparative characterization of aqueous dispersions and cast films of different chitin nanowhiskers/nanofibers.
Y. Fan (2012)
Simple preparation method of chitin nanofibers with a uniform width of 10–20 nm from prawn shell under neutral conditions
S. Ifuku (2011)
Novel chitin and chitosan nanofibers in biomedical applications.
R. Jayakumar (2010)
Self-assembled liquid crystal film from mechanically defibrillated chitosan nanofibers
Dagang Liu (2011)
Chitosan-based nanomaterials: a state-of-the-art review.
S. K. Shukla (2013)
Water-solubility of chitosan and its antimicrobial activity
Caiqin Qin (2006)
This paper is referenced by
Preparation and Characterization of Nano Chitosan from Crab Shell Waste by Beads-milling Method
E. Rochima (2017)
Synthesis of chitin nanofibers, MWCNTs and MnO2 nanoflakes 3D porous network flexible gel-film for high supercapacitive performance electrodes
Shengnan Liu (2017)
A biopolymeric nano-receptor for sensitive and selective recognition of albendazole
Juhi Srivastava (2016)
Coloration of cotton fibers using nano chitosan.
Ruchira N. Wijesena (2015)
Pharmaceutical Amorphous Nanoparticles.
Rajan Jog (2017)
Colloidal stability of chitin nanofibers in aqueous systems: Effect of pH, ionic strength, temperature & concentration.
R. N. Wijesena (2020)
Smart Polymeric Nanoparticles for Cancer Gene Delivery
Guimei Lin (2015)
Chitosan coated silk fibroin surface modified by atmospheric dielectric-barrier discharge (DBD) plasma: a mechanically robust drug release system
Namita Ojah (2019)
Self-bonded composite films based on cellulose nanofibers and chitin nanocrystals as antifungal materials.
Eduardo Robles (2016)
Chitosan nanoparticles as a biocompatible and efficient nanowagon for benzyl isothiocyanate.
Shivani Uppal (2018)
Improving Dyeing Properties of Cotton Fabrics to Natural Dyes via Cationization and Nano Chitosan Treatments
A top-down approach to improve collagen film's performance: The comparisons of macro, micro and nano sized fibers.
Yunhao Ma (2019)
Seafood waste: a source for preparation of commercially employable chitin/chitosan materials
Monika Yadav (2019)
Renewable chitin based nanomaterials from fungi
W. Nawawi (2016)
Emerging Biomedical Applications of Nano-Chitins and Nano-Chitosans Obtained via Advanced Eco-Friendly Technologies from Marine Resources
R. Muzzarelli (2014)
In Vitro and In Silico Studies of Chitin and Chitosan Based Nanocarriers for Curcumin and Insulin Delivery
S. Dhanasekaran (2018)
Extraction of Nanochitin from Marine Resources and Fabrication of Polymer Nanocomposites: Recent Advances
Blessy Joseph (2020)
Fundamentals of chitosan for biomedical applications
E. Vunain (2017)
Surface-initiated ring-opening metathesis polymerization (SI-ROMP) to attach a tethered organic corona onto CdSe/ZnS core/shell quantum dots
Fatma Vatansever (2016)
In-situ formation of supramolecular aggregates between chitin nanofibers and silver nanoparticles.
Ruchira N. Wijesena (2017)
The dispersion of fine chitosan particles by beads-milling
E. Rochima (2018)
Shape-stabilization of polyethylene glycol phase change materials with chitin nanofibers for applications in "smart" windows.
R. Wijesena (2020)
Preparation of Hybrid Chitosan/Silica Composites Via Ionotropic Gelation and Its Electrochemical Impedance Studies
Iling Aema Wonnie Ma (2020)
Preparation and characterization of individual chitin nanofibers with high stability from chitin gels by low-intensity ultrasonication for antibacterial finishing
Haizhong Zou (2017)
Biological synthesis of metallic nanoparticles: plants, animals and microbial aspects
R. K. Das (2017)
Nanoedible films for food packaging: a review
Jeya Jeevahan (2019)
Development of Polyelectrolyte Complex Nanoparticles-PECNs Loaded with Ampicillin by Means of Polyelectrolyte Complexation and Ultra-High Pressure Homogenization (UHPH)
Nicolle Montero (2020)
Nano-MgO reinforced chitosan nanocomposites for high performance packaging applications with improved mechanical, thermal and barrier properties.
R. D. De Silva (2017)
Natural polysaccharides leading to super adsorbent hydroxyapatite nanoparticles for the removal of heavy metals and dyes from aqueous solutions
D. C. Manatunga (2016)
Eco-Friendly, Green Packaging Materials from Akaganeite and Hematite Nanoparticle-Reinforced Chitosan Nanocomposite Films
G. Chandrakumara (2019)
Chitin nanofibers as versatile bio-templates of zeolitic imidazolate frameworks for N-doped hierarchically porous carbon electrodes for supercapacitor
Zhen Shang (2021)
Effects of chitin nano-whiskers on the antibacterial and physicochemical properties of maize starch films.
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