Online citations, reference lists, and bibliographies.
← Back to Search

Deacetylation Affects The Physical Properties And Bioactivity Of Acemannan, An Extracted Polysaccharide From Aloe Vera.

Jaroenporn Chokboribal, Wanpen Tachaboonyakiat, P. Sangvanich, Vithaya Ruangpornvisuti, Suwimon Jettanacheawchankit, P. Thunyakitpisal
Published 2015 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Acemannan, an acetylated polymannose from Aloe vera, induces tissue repair. We investigated the role of acemannan's acetyl-groups on its physical and biological properties. Deacetylated acemannan (DeAcAM) was prepared and characterized. The physical properties and microscopic structure of DeAcAM were evaluated using water solubility, contact angle, X-ray diffraction, and scanning-electron microscopy. The activity of DeAcAM on cell proliferation and gene expression were assessed. Acemannan and DeAcAM structures were simulated and the acemannan tetramer diad and its completely deacetylated structure were also determined. Increased acemannan deacetylation reduced its water solubility and hydrophilicity. Complete deacetylation altered acemannan's conformation to a partial crystal structure. The bioactivity of acemannan was reduced corresponding to its deacetylation. Acemannan induced cell proliferation, and VEGF and Collagen I expression; however, 100% DeAcAM did not. The simulated structures of the acemannan diad and the completely deacetylated diad were different. We conclude acetyl-groups affect acemannan's structure and physical/biological properties.
This paper references
10.1016/J.IJPHARM.2005.11.019
Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan.
K. C. Dos Santos (2006)
10.1016/j.carbpol.2012.05.029
Mass spectrometry characterization of an Aloe vera mannan presenting immunostimulatory activity.
J. Simões (2012)
10.1016/J.GENE.2005.09.010
Acetylation and deacetylation of non-histone proteins.
M. Glozak (2005)
10.1016/S0731-7085(03)00155-9
A validated 1H NMR method for the determination of the degree of deacetylation of chitosan.
M. Lavertu (2003)
10.1016/j.ijbiomac.2014.08.013
Recognization of receptors on bone marrow-derived dendritic cells bound with Pholiota nameko polysaccharides.
H. Li (2015)
10.11223/JARDE.4.149
Effect of acemannan on BMP-2 expression in primary pulpal fibroblasts and periodontal fibroblasts, in vitro study
N. Jittapiromsak (2007)
10.3892/ijo.2012.1728
HGF regulates VEGF expression via the c-Met receptor downstream pathways, PI3K/Akt, MAPK and STAT3, in CT26 murine cells.
A. Matsumura (2013)
10.1016/J.FOODHYD.2013.04.009
Effect of deacetylation on the glucomannan gelation process for making restructured seafood products
Beatriz Solo-de-Zaldívar (2014)
10.1074/jbc.M111.244780
The Acetylase/Deacetylase Couple CREB-binding Protein/Sirtuin 1 Controls Hypoxia-inducible Factor 2 Signaling*
R. Chen (2012)
10.1016/0192-0561(94)00102-T
Nitric oxide production by chicken macrophages activated by Acemannan, a complex carbohydrate extracted from Aloe vera.
K. Karaca (1995)
10.1038/359843A0
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
D. Shweiki (1992)
10.1016/S1567-5769(01)00052-2
Acemannan purified from Aloe vera induces phenotypic and functional maturation of immature dendritic cells.
J. Lee (2001)
10.1034/J.1600-0757.2000.2220104.X
Biology of wound healing.
I. Aukhil (2000)
10.1152/PHYSREV.00031.2003
Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading.
M. Kjaer (2004)
10.1016/j.jss.2008.04.023
The role of vascular endothelial growth factor in wound healing.
Philip Bao (2009)
10.1158/0008-5472.CAN-03-2581
Loss of Vascular Endothelial Growth Factor A Activity in Murine Epidermal Keratinocytes Delays Wound Healing and Inhibits Tumor Formation
H. Rossiter (2004)
10.1111/jre.12090
Acemannan sponges stimulate alveolar bone, cementum and periodontal ligament regeneration in a canine class II furcation defect model.
P. Chantarawaratit (2014)
10.1046/J.1523-1747.2001.14071.X
A mannose-binding receptor is expressed on human keratinocytes and mediates killing of Candida albicans.
G. Szolnoky (2001)
10.1093/NAR/6.3.967
Fluctuations in superhelical DNA.
A. Vologodskii (1979)
10.1254/JPHS.08204FP
Acemannan stimulates gingival fibroblast proliferation; expressions of keratinocyte growth factor-1, vascular endothelial growth factor, and type I collagen; and wound healing.
Suwimon Jettanacheawchankit (2009)
10.1016/J.INTIMP.2004.07.004
Evaluation and comparison of commercially available Aloe vera L. products using size exclusion chromatography with refractive index and multi-angle laser light scattering detection.
C. Turner (2004)
10.1016/S0144-8617(98)00163-5
Compositional features of polysaccharides from Aloe vera (Aloe barbadensis Miller) plant tissues
A. Femenia (1999)
10.1016/S1543-1150(03)00005-X
A review on the relationship between aloe vera components and their biologic effects
S. Choi (2003)
10.1002/JCC.540100208
Optimization of parameters for semiempirical methods I. Method
J. J. Stewart (1989)
10.3390/molecules13030490
Synthesis and Characterization of KonjacGlucomannan-Graft-Polyacrylamide via γ-Irradiation
Zhenlin Xu (2008)
10.1016/J.CARBPOL.2003.07.009
Study on antimicrobial activity of chitosan with different molecular weights
lian-ying Zheng (2003)
10.1016/J.CARRES.2005.02.016
Chemical characterization of the immunomodulating polysaccharide of Aloe vera L.
Jimmy Tai-Nin Chow (2005)
10.1016/j.gde.2013.10.013
Supercoiling in DNA and chromatin☆
N. Gilbert (2014)
10.1016/j.bioorg.2014.03.010
Chemical biology of peptidoglycan acetylation and deacetylation.
P. Moynihan (2014)



This paper is referenced by
10.1007/s10570-019-02419-8
Development, characterization, and biological assessment of biocompatible cellulosic wound dressing grafted Aloe vera bioactive polysaccharide
F. Salah (2019)
10.1080/00914037.2018.1525535
Bio-hybrid acrylic hydrogels containing metronidazole – loaded poly(acrylic acid-co-methyl methacrylate) nanoparticles and Aloe vera as natural healing agent
Katarzyna Bialik-Wąs (2019)
10.1007/s11694-016-9320-5
Development and characterization of reconstituted hydrogel from Aloe vera (Aloe barbadensis Miller) powder
P. Kiran (2016)
10.1080/10942912.2016.1168436
Viscoelastic behavior of reconstituted Aloe vera hydrogels as a function of concentration and temperature
P. Kiran (2017)
10.1016/j.carbpol.2018.03.044
Polyelectrolyte complex of Aloe vera, chitosan, and alginate produced fibroblast and lymphocyte viabilities and migration.
R. Gallardo-Rivera (2018)
10.1016/J.ULTSONCH.2019.03.030
Application of thermosonication for Aloe vera (Aloe barbadensis Miller) juice processing: Impact on the functional properties and the main bioactive polysaccharides.
Guadalupe Alvarado-Morales (2019)
solation , purification , characterization and immunostimulatory ctivity of polysaccharides derived from American ginseng iao
- Hong Yu (2016)
10.18002/10612/5551
Prevalencia y caracterización clínico-lesional de los principales procesos infecciosos de etiología vírica que afectan a las colonias de gatos callejeros en Madrid capital
B. Conde (2016)
10.26717/bjstr.2019.16.002873
Aloe Vera Extracted Polysaccharides Shift the Immune Responses of Tumor Bearing Mice Toward Th1 Pattern: Animal Study
Mohammad Hossein Yazdi (2019)
10.1016/j.carbpol.2017.03.087
Effect of different drying procedures on the bioactive polysaccharide acemannan from Aloe vera (Aloe barbadensis Miller).
R. Minjares-Fuentes (2017)
10.1016/j.carbpol.2018.12.003
Role of acemannan O-acetyl group in murine radioprotection.
S. Kumar (2019)
10.3390/ijms21176250
DoRWA3 from Dendrobium officinale Plays an Essential Role in Acetylation of Polysaccharides
Can Si (2020)
10.3389/fpls.2019.00512
Detection of Seasonal Variation in Aloe Polysaccharides Using Carbohydrate Detecting Microarrays
L. Ahl (2019)
10.1155/2017/4856412
Could We Really Use Aloe vera Food Supplements to Treat Diabetes? Quality Control Issues
S. Habtemariam (2017)
10.1016/J.FOODHYD.2017.06.039
Polysaccharide from leaf skin of Aloe barbadensis Miller: Part I. Extraction, fractionation, physicochemical properties and structural characterization
Xiao-dan Shi (2017)
10.1016/J.INDCROP.2017.09.016
Influence of water deficit on the main polysaccharides and the rheological properties of Aloe vera (Aloe barbadensis Miller) mucilage
R. Minjares-Fuentes (2017)
10.1016/j.tifs.2020.02.016
Plant-derived glucomannans: Sources, preparation methods, structural features, and biological properties
Xiaodan Shi (2020)
10.1039/C8RA10347J
Structural characterization and anti-inflammatory effect in hepatocytes of a galactoglucan from Antrodia camphorata mycelium
Huiling Tang (2019)
10.1002/ADMT.201800007
Nonvolatile Memory Device Based on Bipolar and Unipolar Resistive Switching in Bio‐Organic Aloe Polysaccharides Thin Film
Z. Lim (2018)
10.3390/app10072576
Evaluation of Aloe Vera Coated Polylactic Acid Scaffolds for Bone Tissue Engineering
Ricardo Donate (2020)
10.1007/s10924-020-01931-4
Functional Applications of Aloe vera on Textiles: A Review
M. Mondal (2020)
10.1016/j.carbpol.2016.12.034
Acemannan increases NF-κB/DNA binding and IL-6/-8 expression by selectively binding Toll-like receptor-5 in human gingival fibroblasts.
P. Thunyakitpisal (2017)
10.4028/www.scientific.net/KEM.751.649
Flexural Strength and Cytotoxicity of ZCC, a Resin Modified Zinc-Calcium Liner Prototype
P. Thunyakitpisal (2017)
10.1016/j.jds.2018.06.004
Acemannan increased bone surface, bone volume, and bone density in a calvarial defect model in skeletally-mature rats
Dyna Jeanne D. Godoy (2018)
10.18433/J31P52
Role of Glucomannans in Immunology.
R. Tester (2017)
10.1016/j.joen.2017.01.037
Stimulation of Dentin Regeneration by Using Acemannan in Teeth with Lipopolysaccharide‐induced Pulp Inflammation
Siriporn Songsiripradubboon (2017)
10.1016/J.CARBPOL.2019.114998
Effects of UV-C irradiation and traditional thermal processing on acemannan contained in Aloe vera gel blends.
Maylem Z Rodríguez-Rodríguez (2019)
10.1016/j.carbpol.2019.03.014
Purification, characterization and immunomodulatory activity of fructans from Polygonatum odoratum and P. cyrtonema.
P. Zhao (2019)
10.3390/jfb8010006
Aloe Vera for Tissue Engineering Applications
S. Rahman (2017)
10.1016/j.jksus.2020.07.010
Vitamin C Encapsulation by a Gelation Method using Deacetylated Glucomannan as a Matrix
D. H. Wardhani (2020)
10.1088/2053-1591/AAE0BF
Physico-chemical properties of hybrid electrospun nanofibers containing polyvinylpyrrolidone (PVP), propolis and aloe vera
A. B. Moghaddam (2018)
10.1016/j.ijbiomac.2020.07.186
Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids.
Xiao-dan Shi (2020)
See more
Semantic Scholar Logo Some data provided by SemanticScholar