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Interfacial & Colloidal Aspects Of Lipid Digestion.

P. Wilde, B. Chu
Published 2011 · Chemistry, Medicine

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Amongst the main issues challenging the food manufacturing sector, health and nutrition are becoming increasingly important. Global concerns such as obesity, the ageing population and food security will have to be addressed. Food security is not just about assuring food supply, but is also about optimising nutritional delivery from the food that is available [1]. Therefore one challenge is to optimise the health benefits from the lipids and lipid soluble nutrients. Colloid scientists have an affinity for lipids because they are water insoluble, however this presents a challenge to the digestive system, which has to convert them to structures that are less insoluble so they are available for uptake. Despite this, the human digestive system is remarkably effective at digesting and absorbing most lipids. This is primarily driven through maximising energy intake, as lipids possess the highest calorific value, which was a survival trait to survive times of famine, but is now an underlying cause of obesity in developed countries with high food availability. The critical region here is the lipid-water interface, where the key reactions take place to solubilise lipids and lipid soluble nutrients. Digestive lipases have to adsorb to the oil water interface in order to hydrolyse triacylglycerols into fatty acids and mono glycerides, which accumulate at the interface [2], and inhibit lipase activity. Pancreatic lipase, which is responsible for the majority of lipid hydrolysis, also requires the action of bile salts and colipase to function effectively. Bile salts both aid the adsorption of co-lipase and lipase, and help solubilise the lipolysis products which have accumulated at the interface, into mixed micelles composing bile salts and a range of other lipids, to facilitate transport to the gut mucosal surface prior to uptake and absorption. The process can be affected by the lipid type, as shorter chain, fatty acids are more easily absorbed, whereas the uptake of longer chain fatty acids, particularly the very long chain n-3 fatty acids from fish oils are dependent on source and so may depend on food microstructure for optimal uptake [3]. The uptake of some poorly water soluble nutrients are enhanced by the presence of lipids, but the mechanisms are not clear. In addition, controlling the digestion of lipids can be beneficial as slower release of lipids into the bloodstream can reduce risk of cardiovascular disease, and can promote gut feedback processes that reduce appetite. This presents an opportunity to colloid and interfacial science, as there are many unanswered questions regarding the specific physicochemical mechanisms underlying the process of lipid digestion and uptake. I will review our current knowledge of lipid digestion and present examples of how fundamental research in colloidal and interface science is beginning to address these issues. These include the adsorption behaviour of physiological surfactants such as bile salts; interfacial processes by which different polar lipids can influence lipolysis; and the effect of emulsion based delivery systems on cellular uptake of lipid soluble nutrients. A fundamental understanding of these processes is required if we are to develop intelligent design strategies for foods that will deliver optimal nutrition and improved health benefits in order to address the global challenges facing the food sector in the future.
This paper references
10.1021/jf800741w
Effect of interfacial protein cross-linking on the in vitro digestibility of emulsified corn oil by pancreatic lipase.
S. Sandra (2008)
10.1097/MCO.0b013e328337bbf0
Lipid digestion and absorption in early life: an update
S. Lindquist (2010)
10.1007/S11483-005-9001-0
Influence of Interfacial Composition on in Vitro Digestibility of Emulsified Lipids: Potential Mechanism for Chitosan's Ability to Inhibit Fat Digestion
Saehun Mun (2006)
10.1146/ANNUREV.NUTR.17.1.141
Structure and function of pancreatic lipase and colipase.
M. Lowe (1997)
10.1016/J.CIS.2003.10.011
Proteins and emulsifiers at liquid interfaces.
P. Wilde (2004)
10.1016/0141-8130(91)90006-G
Time-dependent polymerization of beta-lactoglobulin through disulphide bonds at the oil-water interface in emulsions.
E. Dickinson (1991)
10.1016/j.cis.2008.06.001
Lipases at interfaces: a review.
P. Reis (2009)
10.1021/la904114u
Adsorption induced enzyme denaturation: the role of polymer hydrophobicity in adsorption and denaturation of alpha-chymotrypsin on allyl glycidyl ether (AGE)-ethylene glycol dimethacrylate (EGDM) copolymers.
Challa Lahari (2010)
10.1111/j.1470-8744.1998.tb00523.x
Surface‐induced changes in the structure and activity of enzymes physically immobilized at solid/liquid interfaces
W. Norde (1998)
10.1016/j.jcis.2010.01.006
Surface adsorption alters the susceptibility of whey proteins to pepsin-digestion.
Amir Malaki Nik (2010)
10.1074/JBC.M009986200
Colipase Residues Glu64 and Arg65 Are Essential for Normal Lipase-mediated Fat Digestion in the Presence of Bile Salt Micelles*
W. Crandall (2001)
10.1016/S1388-1981(01)00196-2
A physicochemical investigation of two phosphatidylcholine/bile salt interfaces: implications for lipase activation.
M. Wickham (2002)
10.1529/biophysj.107.114215
Comparing experimental and simulated pressure-area isotherms for DPPC.
S. L. Duncan (2008)
10.1016/j.bpc.2010.01.005
Interfacial mechanism of lipolysis as self-regulated process.
P. Reis (2010)
10.1016/j.cell.2009.11.005
Lipid Droplets Finally Get a Little R-E-S-P-E-C-T
Robert V Farese (2009)
10.1021/la800551u
Interfacial characterization of beta-lactoglobulin networks: displacement by bile salts.
Julia Maldonado-Valderrama (2008)
Studies on the inhibition of pancreatic and carboxylester lipases by protamine.
T. Tsujita (1996)
10.1002/prot.22109
Computational study of colipase interaction with lipid droplets and bile salt micelles
B. Kerfelec (2008)
10.1021/LA0208629
Conformational Aspects of Proteins at the Air/Water Interface Studied by Infrared Reflection−Absorption Spectroscopy
A. H. Martin (2003)
10.1053/J.GASTRO.2007.03.053
Drug treatment of the overweight patient.
G. Bray (2007)
10.1039/C0SM00300J
In vitro gastric digestion of interfacial protein structures: visualisation by AFM
Julia Maldonado-Valderrama (2010)
10.1007/s11745-006-5060-3
Enhanced incorporation of n−3 fatty acids from fish compared with fish oils
Edel O. Elvevoll (2006)
Pancreatic colipase: chemistry and physiology.
B. Borgström (1979)
10.1016/J.COCIS.2009.11.005
Colloidal aspects of protein digestion
A. Mackie (2010)
10.1038/ijo.2008.166
Effect of ileal fat perfusion on satiety and hormone release in healthy volunteers
P. Maljaars (2008)
10.1016/S0006-3495(96)79536-X
The affinities of procolipase and colipase for interfaces are regulated by lipids.
G. Schmit (1996)
10.1021/BI961331K
Effects of colipase and bile salts on the catalytic activity of human pancreatic lipase. A study using the oil drop tensiometer.
S. Labourdenne (1997)
10.1006/JCIS.1998.5941
Orogenic Displacement of Protein from the Air/Water Interface by Competitive Adsorption.
Mackie (1999)
10.1016/J.CIS.2005.04.002
The role of interactions in defining the structure of mixed protein-surfactant interfaces.
A. Mackie (2005)
10.1021/la9008174
Modulating pancreatic lipase activity with galactolipids: effects of emulsion interfacial composition.
B. Chu (2009)
10.1021/BI0518803
How gastric lipase, an interfacial enzyme with a Ser-His-Asp catalytic triad, acts optimally at acidic pH.
H. Chahinian (2006)
10.1093/AJCN/33.5.1108
Intestinal fat digestion, absorption, and transport. A review.
H. Friedman (1980)
10.1016/S0009-3084(01)00149-9
Surface behaviour of bile salts and tetrahydrolipstatin at air/water and oil/water interfaces.
A. Tiss (2001)
10.1016/j.physbeh.2006.07.020
Appetite suppression through delayed fat digestion
J. Mei (2006)
10.1016/J.BBALIP.2007.10.006
A comparative study on two fungal lipases from Thermomyces lanuginosus and Yarrowia lipolytica shows the combined effects of detergents and pH on lipase adsorption and activity.
A. Aloulou (2007)
10.1016/S0005-2728(09)91002-7
Biochemical and biophysical properties of thylakoid acyl lipids
M. Webb (1991)
10.1074/jbc.M202839200
Mechanisms of Inhibition of Triacylglycerol Hydrolysis by Human Gastric Lipase*
Y. Pafumi (2002)
10.1074/jbc.M512984200
Val-407 and Ile-408 in the β5′-Loop of Pancreatic Lipase Mediate Lipase-Colipase Interactions in the Presence of Bile Salt Micelles*
Angela B Freie (2006)
10.1021/BI00595A001
Inhibition of lipase adsorption at interfaces. Role of bile salt micelles and colipase.
D. Lairon (1978)
10.1016/0021-9797(67)90011-2
Surface chemistry of the monoglyceride-bile salt system: Its relationship to the function of bile salts in fat absorption
K. Dreher (1967)
10.2217/17460875.2.5.547
Inhibiting lipid absorption using basic biopolymers
T. Tsujita (2007)
10.1021/BM0344957
Effect of surfactant type on surfactant--protein interactions at the air-water interface.
P. Gunning (2004)
Chemistry and biology of bile acids
Samrat Mukhopadhyay (2004)
10.1016/S0163-7827(03)00050-X
The digestion of dietary triacylglycerols.
Huiling Mu (2004)
10.1016/j.cis.2010.12.002
The role of bile salts in digestion.
J. Maldonado-Valderrama (2011)
10.1006/JCRS.1998.0193
The Insertion Behaviour of Wheat Puroindoline-a into Diacylgalactosylglycerol Films☆
M. Kooijman (1998)
10.1126/SCIENCE.432636
Watching fat digestion.
J. Patton (1979)
10.1016/j.physbeh.2008.07.018
Ileal brake: A sensible food target for appetite control. A review
P. Maljaars (2008)
10.1007/BF02686006
Effect of nonionic surfactants on Rhizopus homothallicus lipase activity
J. Diaz (2007)
10.1097/MCO.0b013e3280177687
Lipases and lipolysis in the human digestive tract: where do we stand?
M. Armand (2007)
10.1016/0301-4622(93)E0066-E
The main transition of dipalmitoylphosphatidylcholine monolayers: a liquid expanded to solid condensed high order transformation.
N. Denicourt (1994)
10.1042/BJ20061463
Chloroplast membranes retard fat digestion and induce satiety: effect of biological membranes on pancreatic lipase/co-lipase.
P. Albertsson (2007)
10.1021/JF990976Z
Interfacial shear rheology of aged and heat-treated beta-lactoglobulin films: displacement by nonionic surfactant.
S. Roth (2000)
10.1016/0021-9797(85)90116-X
Phase diagrams and NMR studies of some ternary sodium deoxycholate-surfactant-water systems
C. Mesa (1985)
10.1021/la1000446
Adsorption of bile salts and pancreatic colipase and lipase onto digalactosyldiacylglycerol and dipalmitoylphosphatidylcholine monolayers.
B. Chu (2010)
10.1021/JF00038A043
Review of triacylglycerol digestion, absorption and metabolism with respect to Salatrim triacylglycerols
J. R. Hayes (1994)
10.1016/s0021-9258(17)33890-5
Inhibition of pancreatic lipase B activity by taurodeoxycholate and its reversal by colipase.
W. Momsen (1976)
10.1002/prot.20183
Protein unfolding at interfaces: Slow dynamics of α‐helix to β‐sheet transition
A. Sethuraman (2004)
10.1006/PREP.1998.0946
Purification and interfacial behavior of recombinant human gastric lipase produced from insect cells in a bioreactor.
S. Canaan (1998)
10.1016/j.nut.2009.05.001
Food security measurement in cultural pluralism: missing the point or conceptual misunderstanding?
A. Renzaho (2010)
10.1007/s11483-008-9091-6
Influence of Surfactants on Lipase Fat Digestion in a Model Gastro-intestinal System
P. Reis (2008)
10.1039/B811233A
Emulsification alters simulated gastrointestinal proteolysis of β-casein and β-lactoglobulin
A. Macierzanka (2009)
10.1016/J.FOODHYD.2009.08.012
Interactions of milk protein-stabilized oil-in-water emulsions with bile salts in a simulated upper intestinal model
A. Sarkar (2010)
10.1016/S0001-8686(00)00077-4
Interfacial rheological properties of adsorbed protein layers and surfactants: a review.
M. A. Bos (2001)
10.1194/jlr.M600168-JLR200
Antiobesity action of ϵ-polylysine, a potent inhibitor of pancreatic lipase Published, JLR Papers in Press, May 24, 2006.
T. Tsujita (2006)
10.1021/jf100703c
Impact of interfacial composition on physical stability and in vitro lipase digestibility of triacylglycerol oil droplets coated with lactoferrin and/or caseinate.
U. Lesmes (2010)
10.1016/J.COLSURFA.2006.02.009
Molecular dynamics simulations of spontaneous bile salt aggregation
D. B. Warren (2006)
10.1016/s0021-9258(18)61880-0
On the function of bile salts and proteins as cofactors of lipase.
H. Brockerhoff (1971)



This paper is referenced by
10.1016/B978-0-12-801238-3.00044-1
Lipid Digestion and Absorption
P. Wilde (2014)
10.1039/c1fo10193e
Potential biological fate of ingested nanoemulsions: influence of particle characteristics.
D. J. Mcclements (2012)
10.1039/c6fo01708h
Negative effects of divalent mineral cations on the bioaccessibility of carotenoids from plant food matrices and related physical properties of gastro-intestinal fluids.
J. Côrte-Real (2017)
10.1039/c2fo30085k
In vitro study of triglyceride lipolysis and phase distribution of the reaction products and cholesterol: effects of calcium and bicarbonate.
Zahari Vinarov (2012)
Desempenho produtivo, expressão de genes relacionados com o metabolismo de aminoácidos sulfurados e qualidade da carne de tilápias do Nilo na terminação, alimentadas com dietas suplementadas com metionina e taurina
A. V. Urbich (2020)
Analysis of lipid oxidation during digestion by liquid chromatography–mass spectrometric and nuclear magnetic resonance spectroscopic techniques
Marko Tarvainen (2013)
RATIONALIZING NANOEMULSION FORMATION FOR ENCAPSULATION, PROTECTION AND DELIVERY OF BIOACTIVE FOOD COMPONENTS
Y. Yang (2015)
10.3389/fsufs.2020.585160
Structuring Edible Oils With Fumed Silica Particles
C. Whitby (2020)
10.1039/c7fo00308k
Physical-chemical stability and in vitro digestibility of hybrid nanoparticles based on the layer-by-layer assembly of lactoferrin and BSA on liposomes.
W. Liu (2017)
10.4155/tde.13.46
Nanoemulsion-based oral delivery systems for lipophilic bioactive components: nutraceuticals and pharmaceuticals.
D. J. Mcclements (2013)
10.1039/c3fo60380f
Responsiveness of emulsions stabilized by lactoferrin nano-particles to simulated intestinal conditions.
Dafna Meshulam (2014)
10.1016/J.MOLCATB.2013.04.015
Effect of support surface chemistry on lipase adsorption and activity
P. Ye (2013)
10.1016/j.jff.2020.103865
Milk phospholipid antioxidant activity and digestibility: Kinetics of fatty acids and choline release
Zhiguang Huang (2020)
10.1111/IJFS.14356
Dietary interference on the oxidation and hydrolysis of liposomes during in vitro digestion
Junmeng Lu (2020)
10.1016/j.jcis.2013.11.006
Spectroscopic studies of conformational changes of β-lactoglobulin adsorbed on gold nanoparticle surfaces.
T. Winuprasith (2014)
10.1016/J.COCIS.2017.04.002
Molecular simulation of biosurfactants with relevance to food systems
S. Euston (2017)
10.1007/s11095-013-1260-8
Non-linear Increases in Danazol Exposure with Dose in Older vs. Younger Beagle Dogs: The Potential Role of Differences in Bile Salt Concentration, Thermodynamic Activity, and Formulation Digestion
M. U. Anby (2013)
10.1002/jps.24634
In Situ Lipolysis and Synchrotron Small-Angle X-ray Scattering for the Direct Determination of the Precipitation and Solid-State Form of a Poorly Water-Soluble Drug During Digestion of a Lipid-Based Formulation.
J. Khan (2016)
10.1016/j.foodres.2020.109198
Lessons learnt from MyCyFAPP Project: Effect of cystic fibrosis factors and inherent-to-food properties on lipid digestion in foods.
Joaquim Calvo-Lerma (2020)
10.1016/j.foodhyd.2020.105730
Encapsulation of lycopene in emulsions and hydrogel beads using dual modified rice starch: Characterization, stability analysis and release behaviour during in-vitro digestion
Surangna Jain (2020)
10.1016/J.FOOSTR.2013.11.001
Biopolymer composites for engineering food structures to control product functionality
Elke Scholten (2014)
10.3390/CATAL3020401
Enzymatic Catalysis at Interfaces—Heterophase Systems as Substrates for Enzymatic Action
C. Weiss (2013)
10.1007/s00394-015-1044-5
Digestion of starch in a dynamic small intestinal model
M. R. Jaime-Fonseca (2015)
UTILIZATION OF NATURAL EMULSIFIERS AND THEIR DERIVATIVES TO FORMULATE EMULSION-BASED DELIVERY SYSTEMS FOR HYDROPHOBIC NUTRACEUTICALS
C. E. Gumus (2017)
Properties of Surfactants that Govern their Functions and Applications on Lipid Membranes
Mozhgan Nazari (2012)
10.1016/J.FOODHYD.2014.02.007
Influence of cosurfactant on the behavior of structured emulsions under simulated intestinal lipolysis conditions
Y. Li (2014)
10.1016/j.foodchem.2018.03.142
Emulsion droplet crystallinity attenuates early in vitro digestive lipolysis and beta-carotene bioaccessibility.
Samantha M Hart (2018)
16 Hypertriglyceride Induced Acute Pancreatitis
Joshua Lebenson (2017)
10.1039/c1fo10201j
Digestibility and β-carotene release from lipid nanodispersions depend on dispersed phase crystallinity and interfacial properties.
Amir Malaki Nik (2012)
10.1016/j.tifs.2020.08.012
Research progress on liposomes: Application in food, digestion behavior and absorption mechanism
W. Liu (2020)
10.1002/jbm.a.35403
Biomimetic surface modification of polyurethane with phospholipids grafted carbon nanotubes.
D. Tan (2015)
10.1016/J.JFOODENG.2017.07.025
In vitro digestibility of heteroaggregated droplets coated with sodium caseinate and lactoferrin
Guilherme de Figueiredo Furtado (2017)
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