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Translating Glycolytic Metabolism To Innate Immunity In Dendritic Cells.
Mario Cortese, C. Sinclair, B. Pulendran
Published 2014 · Biology, Medicine
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Growing evidence supports a role for glycolysis in immune activation. Everts et al. (2014) now show that TLR-mediated stimulation of dendritic cells rapidly induces glycolysis, which regenerates NADPH and TCA intermediates to support fatty acid production. This enhances ER and Golgi membrane synthesis and innate activation of dendritic cells.
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