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Strategic Approaches For Improving Entrapment Of Hydrophilic Peptide Drugs By Lipid Nanoparticles.

Hong Yuan, Saiping Jiang, Yong-Zhong Du, Jing Miao, Xing-guo Zhang, F. Hu
Published 2009 · Chemistry, Medicine

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In order to introduce hydrophilic peptide drugs into solid lipid nanoparticles (SLN), a technique of combining hydrophobic ion pairing (HIP) and non-aqueous oil-in-oil (O/O) emulsion-evaporation was developed. Leuprolide (LR) was selected as the model drug, while sodium stearate (SA-Na) was used as the negative charged ion pairing material. The formation of leuprolide-sodium stearate (LR-SA-Na) complex was confirmed by differential scanning calorimetry (DSC). It was observed that when the molar ratio of SA-Na/LR reached 2/1, ca 88.5% LR was incorporated into the hydrophobic ion complexes with SA-Na. Compared with the conventional method of solvent diffusion in an aqueous system, the efficiency of LR drug entrapment with SLN increased from 28.0% to 74.6% by the combined technique of HIP and O/O emulsion-evaporation. In vitro drug release tests revealed that employing technique of HIP obviously reduced the burst release and slowed down the rate of drug release. At meanwhile, applying the method of non-aqueous O/O emulsion-evaporation, the longer time of drug release but relatively higher drug burst release ratio was observed in comparison with those by the solvent diffusion method in an aqueous system. The drug entrapment and release behaviors of LR-SA-Na SLN prepared by the O/O emulsion-evaporation method suggested that it could potentially be exploited as an oral delivery system for leuprolide.
This paper references
Drug incorporation and release of water soluble drugs from novel functionalized poly(glycerol adipate) nanoparticles.
S. Puri (2008)
R. H. Müller (2000)
Strategic approaches for overcoming peptide and protein instability within biodegradable nano- and microparticles.
U. Bilati (2005)
Effective protein release from PEG/PLA nano-particles produced by compressed gas anti-solvent precipitation techniques.
P. Caliceti (2004)
E. B. Souto (2004)
F.-Q. Hu (2006)
Cytotoxicity of magnetite-loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles
R. Mueller (1996)
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.
R. Mueller (2002)
Reduction of structural perturbations in bovine serum albumin by non‐aqueous microencapsulation
K. G. Carrasquillo (2001)
Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery.
E. Souto (2004)
Modifying the release of leuprolide from spray dried OED microparticles.
R. Alcock (2002)
Solid lipid nanoparticles (SLN™) based on binary mixtures of liquid and solid lipids: a 1H-NMR study
V. Jenning (2000)
Solid lipid nanoparticles as drug carriers. I. Incorporation and retention of the lipophilic prodrug 3′-azido-3′-deoxythymidine palmitate
H. Heiati (1997)
Preparation of solid lipid nanoparticles with clobetasol propionate by a novel solvent diffusion method in aqueous system and physicochemical characterization.
F. Hu (2002)
Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system.
F. Hu (2005)
V. Jenning (2000)
Non-aqueous encapsulation of excipient-stabilized spray-freeze dried BSA into poly(lactide-co-glycolide) microspheres results in release of native protein.
K. G. Carrasquillo (2001)
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
R. Mueller (2000)
Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain.
S. Yang (1999)
R. H. Müller (2002)
Hydrophobic ion pair formation between leuprolide and sodium oleate for sustained release from biodegradable polymeric microspheres.
S. Choi (2000)
Microencapsulation of human growth hormone within biodegradable polyester microspheres: protein aggregation stability and incomplete release mechanism.
H. Kim (1999)
Preparation and characterization of solid lipid nanoparticles containing peptide.
F. Hu (2004)
G. G. Stokes (1890)
R. H. Müller (1996)
S. Maaßen (1993)
Preparation and characteristics of monostearin nanostructured lipid carriers.
F. Hu (2006)

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A. Ramadan (2010)
Evaluation of bioavailability, efficacy, and safety profile of doxorubicin-loaded solid lipid nanoparticles
Nagaraju M. Patro (2013)
Approaches for enhancing oral bioavailability of peptides and proteins.
J. Renukuntla (2013)
Lipid-based nanocarriers for oral peptide delivery.
Zhigao Niu (2016)
Design and evaluation of a novel nanoparticulate-based formulation encapsulating a HIP complex of lysozyme
Ripal Gaudana (2013)
Hyaluronate/lactoferrin layer-by-layer-coated lipid nanocarriers for targeted co-delivery of rapamycin and berberine to lung carcinoma.
Dalia M Kabary (2018)
Lipid-based nanosuspensions for oral delivery of peptides, a critical review.
Camille Dumont (2018)
Molecular interaction and localization of tocotrienol-rich fraction (TRF) within the matrices of lipid nanoparticles: evidence studies by Differential Scanning Calorimetry (DSC) and Proton Nuclear Magnetic Resonance spectroscopy ((1)H NMR).
Hazem Ali (2010)
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A review on the methods of preparation of pharmaceutical nanoparticles
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E. Aboutaleb (2014)
Quality by design case study 1: Design of 5-fluorouracil loaded lipid nanoparticles by the W/O/W double emulsion - Solvent evaporation method.
Gulin Amasya (2016)
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Camille Dumont (2019)
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C. Pardeshi (2017)
Size-stable solid lipid nanoparticles loaded with Gd-DOTA for magnetic resonance imaging.
Erica M Andreozzi (2013)
In vivo fate of lipid-based nanoparticles.
J. Qi (2017)
Lipo-PEG-PEI complex as an intracellular transporter for protein therapeutics
Yu-Ling Lin (2019)
Controlling the properties of poly(amino ester urethane)–poly(ethylene glycol)–poly(amino ester urethane) triblock copolymer pH/temperature-sensitive hydrogel
C. Huynh (2012)
Development of a pulmonary peptide delivery system using porous nanoparticle-aggregate particles for systemic application.
L. Yang (2013)
Sodium alginate-cross-linked polymyxin B sulphate-loaded solid lipid nanoparticles: Antibiotic resistance tests and HaCat and NIH/3T3 cell viability studies.
P. Severino (2015)
Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method
T. J. Kashi (2012)
Self-emulsifying drug delivery systems in oral (poly)peptide drug delivery
G. Leonavičiūtė (2015)
Solid lipid nanocarriers in drug delivery: characterization and design
H. Mu (2018)
Encapsulation of Vitamin B2 in solid lipid nanoparticles using supercritical CO2
R. Couto (2017)
Development and in vivo evaluation of a new oral nanoparticulate dosage form for leuprolide based on polyacrylic acid
J. Iqbal (2011)
Etude de systèmes lipidiques de délivrance de principes actifs
A. Ramadan (2010)
Nanocarriers protecting toward an intestinal pre-uptake metabolism.
Wongsakorn Suchaoin (2017)
Parenteral Delivery of Peptides and Proteins
H. Agrawal (2011)
Amphiphilic ion pairs of tobramycin with lipoamino acids.
R. Pignatello (2011)
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