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Strategic Approaches For Improving Entrapment Of Hydrophilic Peptide Drugs By Lipid Nanoparticles.

Hong Yuan, Saiping Jiang, Yong-Zhong Du, Jing Miao, Xing-guo Zhang, F. Hu
Published 2009 · Chemistry, Medicine

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In order to introduce hydrophilic peptide drugs into solid lipid nanoparticles (SLN), a technique of combining hydrophobic ion pairing (HIP) and non-aqueous oil-in-oil (O/O) emulsion-evaporation was developed. Leuprolide (LR) was selected as the model drug, while sodium stearate (SA-Na) was used as the negative charged ion pairing material. The formation of leuprolide-sodium stearate (LR-SA-Na) complex was confirmed by differential scanning calorimetry (DSC). It was observed that when the molar ratio of SA-Na/LR reached 2/1, ca 88.5% LR was incorporated into the hydrophobic ion complexes with SA-Na. Compared with the conventional method of solvent diffusion in an aqueous system, the efficiency of LR drug entrapment with SLN increased from 28.0% to 74.6% by the combined technique of HIP and O/O emulsion-evaporation. In vitro drug release tests revealed that employing technique of HIP obviously reduced the burst release and slowed down the rate of drug release. At meanwhile, applying the method of non-aqueous O/O emulsion-evaporation, the longer time of drug release but relatively higher drug burst release ratio was observed in comparison with those by the solvent diffusion method in an aqueous system. The drug entrapment and release behaviors of LR-SA-Na SLN prepared by the O/O emulsion-evaporation method suggested that it could potentially be exploited as an oral delivery system for leuprolide.
This paper references
10.1016/J.JCONREL.2007.09.009
Drug incorporation and release of water soluble drugs from novel functionalized poly(glycerol adipate) nanoparticles.
S. Puri (2008)
Eur
R. H. Müller (2000)
10.1016/J.EJPB.2004.10.006
Strategic approaches for overcoming peptide and protein instability within biodegradable nano- and microparticles.
U. Bilati (2005)
10.1016/J.JCONREL.2003.10.015
Effective protein release from PEG/PLA nano-particles produced by compressed gas anti-solvent precipitation techniques.
P. Caliceti (2004)
Int
E. B. Souto (2004)
Int
F.-Q. Hu (2006)
10.1016/0378-5173(96)04539-5
Cytotoxicity of magnetite-loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles
R. Mueller (1996)
10.1016/S0169-409X(02)00118-7
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.
R. Mueller (2002)
10.1211/0022357011775091
Reduction of structural perturbations in bovine serum albumin by non‐aqueous microencapsulation
K. G. Carrasquillo (2001)
10.1016/J.IJPHARM.2004.02.032
Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery.
E. Souto (2004)
10.1016/S0168-3659(02)00165-7
Modifying the release of leuprolide from spray dried OED microparticles.
R. Alcock (2002)
10.1016/S0378-5173(00)00462-2
Solid lipid nanoparticles (SLN™) based on binary mixtures of liquid and solid lipids: a 1H-NMR study
V. Jenning (2000)
10.1016/S0378-5173(96)04782-5
Solid lipid nanoparticles as drug carriers. I. Incorporation and retention of the lipophilic prodrug 3′-azido-3′-deoxythymidine palmitate
H. Heiati (1997)
10.1016/S0378-5173(02)00081-9
Preparation of solid lipid nanoparticles with clobetasol propionate by a novel solvent diffusion method in aqueous system and physicochemical characterization.
F. Hu (2002)
10.1016/J.COLSURFB.2005.08.005
Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system.
F. Hu (2005)
Int
V. Jenning (2000)
10.1016/S0168-3659(01)00430-8
Non-aqueous encapsulation of excipient-stabilized spray-freeze dried BSA into poly(lactide-co-glycolide) microspheres results in release of native protein.
K. G. Carrasquillo (2001)
10.1016/S0939-6411(00)00087-4
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
R. Mueller (2000)
10.1016/S0168-3659(99)00007-3
Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain.
S. Yang (1999)
Adv
R. H. Müller (2002)
10.1016/S0378-5173(00)00457-9
Hydrophobic ion pair formation between leuprolide and sodium oleate for sustained release from biodegradable polymeric microspheres.
S. Choi (2000)
10.1002/(SICI)1097-0290(19991220)65:6<659::AID-BIT6>3.0.CO;2-9
Microencapsulation of human growth hormone within biodegradable polyester microspheres: protein aggregation stability and incomplete release mechanism.
H. Kim (1999)
10.1016/J.IJPHARM.2003.12.016
Preparation and characterization of solid lipid nanoparticles containing peptide.
F. Hu (2004)
10.1177/001452469000101110
"J."
G. G. Stokes (1890)
Int
R. H. Müller (1996)
Proc
S. Maaßen (1993)
10.1016/J.IJPHARM.2006.01.040
Preparation and characteristics of monostearin nanostructured lipid carriers.
F. Hu (2006)



This paper is referenced by
A study of some lipid-based drug delivery systems
A. Ramadan (2010)
10.1007/s11051-013-2124-1
Evaluation of bioavailability, efficacy, and safety profile of doxorubicin-loaded solid lipid nanoparticles
Nagaraju M. Patro (2013)
10.1016/j.ijpharm.2013.02.030
Approaches for enhancing oral bioavailability of peptides and proteins.
J. Renukuntla (2013)
10.1016/j.addr.2016.04.001
Lipid-based nanocarriers for oral peptide delivery.
Zhigao Niu (2016)
10.3109/10837450.2012.737806
Design and evaluation of a novel nanoparticulate-based formulation encapsulating a HIP complex of lysozyme
Ripal Gaudana (2013)
10.1016/j.colsurfb.2018.05.008
Hyaluronate/lactoferrin layer-by-layer-coated lipid nanocarriers for targeted co-delivery of rapamycin and berberine to lung carcinoma.
Dalia M Kabary (2018)
10.1016/j.ijpharm.2018.02.038
Lipid-based nanosuspensions for oral delivery of peptides, a critical review.
Camille Dumont (2018)
10.1016/j.colsurfb.2010.02.003
Molecular interaction and localization of tocotrienol-rich fraction (TRF) within the matrices of lipid nanoparticles: evidence studies by Differential Scanning Calorimetry (DSC) and Proton Nuclear Magnetic Resonance spectroscopy ((1)H NMR).
Hazem Ali (2010)
10.1155/2011/458128
Encapsulation of Protein-Polysaccharide HIP Complex in Polymeric Nanoparticles
Ripal Gaudana (2011)
A review on the methods of preparation of pharmaceutical nanoparticles
Khosro Adibkia (2010)
10.4172/2157-7439.1000259
Design and Evaluation of Hydrophobic Ion-Pairing Complexation ofLysozyme with Sodium Dodecyl Sulfate for Improved Encapsulation ofHydrophilic Peptides/Proteins by Lipid-Polymer Hybrid Nanoparticles
B. Devrim (2015)
10.1016/j.ejpb.2016.08.005
Development of novel HDL-mimicking α-tocopherol-coated nanoparticles to encapsulate nerve growth factor and evaluation of biodistribution.
P. Prathipati (2016)
10.1016/j.ijpharm.2019.03.001
Self‐emulsifying drug delivery systems: Impact of stability of hydrophobic ion pairs on drug release
Imran Nazir (2019)
10.1002/jbm.a.34890
Improved brain delivery of vincristine using dextran sulfate complex solid lipid nanoparticles: optimization and in vivo evaluation.
E. Aboutaleb (2014)
10.1016/j.ejps.2016.01.003
Quality by design case study 1: Design of 5-fluorouracil loaded lipid nanoparticles by the W/O/W double emulsion - Solvent evaporation method.
Gulin Amasya (2016)
10.1016/j.ijpharm.2019.05.037
In-vitro evaluation of solid lipid nanoparticles: Ability to encapsulate, release and ensure effective protection of peptides in the gastrointestinal tract.
Camille Dumont (2019)
10.3109/21691401.2016.1167703
Ropinirole-dextran sulfate nanoplex for nasal administration against Parkinson’s disease: in silico molecular modeling and in vitro–ex vivo evaluation
C. Pardeshi (2017)
10.1021/bc300605f
Size-stable solid lipid nanoparticles loaded with Gd-DOTA for magnetic resonance imaging.
Erica M Andreozzi (2013)
10.1016/j.drudis.2016.09.024
In vivo fate of lipid-based nanoparticles.
J. Qi (2017)
10.2147/IJN.S188970
Lipo-PEG-PEI complex as an intracellular transporter for protein therapeutics
Yu-Ling Lin (2019)
10.1007/s00396-012-2624-z
Controlling the properties of poly(amino ester urethane)–poly(ethylene glycol)–poly(amino ester urethane) triblock copolymer pH/temperature-sensitive hydrogel
C. Huynh (2012)
10.1016/j.ijpharm.2013.04.077
Development of a pulmonary peptide delivery system using porous nanoparticle-aggregate particles for systemic application.
L. Yang (2013)
10.1016/j.colsurfb.2015.03.049
Sodium alginate-cross-linked polymyxin B sulphate-loaded solid lipid nanoparticles: Antibiotic resistance tests and HaCat and NIH/3T3 cell viability studies.
P. Severino (2015)
10.2147/IJN.S27709
Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method
T. J. Kashi (2012)
10.1517/17425247.2015.1068287
Self-emulsifying drug delivery systems in oral (poly)peptide drug delivery
G. Leonavičiūtė (2015)
10.1080/17425247.2018.1504018
Solid lipid nanocarriers in drug delivery: characterization and design
H. Mu (2018)
10.1016/J.SUPFLU.2016.05.036
Encapsulation of Vitamin B2 in solid lipid nanoparticles using supercritical CO2
R. Couto (2017)
10.3109/10717544.2011.577108
Development and in vivo evaluation of a new oral nanoparticulate dosage form for leuprolide based on polyacrylic acid
J. Iqbal (2011)
Etude de systèmes lipidiques de délivrance de principes actifs
A. Ramadan (2010)
10.2217/nnm-2016-0331
Nanocarriers protecting toward an intestinal pre-uptake metabolism.
Wongsakorn Suchaoin (2017)
10.1016/B978-0-12-384964-9.00011-6
Parenteral Delivery of Peptides and Proteins
H. Agrawal (2011)
10.1016/j.ejmech.2011.02.015
Amphiphilic ion pairs of tobramycin with lipoamino acids.
R. Pignatello (2011)
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