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Effect Of Porous Silica On Sustained Release Behaviors Of PH Sensitive Pluronic F127/poly(acrylic Acid) Hydrogels Containing Tulobuterol.
K. Kim, S. Park
Published 2010 · Chemistry, Medicine
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pH sensitive Pluronic F127 (PF127)/poly(acrylic acid) (PAAc) hydrogels containing tulobuterol-loaded silica were prepared with PF127 content. The effects of the PF127 content and silica on the sustained release behaviors of the PAAc hydrogels were investigated. The results showed that the swelling ratio and rate of the hydrogels were decreased with increasing PF127 content compared with pure PAAc hydrogel, whereas the stability of the hydrogels was enhanced by the addition of PF127 after swelling. The release behaviors of the PAAc hydrogels showed that the release rate of the pure PAAc hydrogels increased as the pH value of the release medium was increased, whereas it decreased with the addition of PF127 due to a decrease in the swelling rate. Also, the hydrogels containing tulobuterol-loaded silica showed more sustained release behaviors, which was attributed to the delayed diffusion rate of the drugs by physical interaction between the drugs and porous silica.
This paper references
Multifunctional polyvinylpyrrolidinone-polyacrylic acid copolymer hydrogels for biomedical applications.
D. Devine (2006)
Benchtop-magnetic resonance imaging (BT-MRI) characterization of push-pull osmotic controlled release systems.
V. Malaterre (2009)
Novel pH-sensitive citrate cross-linked chitosan film for drug controlled release.
X. Shu (2001)
Metal ion sorption and swelling studies of psyllium and acrylic acid based hydrogels
Baljit Singh (2006)
pH-responsive swelling behavior of poly(vinyl alcohol)/poly(acrylic acid) bi-component fibrous hydrogel membranes
X. Jin (2005)
Application of the Weibull distribution function for modeling the kinetics of isothermal dehydration of equilibrium swollen poly (acrylic acid) hydrogel
B. Adnađević (2009)
A mucoadhesive polymer prepared by template polymerization of acrylic acid in the presence of poly(ethylene glycol) macromer
Myung-Kwan Chun (2002)
Synthesis and characterization of cashew gum/acrylic acid nanoparticles
Durcilene A. Silva (2009)
Design of poly(ethylene glycol)-tethered copolymers as novel mucoadhesive drug delivery systems.
Laura Serra (2006)
Magnetically targeted thrombolysis with recombinant tissue plasminogen activator bound to polyacrylic acid-coated nanoparticles.
Yunn-Hwa Ma (2009)
Characterization and release behaviors of porous PCL/Eudragit RS microcapsules containing tulobuterol.
K. Kim (2010)
Preparation and Characterization of pH‐sensitive Hydrogel Film of Chitosan/Poly(acrylic acid) Copolymer
L. Yang (2005)
Preparation and characterization of a novel pH-sensitive chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium
Q. Wang (2009)
Poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) (Pluronic)/poly(ε-caprolactone) (PCL) amphiphilic block copolymeric nanospheres: I. Preparation and characterization
Jung Chul Ha (1999)
Host-guest interaction between swelling clay minerals and poorly water-soluble drugs. 1: Complex formation between a swelling clay mineral and griseofulvin
Tadahito Takahashi (1991)
Poly(ethylene glycol)-containing hydrogels in drug delivery.
N. Peppas (1999)
Effect of clay content on electrostimulus deformation and volume recovery behavior of a clay-chitosan hybrid composite.
Kun-Ho Liu (2007)
Bioadhesion and biocompatibility evaluations of gelatin and polyacrylic acid as a crosslinked hydrogel in vitro
Rosa Ghavamzadeh (2004)
Polymer microspheres for controlled drug release.
S. Freiberg (2004)
Cell proliferation and controlled drug release studies of nanohybrids based on chitosan-g-lactic acid and montmorillonite.
D. Depan (2009)
Hydrogel nanoparticles in drug delivery.
M. Hamidi (2008)
Synthesis of high loading and encapsulation efficient paclitaxel-loaded poly(n-butyl cyanoacrylate) nanoparticles via miniemulsion.
C. Huang (2007)
Radiation preparation of drug carriers based polyacrylic acid (PAAc) using poly(vinyl pyrrolidone) (PVP) as a template polymer
H. A. El-Rehim (2007)
Development of photocrosslinked polyacrylic acid hydrogel as an adhesive for dermatological patches: involvement of formulation factors in physical properties and pharmacological effects.
Y. Onuki (2008)
Microfabricated drug delivery systems: from particles to pores.
S. Tao (2003)
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Yanzhi Song (2014)
Surface molecular imprinting on polypropylene fibers for rhodamine B selective adsorption.
Xiuzhu Xu (2012)
Production and characterization of hierarchical porous silica made using natural rubber as template: Effects of the template removal methods, the pH of production, and the natural rubber sources
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