Online citations, reference lists, and bibliographies.
← Back to Search

Chitosan Nanocapsules: Effect Of Chitosan Molecular Weight And Acetylation Degree On Electrokinetic Behaviour And Colloidal Stability.

M. J. Santander-Ortega, J. M. Peula-García, F. Goycoolea, J. L. Ortega-Vinuesa
Published 2011 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
In recent years, chitosan nanocapsules have shown promising results as carriers for oral drug or peptide delivery. The success in their applicability strongly depends on the stability of these colloidal systems passing through the digestive tract. In gastric fluids, clear stability comes from the high surface charge density of the chitosan shell, which is completely charged at acidic pH values. However, in the intestinal fluid (where the pH is almost neutral) the effective charge of these nanocapsules approaches zero, and the electrostatic forces cannot provide any stabilization. Despite the lack of surface charge, chitosan nanocapsules remain stable in simulated intestinal fluids. Recently, we have demonstrated that this anomalous stability (at zero charge) is owed to short-range repulsive forces that appear between hydrophilic particles when immersed in saline media. The present work examines the influence of the chitosan hydrophobicity, as well as molecular weight, in the stability of different chitosan nanocapsules. A study has been made of the size, polydispersity, electrophoretic mobility, and colloidal stability of eight core-shell nanocapsule systems, in which the chitosan-shell properties have been modified using low-molecular-weight (LMW) and high-molecular-weight (HMW) chitosan chains having different degrees of acetylation (DA). With regard to the stability mediated by repulsive hydration forces, the LMW chitosan provided the best results. In addition, contrary to initial expectations, greater stability (also mediated by hydration forces) was found in the samples formed with chitosan chains of high DA values (i.e. with less hydrophilic chitosan). Finally, a theoretical treatment was also tested to quantify the hydrophilicity of the chitosan shells.
This paper references
10.1016/J.BIOELECHEM.2003.10.018
Interaction of thin wetting films of lecithin with some divalent cations.
M. Karabaliev (2004)
10.1016/0001-8686(82)85006-9
Hydration forces between mica surfaces in electrolyte solutions
R. Pashley (1982)
10.1021/JP803796A
Hofmeister Effects in Colloidal Systems : Influence of the Surface Nature
T. Lopez-Leon (2008)
10.1021/BM0496357
Physicochemical behavior of homogeneous series of acetylated chitosans in aqueous solution: role of various structural parameters.
G. Lamarque (2005)
Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes.
A. Gabizon (1994)
10.1016/0001-8686(96)00297-7
Electrokinetic properties, colloidal stability and aggregation kinetics of polymer colloids
R. Hidalgo-Álvarez (1996)
10.1021/bm800298u
Highly efficient system to deliver taxanes into tumor cells: docetaxel-loaded chitosan oligomer colloidal carriers.
M. Lozano (2008)
10.1016/J.IJPHARM.2006.06.036
Formation of self-organized nanoparticles by lecithin/chitosan ionic interaction.
F. Sonvico (2006)
10.1016/S0927-7765(99)00020-X
The role played by hydration forces in the stability of protein-coated particles: non-classical DLVO behaviour
J. Molina-Bolívar (1999)
10.1021/LA0487141
Hofmeister effects in the restabilization of IgG--latex particles: testing Ruckenstein's theory.
T. López-León (2005)
10.1021/BM015598X
Electrophoretic light scattering studies of chitosans with different degrees of N-acetylation.
S. Strand (2001)
10.1021/BM025724C
Typical physicochemical behaviors of chitosan in aqueous solution.
C. Schatz (2003)
10.1016/0008-6215(95)00208-B
Molecular weight manipulation of chitosan II: prediction and control of extent of depolymerization by nitrous acid
G. Allan (1995)
10.1038/nature04162
Interfaces and the driving force of hydrophobic assembly
D. Chandler (2005)
10.1021/J100823A028
DETECTION OF METAL ION HYDROLYSIS BY COAGULATION. III.1 ALUMINUM2
E. Matijević (1961)
10.1021/BI00510A009
Binding of divalent cations of dipalmitoylphosphatidylcholine bilayers and its effect on bilayer interaction.
L. Lis (1981)
10.1007/S003960050050
Development of positively charged colloidal drug carriers: Chitosan-coated polyester nanocapsules and submicron-emulsions
P. Calvo (1997)
10.1016/J.JCONREL.2005.12.015
Chitosan-PEG nanocapsules as new carriers for oral peptide delivery. Effect of chitosan pegylation degree.
C. Prego (2006)
10.1016/0005-2736(91)90268-D
Uptake of liposomes by cultured mouse bone marrow macrophages: influence of liposome composition and size.
T. Allen (1991)
10.1006/ABIO.1998.2705
Colorimetric determination of chitosan.
R. Muzzarelli (1998)
10.1016/S1773-2247(06)50061-9
Chitosan nanocapsules: a new carrier for nasal peptide delivery
C. Prego (2006)
10.1016/J.COLSURFB.2007.06.002
Electrophoretic mobility and colloidal stability of PLGA particles coated with IgG.
M. J. Santander-Ortega (2007)
10.1163/156856298X00271
Modelling the kinetics of antigen-antibody reactions at particle enhanced optical immunoassays.
M. Quesada (1998)
10.1016/j.jconrel.2009.08.012
Nanoparticles made from novel starch derivatives for transdermal drug delivery.
M. J. Santander-Ortega (2010)
10.1023/A:1012126301290
The Mechanism of Uptake of Biodegradable Microparticles in Caco-2 Cells Is Size Dependent
M. P. Desai (2004)
10.1016/S0168-3659(00)00339-4
Biodegradable polymeric nanoparticles as drug delivery devices.
K. Soppimath (2001)
10.1016/j.jconrel.2008.02.007
Design and production of nanoparticles formulated from nano-emulsion templates-a review.
N. Anton (2008)
10.1016/S0927-7765(99)00157-5
The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration.
Tobío (2000)
10.1016/J.NANO.2005.12.003
Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles.
C. Reis (2006)
10.1016/0378-5173(89)90281-0
Nanocapsule formation by interfacial polymer deposition following solvent displacement
H. Fessi (1989)
10.1016/J.JCIS.2006.07.031
Colloidal stability of pluronic F68-coated PLGA nanoparticles: a variety of stabilisation mechanisms.
M. J. Santander-Ortega (2006)
10.1016/0021-9797(73)90178-1
Kinetics of flocculation of latex particles by human gamma globulin
J. Singer (1973)
10.1016/j.ijpharm.2009.10.018
Polymer-based nanocapsules for drug delivery.
C. E. Mora-Huertas (2010)
10.1016/b978-0-12-391927-4.10024-6
Intermolecular and surface forces
J. Israelachvili (1985)
10.1021/BM061227A
Large and giant vesicles "decorated" with chitosan: effects of pH, salt or glucose stress, and surface adhesion.
F. Quemeneur (2007)
10.1021/LA981445S
How Proteins Stabilize Colloidal Particles by Means of Hydration Forces
J. Molina-Bolívar (1999)
10.1007/s11095-006-9662-5
Long Circulating Poly(Ethylene Glycol)-Decorated Lipid Nanocapsules Deliver Docetaxel to Solid Tumors
M. Khalid (2006)
10.1016/0021-9797(85)90129-8
Inclusion of structural forces in the theory of stability of colloids and films
N. Churaev (1985)
10.1016/J.IJPHARM.2006.10.021
Nanoparticles--a historical perspective.
J. Kreuter (2007)
10.1016/J.JCONREL.2007.09.011
Thermally sensitive cationic polymer nanocapsules for specific cytosolic delivery and efficient gene silencing of siRNA: swelling induced physical disruption of endosome by cold shock.
S. H. Lee (2008)
10.1007/S00396-009-2132-Y
Novel core-shell lipid-chitosan and lipid-poloxamer nanocapsules: stability by hydration forces
M. J. Santander-Ortega (2010)
10.1016/0001-8686(82)85003-3
Strong and weak points in the interpretation of colloid stability
J. Theodoor (1982)
10.1023/A:1012029517394
The Oral Absorption of Micro- and Nanoparticulates: Neither Exceptional Nor Unusual
A. Florence (2004)



This paper is referenced by
10.1038/s41598-018-23064-4
Parameters influencing the size of chitosan-TPP nano- and microparticles
S. Sreekumar (2018)
10.20944/preprints201805.0021.v1
Mesoscopic Modeling of Encapsulation of Capsaicin 2 by Lecithin / Chitosan Liposomal Nanoparticles 3
Ketzasmin Armando Terrón-Mejía (2018)
Microalgae as a new source of chitosans
Derek Latil de Ros (2017)
10.1016/j.colsurfb.2019.110740
The role of the intestinal-protein corona on the mucodiffusion behaviour of new nanoemulsions stabilised by ascorbyl derivatives.
M. Plaza-Oliver (2019)
10.1007/s00396-020-04653-0
Encapsulation of caffeine in polysaccharide oil-core nanocapsules
Viktoria Milkova (2020)
10.3390/biomedicines8090364
Capsaicin-Loaded Chitosan Nanocapsules for wtCFTR-mRNA Delivery to a Cystic Fibrosis Cell Line
A. K. Kolonko (2020)
10.1016/j.ejps.2016.10.012
Formulation of polysaccharide‐based nanoparticles for local administration into the oral cavity
Sara Pistone (2017)
10.1016/j.colsurfb.2016.05.033
Sucrose ester based cationic liposomes as effective non-viral gene vectors for gene delivery.
Y. Zhao (2016)
10.1007/978-1-62703-462-3_9
Stability and aggregation assays of nanoparticles in biological media.
J. Kah (2013)
10.1016/j.ijpharm.2012.06.039
Galactosylated chitosan nanoparticles for hepatocyte-targeted delivery of oridonin.
Dandan Zheng (2012)
10.1016/j.colsurfb.2012.03.006
Erythrocytes load of low molecular weight chitosan nanoparticles as a potential vascular drug delivery system.
W. Fan (2012)
10.1016/j.colsurfb.2011.10.024
Cellular fusion and whitening effect of a chitosan derivative coated liposome.
Yang-wei Wang (2012)
10.1155/2015/415289
Bone Regeneration from PLGA Micro-Nanoparticles
I. Ortega-Oller (2015)
Mucoadhesive Nanocarriers for Nasal Delivery of Vaccines
R. Sonawane (2016)
10.1016/J.JDDST.2017.07.012
Colloids for drug delivery to the brain
M. J. Santander-Ortega (2017)
Engineering lipid nanocapsule systems for intracellular delivery of anticancer drugs
P. Moreno (2014)
10.1021/acs.langmuir.7b00351
PEGylated Nanoemulsions for Oral Delivery: Role of the Inner Core on the Final Fate of the Formulation.
M. J. Santander-Ortega (2017)
10.1016/j.carbpol.2019.115684
Robust enzymatic-mass spectrometric fingerprinting analysis of the fraction of acetylation of chitosans.
J. Wattjes (2020)
10.1517/17425247.2012.647906
Polypeptides and polyaminoacids in drug delivery
J. V. González-Aramundiz (2012)
10.1016/j.ejps.2013.05.008
Hyaluronan nanocapsules as a new vehicle for intracellular drug delivery.
F. Oyarzun-Ampuero (2013)
10.3390/molecules25143156
Technologies and Formulation Design of Polysaccharide-Based Hydrogels for Drug Delivery
G. Auriemma (2020)
10.25177/JNMS.2.1.RA.410
In vitro cytotoxicity studies on galactosylated chitosan nanoparticles for the delivery of oridonin to liver
Jinglong Wang (2019)
10.1016/j.actbio.2018.12.010
Repurposing suramin for the treatment of breast cancer lung metastasis with glycol chitosan-based nanoparticles.
B. Cheng (2019)
Perspective: Oral Drug Delivery Research in Europe
R. Mrsny (2012)
10.1007/s10856-012-4692-5
Preparation and antibiotic drug release of mineralized collagen coatings on titanium
Junjun Tu (2012)
10.1007/s00289-017-2196-7
Preparation and characterization of eugenol-loaded oligochitosan nanoparticles through sol–gel and emulsion/sol–gel methods
M. Shahriari (2017)
10.1007/s13346-017-0400-9
Veterinary vaccine nanotechnology: pulmonary and nasal delivery in livestock animals
Daniella Calderon-nieva (2017)
NUEVOS TRANSPORTADORES DE FARMACOS: NANOCÁPSULAS DE POLIASPARAGINA Y CASEÍNA
F. Farmacia (2012)
10.1016/j.colsurfb.2015.06.001
Complexation and release of DNA in polyplexes formed with reducible linear poly(β-amino esters).
Azahara Rata-Aguilar (2015)
10.1016/j.ijbiomac.2015.04.041
Improvement of crocin stability by biodegradeble nanoparticles of chitosan-alginate.
S. Rahaiee (2015)
10.1016/j.colsurfb.2011.03.020
Development and characterization of nanocapsules comprising dodecyltrimethylammonium chloride and κ-carrageenan.
A. Rosas-Durazo (2011)
10.1007/s00396-012-2669-z
Chitosan-based nanocapsules: physical characterization, stability in biological media and capsaicin encapsulation
F. Goycoolea (2012)
See more
Semantic Scholar Logo Some data provided by SemanticScholar