Online citations, reference lists, and bibliographies.
← Back to Search

Naproxen-eudragit RS100 Nanoparticles: Preparation And Physicochemical Characterization.

Khosro Adibkia, Y. Javadzadeh, S. Dastmalchi, Ghobad Mohammadi, Fatemeh Kari Niri, Mahmood Alaei-Beirami
Published 2011 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The objective of the present study was to formulate naproxen-eudragit RS100 nanoparticles and investigate the physicochemical characteristics of the prepared nanoparticles. The nanoparticles of naproxen with eudragit RS100 were formulated using the solvent evaporation/extraction technique (the single emulsion technique). The effect of several process parameters, i.e., drug/polymer ratio, aqueous phase volume and speed of homogenization were considered on the size of the nanoformulations. The physicochemical characteristics of nanoparticles were studied applying particle size analysis, differential scanning calorimetry, X-ray crystallography, Fourier transform infrared spectroscopy and scanning electron microscopy. The release rate of naproxen from various drug/polymer nanoparticles was investigated as well. All the prepared formulations using eudragit RS100 resulted in nano-range size particles with relative spherical smooth morphology. The nanoparticles of naproxen-eudragit RS100 displayed lower crystallinity. The intermolecular interaction between naproxen and eudragit RS100 was detected in the FT-IR spectrum of the nanoparticles. All the nanoparticles displayed a slowed release pattern with the reduced burst release in comparison with the intact drug powder and physical mixtures of drug and polymer. According of these findings, formulation of the naproxen-eudragit RS100 nanoparticles was able to improve the physicochemical characteristics of the drug and possibly will increase the anti-inflammatory effects of drug following its ocular or intra-joint administration.
This paper references
10.1089/JOP.2007.0039
Inhibition of endotoxin-induced uveitis by methylprednisolone acetate nanosuspension in rabbits.
Khosro Adibkia (2007)
10.1016/J.BIOMATERIALS.2005.12.021
Sustained release of dexamethasone from hydrophilic matrices using PLGA nanoparticles for neural drug delivery.
D. Kim (2006)
10.1016/S0142-9612(02)00080-7
Flurbiprofen-loaded acrylate polymer nanosuspensions for ophthalmic application.
R. Pignatello (2002)
10.1186/1476-511X-8-6
Lipid nanoparticles for transdermal delivery of flurbiprofen: formulation, in vitro, ex vivo and in vivo studies
K. Bhaskar (2009)
10.1016/J.EJPB.2004.05.005
Solid-state characterization and dissolution properties of naproxen-arginine-hydroxypropyl-beta-cyclodextrin ternary system.
P. Mura (2005)
10.1016/J.JCONREL.2004.03.023
Preparation and characterization of propranolol hydrochloride nanoparticles: a comparative study.
N. Ubrich (2004)
10.1002/JPS.2600780118
Preparation of controlled-release microspheres of ibuprofen with acrylic polymers by a novel quasi-emulsion solvent diffusion method.
Y. Kawashima (1989)
10.1080/10611860701453125
Piroxicam nanoparticles for ocular delivery: Physicochemical characterization and implementation in endotoxin-induced uveitis
Khosro Adibkia (2007)
10.1080/026520499288924
Effect of formulation variables on in vitro drug release and micromeritic properties of modified release ibuprofen microspheres.
D. Perumal (1999)
10.1016/J.ADDR.2004.07.003
Nanotechnology: challenging the limit of creativity in targeted drug delivery
V. Lee (2004)
10.1211/0022357023835
Eudragit RL100 nanoparticle system for the ophthalmic delivery of cloricromene
C. Bucolo (2004)
10.1208/s12249-007-9001-0
Effect of Drying Methods on Swelling, Erosion and Drug Release from Chitosan–Naproxen Sodium Complexes
K. S. Bhise (2007)
10.18433/J3D59T
Kinetic analysis of drug release from nanoparticles.
M. Barzegar-Jalali (2008)
10.1016/S0378-5173(99)00335-X
Surface drug removal from ibuprofen-loaded PLA microspheres.
E. Leo (2000)
10.1016/j.jcis.2009.05.025
Preparation and characterization of nanoparticles based on dextran-drug conjugates.
S. Hornig (2009)
10.1016/J.IJPHARM.2004.11.027
PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution.
R. Mainardes (2005)
10.1016/S0142-9612(00)00115-0
The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices.
R. Jain (2000)
10.1016/S0928-0987(02)00057-X
Eudragit RS100 nanosuspensions for the ophthalmic controlled delivery of ibuprofen.
R. Pignatello (2002)
10.1016/J.IJPHARM.2006.01.041
Evaluation of ciprofloxacin-loaded Eudragit RS100 or RL100/PLGA nanoparticles.
K. Dillen (2006)
10.1016/S0928-0987(01)00093-8
The influence of polyvinylpyrrolidone on naproxen complexation with hydroxypropyl-beta-cyclodextrin.
P. Mura (2001)
Nanoparticles in drug delivery.
S. J. Douglas (1987)
10.1016/0168-3659(89)90059-X
Preparation and characterization of microspheres containing the anti-inflammatory agents, indomethacin, ibuprofen, and ketoprofen
R. Bodmeier (1989)
10.1016/j.ejpb.2009.08.002
Effects of liquisolid formulations on dissolution of naproxen.
N. Tiong (2009)



This paper is referenced by
Unusual anti-leukaemia activity of nanoformulated naproxen and other non-steroidal anti-inflammatory drugs
R. Kumar (2016)
10.1016/j.cis.2015.05.003
Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers.
A. Sosnik (2015)
10.5681/apb.2015.010
Comparison of the Analgesic Effect of Diclofenac Sodium-Eudragit(®) RS100 Solid Dispersion and Nanoparticles Using Formalin Test in the Rats.
Khosro Adibkia (2015)
10.1016/J.JDDST.2016.05.004
Physicochemical characterization and antimicrobial evaluation of gentamicin-loaded CaCO3 nanoparticles prepared via microemulsion method
S. M. Dizaj (2016)
10.4274/tjps.52523
Desloratadine-Eudragit® RS100 Nanoparticles: Formulation and Characterization
E. Yenilmez (2017)
10.1007/978-3-030-44925-4
Nanopharmaceuticals: Principles and Applications Vol. 1
V. K. Yata (2020)
10.3109/21691401.2014.953250
Triamcinolone acetonide–Eudragit® RS100 nanofibers and nanobeads: Morphological and physicochemical characterization
Shahriar Payab (2016)
10.4172/2329-9053.1000E112
Preparation of Pharmaceutical Nanobeads and Nanofibers via Electrospinning Method
Khosro Adibkia (2014)
10.1016/j.ijpharm.2016.11.002
Encapsulation of NSAIDs for inflammation management: Overview, progress, challenges and prospects.
W. Badri (2016)
10.1016/j.colsurfb.2019.01.039
Development and characterization of benznidazole nano- and microparticles: A new tool for pediatric treatment of Chagas disease?
Katia P. Seremeta (2019)
10.7324/japs.2017.70418
Mathematical modeling of drug release from swellable polymeric nanoparticles
S. Azadi (2017)
10.1016/j.msec.2020.111315
Taste-masked nanoparticles containing Saquinavir for pediatric oral administration.
Katherine Krieser (2020)
10.1016/J.JDDST.2015.06.015
Box-Behnken experimental design for preparation and optimization of ciprofloxacin hydrochloride-loaded CaCO3 nanoparticles
S. M. Dizaj (2015)
10.4274/tjps.34392
Levocetirizine Dihydrochloride-Loaded Chitosan Nanoparticles: Formulation and In Vitro Evaluation
A. Öztürk (2020)
10.1177/0885328218779705
Gellan gum macrobeads loaded with naproxen: The impact of various naturally derived polymers on pH-dependent behavior
Tomasz Osmałek (2018)
10.1007/s11051-013-1912-y
Eudragit RS PO nanoparticles for sustained release of pyridostigmine bromide
F. Hoobakht (2013)
10.3109/21691401.2014.965309
Methylprednisolone acetate–Eudragit® RS100 electrospuns: Preparation and physicochemical characterization
N. Jafari-Aghdam (2016)
10.5101/nbe.v11i3.p254-263
Preparation and Characterization of Nanoparticulate Drug Delivery System for Naproxen Sodium Using Various Desolvating Agents
H. Syed (2019)
10.3109/21691401.2016.1161637
Ciprofloxacin HCl-loaded calcium carbonate nanoparticles: preparation, solid state characterization, and evaluation of antimicrobial effect against Staphylococcus aureus
Solmaz Maleki Dizaj (2017)
Chitosan-based magnetic nanoparticles for osteosarcoma theranostic
P. P. Soares (2015)
Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988-1991. Hypertension. 25, 305-13. Canadian Hypertension Education Program 2007, CHEP recommendations for the management
Siahi Shadbad (2015)
10.3109/10837450.2015.1108983
Atorvastatin calcium encapsulated eudragit nanoparticles with enhanced oral bioavailability, safety and efficacy profile
N. Kumar (2017)
10.1016/J.JIEC.2012.05.005
Preparation of bionanoparticles derived from Spirulina platensis and its application for Cr (VI) removal from aqueous solutions
G. Dotto (2012)
10.1016/J.COSSMS.2012.10.004
Nanocrystals for the parenteral delivery of poorly water-soluble drugs.
B. Sun (2012)
Cationic nanocapsules containing Eudragit RS100® and its potential for application in nanomedicine
A. Dalcin (2017)
10.1016/j.colsurfb.2014.09.019
Application of electrospraying as a one-step method for the fabrication of triamcinolone acetonide-PLGA nanofibers and nanobeads.
A. Jahangiri (2014)
IN VITRO EVALUATION AND CHARACTERIZATION METHODS FOR SUB-MICRON PARTICULATE DRUG DELIVERY SYSTEMS
Anand S. Ubhe (2015)
Research Article CODEN: IJPRNK ISSN: 2277-8713 Anand S. Ubhe, IJPRBS, 2015; Volume 4(1): 251-264 IJPRBS
Anand S. Ubhe (2015)
10.3109/03639045.2012.694589
A chitosan lactate/poloxamer 407-based matrix containing Eudragit RS microparticles for vaginal delivery of econazole: design and in vitro evaluation
B. Parodi (2013)
10.2147/IJN.S130404
Doxorubicin-loaded poly (lactic-co-glycolic acid) nanoparticles coated with chitosan/alginate by layer by layer technology for antitumor applications
Fujuan Chai (2017)
10.22038/ijbms.2019.34246.8139
Physicochemical and pharmacological evaluation of carvedilol-eudragit® RS100 electrosprayed nanostructures
Sevil Selselehjonban (2019)
10.1016/J.POWTEC.2014.03.014
In vitro and in vivo evaluation of clarithromycin–urea solid dispersions prepared by solvent evaporation, electrospraying and freeze drying methods
Ghobad Mohammadi (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar