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Mixed Micelle Formation With Hydrophobic And Hydrophilic Pluronic Block Copolymers: Implications For Controlled And Targeted Drug Delivery.
S. S. Kulthe, N. Inamdar, Y. Choudhari, S. Shirolikar, L. Borde, V. Mourya
Published 2011 · Chemistry, Medicine
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Pluronic block copolymers offer affluent phase behavioral characteristics and are extensively investigated for drug delivery applications. Hydrophobic Pluronics produce larger aggregates whereas hydrophilic Pluronics often generate small-sized micelles in aqueous milieu. To overcome the limitations and combine the advantages of different kinds of Pluronics the mixing of such two types of Pluronics is studied here, especially for hydrophobic Pluronic L81 and relatively hydrophilic Pluronic P123. Critical micelle concentration (CMC) of the developed binary mixtures was 0.032 mg/ml as evidenced from pyrene fluorescence spectroscopy and is located in between that of the individual Pluronics. Dynamic light scattering (DLS) showed very small particle sizes (∼20 nm) and low polydispersity indices for most of the mixed micelles. Transmission electron microscopy (TEM) demonstrated spherical shape of micelles. Based upon the ratio of hydrophobic and hydrophilic Pluronics, dispersions of varied stability were obtained. With 0.1/1.0 wt.% and 0.5/3.0 wt.% of Pluronic L81/P123, stable dispersions were obtained. Stability was assessed from turbidity measurement, size analysis and clarity of dispersion on standing. Micelles were also found to be stable in bovine serum albumin (BSA) solution. Mixed micelles showed fairly high entrapment efficiency, loading capacity and sustained release profile for aceclofenac (Acl), a model hydrophobe. Presence of salt lowered Acl solubilization in micelles. Thermodynamic parameters for Acl solubilization in mixed micelles revealed high partition coefficient values and spontaneity of drug solubilization. Thus, the developed novel mixed micelles hold promise in controlled and targeted drug delivery owing to their very small size, high entrapment efficiency and stability.
This paper references
G.G. Stokes (1890)
Preparation and characterization of self-aggregated nanoparticles of cholesterol-modified O-carboxymethyl chitosan conjugates
Wang Yinsong (2007)
The effects of mixed MPEG-PLA/Pluronic copolymer micelles on the bioavailability and multidrug resistance of docetaxel.
Chao-Feng Mu (2010)
Environmental-sensitive micelles based on poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) diblock copolymer for application in drug delivery.
Ging-Ho Hsiue (2006)
Block copolymer-based formulation of doxorubicin. From cell screen to clinical trials
V. Alakhov (1999)
Pharmacokinetics and biodistribution of paclitaxel-loaded pluronic P105 polymeric micelles
Yongzhong Wang (2008)
A novel size-tunable nanocarrier system for targeted anticancer drug delivery.
Y. Li (2010)
Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery.
A. Kabanov (2002)
Mixed micelles self-assembled from block copolymers for drug delivery
A. B. E. Attia (2011)
R. Vakil (2006)
Comb-Dendritic Block Copolymers as Tree-Shaped Macromolecular Amphiphiles for Nanoparticle Self-Assembly
L. Tian (2006)
Phase separation of micellar solutions at extreme dilution: A study of polystyrene-b-poly(sodium acrylate) micelles in aqueous NaCl solutions
R. J. Barlow (1996)
Preparation and physicochemical characteristics of self-assembled nanoparticles of deoxycholic acid modified-carboxymethyl curdlan conjugates
F. Gao (2008)
Y. Gao (2008)
Pharmacokinetics and biodistribution of polymeric micelles of paclitaxel with Pluronic P123
Li-mei Han (2006)
Difunctional Pluronic copolymer micelles for paclitaxel delivery: synergistic effect of folate-mediated targeting and Pluronic-mediated overcoming multidrug resistance in tumor cell lines.
Yongzhong Wang (2007)
Salt induced micellization and micelle structures of' PEO/PPO/PEO block copolymers in aqueous solution
N. Jain (2000)
Stealth MePEG-PCL micelles: effects of polymer composition on micelle physicochemical characteristics, in vitro drug release, in vivo pharmacokinetics in rats and biodistribution in S180 tumor bearing mice
Bin Bin Shi (2005)
Y. Kadam (2009)
Preparation and characterization of Pluronic/TPGS mixed micelles for solubilization of camptothecin.
Y. Gao (2008)
Poly(ethylene glycol)-b-Poly(ε-caprolactone) and PEG-Phospholipid Form Stable Mixed Micelles in Aqueous Media
R. Vakil (2006)
Solubilisation of model adjuvants by Pluronic block copolymers.
M. A. Sharp (2010)
Structure and design of polymeric surfactant-based drug delivery systems.
V. Torchilin (2001)
Effect of an amphiphilic diol (Surfynol®) on the micellar characteristics of PEO-PPO-PEO block copolymers in aqueous solutions
Y. Kadam (2010)
Effect of polymer viscosity on physicochemical properties and ocular tolerance of FB-loaded PLGA nanospheres.
J. Araújo (2009)
Micelles based on AB block copolymers of poly(ethylene oxide) and poly(.beta.-benzyl L-aspartate)
G. Kwon (1993)
Paclitaxel-loaded Pluronic P123/F127 mixed polymeric micelles: formulation, optimization and in vitro characterization.
Z. Wei (2009)
Polymeric micelles - a new generation of colloidal drug carriers.
M. Jones (1999)
Pharmaceutical evaluation of genistein-loaded pluronic micelles for oral delivery
Suk Hyung Kwon (2007)
Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers.
E. Batrakova (2008)
Enhanced antitumor efficacy by paclitaxel-loaded pluronic P123/F127 mixed micelles against non-small cell lung cancer based on passive tumor targeting and modulation of drug resistance.
Wei Zhang (2010)
Micellization and solubilization of a model hydrophobic drug nimesulide in aqueous salt solutions of Tetronic T904.
P. Parekh (2011)
Block copolymeric biotransport carriers as versatile vehicles for drug delivery.
V. Alakhov (2001)
Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(beta-amino ester) block copolymer micelles for cancer therapy.
Jinyoung Ko (2007)
Y. Wang (2008)
Hydrotropic agents for study of in vitro paclitaxel release from polymeric micelles.
Yong Woo Cho (2004)
Micelle formation and solubilization of fluorescent probes in poly(oxyethylene-b-oxypropylene-b-oxyethylene) solutions
A. Kabanov (1995)
Multifunctional Pluronic P123/F127 mixed polymeric micelles loaded with paclitaxel for the treatment of multidrug resistant tumors.
Wei Zhang (2011)
Micellar formulations for drug delivery based on mixtures of hydrophobic and hydrophilic Pluronic block copolymers.
K. Oh (2004)
S. Kwon (2007)
A. Attia (2011)
V. Alakhov (1999)
Relationship between pluronic block copolymer structure, critical micellization concentration and partitioning coefficients of low molecular mass solutes
M. Kozlov (2000)
Binary mixing of micelles using Pluronics for a nano-sized drug delivery system.
E. Lee (2011)
Solubilization of poorly water-soluble drug carbamezapine in pluronic micelles: effect of molecular characteristics, temperature and added salt on the solubilizing capacity.
Y. Kadam (2009)
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Andrew M. Bodratti (2018)
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