Online citations, reference lists, and bibliographies.
← Back to Search

Fine-tuning In Mineral Cross-linking Of Biopolymer Nanoparticle For Incorporation And Release Of Cargo.

Yuuka Fukui, Narumi Kabayama, Keiji Fujimoto
Published 2015 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
We developed a mineral cross-linking strategy to prepare a biopolymer-based nanoparticle using calcium phosphate (CaP) as a cross-linker. Nanoparticles were first formed by mixing deoxyribonucleic acid (DNA) with cationic surfactants, and were cross-linked by CaP precipitation. After removal of the surfactants, we carried out the alternative dialysis of nanoparticles against CaCl2 aqueous solution and phosphate buffered solution for further mineral cross-linking. XRD and FT-IR studies revealed that the resultant nanoparticles were produced by mineral cross-linkages of hydroxyapatite (HAp) and the crystal amount and properties such as morphology and crystallinity could be well-controlled by the reaction conditions. Chemical dyes could be incorporated into nanoparticles via their affinities with crystal faces of HAp and DNA. Their release was tunable by crystal amount and properties of mineral cross-linkages. Also, the release could be triggered by mineral dissolution in response to pH. Such a mineral cross-linking will open up a potential way to provide a nanoparticle with versatile functions such as cleavable cross-linking, binding affinity for cargos, and pH-responsive release.
This paper references
Quantitative estimation of protein binding site polarity. Fluorescence of N-arylaminonaphthalenesulfonates.
D. Turner (1968)
Quartz crystal microbalance analysis of DNA-templated calcium phosphate mineralization.
S. C. Ngourn (2012)
Biomimetic nanoparticles with polynucleotide and PEG mixed-monolayers enhance calcium phosphate mineralization
Kayla B. Vasconcellos (2013)
On the determination of the critical micelle concentration by the pyrene 1:3 ratio method
J. Aguiar (2003)
Counter-ion effect on surfactant-DNA gel particles as controlled DNA delivery systems
M. C. Morán (2012)
Effects of calcination temperature on the drug delivery behaviour of Ibuprofen from hydroxyapatite powders
A. J. Melville (2008)
DNA gel particles from single and double-tail surfactants: supramolecular assemblies and release characteristics
M. Morán (2011)
Surfactant-DNA gel particles: formation and release characteristics.
M. C. Morán (2007)
Agglomeration and sedimentation of titanium dioxide nanoparticles (n-TiO2) in synthetic and real waters
Andrea Brunelli (2013)
Nanogel–Calcium Phosphate Hybrid Nanoparticles with Negative or Positive Charges for Potential Biomedical Applications
S. Yamane (2009)
UV-irradiation-induced DNA immobilization and functional utilization of DNA on nonwoven cellulose fabric.
M. Yamada (2001)
The minerals of milk.
F. Gaucheron (2005)
Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer cells.
M. Kester (2008)
Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation.
M. Jordan (1996)
Calcium apatite prepared from calcium hydroxide and orthophosphoric acid
A. Osaka (1991)
Hydrophobic Self-Association of Cholesterol Moieties Covalently Linked to Polyelectrolytes: Effect of Spacer Bond
S. Yusa (1998)
In situ synthesis of polysaccharide nanoparticles via polyion complex of carboxymethyl cellulose and chitosan.
S. Kaihara (2011)
Control in Mineralization by the Polysaccharide-Coated Liposome via the Counter-Diffusion of Ions
Yuuka Fukui (2011)
Synthesis and characterization of a lamellar hydroxyapatite/DNA nanohybrid
G. Zuo (2011)
Self-assembled Nanogel Engineering for Advanced Biomedical Technology
Yoshihiro Sasaki (2012)
The role of surface functional groups in calcium phosphate nucleation on titanium foil: a self-assembled monolayer technique.
Q. Liu (2002)
Self-assembled calcium phosphate nanocomposites using block copolypeptide templates
Y. Hu (2009)
DNA gel particles: particle preparation and release characteristics.
M. C. Morán (2007)
Novel infrared spectroscopic method for the determination of crystallinity of hydroxyapatite minerals.
N. Pleshko (1991)
Robust PEGylated hyaluronic acid nanoparticles as the carrier of doxorubicin: mineralization and its effect on tumor targetability in vivo.
H. Han (2013)
Separation of double-strand DNA fragments by high-performance liquid chromatography using a ceramic hydroxyapatite column
T. Watanabe (1999)
Membrane perturbation: studies employing a calcium-sensitive dye, arsenazo III, in liposomes.
G. Weissmann (1976)
Nanogel‐Templated Mineralization: Polymer‐Calcium Phosphate Hybrid Nanomaterials
A. Sugawara (2006)
Hybrid Nanoapatite by Polysaccharide Nanogel-templated Mineralization
S. Yamane (2009)
Biomimetic self-assembly of calcium phosphate templated by PNIPAAm nanogels for sustained smart drug delivery
J. Shi (2012)
Utilization of DNA as functional materials: preparation of filters containing DNA insolubilized with alginic acid gel.
K. Iwata (1996)
Hydroxyapatite particles as drug carriers for proteins.
Keishiro Tomoda (2010)
Rapid precipitation of apatite from ethanol-water solution
E. Lerner (1989)
Encapsulation of organic molecules in calcium phosphate nanocomposite particles for intracellular imaging and drug delivery.
Thomas T. Morgan (2008)
Nanosized hydroxyapatite and other calcium phosphates: chemistry of formation and application as drug and gene delivery agents.
V. Uskoković (2011)
Selective adsorption of acidic protein of bovine serum albumin onto sheet-like calcium hydroxyapatite particles produced by microreactor
K. Kandori (2014)

This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar